KEGG   PATHWAY: ptg05169
Entry
ptg05169                    Pathway                                
Name
Epstein-Barr virus infection - Panthera tigris altaica (Amur tiger)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
ptg05169  Epstein-Barr virus infection
ptg05169

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102963617  CR2; complement C3d receptor 2 [KO:K04012]
102953595  CD19; CD19 molecule [KO:K06465]
102958869  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
102954326  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
102961248  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
102959725  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102966781  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102956510  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102956041  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102960386  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107178930  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102954602  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102966493  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
102962241  toll-like receptor 2 [KO:K10159]
102964242  toll-like receptor 2 [KO:K10159]
102952059  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102962570  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102960157  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102950874  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102959790  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102963341  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102949289  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102963734  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102956127  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102964232  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102951132  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102958919  TNF; tumor necrosis factor [KO:K03156]
102968780  IL6; interleukin 6 [KO:K05405]
102953066  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:5.6.2.6]
102963414  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
102952767  TRAF3; TNF receptor associated factor 3 [KO:K03174]
102960158  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102963614  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102956602  IRF3; interferon regulatory factor 3 [KO:K05411]
102956750  interferon alpha-2-like [KO:K05414]
102960421  IFNB1; interferon beta 1 [KO:K05415]
102955444  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102954859  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102960189  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102953204  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
102953174  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102967399  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102955306  IRF9; interferon regulatory factor 9 [KO:K04693]
102951575  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
102952232  OAS3; 2'-5'-oligoadenylate synthetase 3 [KO:K14216] [EC:2.7.7.84]
107179395  OAS2; 2'-5'-oligoadenylate synthetase 2 [KO:K14216] [EC:2.7.7.84]
102956896  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
102971262  ISG15; ISG15 ubiquitin-like modifier [KO:K12159]
102958442  FAS; Fas cell surface death receptor [KO:K04390]
102962460  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102951809  BID; BH3 interacting domain death agonist [KO:K04726]
102956471  BCL2L11; BCL2 like 11 [KO:K16341]
102953487  BCL2; BCL2, apoptosis regulator [KO:K02161]
102949153  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102970767  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102966744  cytochrome c 2-like [KO:K08738]
102952864  cytochrome c-like [KO:K08738]
102960081  cytochrome c [KO:K08738]
102964536  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102967404  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102954729  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102969557  CD3E; CD3e molecule [KO:K06451]
102968170  CD3G; CD3g molecule [KO:K06452]
102969057  CD3D; CD3d molecule [KO:K06450]
102948605  CD247; CD247 molecule [KO:K06453]
102972186  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102952413  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102952740  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102963735  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102964237  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102951790  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102970133  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102968765  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102965316  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102960839  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102969027  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
102966651  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102957237  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102949162  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
102952652  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
102972721  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102962507  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102961319  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102970278  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102969103  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653] [EC:7.4.2.14]
102958303  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654] [EC:7.4.2.14]
102949355  TAPBP; TAP binding protein [KO:K08058]
102966352  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
102964419  CALR; calreticulin [KO:K08057]
102959211  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
102970351  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102970631  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102958279  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102965588  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102965871  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102961195  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
102951857  B2M; beta-2-microglobulin [KO:K08055]
102966219  SNW1; SNW domain containing 1 [KO:K06063]
102970041  SIN3A; SIN3 transcription regulator family member A [KO:K11644]
102952507  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102968123  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
102965776  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
102950145  SAP30L; SAP30 like [KO:K19202]
102971093  SAP30; Sin3A associated protein 30 [KO:K19202]
102958409  CIR1; corepressor interacting with RBPJ, 1 [KO:K06066]
102955590  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like [KO:K06053]
102954301  RBPJ; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
102955935  HES1; hes family bHLH transcription factor 1 [KO:K06054]
102950178  RUNX3; runt related transcription factor 3 [KO:K09279]
102954147  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102950246  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
102965880  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102962571  TP53; tumor protein p53 [KO:K04451]
102964051  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102964763  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102951885  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102961097  DDB2; damage specific DNA binding protein 2 [KO:K10140]
102962803  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
102972430  TRAF5; TNF receptor associated factor 5 [KO:K09849]
102953082  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102965070  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102972487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102949853  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102952993  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102967709  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102952603  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102954757  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102964388  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102970106  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
102960153  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102968597  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102948803  NFKBIB; NFKB inhibitor beta [KO:K02581]
102956483  NFKBIE; NFKB inhibitor epsilon [KO:K05872]
102966812  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102949140  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102959159  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102950880  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102963096  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102966802  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102964459  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
102949954  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102966485  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102968191  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102960306  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102960590  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102968482  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102958666  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102960243  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
102962344  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102953346  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102972342  CD40; CD40 molecule [KO:K03160]
102957786  CD44; CD44 molecule (Indian blood group) [KO:K06256]
102951540  ITGAL; integrin subunit alpha L [KO:K05718]
102949148  CD58; CD58 molecule [KO:K06492]
102969345  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102964431  VIM; vimentin [KO:K07606]
102958897  TNFAIP3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
102966280  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
102957987  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102957150  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
102964642  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102972938  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
102968561  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102948492  BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
102962339  BLNK; B-cell linker [KO:K07371]
102963653  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102964396  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102965656  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
102959906  CCND1; cyclin D1 [KO:K04503]
102970259  CCND2; cyclin D2 [KO:K10151]
102970915  CCND3; cyclin D3 [KO:K10152]
102970281  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102967948  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102970677  CCNA1; cyclin A1 [KO:K06627]
102970341  CCNA2; cyclin A2 [KO:K06627]
102955833  CCNE2; cyclin E2 [KO:K06626]
102966425  CCNE1; cyclin E1 [KO:K06626]
102959572  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102952365  RB1; RB transcriptional corepressor 1 [KO:K06618]
102963506  E2F1; E2F transcription factor 1 [KO:K17454]
102952251  E2F2; E2F transcription factor 2 [KO:K09389]
102948948  E2F3; E2F transcription factor 3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
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Cancers (Basel) 10:E213 (2018)
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PLoS Pathog 5:e1000530 (2009)
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Adv Cancer Res 79:175-200 (2000)
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Front Oncol 8:265 (2018)
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J Cell Physiol 196:207-18 (2003)
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Related
pathway
ptg03050  Proteasome
ptg04010  MAPK signaling pathway
ptg04020  Calcium signaling pathway
ptg04064  NF-kappa B signaling pathway
ptg04110  Cell cycle
ptg04115  p53 signaling pathway
ptg04210  Apoptosis
ptg04612  Antigen processing and presentation
ptg04620  Toll-like receptor signaling pathway
ptg04622  RIG-I-like receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04662  B cell receptor signaling pathway
KO pathway
ko05169   
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