KEGG   PATHWAY: rsz04120
Entry
rsz04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Raphanus sativus (radish)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
rsz04120  Ubiquitin mediated proteolysis
rsz04120

Other DBs
GO: 0016567
Organism
Raphanus sativus (radish) [GN:rsz]
Gene
108818023  polyubiquitin 4 [KO:K08770]
108847508  polyubiquitin [KO:K08770]
108826774  polyubiquitin [KO:K08770]
108834411  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108813369  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108845908  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108849457  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108809261  ubiquitin-60S ribosomal protein L40 [KO:K02927]
130505730  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108857085  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
108844451  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
108835781  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
108806864  ubiquitin-40S ribosomal protein S27a-1 [KO:K02977]
108849040  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
108817892  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
130511793  ubiquitin-40S ribosomal protein S27a-3 [KO:K02977]
130512395  ubiquitin-40S ribosomal protein S27a-1 [KO:K02977]
108845042  uncharacterized protein LOC108845042 [KO:K02977]
108817497  ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:6.2.1.45]
108853807  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
108835004  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
108847315  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
108822518  SUMO-activating enzyme subunit 1A [KO:K10684] [EC:6.2.1.45]
108860303  SUMO-activating enzyme subunit 1A-like [KO:K10684] [EC:6.2.1.45]
108813664  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
108835144  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
108843944  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
108814173  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
108818807  ubiquitin-conjugating enzyme E2 1-like [KO:K10573] [EC:2.3.2.23]
108813905  ubiquitin-conjugating enzyme E2 1 [KO:K10573] [EC:2.3.2.23]
108854237  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108823791  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108822539  ubiquitin-conjugating enzyme E2 1-like [KO:K10573] [EC:2.3.2.23]
108822540  ubiquitin-conjugating enzyme E2 1-like [KO:K10573] [EC:2.3.2.23]
108822541  ubiquitin-conjugating enzyme E2 1 [KO:K10573] [EC:2.3.2.23]
108807379  ubiquitin-conjugating enzyme E2 1 [KO:K10573] [EC:2.3.2.23]
108833855  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108835421  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108829040  ubiquitin-conjugating enzyme E2 3 [KO:K10573] [EC:2.3.2.23]
108812412  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
130500861  ubiquitin-conjugating enzyme E2 3-like [KO:K10573] [EC:2.3.2.23]
130504271  ubiquitin-conjugating enzyme E2 3 [KO:K10573] [EC:2.3.2.23]
108857539  ubiquitin-conjugating enzyme E2 19 [KO:K06688] [EC:2.3.2.23]
108834679  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
108840670  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
108809032  ubiquitin-conjugating enzyme E2 19 [KO:K06688] [EC:2.3.2.23]
108812552  ubiquitin-conjugating enzyme E2 19-like [KO:K06688] [EC:2.3.2.23]
108827010  ubiquitin-conjugating enzyme E2 30 isoform X2 [KO:K06689] [EC:2.3.2.23]
108861774  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
108828725  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108840161  ubiquitin-conjugating enzyme E2 30-like [KO:K06689] [EC:2.3.2.23]
108842841  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108860047  probable ubiquitin-conjugating enzyme E2 31 [KO:K06689] [EC:2.3.2.23]
108807278  ubiquitin-conjugating enzyme E2 29 [KO:K06689] [EC:2.3.2.23]
108840282  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108824281  ubiquitin-conjugating enzyme E2 28 isoform X1 [KO:K06689] [EC:2.3.2.23]
108847346  ubiquitin-conjugating enzyme E2 30 [KO:K06689] [EC:2.3.2.23]
108857689  ubiquitin-conjugating enzyme E2 29 [KO:K06689] [EC:2.3.2.23]
108812636  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
108856923  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
108843873  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108859196  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
108848702  ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:2.3.2.23]
108857532  ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:2.3.2.23]
108834653  ubiquitin-conjugating enzyme E2 14-like [KO:K10575] [EC:2.3.2.23]
108839610  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108824244  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108854508  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
108847081  ubiquitin-conjugating enzyme E2 6 [KO:K10576] [EC:2.3.2.23]
108818477  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
108850057  ubiquitin-conjugating enzyme E2 6 isoform X2 [KO:K10576] [EC:2.3.2.23]
130508979  ubiquitin-conjugating enzyme E2 6 [KO:K10576] [EC:2.3.2.23]
108846402  SUMO-conjugating enzyme UBC9 [KO:K10577]
130509179  SUMO-conjugating enzyme UBC9-like [KO:K10577]
108849725  SUMO-conjugating enzyme SCE1 [KO:K10577]
108859786  SUMO-conjugating enzyme SCE1 [KO:K10577]
108832698  SUMO-conjugating enzyme SCE1 [KO:K10577]
108849050  SUMO-conjugating enzyme SCE1 [KO:K10577]
130511792  SUMO-conjugating enzyme SCE1-like [KO:K10577]
108817119  SUMO-conjugating enzyme UBC9 [KO:K10577]
108819176  SUMO-conjugating enzyme UBC9 [KO:K10577]
108823678  constitutive photomorphogenesis protein 10 isoform X1 [KO:K10577]
108833011  SUMO-conjugating enzyme UBC9 [KO:K10577]
108843987  SUMO-conjugating enzyme UBC9-like [KO:K10577]
108806593  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
108819509  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
108822942  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
108844343  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
108820766  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108824346  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108842110  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108838218  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
130499222  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
130494573  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
130511894  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
108835295  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
108814920  ubiquitin-conjugating enzyme E2 36-like isoform X1 [KO:K10580] [EC:2.3.2.23]
108820106  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
108827310  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
108811153  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
130506361  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
108860077  putative ubiquitin-conjugating enzyme E2 38 isoform X1 [KO:K10581] [EC:2.3.2.24]
108860083  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108861432  probable ubiquitin-conjugating enzyme E2 25 isoform X2 [KO:K10581] [EC:2.3.2.24]
108812090  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
108812092  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108820709  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108853821  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
108830343  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
108807642  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 26 [KO:K10581] [EC:2.3.2.24]
108814400  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108862701  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
108812293  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
108858914  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
108830975  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108844134  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
108814556  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
108856813  ubiquitin-conjugating enzyme 15 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108817876  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108840445  probable ubiquitin-conjugating enzyme E2 17 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
130504500  probable ubiquitin-conjugating enzyme E2 17 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108826201  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108854781  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
130505206  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
108812210  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
108836890  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
108863592  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
108841796  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
108821726  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
108847347  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
108819817  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
108860625  E3 ubiquitin-protein ligase UPL1 isoform X1 [KO:K10592] [EC:2.3.2.26]
108825488  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
108839668  E3 ubiquitin-protein ligase UPL1 isoform X1 [KO:K10592] [EC:2.3.2.26]
130500248  E3 ubiquitin-protein ligase UPL1-like [KO:K10592] [EC:2.3.2.26]
108817562  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
108842582  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
108857135  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108857590  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108859541  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
108820916  LOW QUALITY PROTEIN: pre-mRNA-processing factor 19 homolog 1-like [KO:K10599] [EC:2.3.2.27]
108855287  pre-mRNA-processing factor 19 homolog 2 [KO:K10599] [EC:2.3.2.27]
108805976  pre-mRNA-processing factor 19 homolog 2 [KO:K10599] [EC:2.3.2.27]
108847931  pre-mRNA-processing factor 19 homolog 1 [KO:K10599] [EC:2.3.2.27]
130504745  pre-mRNA-processing factor 19 homolog 1-like [KO:K10599] [EC:2.3.2.27]
130506934  pre-mRNA-processing factor 19 homolog 1-like [KO:K10599] [EC:2.3.2.27]
108836467  E3 ubiquitin-protein ligase SINA-like 5 [KO:K04506] [EC:2.3.2.27]
108830257  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
108848911  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
108816955  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
108827790  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
108832124  E3 ubiquitin-protein ligase SINA-like 5 [KO:K04506] [EC:2.3.2.27]
108836535  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
108816857  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
108847083  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
108817014  E3 ubiquitin-protein ligase SINAT4 [KO:K04506] [EC:2.3.2.27]
108853728  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
108830405  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
108833866  E3 ubiquitin-protein ligase SINAT3-like [KO:K04506] [EC:2.3.2.27]
108844202  putative E3 ubiquitin-protein ligase SINAT1 [KO:K04506] [EC:2.3.2.27]
108850608  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
108852072  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
108856696  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
108832478  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
108832482  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
108832504  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
108816898  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
108863104  LOW QUALITY PROTEIN: probable inactive E3 ubiquitin-protein ligase SINAT6 [KO:K04506] [EC:2.3.2.27]
130494964  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
130495272  probable inactive E3 ubiquitin-protein ligase SINAT6 [KO:K04506] [EC:2.3.2.27]
130497419  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
130497474  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SINA-like 1 [KO:K04506] [EC:2.3.2.27]
130504185  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
108815326  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
130508149  E3 ubiquitin-protein ligase SINAT4 [KO:K04506] [EC:2.3.2.27]
108825656  WD repeat-containing protein RUP2 [KO:K10143] [EC:2.3.2.27]
108846440  LOW QUALITY PROTEIN: WD repeat-containing protein RUP1 [KO:K10143] [EC:2.3.2.27]
108813721  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
130500737  LOW QUALITY PROTEIN: WD repeat-containing protein RUP1-like [KO:K10143] [EC:2.3.2.27]
108845586  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
108843925  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
108858691  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
108813690  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
108844376  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
108834467  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
108817672  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
130503895  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
130509818  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
130509819  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
108821764  E4 SUMO-protein ligase PIAL1 [KO:K04706] [EC:2.3.2.-]
108856248  E4 SUMO-protein ligase PIAL1 [KO:K04706] [EC:2.3.2.-]
108855082  E4 SUMO-protein ligase PIAL2 [KO:K04706] [EC:2.3.2.-]
108818246  E4 SUMO-protein ligase PIAL2 [KO:K04706] [EC:2.3.2.-]
130494248  E4 SUMO-protein ligase PIAL1-like [KO:K04706] [EC:2.3.2.-]
130509094  E4 SUMO-protein ligase PIAL1-like [KO:K04706] [EC:2.3.2.-]
108805945  ERAD-associated E3 ubiquitin-protein ligase HRD1A-like isoform X2 [KO:K10601] [EC:2.3.2.27]
108805971  ERAD-associated E3 ubiquitin-protein ligase HRD1A-like isoform X1 [KO:K10601] [EC:2.3.2.27]
108834064  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
108859199  uncharacterized protein LOC108859199 isoform X1 [KO:K10606] [EC:2.3.2.27]
108827876  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108817515  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108846167  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
130509350  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
108847646  cullin-1 [KO:K03347]
108828214  cullin-1 [KO:K03347]
108828239  cullin-1 [KO:K03347]
130506496  cullin-1-like [KO:K03347]
108860399  SKP1-like protein 13 [KO:K03094]
108821330  SKP1-like protein 13 [KO:K03094]
108824518  SKP1-like protein 8 [KO:K03094]
108826356  SKP1-like protein 14 [KO:K03094]
108860520  SKP1-like protein 13 [KO:K03094]
108807563  SKP1-like protein 4 [KO:K03094]
108816544  SKP1-like protein 1A [KO:K03094]
108833071  SKP1-like protein 1A [KO:K03094]
108838796  SKP1-like protein 4 [KO:K03094]
108812204  SKP1-like protein 18 [KO:K03094]
108818008  SKP1-like protein 1A [KO:K03094]
108818009  SKP1-like protein 1A [KO:K03094]
108820457  SKP1-like protein 1A [KO:K03094]
108846401  SKP1-like protein 1B [KO:K03094]
108818438  SKP1-like protein 1A [KO:K03094]
108833643  SKP1-like protein 1B [KO:K03094]
108817317  F-box protein SKP2B [KO:K03875]
108821994  F-box protein SKP2A [KO:K03875]
108821995  F-box protein SKP2A-like [KO:K03875]
108817460  F-box protein SKP2B [KO:K03875]
108824395  uncharacterized protein LOC108824395 [KO:K03872]
130504880  uncharacterized protein LOC130504880 [KO:K03872]
130508983  uncharacterized protein LOC130508983 [KO:K03872]
108835588  uncharacterized protein LOC108835588 [KO:K03873]
108822488  cullin-3A [KO:K03869]
108808004  cullin-3A [KO:K03869]
130503271  cullin-3A-like [KO:K03869]
108845591  putative cullin-like protein 4 [KO:K10609]
108812384  cullin-4 isoform X1 [KO:K10609]
108828439  cullin-4 [KO:K10609]
130509418  cullin-like protein 5 [KO:K10609]
108818670  DNA damage-binding protein 1b [KO:K10610]
108827795  DNA damage-binding protein 1a [KO:K10610]
108840612  protein DAMAGED DNA-BINDING 2 [KO:K10140]
108809168  WD repeat-containing protein ATCSA-1 isoform X1 [KO:K10570]
108844021  light-mediated development protein DET1 [KO:K10571]
108849279  anaphase-promoting complex subunit 11 isoform X2 [KO:K03358]
108809128  anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
108860542  anaphase-promoting complex subunit 11-like [KO:K03358]
108817926  anaphase-promoting complex subunit 2 [KO:K03349]
108850650  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2 [KO:K03349]
108816726  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
108846027  cell division cycle 20.2, cofactor of APC complex-like isoform X1 [KO:K03363]
108833086  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
108825105  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
108834813  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
108855600  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
130506456  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
130510432  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
108823454  protein FIZZY-RELATED 1 [KO:K03364]
108843006  protein FIZZY-RELATED 2 [KO:K03364]
108849551  protein FIZZY-RELATED 2-like [KO:K03364]
108849599  protein FIZZY-RELATED 2-like [KO:K03364]
108846084  protein FIZZY-RELATED 1 [KO:K03364]
108844659  protein FIZZY-RELATED 3 [KO:K03364]
130509853  protein FIZZY-RELATED 1-like [KO:K03364]
108834336  anaphase-promoting complex subunit 1 [KO:K03348]
108817235  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
108859209  cell division cycle protein 27 homolog A isoform X2 [KO:K03350]
108813553  cell division cycle protein 27 homolog B [KO:K03350]
108826887  anaphase-promoting complex subunit 4 [KO:K03351]
108843877  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
130494754  anaphase-promoting complex subunit 5 [KO:K03352]
108827731  anaphase-promoting complex subunit 6 [KO:K03353]
108813562  anaphase-promoting complex subunit 7 [KO:K03354]
108812267  anaphase-promoting complex subunit 8 isoform X1 [KO:K03355]
108862576  anaphase-promoting complex subunit 10 [KO:K03357]
108816266  anaphase-promoting complex subunit 13 [KO:K12456]
108836704  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
rsz03050  Proteasome
KO pathway
ko04120   
LinkDB

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