KEGG   PATHWAY: sara04062
Entry
sara04062                   Pathway                                
Name
Chemokine signaling pathway - Sorex araneus (European shrew)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
sara04062  Chemokine signaling pathway
sara04062

Other DBs
GO: 0070098
Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101544994  growth-regulated protein homolog [KO:K05505]
101545791  growth-regulated protein homolog gamma-like [KO:K05505]
101546583  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
101546322  PPBP; platelet basic protein [KO:K10029]
101559441  CXCL8; interleukin-8 [KO:K10030]
101557469  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101542348  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101542075  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101548656  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101539189  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101546534  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101546055  platelet factor 4 [KO:K05407]
101538897  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101539445  cytokine SCM-1 beta-like [KO:K05507]
101536982  CX3CL1; fractalkine [KO:K05508]
101545218  C-C motif chemokine 2-like [KO:K14624]
101542043  C-C motif chemokine 2-like [KO:K14624]
101547856  C-C motif chemokine 3-like [KO:K05408]
101548395  C-C motif chemokine 3-like [KO:K05408]
101548127  C-C motif chemokine 3-like [KO:K05408]
101549187  C-C motif chemokine 4 isoform X1 [KO:K12964]
101548921  CCL5; C-C motif chemokine 5 [KO:K12499]
101551722  C-C motif chemokine 5-like [KO:K05510]
105943012  C-C motif chemokine 4 homolog [KO:K05510]
101542314  eotaxin-like [KO:K16596]
101542581  C-C motif chemokine 8-like [KO:K16596]
101542838  C-C motif chemokine 13 [KO:K16595]
101547315  CCL14; C-C motif chemokine 14 [KO:K21092]
101547054  CCL16; C-C motif chemokine 16 [KO:K21093]
101539467  CCL19; C-C motif chemokine 19 [KO:K05512]
101544428  CCL20; C-C motif chemokine 20 [KO:K14625]
101547363  CCL21; C-C motif chemokine 21 [KO:K16062]
101537248  CCL22; C-C motif chemokine 22 [KO:K21095]
101552948  CCL24; C-C motif chemokine 24 [KO:K21097]
101552677  CCL26; C-C motif chemokine 26 [KO:K21096]
101539198  CCL27; C-C motif chemokine 27 [KO:K16598]
101548837  CCL28; C-C motif chemokine 28 [KO:K05513]
101555581  C-X-C chemokine receptor type 2-like [KO:K05050]
101546688  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101547089  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101549004  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101553885  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101553622  XCR1; chemokine XC receptor 1 [KO:K04193]
101540574  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101540315  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101553829  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101554411  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101555452  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101545219  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101549920  CCR2; C-C chemokine receptor type 2 [KO:K04177]
101553092  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101553361  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101550176  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101556532  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101550196  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101553455  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101554357  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101550386  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101552896  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101552185  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101544375  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101538556  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101545200  guanine nucleotide-binding protein G(i) subunit alpha-like [KO:K04630]
101545636  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101557843  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101539413  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101547055  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101539776  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101551819  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101549131  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101543858  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101550559  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101551730  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101539926  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101555578  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101546696  cAMP-dependent protein kinase catalytic subunit-like [KO:K04345] [EC:2.7.11.11]
101554719  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
101544577  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101556901  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
101539494  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101553821  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101550526  SHC2; SHC-transforming protein 2 [KO:K17447]
101550468  SHC3; SHC-transforming protein 3 [KO:K17448]
101537303  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101539743  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101551468  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101537808  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101557147  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101556693  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101550362  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101543163  RELA; transcription factor p65 [KO:K04735]
101549930  BAD; bcl2-associated agonist of cell death [KO:K02158]
101541306  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101536841  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101544431  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
101549936  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
101550254  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101555118  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101553997  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101546136  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101540617  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101552109  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
101544191  transforming protein RhoA [KO:K04513]
101557527  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
101540987  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101539253  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101542668  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101556740  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101547419  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101556046  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101542101  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101537346  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101539394  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101558836  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101548469  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101558565  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101550798  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101555375  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
101550515  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
101540332  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101540304  PXN; paxillin [KO:K05760]
101557104  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
101543637  CRK; adapter molecule crk isoform X1 [KO:K04438]
101547306  CRKL; crk-like protein [KO:K04438]
101544808  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101557809  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101551223  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101546811  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101547690  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101559179  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101554088  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101552845  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101543770  RAP1A; ras-related protein Rap-1A [KO:K04353]
101545287  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101553504  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
101541293  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101547658  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
101547708  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101546517  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101549164  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
101552242  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
101549489  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101548616  ADRBK1; beta-adrenergic receptor kinase 1 isoform X2 [KO:K00910] [EC:2.7.11.15]
101554686  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
101553961  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101537836  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
101548295  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101538489  ARRB1; beta-arrestin-1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
sara04010  MAPK signaling pathway
sara04060  Cytokine-cytokine receptor interaction
sara04120  Ubiquitin mediated proteolysis
sara04630  JAK-STAT signaling pathway
sara04670  Leukocyte transendothelial migration
sara04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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