KEGG   PATHWAY: shon04014
Entry
shon04014                   Pathway                                
Name
Ras signaling pathway - Sturnira hondurensis
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
shon04014  Ras signaling pathway
shon04014

Other DBs
GO: 0032318
Organism
Sturnira hondurensis [GN:shon]
Gene
118977074  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118988493  TGFA; protransforming growth factor alpha [KO:K08774]
118998653  FGF1; fibroblast growth factor 1 [KO:K18496]
118995576  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
118980540  FGF9; fibroblast growth factor 9 [KO:K04358]
118996740  FGF16; fibroblast growth factor 16 [KO:K04358]
118981674  FGF10; fibroblast growth factor 10 [KO:K04358]
118990454  FGF5; fibroblast growth factor 5 [KO:K04358]
118998373  FGF4; fibroblast growth factor 4 [KO:K04358]
118998410  FGF3; fibroblast growth factor 3 [KO:K04358]
118975163  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118999542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119000021  FGF6; fibroblast growth factor 6 [KO:K04358]
118984625  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
118992607  FGF7; fibroblast growth factor 7 [KO:K04358]
118992994  FGF20; fibroblast growth factor 20 [KO:K04358]
118994948  FGF18; fibroblast growth factor 18 [KO:K04358]
118998372  FGF19; fibroblast growth factor 19 [KO:K22603]
118999897  FGF23; fibroblast growth factor 23 [KO:K22428]
118982016  NGF; beta-nerve growth factor [KO:K02582]
118983123  BDNF; brain-derived neurotrophic factor [KO:K04355]
119002400  NTF3; neurotrophin-3 [KO:K04356]
118988340  INS; insulin [KO:K04526]
119002367  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118988333  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
118995064  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119002339  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
119000403  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118995347  PDGFC; platelet-derived growth factor C [KO:K05450]
118981911  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118999914  KITLG; kit ligand isoform X1 [KO:K05461]
118993927  VEGFA; vascular endothelial growth factor A [KO:K05448]
118991667  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118976883  PGF; placenta growth factor isoform X1 [KO:K16859]
118993053  VEGFC; vascular endothelial growth factor C [KO:K05449]
118987248  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
119000987  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118988598  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118999042  ANGPT2; angiopoietin-2 [KO:K05466]
118985591  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
118990168  EFNA1; ephrin-A1 [KO:K05462]
118990172  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118990174  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
118984407  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
118977270  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118983507  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118993177  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118996291  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118987768  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118999740  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118978151  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118979587  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118987715  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118992013  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118978642  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118986157  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118986159  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118978582  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118995806  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118986919  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118995808  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118995107  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118978574  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118996978  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
118986305  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119000762  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118995432  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
118990179  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118984370  SHC2; SHC-transforming protein 2 [KO:K17447]
118993733  SHC3; SHC-transforming protein 3 [KO:K17448]
118992600  SHC4; SHC-transforming protein 4 [KO:K17449]
118991117  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118992372  SOS2; son of sevenless homolog 2 [KO:K03099]
119001478  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118985484  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118983037  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118993611  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
118991686  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
119001280  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118976320  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
118995118  uncharacterized protein LOC118995118 [KO:K10784]
118992968  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
118987970  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
118998185  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118992860  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119002185  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118995666  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118992638  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
118992392  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118991623  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118980656  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118997366  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119001978  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118984459  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118995956  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118979604  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118980212  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
118987353  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118984142  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
118984613  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118978877  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118987352  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118978071  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118997372  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118984085  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118991856  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
118977267  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
118980121  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119002924  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118978468  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118990028  calmodulin-1 [KO:K02183]
118998106  CALML6; calmodulin-like protein 6 [KO:K02183]
118999921  calmodulin-alpha-like [KO:K02183]
118976572  CALM1; calmodulin-1 [KO:K02183]
118992351  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
119000796  calmodulin-A-like [KO:K02183]
119000797  CALML3; calmodulin-like protein 3 [KO:K02183]
119001010  calmodulin-2/4 [KO:K02183]
119001255  CALM2; calmodulin-2 [KO:K02183]
118995942  CALM3; calmodulin-3 [KO:K02183]
118982230  HRAS; GTPase HRas isoform X1 [KO:K02833]
118978497  KRAS; GTPase KRas isoform X1 [KO:K07827]
118981977  NRAS; GTPase NRas [KO:K07828]
118997527  MRAS; ras-related protein M-Ras [KO:K07831]
118989732  RRAS2; ras-related protein R-Ras2 [KO:K07830]
119003416  NF1; neurofibromin isoform X1 [KO:K08052]
118977386  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
118990759  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
118984267  RASA3; ras GTPase-activating protein 3 [KO:K12380]
118992827  ras GTPase-activating protein 4 isoform X1 [KO:K17630]
118991494  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
118991124  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
118979121  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
118993280  RASAL3; RAS protein activator like-3 [KO:K17634]
118989445  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
119001649  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
118985521  STK4; serine/threonine-protein kinase 4 [KO:K04411]
118983246  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118995001  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119002327  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119002854  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118980972  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118996645  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
118976301  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
118990866  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118993596  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
118989480  RHOA; transforming protein RhoA [KO:K04513]
118997522  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118986375  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118995662  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118982454  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118975178  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118998595  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118988441  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119003271  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118988089  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118994325  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118999523  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118993207  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118979949  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118991736  RELA; transcription factor p65 [KO:K04735]
118991674  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
118985337  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118979183  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118993925  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
118994369  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
118985472  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
118980105  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
118979273  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
118991487  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
119001847  ras-related protein Ral-A-like [KO:K07834]
118994012  RALA; ras-related protein Ral-A [KO:K07834]
118989536  RALB; ras-related protein Ral-B [KO:K07835]
119001060  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
118987399  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
119003791  EXOC2; exocyst complex component 2 [KO:K17637]
118998723  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
118988401  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
118976281  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118994117  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118995102  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118989987  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
118977719  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118998349  AFDN; afadin isoform X1 [KO:K05702]
118999421  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
118990300  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118992336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118984505  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119000423  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119001903  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118986587  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
118991305  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118991355  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118977080  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118977747  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118977750  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
118977764  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
118977774  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
118977813  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
118977820  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
118993466  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
119002062  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
118979140  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
119002165  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
118991645  phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118991681  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
118998304  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
118981504  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
118984827  ETS2; protein C-ets-2 [KO:K21932]
118991101  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
119003610  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
118991336  kinase suppressor of Ras 2-like [KO:K18529] [EC:2.7.11.1]
118991337  kinase suppressor of Ras 2-like [KO:K18529] [EC:2.7.11.1]
118982036  RAP1A; ras-related protein Rap-1A [KO:K04353]
118989371  RAP1B; ras-related protein Rap-1b [KO:K07836]
118987999  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
119003729  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119004000  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118986634  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
118991773  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
118980343  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
118979207  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
119004015  RAB5A; ras-related protein Rab-5A [KO:K07887]
118975928  RAB5B; ras-related protein Rab-5B [KO:K07888]
118977983  RAB5C; ras-related protein Rab-5C [KO:K07889]
118992368  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
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pathway
shon04010  MAPK signaling pathway
shon04015  Rap1 signaling pathway
shon04020  Calcium signaling pathway
shon04144  Endocytosis
shon04151  PI3K-Akt signaling pathway
shon04660  T cell receptor signaling pathway
shon04720  Long-term potentiation
shon04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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