Entry
Name
Salmonella infection - Xiphias gladius (swordfish)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Xiphias gladius (swordfish) [GN:
xgl ]
Gene
120794582 plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
120803106 vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
120787454 vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
120789247 vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
120805788 vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
120790076 vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
120798531 dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415 ]
120801854 dync1i2a; dynein, cytoplasmic 1, intermediate chain 2a [KO:K10415 ]
120791733 dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
120786190 dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416 ]
120796841 dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
120783058 dynlrb1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419 ]
120799066 FYVE and coiled-coil domain-containing protein 1-like isoform X1 [KO:K21954 ]
120790750 fyco1a; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
120803623 plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
120794855 exoc7; LOW QUALITY PROTEIN: exocyst complex component 7 [KO:K07195 ]
120785033 ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
120800309 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
120795309 neuroblast differentiation-associated protein AHNAK-like [KO:K23934 ]
120807186 elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
120805274 myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351 ]
120804661 myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
120802566 myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756 ]
120785959 mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758 ]
120797205 si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
120792559 fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
120807080 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
120791035 cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749 ]
120802797 wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
120797474 zgc:109889; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
120800249 wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
120790144 wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083 ]
120784547 zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757 ]
120797016 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
120791340 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
120791909 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
120804015 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
120804053 si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
120798781 pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
120792700 pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
120793021 pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
120807452 pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
120800722 waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612 ]
120792090 toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
120789782 myeloid differentiation primary response protein MyD88-like [KO:K04729 ]
120800783 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
120789016 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
120791244 tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
120795821 nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734 ]
120785165 LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580 ]
120784263 nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
120789116 hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079 ]
120786834 map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
120793976 map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
120789444 fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379 ]
120786357 tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156 ]
120784265 tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156 ]
120804310 si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
120784104 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
120799817 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
120790035 tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
120795438 tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721 ]
120806581 tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722 ]
120784018 pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
xgl04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs