KEGG   PATHWAY: pcad04510
Entry
pcad04510                   Pathway                                
Name
Focal adhesion - Physeter macrocephalus (sperm whale)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pcad04510  Focal adhesion
pcad04510

Other DBs
GO: 0005925
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973456  MYL10; myosin regulatory light chain 10 [KO:K12756]
102973544  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102973743  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102973790  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
102974010  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
102974155  LAMA5; laminin subunit alpha-5 [KO:K06240]
102974221  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102974315  SHC2; SHC-transforming protein 2 [KO:K17447]
102974331  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102974383  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102974530  [KO:K04349]
102974557  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102974655  BAD; bcl2-associated agonist of cell death [KO:K02158]
102974736  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102975066  PXN; paxillin isoform X2 [KO:K05760]
102975231  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102975311  SPP1; osteopontin [KO:K06250]
102975365  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102975458  JUN; transcription factor Jun [KO:K04448]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102975576  COMP; cartilage oligomeric matrix protein [KO:K04659]
102975888  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102976041  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
102976346  VAV1; proto-oncogene vav [KO:K05730]
102976519  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102976588  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
102976778  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102976793  ITGB7; integrin beta-7 [KO:K06590]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102977227  THBS4; thrombospondin-4 [KO:K04659]
102977392  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102977417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102977456  SHC3; SHC-transforming protein 3 [KO:K17448]
102977795  ITGA2; integrin alpha-2 [KO:K06481]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102977938  ITGA4; integrin alpha-4 [KO:K06483]
102977968  CAV2; caveolin-2 [KO:K12958]
102978005  [KO:K04409] [EC:2.7.11.1]
102978142  FN1; fibronectin isoform X1 [KO:K05717]
102978151  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102978243  CAV1; caveolin-1 isoform X1 [KO:K06278]
102978378  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
102978462  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
102978518  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
102978662  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102978702  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102978798  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102978896  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102979195  [KO:K04392]
102979244  PGF; placenta growth factor isoform X1 [KO:K16859]
102979304  [KO:K06238]
102979827  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
102980033  VWF; von Willebrand factor [KO:K03900]
102980052  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
102980106  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
102980129  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
102980344  RAP1B; ras-related protein Rap-1b [KO:K07836]
102980523  VEGFD; vascular endothelial growth factor D [KO:K05449]
102980851  ITGAV; integrin alpha-V [KO:K06487]
102981261  [KO:K05740]
102981359  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102981656  LAMA2; laminin subunit alpha-2 [KO:K05637]
102981677  [KO:K03099]
102981679  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102981700  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102981740  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102981826  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
102981991  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102982121  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102982140  ZYX; zyxin [KO:K06273]
102982196  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102982229  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102982276  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102982293  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102982405  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102982420  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
102982443  LAMC2; laminin subunit gamma-2 [KO:K06246]
102982672  ITGB8; integrin beta-8 [KO:K06591]
102982705  LAMC1; laminin subunit gamma-1 [KO:K05635]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102983001  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102983025  VCL; vinculin isoform X2 [KO:K05700]
102983046  ITGA5; integrin alpha-5 [KO:K06484]
102983262  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102983557  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102983639  RHOA; transforming protein RhoA [KO:K04513]
102983841  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102983882  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102984074  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102984195  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102984346  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102984497  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
102984551  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102984702  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
102984741  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102984824  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102984868  TNXB; tenascin-X isoform X1 [KO:K06252]
102985243  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
102985262  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
102985278  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
102985349  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102985354  MYL5; myosin light chain 5 [KO:K12753]
102985630  TLN2; talin-2 [KO:K06271]
102985661  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102985793  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102986411  VTN; vitronectin [KO:K06251]
102986665  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
102986674  TNN; tenascin-N isoform X1 [KO:K06252]
102986739  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
102986785  KDR; vascular endothelial growth factor receptor 2 isoform X5 [KO:K05098] [EC:2.7.10.1]
102986916  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
102986927  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102987028  FLNB; filamin-B isoform X1 [KO:K27392]
102987074  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
102987169  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102987227  CTNNB1; catenin beta-1 [KO:K02105]
102987332  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102987349  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102987522  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102987616  TNR; tenascin-R [KO:K06252]
102987626  PARVG; gamma-parvin [KO:K06275]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102987884  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102987916  PARVB; beta-parvin isoform X4 [KO:K06275]
102987942  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102988048  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102988075  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
102988564  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102988652  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
102988692  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102988740  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
102988864  FLNA; filamin-A [KO:K04437]
102988868  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102988905  [KO:K05692]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102989664  [KO:K06247]
102989754  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102989853  [KO:K07836]
102989984  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
102990087  [KO:K04456] [EC:2.7.11.1]
102990100  CRKL; crk-like protein [KO:K04438]
102990192  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990518  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102990550  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102990552  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102990690  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102990722  [KO:K06271]
102991062  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102991486  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102991626  CAV3; caveolin-3 [KO:K12959]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102992196  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102992323  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
102992382  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102992464  EMP1; epithelial membrane protein 1 [KO:K26255]
102992553  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102992563  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102992685  LAMA1; laminin subunit alpha-1 [KO:K05637]
102992707  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
102992923  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102992996  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102993220  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102993300  [KO:K12757]
102993444  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
102993761  [KO:K12757]
102994051  ITGA2B; integrin alpha-IIb isoform X5 [KO:K06476]
102994214  CRK; adapter molecule crk isoform X1 [KO:K04438]
102994284  EMP2; epithelial membrane protein 2 [KO:K26256]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102994518  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
102994576  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102994673  IBSP; bone sialoprotein 2 [KO:K06253]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102994772  PARVA; alpha-parvin [KO:K06275]
102994805  TNC; tenascin isoform X1 [KO:K06252]
102994912  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102995205  ITGB5; integrin beta-5 [KO:K06588]
102995328  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
102995420  THBS1; thrombospondin-1 [KO:K16857]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102996119  LAMB1; laminin subunit beta-1 [KO:K05636]
102996353  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
102996446  MYL11; myosin regulatory light chain 11 [KO:K12758]
102996458  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102996914  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112063645  [KO:K05692]
112064949  [KO:K12959]
114483947  [KO:K04364]
114487158  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114487451  LAMC3; laminin subunit gamma-3 [KO:K06247]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pcad04010  MAPK signaling pathway
pcad04060  Cytokine-cytokine receptor interaction
pcad04070  Phosphatidylinositol signaling system
pcad04110  Cell cycle
pcad04151  PI3K-Akt signaling pathway
pcad04310  Wnt signaling pathway
pcad04512  ECM-receptor interaction
pcad04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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