KEGG   PATHWAY: pcoq04014
Entry
pcoq04014                   Pathway                                
Name
Ras signaling pathway - Propithecus coquereli (Coquerel's sifaka)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoq04014  Ras signaling pathway
pcoq04014

Other DBs
GO: 0032318
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105805030  [KO:K04358]
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105805058  NTF3; neurotrophin-3 [KO:K04356]
105805188  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105805284  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
105805709  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105805749  FIGF; vascular endothelial growth factor D [KO:K05449]
105805866  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
105805895  CALM2; calmodulin [KO:K02183]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105806045  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105806063  LAT; linker for activation of T-cells family member 1 [KO:K07362]
105806103  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
105806183  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105806600  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105806618  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
105806629  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
105806782  RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
105806839  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105806890  ETS2; protein C-ets-2 [KO:K21932]
105806976  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105807051  [KO:K17630]
105807119  CALM1; calmodulin [KO:K02183]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105807545  KRAS; GTPase KRas [KO:K07827]
105807665  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105807681  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105807691  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105808133  FGF9; fibroblast growth factor 9 [KO:K04358]
105808257  ZAP70; tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
105808407  RAP1B; ras-related protein Rap-1b [KO:K07836]
105808489  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105808559  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
105808669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
105808974  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
105809043  [KO:K04353]
105809290  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
105809321  FGF21; fibroblast growth factor 21 [KO:K22429]
105809394  NTF4; neurotrophin-4 [KO:K12457]
105809401  RRAS; ras-related protein R-Ras [KO:K07829]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810005  FOXO4; forkhead box protein O4 [KO:K12358]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810582  NGF; beta-nerve growth factor [KO:K02582]
105810591  NRAS; GTPase NRas [KO:K07828]
105810655  RALB; ras-related protein Ral-B [KO:K07835]
105810718  RASA1; ras GTPase-activating protein 1 [KO:K04352]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811016  HGF; hepatocyte growth factor [KO:K05460]
105811099  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105811166  ANGPT1; angiopoietin-1 [KO:K05465]
105811228  SHC2; SHC-transforming protein 2 [KO:K17447]
105811295  FGF22; fibroblast growth factor 22 [KO:K04358]
105811312  EFNA2; ephrin-A2 [KO:K05462]
105811507  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105811549  FGF1; fibroblast growth factor 1 [KO:K18496]
105811628  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105811840  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105812073  TGFA; protransforming growth factor alpha [KO:K08774]
105812103  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105812142  ABL2; Abelson tyrosine-protein kinase 2 [KO:K08887] [EC:2.7.10.2]
105812157  RASAL2; ras GTPase-activating protein nGAP [KO:K17633]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812813  EFNA5; ephrin-A5 [KO:K05462]
105812871  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105812945  [KO:K04546]
105813016  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105813141  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105813188  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105813491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105813574  NF1; neurofibromin [KO:K08052]
105813587  KSR1; LOW QUALITY PROTEIN: kinase suppressor of Ras 1 [KO:K14958]
105813625  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814175  [KO:K10784]
105814232  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105814234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105814235  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105814236  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105814272  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105814299  SHC4; SHC-transforming protein 4 [KO:K17449]
105814454  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
105814474  FGF7; fibroblast growth factor 7 [KO:K04358]
105814556  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105814653  FGF18; fibroblast growth factor 18 [KO:K04358]
105814728  [KO:K04570]
105814785  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105815035  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105815048  KSR2; LOW QUALITY PROTEIN: kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815256  FGF2; fibroblast growth factor 2 [KO:K18497]
105815695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105815778  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
105815854  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105815960  KITLG; kit ligand isoform X1 [KO:K05461]
105815999  [KO:K04440] [EC:2.7.11.24]
105816267  VEGFC; vascular endothelial growth factor C [KO:K05449]
105816291  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
105816530  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105816531  INS; insulin [KO:K04526]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105816683  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105816884  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105817331  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105817634  CALM3; calmodulin [KO:K02183]
105817773  SHC3; SHC-transforming protein 3 [KO:K17448]
105817842  RAB5B; ras-related protein Rab-5B [KO:K07888]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818229  [KO:K01047] [EC:3.1.1.4]
105818410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105818508  RALA; ras-related protein Ral-A [KO:K07834]
105818713  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105818935  EGF; pro-epidermal growth factor [KO:K04357]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105819783  PGF; placenta growth factor isoform X1 [KO:K16859]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105820016  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105820246  RAB5C; ras-related protein Rab-5C [KO:K07889]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820440  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105820441  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105820449  [KO:K01047] [EC:3.1.1.4]
105820452  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105820453  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105820520  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820606  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105820687  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
105820791  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105820913  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105821273  STK4; serine/threonine-protein kinase 4 [KO:K04411]
105821280  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105821560  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
105821582  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105821583  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105821667  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
105821676  SYNGAP1; ras/Rap GTPase-activating protein SynGAP [KO:K17631]
105821872  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105821881  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105821936  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105821937  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105821975  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105822030  MLLT4; afadin [KO:K05702]
105822091  RAP1A; ras-related protein Rap-1A [KO:K04353]
105822163  [KO:K05450]
105822164  [KO:K05450]
105822458  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
105822617  FGF23; fibroblast growth factor 23 [KO:K22428]
105822621  [KO:K04358]
105822671  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105822719  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105822757  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105822882  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105823045  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823513  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823644  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105824289  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105824410  RASA3; ras GTPase-activating protein 3 [KO:K12380]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824991  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825076  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
105825115  RALGAPB; ral GTPase-activating protein subunit beta [KO:K25769]
105825247  FGF20; fibroblast growth factor 20 [KO:K04358]
105825272  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105825293  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105825456  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105825541  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105825584  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
105825626  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
105825663  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105825892  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105826004  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
105826180  FGF16; fibroblast growth factor 16 [KO:K04358]
105826215  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105826386  RAB5A; ras-related protein Rab-5A [KO:K07887]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826554  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105826598  MRAS; ras-related protein M-Ras [KO:K07831]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826735  FGF10; fibroblast growth factor 10 [KO:K04358]
105826776  FGF3; fibroblast growth factor 3 [KO:K04358]
105826829  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105826912  CALML3; calmodulin-like protein 3 [KO:K02183]
105826917  CALML5; calmodulin-like protein 5 [KO:K02183]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827300  VEGFB; vascular endothelial growth factor B [KO:K16858]
105827330  FGF19; fibroblast growth factor 19 [KO:K22603]
105827331  FGF4; fibroblast growth factor 4 [KO:K04358]
105827379  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105827401  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
105827470  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105827472  HRASLS2; HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105827576  ANGPT4; angiopoietin-4 [KO:K05467]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
pcoq04010  MAPK signaling pathway
pcoq04015  Rap1 signaling pathway
pcoq04020  Calcium signaling pathway
pcoq04144  Endocytosis
pcoq04151  PI3K-Akt signaling pathway
pcoq04660  T cell receptor signaling pathway
pcoq04720  Long-term potentiation
pcoq04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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