KEGG   PATHWAY: pmaj04010
Entry
pmaj04010                   Pathway                                
Name
MAPK signaling pathway - Parus major (Great Tit)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmaj04010  MAPK signaling pathway
pmaj04010

Other DBs
GO: 0000165
Organism
Parus major (Great Tit) [GN:pmaj]
Gene
107211935  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
107204397  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107210294  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
107208269  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
107212499  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X16 [KO:K04854]
107211335  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
107205110  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
107214754  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107204625  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4 [KO:K04858]
107210462  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
107210399  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
107204208  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
107199944  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
107198564  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
107207455  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
107212342  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
107205194  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
107211361  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
107212338  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
107212340  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
107208204  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107212334  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107211235  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107211274  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107208454  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107206630  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107203186  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107213934  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107201468  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
107209551  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
107198175  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
107205693  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
107201851  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
107203090  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
107212797  NF1; neurofibromin isoform X1 [KO:K08052]
107215992  RASA1; ras GTPase-activating protein 1 [KO:K04352]
107208734  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
107214847  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
107204636  RAP1B; ras-related protein Rap-1b [KO:K07836]
107203603  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
107203163  AREG; amphiregulin [KO:K09782]
107210662  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107202986  FGF2; fibroblast growth factor 2 [KO:K18497]
107205474  FGF4; fibroblast growth factor 4 [KO:K04358]
107207567  FGF9; fibroblast growth factor 9 [KO:K04358]
107206622  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
107204934  FGF6; fibroblast growth factor 6 [KO:K04358]
107209251  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
107215713  FGF10; fibroblast growth factor 10 [KO:K04358]
107203620  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
107198543  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
107202807  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
107205342  FGF3; fibroblast growth factor 3 [KO:K04358]
107215372  FGF22; fibroblast growth factor 22 [KO:K04358]
107203899  FGF16; fibroblast growth factor 16 [KO:K04358]
107213981  FGF17; fibroblast growth factor 17 [KO:K04358]
107205427  FGF19; fibroblast growth factor 19 [KO:K22603]
107204156  FGF23; fibroblast growth factor 23 [KO:K22428]
107214905  NGF; beta-nerve growth factor [KO:K02582]
107206143  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
107204988  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
107205419  INS; insulin [KO:K04526]
107204610  IGF1; insulin-like growth factor I [KO:K05459]
107206324  IGF2; insulin-like growth factor II [KO:K13769]
107211209  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
107205105  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107209392  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107203600  PDGFC; platelet-derived growth factor C [KO:K05450]
107214717  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
107205063  KITLG; kit ligand isoform X1 [KO:K05461]
107199056  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
107201252  VEGFA; vascular endothelial growth factor A [KO:K05448]
107206015  PGF; placenta growth factor isoform X1 [KO:K16859]
107212276  VEGFD; vascular endothelial growth factor D [KO:K05449]
107203121  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
107205229  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107201024  ANGPT1; angiopoietin-1 [KO:K05465]
107201810  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
107213117  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
107214517  EFNA4; ephrin-A4 [KO:K05462]
107214525  EFNA3; ephrin-A3 [KO:K05462]
107215493  EFNA2; ephrin-A2 [KO:K05462]
107214604  EFNA1; ephrin-A1 [KO:K05462]
107198198  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
107198478  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
107215511  NRTN; neurturin [KO:K25414]
107208309  ARTN; artemin isoform X1 [KO:K25415]
107200328  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107215327  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107207560  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
107213845  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107206911  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107203422  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
107210899  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
107198675  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
107214529  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107216220  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
107215564  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
107209439  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107203533  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107210844  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107210711  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107203543  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
107213698  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
107202343  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107203705  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
107210757  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
107202958  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107204940  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
107216128  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
107213776  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
107207043  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107212507  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107206011  SOS2; son of sevenless homolog 2 [KO:K03099]
107201824  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
107205559  HRAS; GTPase HRas [KO:K02833]
107204562  KRAS; GTPase KRas isoform X1 [KO:K07827]
107214761  NRAS; GTPase NRas [KO:K07828]
107205650  RRAS2; ras-related protein R-Ras2 [KO:K07830]
107207566  MRAS; ras-related protein M-Ras [KO:K07831]
107204658  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
107210130  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107209483  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107215477  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107203323  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
107211727  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107215565  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
107208397  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
107202385  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
107203908  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
107214031  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
107207497  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
107204914  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
107214971  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
107200993  MYC; myc proto-oncogene protein [KO:K04377]
107201885  SRF; serum response factor [KO:K04378]
107206453  FOS; proto-oncogene c-Fos [KO:K04379]
107215247  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
107214235  STMN1; stathmin [KO:K04381]
107206358  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
107206419  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107205985  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
107205355  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107205356  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107205357  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107206344  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107206345  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107206346  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
107208208  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
107213896  interleukin-1 receptor antagonist protein-like [KO:K04519]
107198990  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
107202393  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
107205526  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
107208773  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
107210317  interleukin-1 receptor type 1-like isoform X3 [KO:K04386]
107208944  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
107200568  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
107200593  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107207553  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107207877  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107206851  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107211176  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107205038  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
107212321  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
107213677  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107210000  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107203069  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107212160  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
107200823  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
107204545  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
107206210  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107208453  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
107198526  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
107215503  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107204714  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107202278  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
107201902  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
107203917  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
107205542  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
107200206  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107208951  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107213380  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
107200357  STK3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
107200816  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
107216401  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
107199524  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
107207590  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
107200237  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
107215258  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
107206205  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
107201984  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
107198728  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
107208746  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
107207509  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
107201551  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
107201717  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107201928  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X4 [KO:K04428] [EC:2.7.11.25]
107211602  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
107212868  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
107212510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
107198843  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107211348  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
107212284  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
107206189  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
107199304  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
107211149  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
107212927  CRK; adapter molecule crk isoform X3 [KO:K04438]
107211597  CRKL; crk-like protein [KO:K04438]
107207016  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
107210724  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107203419  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107206805  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107214801  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
107214802  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107204408  MAPK12; LOW QUALITY PROTEIN: mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107204409  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
107211692  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
107214766  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107210185  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
107205560  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
107200735  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
107209864  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107208073  JUN; transcription factor AP-1 [KO:K04448]
107207532  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
107199033  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
107205598  MAX; protein max isoform X1 [KO:K04453]
107216154  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
107212733  HSPB1; heat shock protein beta-1 [KO:K04455]
107201442  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107205807  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107205936  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
107204534  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
107205708  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X2 [KO:K18018] [EC:3.1.3.48]
107214712  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
107210905  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107206116  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107203160  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107207150  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107204211  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107210476  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107205186  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107202262  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107201906  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
107214420  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107208729  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
107209134  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
107199450  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
107198608  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
107215307  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
107206726  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
107213912  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107198881  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
107212813  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
107202925  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107206811  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pmaj04070  Phosphatidylinositol signaling system
pmaj04110  Cell cycle
pmaj04115  p53 signaling pathway
pmaj04210  Apoptosis
pmaj04310  Wnt signaling pathway
KO pathway
ko04010   
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