KEGG   PATHWAY: pvp04015
Entry
pvp04015                    Pathway                                
Name
Rap1 signaling pathway - Pteropus vampyrus (large flying fox)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04015  Rap1 signaling pathway
pvp04015

Other DBs
GO: 0007264
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105288737  FGF7; fibroblast growth factor 7 [KO:K04358]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105289073  LPAR3; lysophosphatidic acid receptor 3 isoform X2 [KO:K04294]
105289311  CRKL; crk-like protein [KO:K04438]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289354  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
105289768  PFN4; profilin-4 [KO:K05759]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105290127  CALM1; calmodulin-1 [KO:K02183]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105290355  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
105290427  RAP1GAP; rap1 GTPase-activating protein 1 isoform X3 [KO:K17700]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105290959  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105290992  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8 [KO:K05631]
105291304  ADORA2B; adenosine receptor A2b [KO:K04267]
105291441  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105291766  PFN1; profilin-1 [KO:K05759]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105292074  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105292122  FGF9; fibroblast growth factor 9 [KO:K04358]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105292386  FGF5; fibroblast growth factor 5 [KO:K04358]
105292586  ENAH; protein enabled homolog isoform X7 [KO:K05746]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105292986  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105293064  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105293148  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
105293228  KITLG; kit ligand isoform X1 [KO:K05461]
105293259  FGF6; fibroblast growth factor 6 [KO:K04358]
105293279  FGF23; fibroblast growth factor 23 [KO:K22428]
105293508  PFN3; profilin-3 [KO:K05759]
105293510  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
105293516  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105293536  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105293773  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294314  TLN2; talin-2 [KO:K06271]
105294337  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105294479  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
105294497  KRIT1; krev interaction trapped protein 1 isoform X4 [KO:K17705]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105295155  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105295316  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105295432  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105295466  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105295517  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105295548  FGF20; fibroblast growth factor 20 [KO:K04358]
105295663  DRD2; D(2) dopamine receptor [KO:K04145]
105295963  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105296048  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105296083  [KO:K04632]
105296141  RALB; ras-related protein Ral-B isoform X2 [KO:K07835]
105296373  EFNA1; ephrin-A1 [KO:K05462]
105296374  EFNA4; ephrin-A4 [KO:K05462]
105296443  EFNA3; ephrin-A3 [KO:K05462]
105296475  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296547  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296556  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296640  F2RL3; proteinase-activated receptor 4 isoform X2 [KO:K04236]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105296985  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
105297044  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105297072  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
105297140  [KO:K02649]
105297143  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105297202  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105297320  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
105297322  CALM3; calmodulin-3 [KO:K02183]
105297337  VASP; vasodilator-stimulated phosphoprotein isoform X6 [KO:K06274]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105297498  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
105297518  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297907  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105297993  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105298011  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105298133  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105298291  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105298564  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105298674  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
105298681  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298936  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299100  FYB1; FYN-binding protein 1 isoform X2 [KO:K17698]
105299180  [KO:K02183]
105299223  PGF; placenta growth factor isoform X1 [KO:K16859]
105299262  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X4 [KO:K17701]
105299314  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
105299317  FGF18; fibroblast growth factor 18 [KO:K04358]
105299341  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299435  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105299662  DOCK4; dedicator of cytokinesis protein 4 [KO:K17697]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105300076  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
105300159  [KO:K04456] [EC:2.7.11.1]
105300198  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105300315  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105300647  RASSF5; ras association domain-containing protein 5 [KO:K08015]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301110  VAV1; proto-oncogene vav [KO:K05730]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105301274  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105301286  FGF10; fibroblast growth factor 10 [KO:K04358]
105301523  PFN2; profilin-2 isoform X2 [KO:K05759]
105301735  RRAS; ras-related protein R-Ras [KO:K07829]
105301799  FGF21; fibroblast growth factor 21 [KO:K22429]
105301871  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105302193  F2R; proteinase-activated receptor 1 [KO:K03914]
105302235  EFNA2; ephrin-A2 [KO:K05462]
105302250  FGF22; fibroblast growth factor 22 [KO:K04358]
105302287  EVL; ena/VASP-like protein isoform X4 [KO:K23487]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302452  [KO:K04634]
105302783  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105302942  [KO:K05730]
105302980  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303015  PARD3; partitioning defective 3 homolog [KO:K04237]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303043  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105303207  RALA; ras-related protein Ral-A [KO:K07834]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105303529  ITGA2B; integrin alpha-IIb [KO:K06476]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105303610  PRKCZ; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105303711  AFDN; afadin [KO:K05702]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105304165  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105304501  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105304532  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304587  LAT; linker for activation of T-cells family member 1 [KO:K07362]
105304647  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105304738  CTNND1; catenin delta-1 isoform X3 [KO:K05690]
105305262  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 [KO:K17702]
105305272  ANGPT2; angiopoietin-2 [KO:K05466]
105305354  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
105305482  ANGPT4; angiopoietin-4 [KO:K05467]
105305501  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
105305616  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105305725  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
105305756  CDH1; cadherin-1 isoform X1 [KO:K05689]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105305982  P2RY1; P2Y purinoceptor 1 [KO:K04270]
105306141  [KO:K04361] [EC:2.7.10.1]
105306467  TLN1; talin-1 [KO:K06271]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105307100  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105307123  [KO:K22603]
105307127  [KO:K22603]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307280  [KO:K17699]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307777  [KO:K05096] [EC:2.7.10.1]
105307779  [KO:K05759]
105308212  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105308283  [KO:K04441] [EC:2.7.11.24]
105308299  [KO:K08041] [EC:4.6.1.1]
105308731  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105308818  [KO:K19662] [EC:2.7.11.13]
105308889  FGF16; fibroblast growth factor 16 [KO:K04358]
105308953  [KO:K07831]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105309794  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105309888  [KO:K04358]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105311236  [KO:K12490]
105311363  FGF4; fibroblast growth factor 4 [KO:K04358]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
pvp04010  MAPK signaling pathway
pvp04014  Ras signaling pathway
pvp04020  Calcium signaling pathway
pvp04151  PI3K-Akt signaling pathway
pvp04510  Focal adhesion
pvp04520  Adherens junction
pvp04660  T cell receptor signaling pathway
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

DBGET integrated database retrieval system