KEGG   PATHWAY: tmu05010
Entry
tmu05010                    Pathway                                
Name
Alzheimer disease - Trichechus manatus latirostris (Florida manatee)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
tmu05010  Alzheimer disease
tmu05010

Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101350043  disintegrin and metalloproteinase domain-containing protein 10 isoform X4 [KO:K06704] [EC:3.4.24.81]
101350544  disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
101347228  amyloid-beta A4 protein isoform X1 [KO:K04520]
101344097  NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
101349337  amyloid-beta A4 precursor protein-binding family B member 1 [KO:K04529]
101350847  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101354290  beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
101360622  beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
101357489  reticulon-3 isoform X3 [KO:K20723]
101340873  reticulon-4 [KO:K20720]
111821300  reticulon-4-like [KO:K20720]
101348306  gamma-secretase subunit PEN-2 [KO:K06170]
101347137  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101356799  presenilin-2 [KO:K04522] [EC:3.4.23.-]
101353622  nicastrin isoform X2 [KO:K06171]
101353716  gamma-secretase subunit APH-1A [KO:K06172]
101356207  gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
101340940  insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
101359371  neprilysin [KO:K01389] [EC:3.4.24.11]
101360746  microtubule-associated protein tau isoform X1 [KO:K04380]
101342189  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
101344328  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
101352739  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
111821539  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
111821167  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101347434  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101356399  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101341663  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101356177  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101362071  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101342417  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101351585  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101352289  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101347207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101355425  acyl carrier protein, mitochondrial [KO:K03955]
101353746  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101343020  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
111822042  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101361940  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101345814  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101343512  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101348161  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101347019  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101361585  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101350430  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101342802  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101348157  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101356612  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101355955  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101354085  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101348326  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101355560  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101349133  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101357778  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101340730  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101347171  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101341003  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101346167  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101345302  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101357812  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [KO:K00234] [EC:1.3.5.1]
101353562  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101346550  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101348027  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101349349  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101359231  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101350351  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101350954  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101349519  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101359862  cytochrome b-c1 complex subunit 7 [KO:K00417]
101353511  cytochrome b-c1 complex subunit 8 [KO:K00418]
101358587  cytochrome b-c1 complex subunit 9 [KO:K00419]
101352977  cytochrome b-c1 complex subunit 10 [KO:K00420]
101346963  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101351241  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101357118  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101343047  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101358698  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101358762  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101357728  cytochrome c oxidase subunit 6B2 [KO:K02267]
101349067  cytochrome c oxidase subunit 6B1 [KO:K02267]
101354643  cytochrome c oxidase subunit 6C [KO:K02268]
101355564  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101346028  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101353725  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101355622  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
101347679  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111821449  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
101345533  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111821885  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101357898  ATP synthase subunit alpha, mitochondrial [KO:K02132]
101346922  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101354520  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101354265  ATP synthase subunit delta, mitochondrial [KO:K02134]
111822811  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
101353320  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101361354  ATP synthase F(0) complex subunit C1, mitochondrial isoform X2 [KO:K02128]
101359449  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101356865  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101355087  ATP synthase subunit d, mitochondrial [KO:K02138]
101340662  ATP synthase subunit O, mitochondrial isoform X2 [KO:K02137]
101359345  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101360197  3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101361956  peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
101351096  voltage-dependent anion-selective channel protein 1 [KO:K05862]
101346677  voltage-dependent anion-selective channel protein 2 [KO:K15040]
101351954  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101351885  ADP/ATP translocase 3 [KO:K05863]
101350620  ADP/ATP translocase 4 [KO:K05863]
101341492  ADP/ATP translocase 2 [KO:K05863]
101354695  ADP/ATP translocase 1 [KO:K05863]
101361632  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101345905  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
101354723  apolipoprotein E [KO:K04524]
101342764  prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
101346704  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101341867  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101352734  FAS-associated death domain protein [KO:K02373]
101344302  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101356396  BH3-interacting domain death agonist [KO:K04726]
101347126  calmodulin-2 isoform X2 [KO:K02183]
101361121  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101358846  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
101346240  calmodulin-3 [KO:K02183]
101358487  calmodulin [KO:K02183]
101346473  calmodulin-like protein 4 [KO:K02183]
101359111  calmodulin-like [KO:K02183]
101353424  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101357894  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101347440  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101343394  calcineurin subunit B type 1 isoform X2 [KO:K06268]
101355330  calcineurin subunit B type 2 [KO:K06268]
101352047  bcl2-associated agonist of cell death [KO:K02158]
101355182  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
101354940  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101340375  cytochrome c [KO:K08738]
101351271  cytochrome c-like [KO:K08738]
101349393  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101355103  caspase-9 [KO:K04399] [EC:3.4.22.62]
101354307  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101360696  muscarinic acetylcholine receptor M1 [KO:K04129]
101349109  muscarinic acetylcholine receptor M3 [KO:K04131]
101361367  muscarinic acetylcholine receptor M5 [KO:K04133]
101340926  metabotropic glutamate receptor 5 [KO:K04604]
101347192  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101352296  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101349967  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101344242  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101361375  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101349517  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101353799  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101340402  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101355341  glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101358510  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101360945  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101357085  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101340818  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101343945  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101347897  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101347686  ryanodine receptor 3 [KO:K04963]
101346534  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101356404  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101354392  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101354431  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101353652  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
101358002  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101353266  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101354466  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101361189  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
101352446  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101342812  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101354911  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101346612  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101346746  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101351734  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101351967  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101343546  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101356436  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101345357  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101355611  proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101355548  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101356505  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101347133  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101354620  proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
101347799  proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101352422  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101340422  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101343598  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101359620  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101348858  proteasome subunit beta type-3 isoform X1 [KO:K02735] [EC:3.4.25.1]
101346461  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101343830  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101359762  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101343402  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101360911  26S proteasome regulatory subunit 7 [KO:K03061]
101341654  26S proteasome regulatory subunit 4 [KO:K03062]
101356704  26S proteasome regulatory subunit 6B [KO:K03063]
101354396  26S proteasome regulatory subunit 10B [KO:K03064]
101353268  26S proteasome regulatory subunit 6A [KO:K03065]
101353736  26S proteasome regulatory subunit 8 [KO:K03066]
101358856  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101355826  26S proteasome non-ATPase regulatory subunit 1 isoform X3 [KO:K03032]
101359024  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101355804  26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101349534  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101345656  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101344747  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101351436  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101340678  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101345005  26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
101346477  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101355652  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101346449  proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
101359313  26S proteasome complex subunit SEM1 [KO:K10881]
101352646  LOW QUALITY PROTEIN: caspase-12 [KO:K04741] [EC:3.4.22.-]
101342004  nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101341766  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101341399  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101346082  cyclin-dependent kinase 5 activator 1 [KO:K11716]
101347344  zinc transporter ZIP3 [KO:K14709]
101344754  zinc transporter ZIP1 [KO:K14709]
101355574  zinc transporter ZIP2 [KO:K14709]
101351894  zinc transporter ZIP4 [KO:K14710]
101351072  zinc transporter ZIP5 [KO:K14711]
101342015  zinc transporter ZIP6 [KO:K14712]
101349343  zinc transporter SLC39A7 [KO:K14713]
101351603  zinc transporter ZIP8 [KO:K14714]
101361322  zinc transporter ZIP9 isoform X1 [KO:K14715]
101356219  zinc transporter ZIP10 isoform X1 [KO:K14716]
101359446  zinc transporter ZIP11 [KO:K14717]
101349709  zinc transporter ZIP12 isoform X1 [KO:K14718]
101352827  zinc transporter ZIP13 isoform X1 [KO:K14719]
101360340  zinc transporter ZIP14 [KO:K14720]
101340601  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
101357699  cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
101349186  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101346298  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
101351819  dickkopf-related protein 1 [KO:K02165]
101343707  dickkopf-related protein 2 [KO:K02165]
101343886  dickkopf-related protein 4 [KO:K02165]
101352160  proto-oncogene Wnt-1 [KO:K03209]
101344186  protein Wnt-2 [KO:K00182]
101351340  protein Wnt-2b [KO:K00182]
101345396  protein Wnt-3a [KO:K00312]
101341899  proto-oncogene Wnt-3 [KO:K00312]
101361433  LOW QUALITY PROTEIN: protein Wnt-4 [KO:K00408]
101358885  protein Wnt-5a isoform X2 [KO:K00444]
101359902  protein Wnt-5b [KO:K00444]
101341737  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
101341781  protein Wnt-7a [KO:K00572]
101348949  protein Wnt-7b [KO:K00572]
101342296  protein Wnt-8b [KO:K00714]
101342423  protein Wnt-8a [KO:K00714]
101360002  protein Wnt-9a [KO:K01064]
101342156  protein Wnt-9b [KO:K01064]
101347671  protein Wnt-10a [KO:K01357]
101351717  protein Wnt-10b [KO:K01357]
101340313  protein Wnt-11 [KO:K01384]
101359317  protein Wnt-16 [KO:K01558]
101348994  frizzled-1 [KO:K02432]
101347003  frizzled-7 [KO:K02432]
101347661  frizzled-2 [KO:K02235]
101357820  frizzled-3 [KO:K02329]
101359840  frizzled-4 [KO:K02354]
101361647  frizzled-8 [KO:K02375]
101358150  frizzled-5 [KO:K02375]
101348322  frizzled-6 [KO:K02376]
101356576  frizzled-10 [KO:K02842]
101360249  frizzled-9 [KO:K02842]
101355288  low-density lipoprotein receptor-related protein 5 [KO:K03068]
101358700  low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
101361763  casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
101362049  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
101360142  segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101353682  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
101352077  proto-oncogene FRAT1 [KO:K03069]
101352330  GSK-3-binding protein FRAT2 [KO:K03096]
101350263  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
101349005  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101345345  casein kinase II subunit beta [KO:K03115]
101346985  axin-1 isoform X2 [KO:K02157]
101347495  axin-2 [KO:K04385]
101346660  adenomatous polyposis coli protein 2 [KO:K02085]
101341158  adenomatous polyposis coli protein isoform X1 [KO:K02085]
101351897  catenin beta-1 [KO:K02105]
101341353  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
101348254  kinesin heavy chain isoform X1 [KO:K10396]
101359636  kinesin heavy chain isoform X1 [KO:K10396]
101345488  kinesin-1 heavy chain isoform X1 [KO:K10396]
101357555  kinesin light chain 1 isoform X3 [KO:K10407]
101353832  kinesin light chain 3 isoform X1 [KO:K10407]
101355466  kinesin light chain 2 [KO:K10407]
101357978  kinesin light chain 4 [KO:K10407]
101350966  tubulin alpha-4A chain [KO:K07374]
101354297  tubulin alpha-1A chain isoform X2 [KO:K07374]
101341590  tubulin alpha-8 chain [KO:K07374]
101359819  LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
101343251  tubulin alpha-1D chain-like [KO:K07374]
101354547  tubulin alpha-1C chain [KO:K07374]
101354885  tubulin alpha-1A chain-like [KO:K07374]
101353946  tubulin alpha-3 chain-like [KO:K07374]
101354459  tubulin alpha-3 chain [KO:K07374]
101361577  tubulin beta-1 chain [KO:K07375]
101352976  tubulin beta-4A chain [KO:K07375]
101362075  tubulin beta-2B chain [KO:K07375]
101340765  tubulin beta-2A chain [KO:K07375]
101341456  tubulin beta chain [KO:K07375]
101347734  tubulin beta-4B chain [KO:K07375]
101351152  tubulin beta-3 chain [KO:K07375]
101346852  tubulin beta-6 chain [KO:K07375]
101354153  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101351589  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101353421  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101344219  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
101356942  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
101361706  transcription factor p65 [KO:K04735]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101356579  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101345018  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101342656  TNF; tumor necrosis factor [KO:K03156]
101351590  interleukin-6 [KO:K05405]
101359155  interleukin-1 alpha isoform X1 [KO:K04383]
101359415  IL1B; interleukin-1 beta [KO:K04519]
101357438  macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
101356514  alpha-synuclein [KO:K04528]
101359071  interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101346705  insulin [KO:K04526]
101360415  insulin receptor [KO:K04527] [EC:2.7.10.1]
101356151  insulin receptor substrate 1 [KO:K16172]
101345051  insulin receptor substrate 2 [KO:K07187]
101362072  insulin receptor substrate 1-like [KO:K17445]
101350401  insulin receptor substrate 4 isoform X1 [KO:K17446]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101343808  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101357581  serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101345383  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101346865  autophagy-related protein 101 [KO:K19730]
101346435  autophagy-related protein 13 isoform X1 [KO:K08331]
101351891  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101345407  activating molecule in BECN1-regulated autophagy protein 1 isoform X2 [KO:K17985]
101359690  beclin-1 isoform X1 [KO:K08334]
101349952  LOW QUALITY PROTEIN: beclin-2 [KO:K08334]
101345725  phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
101359341  beclin 1-associated autophagy-related key regulator [KO:K17889]
101341374  nuclear receptor-binding factor 2 [KO:K21246]
101345298  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101355263  autophagy-related protein 2 homolog B [KO:K17906]
101345997  autophagy-related protein 2 homolog A [KO:K17906]
101359379  WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [KO:K17908]
101345874  WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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PLoS One 3:e2718 (2008)
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Related
pathway
tmu00190  Oxidative phosphorylation
tmu03050  Proteasome
tmu04020  Calcium signaling pathway
tmu04140  Autophagy - animal
tmu04141  Protein processing in endoplasmic reticulum
tmu04210  Apoptosis
tmu04310  Wnt signaling pathway
tmu04910  Insulin signaling pathway
tmu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system