KEGG   ORTHOLOGY: K08367Help
Entry
K08367                      KO                                     

Name
RUNX1, AML1
Definition
runt-related transcription factor 1
Pathway
ko04530  Tight junction
ko04659  Th17 cell differentiation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
Disease
H00001  B-cell acute lymphoblastic leukemia
H00003  Acute myeloid leukemia
H00004  Chronic myeloid leukemia
H00978  Thrombocytopenia (THC)
H01481  Myelodysplastic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1
BRITE hierarchy
Genes
HSA: 861(RUNX1)
PTR: 101058316(RUNX1)
PPS: 100985479(RUNX1)
GGO: 101124359(RUNX1)
PON: 100449725(RUNX1)
NLE: 100594110(RUNX1)
MCC: 696749(RUNX1)
MCF: 102145008(RUNX1)
CSAB: 103218488(RUNX1)
RRO: 104658772(RUNX1)
RBB: 108536870(RUNX1)
CJC: 100385071(RUNX1)
SBQ: 101047789(RUNX1)
MMU: 12394(Runx1)
MCAL: 110311558(Runx1)
MPAH: 110329713(Runx1)
RNO: 50662(Runx1)
MUN: 110542151(Runx1)
CGE: 100758283(Runx1)
NGI: 103736431(Runx1)
HGL: 101705852(Runx1)
CCAN: 109700411(Runx1)
OCU: 100358993(RUNX1)
TUP: 102496134(RUNX1) 106735442
CFA: 487746(RUNX1)
VVP: 112910264(RUNX1)
AML: 100484679(RUNX1)
UMR: 103673224(RUNX1)
UAH: 113262125(RUNX1)
ORO: 101367976(RUNX1)
FCA: 101084898(RUNX1)
PTG: 102950610(RUNX1)
AJU: 106966472(RUNX1)
BTA: 529631(RUNX1)
BOM: 102282115(RUNX1)
BIU: 109561422(RUNX1)
BBUB: 102392702(RUNX1)
PHD: 102320150(RUNX1)
CHX: 102178020(RUNX1)
OAS: 101108280(RUNX1)
SSC: 100512633(RUNX1)
CFR: 102521748(RUNX1)
CDK: 105089882(RUNX1)
BACU: 103006498(RUNX1)
LVE: 103074813(RUNX1)
OOR: 101288785(RUNX1)
DLE: 111163859(RUNX1)
ECB: 100051950(RUNX1)
EPZ: 103549174(RUNX1)
EAI: 106832821(RUNX1)
MYB: 102247211(RUNX1)
MYD: 102768477(RUNX1)
MNA: 107533502(RUNX1)
HAI: 109391240(RUNX1)
RSS: 109446642(RUNX1)
DRO: 112305670(RUNX1)
PALE: 102879444(RUNX1)
LAV: 100665882(RUNX1)
TMU: 101357079
MDO: 100025525(RUNX1)
SHR: 100921236(RUNX1)
PCW: 110214791(RUNX1)
OAA: 100082553(RUNX1)
GGA: 396152(RUNX1)
MGP: 100540674(RUNX1)
CJO: 107323234(RUNX1)
APLA: 101799657(RUNX1)
ACYG: 106043406(RUNX1)
TGU: 100224516
GFR: 102032799(RUNX1) 102042762
FAB: 101820379(RUNX1)
PHI: 102099092(RUNX1)
PMAJ: 107207834 107209383(RUNX1)
CCAE: 111929229(RUNX1) 111929277
CCW: 104696772(RUNX1)
FPG: 101916329(RUNX1) 106112951
FCH: 102053520(RUNX1)
CLV: 102087117(RUNX1)
EGZ: 104128174(RUNX1)
NNI: 104020181(RUNX1)
ACUN: 113478993(RUNX1)
AAM: 106494897(RUNX1)
ASN: 102385681(RUNX1)
AMJ: 102572910(RUNX1)
PSS: 102455885(RUNX1)
CMY: 102944269(RUNX1)
CPIC: 101938129(RUNX1)
ACS: 100564051(runx1)
PVT: 110076828(RUNX1)
PBI: 103055722(RUNX1)
GJA: 107117549
XLA: 108709238 379657(runx1.L)
XTR: 100485449(runx1)
NPR: 108791098(RUNX1)
DRE: 58126(runx1)
SRX: 107709287(runx1) 107751097
IPU: 108259037(runx1)
PHYP: 113537666(runx1)
AMEX: 103025657
EEE: 113582633
TRU: 100049631(runx1)
LCO: 104936698
NCC: 104961881
MZE: 101482179
OLA: 101173202
XMA: 102230567
XCO: 114140828
PRET: 103477443
NFU: 107384523
CSEM: 103389730
LCF: 108902563
SDU: 111232758
HCQ: 109528744
BPEC: 110156597
OTW: 112238382(runx1)
ELS: 105019777(runx1)
SFM: 108931706 108938311(runx1)
PKI: 111856070(runx1)
LCM: 102360635(RUNX1)
CMK: 103186755(runx1)
SPU: 373468(SpRunt-1)
APLC: 110978851
SKO: 100302713(runt)
EPA: 110249929
ADF: 107351415
PDAM: 113676023
SPIS: 111342489
AQU: 100638951
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1720541
  Authors
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M
  Title
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
  Journal
Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431
  Sequence
[hsa:861]
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