KEGG ORTHOLOGY: K08367

ORTHOLOGY: K08367

Entry

K08367                      KO

Symbol

RUNX1, AML1

Name

runt-related transcription factor 1

Pathway

map04530

Tight junction

map04659

Th17 cell differentiation

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

Disease

H00001

B-cell acute lymphoblastic leukemia

H00003

Acute myeloid leukemia

H00004

Chronic myeloid leukemia

H00978

Thrombocytopenia (THC)

H02410

Myelodysplastic/myeloproliferative neoplasms

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1

Genes

HSA:	861(RUNX1)

PTR:	101058316(RUNX1)

PPS:	100985479(RUNX1)

GGO:	101124359(RUNX1)

PON:	100449725(RUNX1)

NLE:	100594110(RUNX1)

HMH:	116481760(RUNX1)

MCC:	696749(RUNX1)

MCF:	102145008(RUNX1)

MTHB:

126950720

MNI:	105472675(RUNX1)

CSAB:

103218488(RUNX1)

CATY:

105575404(RUNX1)

PANU:

101020650(RUNX1)

TGE:	112620453(RUNX1)

MLEU:

105553168(RUNX1)

RRO:	104658772(RUNX1)

RBB:	108536870(RUNX1)

TFN:	117095741(RUNX1)

PTEH:

111525572(RUNX1)

CANG:

105517495(RUNX1)

CJC:	100385071(RUNX1)

SBQ:	101047789(RUNX1)

CIMI:

108302545(RUNX1)

CSYR:

103276661(RUNX1)

MMUR:

105881312(RUNX1)

LCAT:

123630713(RUNX1)

PCOQ:

105824396(RUNX1)

OGA:	100940749(RUNX1)

MMU:	12394(Runx1)

MCAL:

110311558(Runx1)

MPAH:

110329713(Runx1)

RNO:	50662(Runx1)

MCOC:

116086157(Runx1)

ANU:	117717806(Runx1)

MUN:	110542151(Runx1)

CGE:	100758283(Runx1)

MAUA:

101825482(Runx1)

PROB:

127227534(Runx1)

PLEU:

114698416(Runx1)

MORG:

121461825(Runx1)

MFOT:

126515255

AAMP:

119824910(Runx1)

NGI:	103736431(Runx1)

HGL:	101705852(Runx1)

CPOC:

100724149(Runx1)

CCAN:

109700411(Runx1)

DORD:

105994104(Runx1)

DSP:	122114233(Runx1)

PLOP:

125351473(Runx1)

NCAR:

124992488

MMMA:

107136457(Runx1)

OCU:

100358993

OPI:	101527002(RUNX1)

TUP:	102496134(RUNX1)

GVR:	103586963(RUNX1)

CFA:	487746(RUNX1)

CLUD:

112661562(RUNX1)

VVP:	112910264(RUNX1)

VLG:	121479549(RUNX1)

NPO:	129502033(RUNX1)

AML:	100484679(RUNX1)

UMR:	103673224(RUNX1)

UAH:	113262125(RUNX1)

UAR:	123784224(RUNX1)

ELK:

111155817

LLV:

125094779

MPUF:

101682300(RUNX1)

MNP:	132012376(RUNX1)

MLK:	131825345(RUNX1)

NVS:	122908311(RUNX1)

ORO:	101367976(RUNX1)

EJU:	114218980(RUNX1)

ZCA:	113916631(RUNX1)

MLX:	118018850(RUNX1)

NSU:	110570078(RUNX1)

LWW:	102742597(RUNX1)

FCA:	101084898(RUNX1)

PYU:	121036458(RUNX1)

PCOO:

112849752(RUNX1)

PBG:	122491197(RUNX1)

PVIV:

125175497(RUNX1)

LRUF:

124526329

PPAD:

109249750(RUNX1)

PUC:

125921695

AJU:

106966472

HHV:	120229403(RUNX1)

BTA:	529631(RUNX1)

BOM:	102282115(RUNX1)

BIU:	109561422(RUNX1)

BBUB:

102392702(RUNX1)

BBIS:

104984993(RUNX1)

CHX:	102178020(RUNX1)

OAS:	101108280(RUNX1)

BTAX:

128067301(RUNX1)

ODA:	120880896(RUNX1)

CCAD:

122445458(RUNX1)

MBEZ:

129548990(RUNX1)

SSC:	100512633(RUNX1)

CFR:	102521748(RUNX1)

CBAI:

105070210(RUNX1)

CDK:	105089882(RUNX1)

VPC:	102539586(RUNX1)

BACU:

103006498(RUNX1)

BMUS:

118894572(RUNX1)

LVE:	103074813(RUNX1)

OOR:	101288785(RUNX1)

DLE:	111163859(RUNX1)

PCAD:

102984857(RUNX1)

PSIU:

116752916(RUNX1)

NASI:

112408651(RUNX1)

ECB:	100051950(RUNX1)

EPZ:	103549174(RUNX1)

EAI:	106832821(RUNX1)

MYB:	102247211(RUNX1)

MYD:	102768477(RUNX1)

MMYO:

118675205(RUNX1)

MLF:	102436751(RUNX1)

PKL:	118714829(RUNX1)

EFUS:

103289919(RUNX1)

MNA:	107533502(RUNX1)

DRO:	112305670(RUNX1)

SHON:

118983269(RUNX1)

AJM:	119035732(RUNX1)

PDIC:

114490064(RUNX1)

PHAS:

123827989(RUNX1)

MMF:	118616857(RUNX1)

PPAM:

129074356(RUNX1)

HAI:	109391240(RUNX1)

RFQ:	117034711(RUNX1)

PALE:

102879444(RUNX1)

PGIG:

120598670(RUNX1)

PVP:	105295829(RUNX1)

RAY:	107520364(RUNX1)

MJV:	108384793(RUNX1)

TOD:	119257211(RUNX1)

SARA:

101541108(RUNX1)

LAV:	100665882(RUNX1)

TMU:

101357079

ETF:	101662179(RUNX1)

DNM:	101443635(RUNX1)

MDO:	100025525(RUNX1)

GAS:	123242465(RUNX1)

SHR:	100921236(RUNX1)

AFZ:

127553849

PCW:	110214791(RUNX1)

OAA:	100082553(RUNX1)

GGA:	396152(RUNX1)

PCOC:

116241954(RUNX1)

MGP:	100540674(RUNX1)

CJO:	107323234(RUNX1)

TPAI:

128076371(RUNX1)

LMUT:

125699841(RUNX1)

NMEL:

110402700(RUNX1)

APLA:

101799657(RUNX1)

ACYG:

106043406(RUNX1)

CATA:

118247677(RUNX1)

AFUL:

116495487(RUNX1)

TGU:	100222588(RUNX1)

LSR:	110475368(RUNX1)

SCAN:

103815716 108961955

PMOA:

120502541(RUNX1)

OTC:	121334718(RUNX1)

PRUF:

121357999

GFR:

102042762

FAB:	101820379(RUNX1)

OMA:	130249704(RUNX1)

PHI:	102099092(RUNX1)

PMAJ:

107207834 107209383

CCAE:

111929229(RUNX1)

CCW:	104696772(RUNX1)

CBRC:

103617027(RUNX1)

ETL:	114071857 114072382

ACHL:

103807554(RUNX1)

SVG:	106863236(RUNX1)

HRT:	120749442(RUNX1)

FPG:	101916329(RUNX1) 106112951

FCH:	102053520(RUNX1)

CLV:	102087117(RUNX1)

EGZ:	104128174(RUNX1)

NNI:	104020181(RUNX1)

PLET:

104616076

PCAO:

104048835(RUNX1)

ACUN:

113478993(RUNX1)

TALA:

104361251(RUNX1)

PADL:

103920324(RUNX1)

AFOR:

103902076(RUNX1)

ACHC:

115343870(RUNX1)

HLE:	104839819(RUNX1)

AGEN:

126053078

GCL:

127029605

CCRI:

104169599(RUNX1)

CMAC:

104475976(RUNX1)

MUI:	104546970(RUNX1)

GSTE:

104263538

OHA:	104327770(RUNX1)

SHAB:

115604604(RUNX1)

DPUB:

104304940(RUNX1)

PGUU:

104466514(RUNX1)

ACAR:

104520012

CPEA:

104391196(RUNX1)

AVIT:

104277540(RUNX1)

CVF:	104292038(RUNX1)

RTD:	128919163(RUNX1)

CUCA:

104064743(RUNX1)

AAM:	106494897(RUNX1)

AROW:

112971833(RUNX1)

NPD:	112948161(RUNX1)

TGT:

104573442

DNE:	112996178(RUNX1)

SCAM:

104139440(RUNX1)

ASN:	102385681(RUNX1)

AMJ:	102572910(RUNX1)

CPOO:

109305802(RUNX1)

GGN:	109302327(RUNX1)

PSS:	102455885(RUNX1)

CMY:	102944269(RUNX1)

CCAY:

125644031(RUNX1)

DCC:	119863355(RUNX1)

CPIC:

101938129(RUNX1)

TST:	117867441(RUNX1)

CABI:

116823670(RUNX1)

MRV:	120369420(RUNX1)

ACS:	100564051(runx1)

ASAO:

132771866(RUNX1)

PVT:	110076828(RUNX1)

SUND:

121927358(RUNX1)

PBI:	103055722(RUNX1)

PMUR:

107291521

CTIG:

120296644(RUNX1)

TSR:	106549617(RUNX1)

PGUT:

117678673(RUNX1)

APRI:

131199548(RUNX1)

PTEX:

113436250(RUNX1)

NSS:	113409898(RUNX1)

VKO:	123029379(RUNX1)

PMUA:

114596073(RUNX1)

PRAF:

128412997(RUNX1)

ZVI:	118084720(RUNX1)

HCG:	128351140(RUNX1)

GJA:

107117549

STOW:

125431869(RUNX1)

EMC:	129325931(RUNX1)

XLA:	108709238 379657(runx1.L)

XTR:	100485449(runx1)

NPR:	108791098(RUNX1)

RTEM:

120927927(RUNX1)

BBUF:

120994505(RUNX1)

BGAR:

122930826(RUNX1)

MUO:	115469485(RUNX1)

GSH:	117363083(RUNX1)

DRE:	58126(runx1)

SRX:	107709287(runx1) 107751097

SANH:

107653683 107698911

SGH:	107555250 107571884

CCAR:

109071062

CAUA:

113044609 113097601

CGIB:

127945896 127948782 128013330

PTET:

122349769(runx1)

LROH:

127171150(runx1)

OMC:	131530568(runx1)

PPRM:

120460533(runx1)

RKG:	130096670(runx1)

MAMB:

125272953(runx1)

CIDE:

127521140

MASI:

127443368 127445343

TROS:

130553126(runx1)

TDW:	130438776(runx1)

MANU:

129445107(runx1)

IPU:

108259037

IFU:	128602446(runx1)

PHYP:

113537666(runx1)

SMEO:

124378141(runx1)

TFD:	113648874(runx1)

TVC:	132839228(runx1)

AMEX:

103025657

CMAO:

118798144(runx1)

EEE:

113582633

CHAR:

105889601(runx1)

TRU:	100049631(runx1)

TFS:	130522690(runx1)

TNG:	GSTEN00034595G001

LCO:

104936698

NCC:

104961881

TBEN:

117498938(runx1)

CGOB:

115018094

PGEO:

117458677(runx1)

GACU:

117546623(runx1)

EMAC:

134861146(runx1)

ELY:	117249915(runx1)

EFO:	125885173(runx1)

PLEP:

121964414

SLUC:

116036434(runx1)

ECRA:

117939492(runx1)

ESP:

116677658

PFLV:

114551073

GAT:	120821894(runx1)

PPUG:

119221892(runx1)

AFB:	129111552(runx1)

CLUM:

117746364(runx1)

PSWI:

130204236

MSAM:

119900649(runx1)

SCHU:

122872043(runx1)

CUD:	121506178(runx1)

ALAT:

119015595(runx1)

MZE:

101482179

ONL:

100691239

OAU:	116326998(runx1)

OLA:

101173202

OML:	112141993(runx1)

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826911(runx1)

PPRL:

129356470(runx1)

CVG:

107098178

CTUL:

119779581(runx1)

GMU:	124861290(runx1)

NFU:

107384523

KMR:	108249382(runx1)

ALIM:

106534917

NWH:	119428785(runx1)

AOCE:

111562778

MCEP:

125000944(runx1)

CSEM:

103389730

POV:	109640042(runx1)

SSEN:

122765146(runx1)

HHIP:

117777362(runx1)

HSP:	118103459(runx1)

SMAU:

118302323(runx1)

LCF:	108902563(runx1)

SDU:

111232758

SLAL:

111670267

XGL:	120798265(runx1)

HCQ:

109528744

SSCV:

125989217

SBIA:

133504475(runx1)

PEE:	133397843(runx1)

PTAO:

133482689(runx1)

BPEC:

110156597

MALB:

109952206 109961125

BSPL:

114848842(runx1)

SJO:	128354486(runx1)

SASA:

106574394 106575592 106595378

STRU:

115179193 115196293

OTW:	112267670(runx1) 121846747

OMY:	110495653 110527326

OGO:	124008497 124011043

ONE:

115129817

OKI:

109883367

OKE:	118363206 118379083

SNH:	120042747 120051428(runx1)

CCLU:

121543332(runx1)

ELS:	105019777(runx1)

SFM:	108931706 108938311(runx1)

PKI:	111856070(runx1)

AANG:

118214293(runx1) 118223562

LOC:	102682529(runx1)

PSPA:

121320993 121327982

ARUT:

117407217

PSEX:

120522828(runx1)

LCM:	102360635(RUNX1)

CMK:	103186755(runx1)

RTP:	109914103(runx1)

CPLA:

122554840(runx1)

HOC:	132821152(runx1)

LERI:

129702976(runx1)

PMRN:

116952997 116953354

LRJ:	133351276 133353458 133357060

BFO:

BBEL:

CIN:

SCLV:

SPU:	373468(SpRunt-1) 576197

APLC:

110978851

SKO:	100302713(runt)

LSQ:

ECOE:

AFLR:

VCAN:

AROA:

SOY:	115887579 115887589

CSET:

123317073 123317220 123317565

AGB:	108903535 108903536 108907089 111691513

LDC:

111512323

APLN:

108738268 108738269 108741870

PPYR:

116178939 116179797

OTU:	111416297 111419177

MSEX:

BANY:

PXU:

PRAP:

SLIU:

PGW:

CCRN:

AGS:

ACOO:

126835825 126841822 126841983

DVT:	126895183 126907234 126907774

DCI:

103516019

NLU:

120356734

HVI:	124362365 124362366

MQU:	128988728 128990133 128990979

IEL:

124171572

DMK:	116918153 116921892

CQD:

128702869

HAZT:

108676912

DFR:	124492668 124498985

ABRU:

129962580 129985350

UDV:	129224737 129225670 129225889

SDM:

118187943

PVUL:

126811682

BGT:

106059914

GAE:	121370556 121391817

HRF:

HRJ:

CRG:

CANU:

OED:

MMER:

DPOL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_25179

AQU:

100638951

MPHI:

EG856_01160

» show all

Reference

PMID:1720541

Authors

Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M

Title

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

Journal

Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431

Sequence

[hsa:861]

LinkDB

DBGET integrated database retrieval system