KEGG   PATHWAY: dnm05166
Entry
dnm05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Dasypus novemcinctus (nine-banded armadillo)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
dnm05166  Human T-cell leukemia virus 1 infection
dnm05166

Disease
H00009  Adult T-cell leukemia
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410814  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101410832  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
101410864  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101410879  [KO:K04374]
101410920  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101410933  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101411165  [KO:K06751]
101411174  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101411312  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
101411329  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101411381  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
101411454  [KO:K06751]
101411559  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101411573  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101411588  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101411831  [KO:K06751]
101411867  CDC26; anaphase-promoting complex subunit CDC26 isoform X3 [KO:K03359]
101411890  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101411992  [KO:K03120]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101412139  [KO:K06751]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101412249  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
101412315  TLN1; talin-1 [KO:K06271]
101412450  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
101412468  [KO:K06751]
101412608  [KO:K06751]
101412730  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
101412902  [KO:K06751]
101413064  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101413116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101413410  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101413471  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
101413586  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101413678  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101413757  IL2; interleukin-2 precursor [KO:K05429]
101413764  [KO:K06751]
101413809  [KO:K04345] [EC:2.7.11.11]
101413963  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101414225  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101414240  [KO:K07828]
101414348  IL15; interleukin-15 [KO:K05433]
101414493  [KO:K06751]
101414637  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101414715  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101415022  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101415143  CRTC3; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 3 [KO:K16334]
101415145  [KO:K06752]
101415212  [KO:K06751]
101415391  [KO:K06751]
101415573  [KO:K06752]
101415823  [KO:K06751]
101415824  [KO:K06751]
101415898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101415930  ETS2; protein C-ets-2 [KO:K21932]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416305  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101416412  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
101417008  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101417015  [KO:K06752]
101417345  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101417743  [KO:K06752]
101417885  RELA; transcription factor p65 [KO:K04735]
101418100  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101418436  [KO:K03354]
101418445  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101418741  [KO:K06751]
101418742  [KO:K02537]
101419007  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419119  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
101419186  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101419219  KAT5; histone acetyltransferase KAT5 [KO:K11304] [EC:2.3.1.48]
101419332  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101419419  [KO:K06751]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419876  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
101420045  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101420075  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101420445  TNF; tumor necrosis factor [KO:K03156]
101420466  [KO:K15040]
101420546  [KO:K04369] [EC:2.7.12.2]
101420648  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101420800  [KO:K06751]
101420892  LTA; lymphotoxin-alpha [KO:K05468]
101421271  [KO:K06752]
101421532  [KO:K06751]
101421706  [KO:K06752]
101421795  E2F3; transcription factor E2F3 [KO:K06620]
101421796  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101421842  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101422217  MSX1; homeobox protein MSX-1 [KO:K09341]
101422259  [KO:K06751]
101422560  [KO:K06751]
101422608  [KO:K03120]
101422732  [KO:K08048] [EC:4.6.1.1]
101422825  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101422917  [KO:K06751]
101423520  RELB; transcription factor RelB [KO:K09253]
101423556  [KO:K06621]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101423744  [KO:K02649]
101423941  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101424334  [KO:K06751]
101424450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101424631  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101424781  [KO:K06751]
101424799  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101424904  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101425317  MSX2; homeobox protein MSX-2 [KO:K09341]
101425368  FOSL1; LOW QUALITY PROTEIN: fos-related antigen 1 [KO:K04502]
101425452  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101426177  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
101426244  CALR; calreticulin [KO:K08057]
101426399  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101426661  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
101426756  [KO:K06751]
101426829  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101427038  [KO:K06751]
101427107  [KO:K15305]
101427150  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
101427325  [KO:K06751]
101427372  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101427430  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
101427629  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101427751  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101427870  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101427882  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101427892  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101427927  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101428001  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101428148  NRP1; neuropilin-1 isoform X1 [KO:K06724]
101428513  [KO:K06751]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428809  [KO:K06751]
101429090  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101429422  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101429481  [KO:K05405]
101429504  ITGAL; integrin alpha-L [KO:K05718]
101429531  CDC16; cell division cycle protein 16 homolog [KO:K03353]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101429977  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
101430016  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101430113  [KO:K06751]
101430137  FDPS; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
101430252  [KO:K06751]
101430266  [KO:K08065]
101430345  [KO:K11218] [EC:2.7.10.2]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430817  NRAS; GTPase NRas [KO:K07828]
101431286  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
101431782  FOS; proto-oncogene c-Fos [KO:K04379]
101431829  TSPO; translocator protein [KO:K05770]
101431862  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101432032  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
101432034  [KO:K06751]
101432154  BAX; apoptosis regulator BAX [KO:K02159]
101432336  SRF; serum response factor [KO:K04378]
101432723  [KO:K05863]
101432742  [KO:K06751]
101432776  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101433013  MAD2L1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101433135  [KO:K05863]
101433274  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
101433313  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433781  [KO:K06752]
101434076  PTTG1; securin [KO:K06635]
101434549  TGFB3; transforming growth factor beta-3 [KO:K13377]
101434680  CCNA1; cyclin-A1 [KO:K06627]
101434857  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
101434860  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
101435044  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
101435173  RAN; GTP-binding nuclear protein Ran [KO:K07936]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435274  TBP; LOW QUALITY PROTEIN: TATA-box-binding protein [KO:K03120]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435433  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101435448  [KO:K06751]
101435501  [KO:K06752]
101435604  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101435675  [KO:K06751]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435770  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101435854  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101435917  [KO:K06752]
101436037  [KO:K06464]
101436345  [KO:K06752]
101436527  TLN2; talin-2 isoform X2 [KO:K06271]
101436907  B2M; beta-2-microglobulin [KO:K08055]
101436974  GPS2; G protein pathway suppressor 2 [KO:K15307]
101437028  [KO:K06752]
101437298  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101437302  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437737  TGFB1; transforming growth factor beta-1 [KO:K13375]
101437751  [KO:K06752]
101437850  [KO:K06751]
101438057  CANX; calnexin [KO:K08054]
101438422  TRRAP; LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [KO:K08874]
101438478  [KO:K06752]
101438484  [KO:K06751]
101438805  XPO1; exportin-1 [KO:K14290]
101438974  [KO:K06635]
101439095  [KO:K06751]
101439136  [KO:K06751]
101439276  [KO:K08057]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101439564  [KO:K06751]
101439717  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101439751  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
101439768  ESPL1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
101439820  KAT2A; histone acetyltransferase KAT2A isoform X3 [KO:K06062] [EC:2.3.1.48]
101439842  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
101440382  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101440447  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101440679  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
101440773  [KO:K06752]
101440851  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101440970  [KO:K06268]
101441252  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101441690  [KO:K06751]
101441708  [KO:K06618]
101442054  TSPO2; translocator protein 2 isoform X1 [KO:K05770]
101442251  [KO:K06751]
101442310  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101442557  [KO:K06751]
101442654  [KO:K06751]
101442691  [KO:K06751]
101442840  [KO:K06751]
101442886  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
101442901  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101442950  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101443141  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101443412  [KO:K06752]
101443494  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101443775  STAT5A; signal transducer and activator of transcription 5A isoform X2 [KO:K11223]
101443963  IL6; interleukin-6 [KO:K05405]
101444066  [KO:K09063]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444584  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
101444673  [KO:K06751]
101444704  [KO:K06751]
101444912  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101445087  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
101445129  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
101445227  [KO:K06751]
101445493  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101445532  EGR1; early growth response protein 1 [KO:K09203]
101445592  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
101445596  [KO:K04345] [EC:2.7.11.11]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101446004  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101446223  [KO:K06751]
101446715  DLG1; disks large homolog 1 isoform X7 [KO:K12076]
101446780  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
101446968  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101447050  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101447218  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101447227  [KO:K06751]
101447399  RANBP1; ran-specific GTPase-activating protein [KO:K15306]
101447422  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101447907  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
101447966  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
105744121  CCNA2; cyclin-A2 [KO:K06627]
105744147  [KO:K06751]
111758663  [KO:K06751]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
dnm03013  Nucleocytoplasmic transport
dnm04010  MAPK signaling pathway
dnm04064  NF-kappa B signaling pathway
dnm04110  Cell cycle
dnm04115  p53 signaling pathway
dnm04151  PI3K-Akt signaling pathway
dnm04210  Apoptosis
dnm04350  TGF-beta signaling pathway
dnm04612  Antigen processing and presentation
dnm04660  T cell receptor signaling pathway
dnm04668  TNF signaling pathway
KO pathway
ko05166   

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