KEGG   PATHWAY: lav05010
Entry
lav05010                    Pathway                                
Name
Alzheimer disease - Loxodonta africana (African savanna elephant)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
lav05010  Alzheimer disease
lav05010

Disease
H00056  Alzheimer disease
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100141371  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
100141375  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100141376  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100568297  SNCA; alpha-synuclein [KO:K04528]
100653538  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100653551  WNT2B; protein Wnt-2b [KO:K00182]
100653591  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
100653679  [KO:K07375]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100653866  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [KO:K17908]
100653935  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
100654286  [KO:K08738]
100654354  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100654461  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100654713  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
100654730  RELA; transcription factor p65 isoform X2 [KO:K04735]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100654997  FZD2; frizzled-2 [KO:K02235]
100655153  ATG2B; autophagy-related protein 2 homolog B isoform X3 [KO:K17906]
100655323  KIF5A; kinesin heavy chain [KO:K10396]
100655324  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100655439  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
100655578  [KO:K02263]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100655730  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100655765  AXIN1; axin-1 [KO:K02157]
100655781  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
100655805  WNT10B; protein Wnt-10b [KO:K01357]
100655829  BECN2; LOW QUALITY PROTEIN: beclin-2 [KO:K08334]
100655878  [KO:K21421] [EC:1.-.-.-]
100655924  [KO:K00237]
100656057  TUBB1; tubulin beta-1 chain [KO:K07375]
100656157  [KO:K04809]
100656237  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100656243  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100656290  KLC1; kinesin light chain 1 isoform X15 [KO:K10407]
100656308  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100656597  CASP9; caspase-9 isoform X3 [KO:K04399] [EC:3.4.22.62]
100656630  WNT11; protein Wnt-11 [KO:K01384]
100656672  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100656792  DKK4; dickkopf-related protein 4 [KO:K02165]
100656819  KLC2; LOW QUALITY PROTEIN: kinesin light chain 2 [KO:K10407]
100656914  [KO:K02267]
100657046  WNT2; protein Wnt-2 [KO:K00182]
100657132  [KO:K08738]
100657307  [KO:K02270]
100657335  FZD1; frizzled-1 [KO:K02432]
100657363  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100657374  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100657505  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100657531  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100657555  [KO:K04741] [EC:3.4.22.-]
100657587  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100657612  [KO:K02183]
100657649  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100657688  SLC39A3; zinc transporter ZIP3 [KO:K14709]
100657700  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100657715  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100657749  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100657844  [KO:K04741] [EC:3.4.22.-]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100658039  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100658110  DKK2; dickkopf-related protein 2 [KO:K02165]
100658150  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
100658155  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
100658208  [KO:K02183]
100658215  [KO:K02271]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100658479  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
100658489  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
100658561  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100658596  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
100658646  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
100658706  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100658734  LRP6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
100658813  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100658849  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100658936  FZD7; frizzled-7 [KO:K02432]
100658962  CALML3; calmodulin-like protein 3 [KO:K02183]
100658979  WNT9B; protein Wnt-9b [KO:K01064]
100659010  [KO:K02265]
100659017  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100659037  WNT16; protein Wnt-16 [KO:K01558]
100659051  NRAS; GTPase NRas [KO:K07828]
100659078  [KO:K02270]
100659084  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
100659182  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100659326  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100659329  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100659426  [KO:K02263]
100659665  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100659666  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100659857  [KO:K00419]
100659992  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100660112  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100660353  [KO:K17445]
100660360  LRP1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
100660389  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
100660542  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100660618  [KO:K07374]
100660629  WNT7B; protein Wnt-7b [KO:K00572]
100660631  FZD10; frizzled-10 [KO:K02842]
100660738  GRIN2B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100660762  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100660846  IL6; interleukin-6 [KO:K05405]
100660941  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
100661044  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100661112  INS; insulin [KO:K04526]
100661123  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X3 [KO:K03959]
100661178  SLC39A11; zinc transporter ZIP11 isoform X2 [KO:K14717]
100661324  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100661329  NDUFB6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100661492  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
100661497  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
100661505  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100661512  KRAS; GTPase KRas isoform X2 [KO:K07827]
100661626  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100661689  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
100661910  TUBA8; tubulin alpha-8 chain [KO:K07374]
100662057  WNT9A; protein Wnt-9a [KO:K01064]
100662194  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100662196  BID; BH3-interacting domain death agonist [KO:K04726]
100662337  WNT3A; protein Wnt-3a [KO:K00312]
100662420  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100662438  [KO:K00418]
100662469  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100662489  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
100662521  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
100662563  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
100662599  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
100662633  FADD; FAS-associated death domain protein [KO:K02373]
100662918  SLC39A4; LOW QUALITY PROTEIN: zinc transporter ZIP4 [KO:K14710]
100663058  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100663073  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X2 [KO:K17908]
100663098  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100663191  [KO:K02270]
100663225  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100663226  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
100663252  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100663268  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
100663363  [KO:K02266]
100663507  CALM1; calmodulin-1 [KO:K02183]
100663575  [KO:K04398] [EC:3.4.22.61]
100663624  MAPT; microtubule-associated protein tau [KO:K04380]
100663654  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100663668  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
100663713  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100663737  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
100663779  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
100663804  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100663807  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
100663829  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100663921  AXIN2; axin-2 [KO:K04385]
100664015  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100664059  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100664361  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100664388  WNT4; LOW QUALITY PROTEIN: protein Wnt-4 [KO:K00408]
100664407  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100664422  ATG101; autophagy-related protein 101 [KO:K19730]
100664544  WNT5B; protein Wnt-5b isoform X2 [KO:K00444]
100664545  KIF5B; kinesin-1 heavy chain [KO:K10396]
100664679  CALM2; calmodulin-2 [KO:K02183]
100664832  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100664844  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100664859  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100664946  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
100664968  IRS1; insulin receptor substrate 1 [KO:K16172]
100665028  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100665091  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
100665119  SLC39A14; zinc transporter ZIP14 [KO:K14720]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100665257  [KO:K02273]
100665309  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
100665312  [KO:K07374]
100665644  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
100665650  KLC4; kinesin light chain 4 [KO:K10407]
100665788  WNT8B; protein Wnt-8b [KO:K00714]
100665872  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100665908  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
100665921  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100666014  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
100666038  [KO:K00420]
100666209  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
100666249  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100666300  [KO:K08960] [EC:2.7.11.1]
100666335  TUBB6; tubulin beta-6 chain [KO:K07375]
100666359  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100666414  [KO:K00413]
100666465  FZD3; frizzled-3 [KO:K02329]
100666499  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100666567  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100666690  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
100666715  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100666763  [KO:K02271]
100666770  CSNK2A2; LOW QUALITY PROTEIN: casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
100666773  [KO:K07375]
100667038  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100667055  [KO:K07375]
100667215  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100667241  [KO:K00411] [EC:7.1.1.8]
100667263  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100667285  SLC39A10; LOW QUALITY PROTEIN: zinc transporter ZIP10 [KO:K14716]
100667323  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
100667324  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
100667388  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100667667  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100667686  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
100667776  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100667823  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100667845  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100668088  NCSTN; nicastrin [KO:K06171]
100668090  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100668116  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
100668161  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100668175  APBB1; LOW QUALITY PROTEIN: amyloid-beta A4 precursor protein-binding family B member 1 [KO:K04529]
100668197  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100668345  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
100668387  BAD; bcl2-associated agonist of cell death [KO:K02158]
100668409  WNT8A; protein Wnt-8a [KO:K00714]
100668575  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100668630  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100668807  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100668904  [KO:K03948]
100668947  [KO:K00415]
100668998  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100669057  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
100669183  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
100669323  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
100669401  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100669466  FRAT1; proto-oncogene FRAT1 [KO:K03069]
100669509  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100669546  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
100669563  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
100669636  APOE; apolipoprotein E [KO:K04524]
100669746  PSEN1; LOW QUALITY PROTEIN: presenilin-1 [KO:K04505] [EC:3.4.23.-]
100669755  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100669867  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
100669885  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100669927  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100669937  [KO:K00417]
100669954  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100670303  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100670393  TUBB; LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
100670400  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100670501  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100670560  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
100670586  [KO:K07374]
100670617  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100670704  CSF1; macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
100670745  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
100670753  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100670866  [KO:K07374]
100670890  CASP7; caspase-7 isoform X3 [KO:K04397] [EC:3.4.22.60]
100670894  ATP5PO; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
100670988  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
100671145  SLC39A5; zinc transporter ZIP5 [KO:K14711]
100671276  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
100671404  ARAF; serine/threonine-protein kinase A-Raf isoform X3 [KO:K08845] [EC:2.7.11.1]
100671498  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100671569  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
100671690  [KO:K07375]
100671700  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100671712  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
100671775  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6 [KO:K05853] [EC:7.2.2.10]
100671885  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100671886  RTN3; reticulon-3 isoform X1 [KO:K20723]
100671911  [KO:K07374]
100671938  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
100672097  SLC39A2; zinc transporter ZIP2 isoform X3 [KO:K14709]
100672143  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100672207  [KO:K07374]
100672256  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100672435  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100672637  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100672932  RTN4; reticulon-4 isoform X1 [KO:K20720]
100673089  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100673195  SLC39A13; LOW QUALITY PROTEIN: zinc transporter ZIP13 [KO:K14719]
100673238  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100673272  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100673278  [KO:K02268]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673399  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
100673586  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100673733  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100673749  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100673778  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100673992  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
100674152  SLC39A8; zinc transporter ZIP8 [KO:K14714]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674349  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
100674374  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
100674424  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
100674586  FZD5; frizzled-5 [KO:K02375]
100674649  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100674746  IL1B; interleukin-1 beta [KO:K04519]
100674782  WNT10A; protein Wnt-10a [KO:K01357]
100674793  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100674800  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
100674803  [KO:K00414]
100674815  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100674818  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
100674944  [KO:K02266]
100675032  IL1A; interleukin-1 alpha [KO:K04383]
100675069  WNT6; protein Wnt-6 [KO:K00445]
100675084  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100675105  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100675111  BECN1; beclin-1 isoform X1 [KO:K08334]
100675297  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100675317  FZD4; frizzled-4 [KO:K02354]
100675388  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
100675396  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100675463  WNT7A; protein Wnt-7a [KO:K00572]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100675552  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100675610  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100675691  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
100675710  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100675936  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
100675949  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100675957  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100676000  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100676021  [KO:K02267]
100676035  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100676048  ATG13; autophagy-related protein 13 isoform X2 [KO:K08331]
100676161  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100676265  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100676453  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100676457  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
100676572  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100676634  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100676641  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
100676710  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
100676740  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100676791  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100676904  IRS2; insulin receptor substrate 2 isoform X3 [KO:K07187]
100676911  [KO:K00416]
100677118  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
100677125  TNF; tumor necrosis factor isoform X2 [KO:K03156]
100677129  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100677213  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
100677270  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
100677352  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100677440  FZD6; frizzled-6 [KO:K02376]
100677530  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
100677532  PSMA8; proteasome subunit alpha type-7-like isoform X2 [KO:K02731] [EC:3.4.25.1]
100677730  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
104845884  [KO:K00134] [EC:1.2.1.12]
104846185  [KO:K03967]
104846724  [KO:K00134] [EC:1.2.1.12]
104846789  [KO:K07374]
104847353  TUBB4B; tubulin beta-4B chain [KO:K07375]
111748544  [KO:K02135]
111749757  [KO:K02135]
111749980  [KO:K02272]
111751572  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111751867  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
111752617  NDUFA10; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
808783  CYTB; cytochrome b [KO:K00412]
808784  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808785  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808786  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808787  COX3; cytochrome c oxidase subunit III [KO:K02262]
808788  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
808790  COX2; cytochrome c oxidase subunit II [KO:K02261]
808791  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808792  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808793  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808794  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808795  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
lav00190  Oxidative phosphorylation
lav03050  Proteasome
lav04020  Calcium signaling pathway
lav04140  Autophagy - animal
lav04141  Protein processing in endoplasmic reticulum
lav04210  Apoptosis
lav04310  Wnt signaling pathway
lav04910  Insulin signaling pathway
lav04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system