KEGG   PATHWAY: lcat04062
Entry
lcat04062                   Pathway                                
Name
Chemokine signaling pathway - Lemur catta (Ring-tailed lemur)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
lcat04062  Chemokine signaling pathway
lcat04062

Other DBs
GO: 0070098
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620186  [KO:K14624]
123620187  [KO:K16597]
123620188  [KO:K16595]
123620350  CCL5; C-C motif chemokine 5 [KO:K12499]
123620352  CCL14; C-C motif chemokine 14 [KO:K21092]
123620354  [KO:K05511]
123620355  [KO:K05511]
123620356  [KO:K21094]
123620357  [KO:K05408]
123620358  [KO:K05408]
123620359  [KO:K12964]
123620702  CRK; adapter molecule crk isoform X1 [KO:K04438]
123620748  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123620877  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
123620957  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
123620960  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
123620972  CCR10; C-C chemokine receptor type 10 [KO:K04185]
123621158  CCL16; C-C motif chemokine 16 [KO:K21093]
123621160  [KO:K08291] [EC:2.7.11.16]
123621227  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
123621229  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
123621906  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622219  GRK4; LOW QUALITY PROTEIN: G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123622389  SHC4; SHC-transforming protein 4 [KO:K17449]
123622694  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123622795  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123622835  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
123623093  CCR9; C-C chemokine receptor type 9 [KO:K04184]
123623095  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
123623096  XCR1; chemokine XC receptor 1 [KO:K04193]
123623097  CCR1; C-C chemokine receptor type 1 [KO:K04176]
123623098  CCR3; C-C chemokine receptor type 3 [KO:K04178]
123623099  CCR2; C-C chemokine receptor type 2 [KO:K04177]
123623100  CCR5; C-C chemokine receptor type 5 [KO:K04180]
123623138  CCR8; C-C chemokine receptor type 8 [KO:K04183]
123623170  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
123623249  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123623451  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
123623917  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123624044  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
123624110  [KO:K05505]
123624135  [KO:K10029]
123624136  [KO:K05407]
123624256  [KO:K05506]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624357  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624520  CXCL8; interleukin-8 [KO:K10030]
123624714  [KO:K05505]
123624715  [KO:K05505]
123624738  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
123624739  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
123624740  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
123624755  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
123625286  CCL17; C-C motif chemokine 17 [KO:K21083]
123625287  CX3CL1; fractalkine [KO:K05508]
123625288  CCL22; C-C motif chemokine 22 [KO:K21095]
123625428  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123625466  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123625473  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123625781  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
123625938  PXN; paxillin isoform X1 [KO:K05760]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626242  CRKL; crk-like protein isoform X1 [KO:K04438]
123626590  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123626648  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
123627001  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627584  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123627760  CCR4; C-C chemokine receptor type 4 [KO:K04179]
123628361  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123628732  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630112  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630284  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123630505  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123630677  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123631427  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123632025  CCL26; C-C motif chemokine 26 [KO:K21096]
123632067  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
123632266  CCR6; C-C chemokine receptor type 6 [KO:K04181]
123632319  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632598  CCL24; C-C motif chemokine 24 [KO:K21097]
123632639  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123633137  FOXO3; forkhead box protein O3 [KO:K09408]
123633190  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123634038  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
123634187  [KO:K02649]
123634330  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123634680  XCL1; lymphotactin [KO:K05507]
123634968  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123635002  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123635037  RAP1A; ras-related protein Rap-1A [KO:K04353]
123635081  NRAS; GTPase NRas [KO:K07828]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635534  CCL25; C-C motif chemokine 25 [KO:K13072]
123635536  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123635877  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
123635996  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
123636000  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123636599  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
123636670  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123637148  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637795  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
123637974  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
123638024  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123639294  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123639540  RAP1B; ras-related protein Rap-1b [KO:K07836]
123639564  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123639648  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123639921  KRAS; GTPase KRas [KO:K07827]
123640104  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123640442  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
123641024  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
123641343  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641412  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123641505  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
123642301  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123642864  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123643287  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123643290  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
123643346  [KO:K05050]
123643506  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
123643616  [KO:K04513]
123643619  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
123643644  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123644339  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123644610  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
123645814  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
123645857  SHC3; SHC-transforming protein 3 [KO:K17448]
123646184  CCL21; C-C motif chemokine 21 [KO:K16062]
123646185  CCL27; C-C motif chemokine 27 [KO:K16598]
123646186  CCL19; C-C motif chemokine 19 [KO:K05512]
123646187  [KO:K16598]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123646542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
123646669  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
123647150  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123647151  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123647339  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
123647376  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123647726  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
123648063  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123648146  CCL28; C-C motif chemokine 28 [KO:K05513]
123648542  [KO:K04542]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123648827  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123649875  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
123650127  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123650408  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
123650656  [KO:K16596]
123650680  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123650723  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123650820  [KO:K16595]
123650941  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
123650942  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
lcat04010  MAPK signaling pathway
lcat04060  Cytokine-cytokine receptor interaction
lcat04120  Ubiquitin mediated proteolysis
lcat04630  JAK-STAT signaling pathway
lcat04670  Leukocyte transendothelial migration
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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