KEGG   PATHWAY: ocu04380
Entry
ocu04380                    Pathway                                
Name
Osteoclast differentiation - Oryctolagus cuniculus (rabbit)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
ocu04380  Osteoclast differentiation
ocu04380

Other DBs
GO: 0030316
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008602  IFNG; interferon gamma precursor [KO:K04687]
100008645  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100008800  CYBA; cytochrome b-245 light chain [KO:K08009]
100008802  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100008803  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100008852  [KO:K08008]
100008856  JUN; transcription factor Jun [KO:K04448]
100008892  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
100008939  [KO:K04960]
100008990  IL1B; interleukin-1 beta precursor [KO:K04519]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100009231  CALCR; calcitonin receptor precursor [KO:K04576]
100009250  IL1A; interleukin-1 alpha [KO:K04383]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009334  CTSK; cathepsin K precursor [KO:K01371] [EC:3.4.22.38]
100009359  NCF4; neutrophil cytosol factor 4 [KO:K08012]
100009371  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100009505  [KO:K04958]
100037716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100038308  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100337822  [KO:K00922] [EC:2.7.1.153]
100337909  [KO:K06463]
100337959  [KO:K14380]
100337999  [KO:K04440] [EC:2.7.11.24]
100338097  [KO:K05131]
100338208  [KO:K04502]
100338345  [KO:K04379]
100338413  [KO:K06472]
100338577  [KO:K05453]
100338604  [KO:K05130]
100338854  [KO:K05133]
100338913  [KO:K06463]
100339386  [KO:K04694]
100339465  [KO:K07361]
100339741  [KO:K05703] [EC:2.7.10.2]
100339873  [KO:K04392]
100339928  [KO:K04469]
100340139  [KO:K05859] [EC:3.1.4.11]
100340992  [KO:K05090] [EC:2.7.10.1]
100341009  [KO:K05473]
100341695  [KO:K04441] [EC:2.7.11.24]
100341787  [KO:K05132]
100341923  [KO:K07364] [EC:2.7.10.2]
100342157  [KO:K14381]
100342249  [KO:K04404]
100342500  [KO:K04364]
100342664  [KO:K04440] [EC:2.7.11.24]
100342852  [KO:K04456] [EC:2.7.11.1]
100342931  [KO:K05415]
100343190  [KO:K03175] [EC:2.3.2.27]
100343571  [KO:K04427] [EC:2.7.11.25]
100343893  [KO:K11220]
100344161  [KO:K04441] [EC:2.7.11.24]
100344335  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
100344432  [KO:K04693]
100344467  [KO:K11221]
100344533  [KO:K06268]
100344622  [KO:K11219] [EC:2.7.10.2]
100344730  [KO:K09455]
100345136  [KO:K06512]
100345181  [KO:K00922] [EC:2.7.1.153]
100345250  [KO:K02649]
100345556  [KO:K05855] [EC:2.7.10.2]
100345649  [KO:K06512]
100345812  [KO:K04674] [EC:2.7.11.30]
100346106  [KO:K03158]
100346929  [KO:K04440] [EC:2.7.11.24]
100347041  [KO:K06512]
100347042  [KO:K09030]
100347345  [KO:K04371] [EC:2.7.11.24]
100348133  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
100348561  [KO:K04371] [EC:2.7.11.24]
100348663  [KO:K00922] [EC:2.7.1.153]
100348711  [KO:K06512]
100348748  [KO:K14378]
100349102  [KO:K05856] [EC:2.7.10.2]
100349301  [KO:K08091]
100349426  [KO:K02580]
100350239  [KO:K06551]
100350480  [KO:K06551]
100350614  [KO:K04441] [EC:2.7.11.24]
100351032  [KO:K04466] [EC:2.7.11.25]
100351485  [KO:K06551]
100351999  [KO:K05870]
100352301  [KO:K13375]
100352378  [KO:K04446]
100352594  [KO:K11217] [EC:2.7.10.2]
100352905  [KO:K04386]
100353005  [KO:K26770]
100353706  [KO:K04456] [EC:2.7.11.1]
100353824  [KO:K17332]
100354225  [KO:K07370] [EC:2.7.10.2]
100354572  [KO:K08601] [EC:3.4.19.12]
100354716  [KO:K07371]
100354976  [KO:K05853] [EC:7.2.2.10]
100355230  [KO:K04433] [EC:2.7.12.2]
100355888  [KO:K04467] [EC:2.7.11.10]
100356245  [KO:K04348] [EC:3.1.3.16]
100356401  [KO:K07209] [EC:2.7.11.10]
100356806  [KO:K04959]
100357341  [KO:K04734]
100357554  [KO:K06512]
100357841  [KO:K02649]
100358246  [KO:K04403]
100358260  [KO:K05147]
100358696  [KO:K06498]
100359306  [KO:K12560]
103345118  [KO:K05869] [EC:2.7.11.17]
103345313  [KO:K04431] [EC:2.7.12.2]
103345430  [KO:K07992]
103345448  [KO:K13375]
103346035  [KO:K04441] [EC:2.7.11.24]
103346239  [KO:K06512]
103346323  [KO:K09253]
103346588  [KO:K04696]
103347271  [KO:K06512]
103351779  [KO:K09438]
127485184  [KO:K04735]
127486116  [KO:K04456] [EC:2.7.11.1]
127487650  [KO:K08601] [EC:3.4.19.12]
127488466  [KO:K09028]
127488928  [KO:K11220]
127488978  [KO:K06512]
127489461  [KO:K04368] [EC:2.7.12.2]
127489594  [KO:K08011]
127491150  [KO:K11221]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
ocu04010  MAPK signaling pathway
ocu04020  Calcium signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04630  JAK-STAT signaling pathway
KO pathway
ko04380   

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