KEGG   PATHWAY: omy04120
Entry
omy04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Oncorhynchus mykiss (rainbow trout)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
omy04120  Ubiquitin mediated proteolysis
omy04120

Other DBs
GO: 0016567
Organism
Oncorhynchus mykiss (rainbow trout) [GN:omy]
Gene
100135798  [KO:K02927]
100136237  [KO:K06689] [EC:2.3.2.23]
100272210  socs1; suppressor of cytokine signaling 1 [KO:K04694]
100272212  socs3; suppressor of cytokine signaling 3 [KO:K04696]
100301680  ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
100301688  hs020; HSPC020 homolog [KO:K25228]
100301703  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
100301781  cj104; CJ104 protein [KO:K25229]
100301822  ube2n; ubiquitin-conjugating enzyme E2N [KO:K10580] [EC:2.3.2.23]
100301858  rbx1; RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
100305225  ub2r1; Ubiquitin-conjugating enzyme E2-32 kDa complementing [KO:K10575] [EC:2.3.2.23]
100305246  ube2w; probable ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
110485245  [KO:K10593] [EC:2.3.2.26]
110485638  keap1b; kelch-like ECH-associated protein 1B [KO:K10456]
110485931  [KO:K03358]
110485950  [KO:K10581] [EC:2.3.2.24]
110485958  [KO:K04678] [EC:2.3.2.26]
110486131  [KO:K10577]
110486136  [KO:K03350]
110486177  [KO:K10585] [EC:2.3.2.23]
110486196  [KO:K10579] [EC:2.3.2.34]
110486328  ube2ia; SUMO-conjugating enzyme UBC9-B [KO:K10577]
110486339  [KO:K10604] [EC:2.3.2.27]
110486413  [KO:K03868] [EC:2.3.2.32]
110486546  [KO:K04678] [EC:2.3.2.26]
110486673  [KO:K03873]
110487443  [KO:K09561] [EC:2.3.2.27]
110487456  [KO:K09561] [EC:2.3.2.27]
110488020  ube2e2; ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
110488035  [KO:K20217] [EC:2.3.2.23]
110488107  [KO:K10582] [EC:2.3.2.23]
110488159  [KO:K20217] [EC:2.3.2.23]
110488161  [KO:K20217] [EC:2.3.2.23]
110488702  fbxw11a; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
110488709  [KO:K04649] [EC:2.3.2.23]
110488721  [KO:K10599] [EC:2.3.2.27]
110488965  [KO:K10609]
110488978  [KO:K10573] [EC:2.3.2.23]
110489090  ube2d2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
110489126  [KO:K04725] [EC:2.3.2.27]
110489190  [KO:K10601] [EC:2.3.2.27]
110489525  [KO:K03872]
110489989  ube3c; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
110490032  [KO:K03870]
110490114  cblb; E3 ubiquitin-protein ligase CBL-B isoform X2 [KO:K22517] [EC:2.3.2.27]
110490533  [KO:K10580] [EC:2.3.2.23]
110490612  [KO:K10576] [EC:2.3.2.23]
110490613  [KO:K10576] [EC:2.3.2.23]
110491591  ube2ib; LOW QUALITY PROTEIN: SUMO-conjugating enzyme UBC9-A [KO:K10577]
110491624  [KO:K09561] [EC:2.3.2.27]
110491673  [KO:K10605] [EC:2.3.2.27]
110491761  [KO:K03873]
110491883  [KO:K10597] [EC:2.3.2.27]
110491946  huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
110492159  [KO:K10686] [EC:6.2.1.64]
110492204  itchb; E3 ubiquitin-protein ligase Itchy isoform X1 [KO:K05632] [EC:2.3.2.26]
110492502  [KO:K16061]
110493657  [KO:K03358]
110493680  [KO:K04678] [EC:2.3.2.26]
110493855  det1; DET1 homolog [KO:K10571]
110493899  [KO:K05632] [EC:2.3.2.26]
110493917  [KO:K10685] [EC:6.2.1.45]
110494002  ube2r2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
110494212  [KO:K05630] [EC:2.3.2.26]
110494307  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
110494604  siah1; E3 ubiquitin-protein ligase Siah1 isoform X2 [KO:K04506] [EC:2.3.2.27]
110494671  uba7; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
110495137  [KO:K10581] [EC:2.3.2.24]
110495743  keap1a; kelch-like ECH-associated protein 1A [KO:K10456]
110495818  [KO:K08285] [EC:2.3.2.27]
110496423  [KO:K20217] [EC:2.3.2.23]
110496467  [KO:K10582] [EC:2.3.2.23]
110496780  [KO:K10576] [EC:2.3.2.23]
110497019  [KO:K10587] [EC:2.3.2.26]
110497435  [KO:K10599] [EC:2.3.2.27]
110497727  [KO:K10580] [EC:2.3.2.23]
110498306  [KO:K06689] [EC:2.3.2.23]
110498323  [KO:K10260]
110498423  [KO:K10260]
110498429  herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
110498458  [KO:K10614] [EC:2.3.2.26]
110498651  fbxw7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
110498853  [KO:K10577]
110499415  [KO:K04696]
110501259  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
110501394  pias1b; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
110501400  [KO:K08285] [EC:2.3.2.27]
110501667  [KO:K10447]
110501764  ube2e3; ubiquitin-conjugating enzyme E2 E3 isoform X2 [KO:K20217] [EC:2.3.2.23]
110501860  [KO:K10687] [EC:2.3.2.34]
110501978  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
110502026  [KO:K10573] [EC:2.3.2.23]
110502424  [KO:K10586] [EC:2.3.2.23]
110502520  [KO:K10582] [EC:2.3.2.23]
110502527  [KO:K06689] [EC:2.3.2.23]
110502567  [KO:K02977]
110502583  [KO:K03348]
110502743  [KO:K04696]
110503187  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
110503519  [KO:K03869]
110503541  [KO:K04707] [EC:2.3.2.27]
110503545  [KO:K10596] [EC:2.3.2.27]
110503717  [KO:K10684] [EC:6.2.1.45]
110503734  [KO:K10611]
110503741  trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
110503817  [KO:K10612]
110504356  [KO:K10601] [EC:2.3.2.27]
110504588  [KO:K04725] [EC:2.3.2.27]
110504684  [KO:K06689] [EC:2.3.2.23]
110504897  [KO:K03362]
110504905  [KO:K04649] [EC:2.3.2.23]
110504917  [KO:K10599] [EC:2.3.2.27]
110504919  [KO:K06689] [EC:2.3.2.23]
110505172  [KO:K10609]
110505186  [KO:K10573] [EC:2.3.2.23]
110505984  [KO:K10602] [EC:2.3.2.27]
110506216  [KO:K03175] [EC:2.3.2.27]
110506294  [KO:K10610]
110506457  [KO:K10582] [EC:2.3.2.23]
110506546  [KO:K10591] [EC:2.3.2.26]
110506983  [KO:K03175] [EC:2.3.2.27]
110507355  [KO:K03869]
110507383  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
110507388  [KO:K10596] [EC:2.3.2.27]
110507599  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
110507608  [KO:K10590] [EC:2.3.2.26]
110507619  [KO:K10611]
110507657  [KO:K10612]
110508338  [KO:K03869]
110508382  [KO:K16061]
110508409  [KO:K03364]
110508662  cdc20; cell division cycle protein 20 homolog [KO:K03363]
110508677  [KO:K03347]
110508743  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
110508838  [KO:K10583] [EC:2.3.2.23]
110508899  [KO:K02927]
110509037  [KO:K10584] [EC:2.3.2.23]
110509426  [KO:K03355]
110509682  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
110509734  [KO:K10575] [EC:2.3.2.23]
110509772  [KO:K03349]
110509816  trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
110510018  klhl13; kelch-like protein 13 isoform X3 [KO:K10447]
110510106  [KO:K22518] [EC:2.3.2.27]
110510110  [KO:K06689] [EC:2.3.2.23]
110510928  [KO:K10571]
110511375  [KO:K10593] [EC:2.3.2.26]
110511950  uba2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
110513649  [KO:K03871]
110514334  [KO:K06643] [EC:2.3.2.27]
110514470  [KO:K03178] [EC:6.2.1.45]
110514481  [KO:K07868]
110514595  [KO:K07868]
110514649  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
110514691  [KO:K10699] [EC:6.2.1.45]
110515488  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
110515597  [KO:K20217] [EC:2.3.2.23]
110515611  [KO:K20217] [EC:2.3.2.23]
110515971  wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
110516851  [KO:K04678] [EC:2.3.2.26]
110516940  [KO:K06643] [EC:2.3.2.27]
110517247  vhll; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
110518874  [KO:K06689] [EC:2.3.2.23]
110518946  [KO:K10587] [EC:2.3.2.26]
110519290  [KO:K25229]
110519964  [KO:K03353]
110520078  [KO:K04506] [EC:2.3.2.27]
110520213  [KO:K10687] [EC:2.3.2.34]
110520315  [KO:K20217] [EC:2.3.2.23]
110520412  [KO:K10447]
110520480  [KO:K10573] [EC:2.3.2.23]
110520618  [KO:K08285] [EC:2.3.2.27]
110520782  [KO:K10587] [EC:2.3.2.26]
110521158  [KO:K04706] [EC:2.3.2.-]
110521229  [KO:K10582] [EC:2.3.2.23]
110521438  [KO:K16065] [EC:2.3.2.27]
110521470  [KO:K02207] [EC:2.3.2.23]
110522112  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
110522154  [KO:K10576] [EC:2.3.2.23]
110522758  ube2na; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
110522913  [KO:K10607] [EC:2.3.2.27]
110523047  [KO:K10587] [EC:2.3.2.26]
110523060  herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
110523170  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
110523403  [KO:K08770]
110523464  [KO:K03359]
110523523  [KO:K10575] [EC:2.3.2.23]
110523563  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
110523824  [KO:K04552] [EC:2.3.2.23]
110524136  [KO:K02927]
110524294  [KO:K16065] [EC:2.3.2.27]
110524333  [KO:K02207] [EC:2.3.2.23]
110524451  [KO:K03364]
110524540  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
110525058  [KO:K10594] [EC:2.3.2.26]
110525143  [KO:K16063] [EC:2.3.2.-]
110525192  ube2l3b; ubiquitin-conjugating enzyme E2 L3b [KO:K04552] [EC:2.3.2.23]
110525288  rhobtb4; rho related BTB domain containing 4 isoform X1 [KO:K07868]
110525357  [KO:K10588] [EC:2.3.2.26]
110525393  [KO:K02207] [EC:2.3.2.23]
110525420  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
110525526  anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
110525533  [KO:K10575] [EC:2.3.2.23]
110525640  [KO:K07868]
110525674  ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X2 [KO:K06689] [EC:2.3.2.23]
110525959  [KO:K10600] [EC:2.3.2.27]
110525978  fbxo4; F-box only protein 4 isoform X1 [KO:K10291]
110526010  fbxw8; F-box/WD repeat-containing protein 8 isoform X2 [KO:K10264]
110526176  [KO:K10610]
110526220  herc4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
110526341  [KO:K10582] [EC:2.3.2.23]
110526425  [KO:K10591] [EC:2.3.2.26]
110527003  [KO:K04706] [EC:2.3.2.-]
110527031  [KO:K10594] [EC:2.3.2.26]
110527162  [KO:K10609]
110527163  [KO:K10609]
110527247  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
110527438  [KO:K08285] [EC:2.3.2.27]
110527957  [KO:K10686] [EC:6.2.1.64]
110528039  fbxo2; F-box only protein 2 [KO:K10099]
110528213  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
110528455  [KO:K02207] [EC:2.3.2.23]
110528544  itcha; itchy E3 ubiquitin protein ligase a isoform X1 [KO:K05632] [EC:2.3.2.26]
110528620  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
110528634  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
110529501  [KO:K10578] [EC:2.3.2.23]
110529711  [KO:K06689] [EC:2.3.2.23]
110530107  [KO:K02977]
110530139  [KO:K02927]
110530310  [KO:K10143] [EC:2.3.2.27]
110530372  [KO:K03347]
110530537  fzr1b; fizzy-related protein homolog [KO:K03364]
110530687  [KO:K02207] [EC:2.3.2.23]
110530697  pias4b; E3 SUMO-protein ligase PIAS4b isoform X1 [KO:K16065] [EC:2.3.2.27]
110530703  [KO:K03364]
110530801  [KO:K03869]
110530933  aire; autoimmune regulator [KO:K10603]
110531242  [KO:K10592] [EC:2.3.2.26]
110531292  [KO:K06689] [EC:2.3.2.23]
110531294  [KO:K03178] [EC:6.2.1.45]
110532328  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
110532404  [KO:K05632] [EC:2.3.2.26]
110533119  [KO:K10447]
110533228  [KO:K16060]
110533316  [KO:K10575] [EC:2.3.2.23]
110533383  [KO:K03094]
110533471  [KO:K10612]
110533571  [KO:K04707] [EC:2.3.2.27]
110533627  [KO:K08770]
110533895  [KO:K03362]
110534113  [KO:K03355]
110534117  [KO:K06689] [EC:2.3.2.23]
110534395  [KO:K10614] [EC:2.3.2.26]
110534444  [KO:K10599] [EC:2.3.2.27]
110534508  [KO:K10260]
110534878  [KO:K10608] [EC:2.3.2.27]
110535176  flj11011l; probable ubiquitin-conjugating enzyme E2 W-B [KO:K10688] [EC:2.3.2.23 2.3.2.25]
110535177  [KO:K03872]
110535412  cul1b; cullin-1b [KO:K03347]
110535527  [KO:K05633] [EC:2.3.2.26]
110535591  [KO:K10589] [EC:2.3.2.26]
110535706  [KO:K07868]
110535760  [KO:K10588] [EC:2.3.2.26]
110535790  [KO:K02207] [EC:2.3.2.23]
110535813  [KO:K10144] [EC:2.3.2.27]
110535903  [KO:K10575] [EC:2.3.2.23]
110535929  anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
110536010  [KO:K07868]
110536042  [KO:K06689] [EC:2.3.2.23]
110536302  ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
110536348  ubox5; RING finger protein 37 isoform X1 [KO:K10600] [EC:2.3.2.27]
110536452  [KO:K04552] [EC:2.3.2.23]
110536499  pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
110536501  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
110536590  [KO:K03870]
110536778  [KO:K10594] [EC:2.3.2.26]
110536933  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
110536976  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
110537101  [KO:K04552] [EC:2.3.2.23]
110537145  [KO:K03875]
110537224  [KO:K03362]
110537496  ubb; polyubiquitin-B isoform X1 [KO:K08770]
110537545  [KO:K10608] [EC:2.3.2.27]
110537552  [KO:K04707] [EC:2.3.2.27]
110537616  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
110537671  [KO:K10612]
110537727  [KO:K10574] [EC:2.3.2.23]
110537730  [KO:K03094]
110537752  [KO:K22518] [EC:2.3.2.27]
110537823  ube2g1a; ubiquitin-conjugating enzyme E2 G1a isoform X1 [KO:K10575] [EC:2.3.2.23]
110538025  [KO:K10577]
110538033  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
110538099  [KO:K10585] [EC:2.3.2.23]
110538124  [KO:K10579] [EC:2.3.2.34]
110538272  [KO:K10577]
110538458  mgrn1b; probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
110538510  [KO:K04678] [EC:2.3.2.26]
110538630  elob; elongin-B isoform X2 [KO:K03873]
118936482  [KO:K04706] [EC:2.3.2.-]
118936818  [KO:K10699] [EC:6.2.1.45]
118936832  [KO:K04649] [EC:2.3.2.23]
118936875  [KO:K04649] [EC:2.3.2.23]
118937780  [KO:K04696]
118938209  [KO:K10456]
118940426  [KO:K06688] [EC:2.3.2.23]
118940974  [KO:K10573] [EC:2.3.2.23]
118941180  [KO:K20217] [EC:2.3.2.23]
118947900  [KO:K04678] [EC:2.3.2.26]
118948711  [KO:K04694]
118965226  [KO:K03359]
118965967  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
omy03050  Proteasome
KO pathway
ko04120   

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