KEGG   PATHWAY: afb04020
Entry
afb04020                    Pathway                                
Name
Calcium signaling pathway - Anoplopoma fimbria (sablefish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
afb04020  Calcium signaling pathway
afb04020

Other DBs
GO: 0019722
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129111514  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
129113132  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
129113452  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
129092170  slc8a1b; LOW QUALITY PROTEIN: sodium/calcium exchanger 1b [KO:K05849]
129103169  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
129116808  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
129093147  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
129088612  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
129105258  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129106094  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
129112720  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
129108878  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
129099215  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
129092159  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
129093885  muscarinic acetylcholine receptor M1-like [KO:K04131]
129106991  muscarinic acetylcholine receptor M5-like isoform X1 [KO:K04133]
129103867  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
129101296  adora2aa; adenosine A2a receptor a [KO:K04266]
129102419  adora2ab; LOW QUALITY PROTEIN: adenosine A2a receptor b [KO:K04266]
129113858  adora2b; adenosine receptor A2b [KO:K04267]
129091184  adrb1; beta-1 adrenergic receptor [KO:K04141]
129090432  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
129113426  beta-2 adrenergic receptor-like [KO:K04142]
129100746  adrb3a; adrenoceptor beta 3a [KO:K04143]
129089842  drd1a; D(1) dopamine receptor [KO:K04144]
129095743  D(1) dopamine receptor-like [KO:K04144]
129113939  drd1b; dopamine receptor D1b [KO:K04144]
129091372  D(5)-like dopamine receptor [KO:K05840]
129106166  drd5a; D(1B) dopamine receptor [KO:K05840]
129092709  D(1)-like dopamine receptor [KO:K05840]
129090217  hrh2a; histamine receptor H2a [KO:K04150]
129113932  hrh2b; histamine receptor H2b [KO:K04150]
129090292  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
129095355  5-hydroxytryptamine receptor 4 [KO:K04160]
129102070  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
129111051  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
129100400  htr6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
129101491  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
129092713  5-hydroxytryptamine receptor 7-like [KO:K04163]
129099344  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
129105687  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
129089387  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
129110705  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
129094658  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129088688  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129109595  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129097035  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
129110257  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
129107005  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
129105651  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
129112315  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129107575  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129095336  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129098413  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
129095446  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129113516  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
129094159  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
129098873  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
129111970  pln; cardiac phospholamban [KO:K05852]
129096513  sarcolipin [KO:K22642]
129095251  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129090913  atp2a1l; LOW QUALITY PROTEIN: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
129100758  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
129102473  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1 [KO:K05853] [EC:7.2.2.10]
129114028  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
129097969  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
129113077  stim1b; stromal interaction molecule 1b [KO:K16059]
129103483  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
129095747  stim2a; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
129093142  stim2b; stromal interaction molecule 2 [KO:K18196]
129101114  calcium release-activated calcium channel protein 1-like [KO:K16056]
129102136  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
129113615  orai2; protein orai-2 [KO:K16057]
129112503  cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129106296  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
129099230  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129099479  cacna1fa; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
129105522  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
129099233  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
129096531  cacna1ab; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
129098553  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
129101270  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
129102280  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129094535  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
129113385  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
129091823  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
129102796  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04855]
129099164  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
129095295  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
129099110  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
129089705  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
129096198  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
129101537  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
129097469  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
129108667  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
129108996  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
129101168  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
129102404  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
129098255  grin2aa; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129095433  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
129098667  grin2ba; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129091433  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
129098757  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
129109294  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129102665  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
129094894  grin3bb; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129103632  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
129113134  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
129101629  p2rx2; P2X purinoceptor 2 [KO:K05216]
129089753  p2rx3a; P2X purinoceptor 3a [KO:K05217]
129095424  p2rx3b; P2X purinoceptor 3b [KO:K05217]
129100689  p2rx4b; P2X purinoceptor 4b [KO:K05218]
129094385  LOW QUALITY PROTEIN: P2X purinoceptor 5-like [KO:K05219]
129113096  p2rx5; P2X purinoceptor 5 [KO:K05219]
129101353  p2rx7; P2X purinoceptor 7 [KO:K05220]
129113876  ryanodine receptor 1-like [KO:K04961]
129097610  ryr1b; LOW QUALITY PROTEIN: ryanodine receptor 1b [KO:K04961]
129092719  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
129093640  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
129106993  ryr3; ryanodine receptor 3 [KO:K04963]
129103019  LOW QUALITY PROTEIN: ryanodine receptor 3-like [KO:K04963]
129093571  casq1b; calsequestrin-1b [KO:K23468]
129088825  casq1a; calsequestrin-1a [KO:K23468]
129111884  calsequestrin-2-like [KO:K23445]
129104759  casq2; calsequestrin-2 [KO:K23445]
129110437  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
129089809  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
129093797  cysteinyl leukotriene receptor 2-like [KO:K04322]
129112658  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
129108695  muscarinic acetylcholine receptor M2-like [KO:K04130]
129101645  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
129102518  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
129089887  alpha-1A adrenergic receptor-like [KO:K04136]
129113234  alpha-1A adrenergic receptor-like [KO:K04136]
129095298  adra1d; alpha-1D adrenergic receptor [KO:K04137]
129110899  agtr1b; type-1 angiotensin II receptor [KO:K04166]
129095496  ednraa; endothelin receptor type Aa [KO:K04197]
129093829  endothelin-1 receptor-like [KO:K04197]
129089860  endothelin receptor type B-like isoform X1 [KO:K04198]
129088775  ednrba; endothelin receptor Ba [KO:K04198]
129104722  ednrbb; endothelin receptor type B [KO:K04198]
129101257  f2r; proteinase-activated receptor 1 [KO:K03914]
129102558  proteinase-activated receptor 1-like [KO:K03914]
129107288  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
129103464  grm1b; metabotropic glutamate receptor 1b [KO:K04603]
129113160  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
129108672  grm5b; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5b [KO:K04604]
129105024  gastrin-releasing peptide receptor-like [KO:K04169]
129106178  gastrin-releasing peptide receptor-like [KO:K04169]
129106214  hrh1; histamine H1 receptor [KO:K04149]
129104980  5-hydroxytryptamine receptor 2A-like [KO:K04157]
129093839  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
129094272  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
129092747  lhcgr; LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor [KO:K04248]
129092803  LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
129099395  ntsr1; neurotensin receptor type 1 [KO:K04211]
129105575  oxtra; oxytocin receptor [KO:K04229]
129105592  oxtrb; oxytocin receptor b [KO:K04229]
129112312  arg8-vasotocin receptor-like [KO:K04226]
129108153  avpr1aa; arginine vasopressin receptor 1Aa isoform X1 [KO:K04226]
129089136  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
129103465  ptafr; platelet-activating factor receptor [KO:K04279]
129096368  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
129098332  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
129098536  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
129094444  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
129095105  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
129103039  B1 bradykinin receptor-like [KO:K03916]
129103040  B1 bradykinin receptor-like [KO:K03916]
129103771  B2 bradykinin receptor-like [KO:K03916]
129103812  B2 bradykinin receptor-like [KO:K03916]
129103816  B2 bradykinin receptor-like [KO:K03916]
129103848  B2 bradykinin receptor-like [KO:K03916]
129103896  B2 bradykinin receptor-like [KO:K03916]
129103991  bdkrb1; B1 bradykinin receptor [KO:K03916]
129101399  tacr1a; tachykinin receptor 1a [KO:K04222]
129102563  substance-P receptor-like [KO:K04222]
129105197  tacr2; substance-K receptor [KO:K04223]
129096108  tacr3a; tachykinin receptor 3a [KO:K04224]
129096109  tacr3l; tachykinin receptor 3-like [KO:K04224]
129094306  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
129109970  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
129100229  thyrotropin-releasing hormone receptor-like [KO:K04282]
129097489  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
129107948  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
129116476  thyrotropin-releasing hormone receptor-like [KO:K04282]
129111802  cckbra; cholecystokinin receptor-like [KO:K04194]
129093680  cckar; cholecystokinin receptor type A [KO:K04194]
129104376  cholecystokinin receptor [KO:K04194]
129088873  C-X-C chemokine receptor type 4-like [KO:K04189]
129104510  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
129101647  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129102873  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
129093856  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
129094874  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
129103986  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
129101048  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
129094873  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
129090086  egf; pro-epidermal growth factor [KO:K04357]
129106120  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
129098582  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
129095376  si:ch211-79m20.1; serine/threonine-protein kinase LATS1 [KO:K17386]
129090242  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
129092690  pdgfd; platelet-derived growth factor D [KO:K05450]
129090404  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
129113674  putative fibroblast growth factor 1 [KO:K18496]
129090393  fgf2; fibroblast growth factor 2 [KO:K18497]
129104889  fgf9; fibroblast growth factor 4A [KO:K04358]
129089777  fgf24; fibroblast growth factor 24 [KO:K04358]
129090083  fgf18a; fibroblast growth factor 18a [KO:K04358]
129095053  fgf22; fibroblast growth factor 22 [KO:K04358]
129090283  fibroblast growth factor 4-like [KO:K04358]
129090290  fgf20b; fibroblast growth factor 20b [KO:K04358]
129090403  fgf16; fibroblast growth factor 16 [KO:K04358]
129095661  fgf8b; fibroblast growth factor 8b [KO:K04358]
129100742  fgf5; fibroblast growth factor 5 [KO:K04358]
129101464  fgf17; fibroblast growth factor 17 [KO:K04358]
129101696  fgf10b; fibroblast growth factor 10b [KO:K04358]
129112718  fibroblast growth factor 6-like [KO:K04358]
129096329  fibroblast growth factor 20-like [KO:K04358]
129107590  fgf7; fibroblast growth factor 7 [KO:K04358]
129092427  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
129107815  fgf4; fibroblast growth factor 4 [KO:K04358]
129108578  fgf3; fibroblast growth factor 3 [KO:K04358]
129108688  fibroblast growth factor 4B-like [KO:K04358]
129107543  fgf19; fibroblast growth factor 19 [KO:K22603]
129091798  fgf21; fibroblast growth factor 21 [KO:K22429]
129112757  fgf23; fibroblast growth factor 23 [KO:K22428]
129108781  fibroblast growth factor 23-like [KO:K22428]
129090416  vegfba; vascular endothelial growth factor A-A [KO:K05448]
129107025  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
129109175  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
129111975  vascular endothelial growth factor C-like [KO:K05449]
129096485  vegfc; vascular endothelial growth factor C [KO:K05449]
129108697  vegfd; vascular endothelial growth factor D [KO:K05449]
129099308  ngfa; neurotrophin-7 [KO:K02582]
129106371  ngfb; nerve growth factor [KO:K02582]
129112829  hgfa; hepatocyte growth factor a [KO:K05460]
129108117  hepatocyte growth factor [KO:K05460]
129105776  mst1; hepatocyte growth factor-like protein [KO:K23441]
129101637  gdnfb; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129102810  gdnfa; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452]
129110777  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
129111957  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
129090945  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129099350  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
129106491  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
129112018  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
129104178  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
129094441  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129090064  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129113389  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
129101786  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
129102869  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
129092578  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129103846  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129113075  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129090091  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
129110610  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
129089669  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129094563  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129109152  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129100957  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
129102532  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
129108280  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
129103908  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
129108330  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129106073  mst1rb; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
129106472  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
129092095  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129110478  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
129110571  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
129111680  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
129091353  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
129097965  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
129104315  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
129106900  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
129107211  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
129092102  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
129103018  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
129093115  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129100358  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129094102  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
129107826  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
129091088  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
129108238  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
129105846  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
129106149  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129108800  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129100010  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
129110584  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129111088  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129100866  tpcn1; LOW QUALITY PROTEIN: two pore channel protein 1 [KO:K16896]
129102198  tpcn2; two pore channel protein 2 [KO:K14077]
129095490  mcoln1a; mucolipin-1a [KO:K04992]
129098984  mcoln1b; mucolipin-1b [KO:K04992]
129094546  mcoln2; mucolipin-2 [KO:K04993]
129088768  mcoln3a; mucolipin-3 [KO:K04994]
129094293  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
129110024  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
129096202  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
129098263  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
129092283  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
129113161  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129091018  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
129092008  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129101398  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129102268  zgc:56235; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15041]
129089861  slc25a5; ADP/ATP translocase 2 [KO:K05863]
129095820  slc25a4; ADP/ATP translocase 1 [KO:K05863]
129113766  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
129091857  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129092070  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
129099660  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
129099741  tnnc1a; troponin C type 1a (slow) [KO:K05865]
129100006  troponin C, skeletal muscle-like [KO:K12042]
129100033  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
129091256  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
129106329  LOW QUALITY PROTEIN: calglandulin-like [KO:K02183]
129091919  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
129107506  calmodulin-1 [KO:K02183]
129104018  calm1a; calmodulin-1a [KO:K02183]
129104479  calmodulin-like protein 4 [KO:K02183]
129108648  calml4b; calmodulin-like protein 4 [KO:K02183]
129091247  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
129094266  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
129100341  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
129093314  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
129104422  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
129089223  mylk4a; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
129094963  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
129091284  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
129104231  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
129098949  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
129105335  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
129100089  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
129105560  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
129112559  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
129106154  camk1ga; calcium/calmodulin-dependent protein kinase IGa [KO:K08794] [EC:2.7.11.17]
129091211  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
129101314  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
129096402  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
129102112  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
129113832  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
129092372  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129093219  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain [KO:K04515] [EC:2.7.11.17]
129094119  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
129089693  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
129102130  ppp3ccb; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
129113550  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129093045  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
129093100  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
129096086  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
129092449  calcineurin subunit B type 1 isoform X1 [KO:K06268]
129105759  tfeb; transcription factor EB [KO:K15590]
129097321  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
129109274  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
129099889  nfatc2a; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
129105506  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
129101233  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
129108073  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
129115391  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
129100941  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
129105632  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
129110550  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
129111882  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
129104663  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
129111585  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
129107377  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
129096424  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
129106984  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
129103501  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
129113721  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
129096510  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
129097995  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129095247  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129099170  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
129109298  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
afb04010  MAPK signaling pathway
afb04070  Phosphatidylinositol signaling system
afb04210  Apoptosis
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system