KEGG   PATHWAY: epz05170
Entry
epz05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Equus przewalskii (Przewalski's horse)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
epz05170  Human immunodeficiency virus 1 infection
epz05170

Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103547015  CD4; CD4 molecule [KO:K06454]
103542811  FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
103551399  BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
103543154  SKP1; S-phase kinase associated protein 1 [KO:K03094]
103553705  CUL1; cullin 1 [KO:K03347]
103556120  RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
103548930  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
103567211  C-C chemokine receptor type 5 [KO:K04180]
103552141  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
103553052  GNAI3; G protein subunit alpha i3 [KO:K04630]
103557343  GNAI2; G protein subunit alpha i2 [KO:K04630]
103555391  GNAO1; G protein subunit alpha o1 [KO:K04534]
103549076  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103554655  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
103552150  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103548220  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103551868  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103561550  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103561848  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103550428  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
103540628  PXN; paxillin [KO:K05760]
103547531  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
103543614  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
103560497  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103540249  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103555421  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103552237  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103565282  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103559935  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103556719  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103543692  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103548618  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103542187  BAD; BCL2 associated agonist of cell death [KO:K02158]
103567332  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103546629  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103552675  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103554541  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103549630  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103543290  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
103547261  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103562408  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103553450  GNAQ; G protein subunit alpha q [KO:K04634]
103543382  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04635]
103562208  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103558212  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103550297  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103546630  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103548182  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
103564724  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103548885  CALML5; calmodulin like 5 [KO:K02183]
103548886  CALML3; calmodulin like 3 [KO:K02183]
103549905  CALM1; calmodulin 1 [KO:K02183]
103558105  CALM2; calmodulin 2 [KO:K02183]
103564053  calmodulin-like protein 4 [KO:K02183]
103544963  calmodulin-alpha-like [KO:K02183]
103567415  CALML6; calmodulin like 6 [KO:K02183]
103549452  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103552390  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103552773  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103548960  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103552460  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103563745  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
103554877  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
103549708  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
103561060  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
103558165  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103556196  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103567413  GNB1; G protein subunit beta 1 [KO:K04536]
103555641  GNB2; G protein subunit beta 2 [KO:K04537]
103547020  GNB3; G protein subunit beta 3 [KO:K07825]
103551737  GNB4; G protein subunit beta 4 [KO:K04538]
103548465  GNB5; G protein subunit beta 5 [KO:K04539]
103543306  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103558941  GNG3; G protein subunit gamma 3 [KO:K04540]
103547680  GNG4; G protein subunit gamma 4 [KO:K04541]
103557283  GNG5; G protein subunit gamma 5 [KO:K04542]
103542500  GNG8; G protein subunit gamma 8 [KO:K04544]
103542169  GNG11; G protein subunit gamma 11 [KO:K04546]
103564847  GNG12; G protein subunit gamma 12 [KO:K04347]
103542772  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
103565302  GNG13; G protein subunit gamma 13 [KO:K04547]
103568001  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
103551067  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103552260  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103564464  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103551104  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
103553799  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103559943  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103566208  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
103566036  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
103559731  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
103561631  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
103562888  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103565974  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103546412  CFL2; cofilin 2 [KO:K05765]
103559372  CFL1; cofilin 1 [KO:K05765]
103562469  TNF; tumor necrosis factor [KO:K03156]
103552189  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
103559165  BCL2L1; BCL2 like 1 [KO:K04570]
103553736  TLR2; toll like receptor 2 [KO:K10159]
103562040  TLR4; toll like receptor 4 [KO:K10160]
103557961  MYD88; myeloid differentiation primary response 88 [KO:K04729]
103547487  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103545279  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103560236  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103542619  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103548723  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103548805  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103567228  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103562903  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103543979  NF-kappa-B essential modulator-like [KO:K07210]
103546400  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103558747  interferon alpha-2-like [KO:K05414]
103558748  interferon alpha-3 [KO:K05414]
103558749  interferon alpha-6-like [KO:K05414]
103558750  interferon alpha-2 [KO:K05414]
103544584  interferon alpha-14-like [KO:K05414]
103563152  interferon alpha-2-like [KO:K05414]
103563154  interferon alpha-2-like [KO:K05414]
103567855  interferon alpha-1-like [KO:K05414]
103563147  interferon beta-like [KO:K05415]
103563148  interferon beta [KO:K05415]
103563150  interferon beta-like [KO:K05415]
103565534  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103563198  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103559485  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103559491  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103549414  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103553980  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103567629  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103562297  MB21D1; Mab-21 domain containing 1 [KO:K17834] [EC:2.7.7.86]
103548002  TMEM173; transmembrane protein 173 [KO:K12654]
103557811  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103541756  IRF3; interferon regulatory factor 3 [KO:K05411]
103544338  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103545867  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103546008  DNA dC->dU-editing enzyme APOBEC-3C-like [KO:K18750] [EC:3.5.4.-]
103565680  APOBEC3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H [KO:K18750] [EC:3.5.4.-]
103545195  DNA dC->dU-editing enzyme APOBEC-3G-like [KO:K18750] [EC:3.5.4.-]
103545296  DNA dC->dU-editing enzyme APOBEC-3F-like [KO:K18750] [EC:3.5.4.-]
103545544  DNA dC->dU-editing enzyme APOBEC-3C-like [KO:K18750] [EC:3.5.4.-]
103545356  DNA dC->dU-editing enzyme APOBEC-3A-like [KO:K18750] [EC:3.5.4.-]
103565738  SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [KO:K22544] [EC:3.1.5.-]
103553684  E3 ubiquitin-protein ligase TRIM22-like [KO:K10648] [EC:2.3.2.27]
103554374  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
103565910  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
103541807  BST2; bone marrow stromal cell antigen 2 [KO:K06731]
103546993  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103556321  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
103542683  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103551972  TRAF5; TNF receptor associated factor 5 [KO:K09849]
103567822  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103563092  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103564566  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103543808  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103554252  FASLG; Fas ligand [KO:K04389]
103558124  FAS; Fas cell surface death receptor [KO:K04390]
103566999  FADD; Fas associated via death domain [KO:K02373]
103565685  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103559205  BID; BH3 interacting domain death agonist [KO:K04726]
103553312  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103544222  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103550767  BCL2; BCL2, apoptosis regulator [KO:K02161]
103547975  cytochrome c, testis-specific [KO:K08738]
103561978  cytochrome c [KO:K08738]
103565016  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103549132  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103541108  uncharacterized LOC103541108 [KO:K10784]
103567401  uncharacterized LOC103567401 [KO:K10784]
103564100  uncharacterized LOC103564100 [KO:K10785]
103542083  uncharacterized LOC103542083 [KO:K10785]
103546676  CD3E; CD3e molecule [KO:K06451]
103546674  CD3G; CD3g molecule [KO:K06452]
103546675  CD3D; CD3d molecule [KO:K06450]
103551552  CD247; CD247 molecule [KO:K06453]
103567112  TAPBP; TAP binding protein [KO:K08058]
103540688  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
103550639  calreticulin-like [KO:K08057]
103542640  CALR; calreticulin [KO:K08057]
103544108  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103544263  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103544779  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
103544915  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
103544893  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103543990  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
103544101  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
103544987  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
103545903  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545933  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
103567269  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103542270  HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
103542271  popy class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103545683  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103545236  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103545593  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103548098  AP1B1; adaptor related protein complex 1 beta 1 subunit [KO:K12392]
103551741  AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
103563007  AP1G2; adaptor related protein complex 1 gamma 2 subunit [KO:K12391]
103558370  AP1M1; adaptor related protein complex 1 mu 1 subunit [KO:K12393]
103562419  AP1M2; adaptor related protein complex 1 mu 2 subunit [KO:K12393]
103541184  AP1S1; adaptor related protein complex 1 sigma 1 subunit [KO:K12394]
103543754  AP-1 complex subunit sigma-2 [KO:K12394]
103550310  AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
103558321  b-2-m; beta-2-microglobulin [KO:K08055]
103558323  beta-2-microglobulin-like [KO:K08055]
103551650  ELOB; elongin B [KO:K03873]
103565250  ELOC; elongin C [KO:K03872]
103561095  CUL5; cullin 5 [KO:K10612]
103561365  DCAF1; DDB1 and CUL4 associated factor 1 [KO:K11789] [EC:2.7.11.1]
103563968  DDB1; damage specific DNA binding protein 1 [KO:K10610]
103549668  CUL4A; cullin 4A [KO:K10609]
103561722  cullin-4B-like [KO:K10609]
103564256  CUL4B; cullin 4B [KO:K10609]
103561090  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
103541038  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
103557005  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
103551352  CDC25C; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
103546922  WEE1; WEE1 G2 checkpoint kinase [KO:K06632] [EC:2.7.11.1]
103555284  WEE2; WEE1 homolog 2 [KO:K06632] [EC:2.7.11.1]
103567186  CCNB1; cyclin B1 [KO:K05868]
103555305  CCNB2; cyclin B2 [KO:K21770]
103543116  CCNB3; cyclin B3 [KO:K21771]
103559244  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
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Related
pathway
epz03050  Proteasome
epz04010  MAPK signaling pathway
epz04020  Calcium signaling pathway
epz04064  NF-kappa B signaling pathway
epz04110  Cell cycle
epz04141  Protein processing in endoplasmic reticulum
epz04142  Lysosome
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04210  Apoptosis
epz04612  Antigen processing and presentation
epz04620  Toll-like receptor signaling pathway
epz04623  Cytosolic DNA-sensing pathway
epz04668  TNF signaling pathway
epz04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
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