KEGG   PATHWAY: lcat04014
Entry
lcat04014                   Pathway                                
Name
Ras signaling pathway - Lemur catta (Ring-tailed lemur)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
lcat04014  Ras signaling pathway
lcat04014

Other DBs
GO: 0032318
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123637024  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123637917  FGF1; fibroblast growth factor 1 [KO:K18496]
123638827  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123637964  FGF18; fibroblast growth factor 18 [KO:K04358]
123622454  FGF7; fibroblast growth factor 7 [KO:K04358]
123632208  FGF22; fibroblast growth factor 22 [KO:K04358]
123640719  FGF6; fibroblast growth factor 6 [KO:K04358]
123648417  FGF10; fibroblast growth factor 10 [KO:K04358]
123649197  FGF9; fibroblast growth factor 9 [KO:K04358]
123641892  FGF4; fibroblast growth factor 4 [KO:K04358]
123626358  FGF20; fibroblast growth factor 20 [KO:K04358]
123626704  FGF17; fibroblast growth factor 17 [KO:K04358]
123642170  FGF3; fibroblast growth factor 3 [KO:K04358]
123650103  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123627370  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
123642172  FGF19; fibroblast growth factor 19 [KO:K22603]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123640148  FGF23; fibroblast growth factor 23 [KO:K22428]
123635087  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
123642542  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123640712  NTF3; neurotrophin-3 [KO:K04356]
123623840  NTF4; neurotrophin-4 [KO:K12457]
123642915  INS; insulin [KO:K04526]
123639374  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123642914  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123635010  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123639466  KITLG; kit ligand isoform X1 [KO:K05461]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123646604  PGF; placenta growth factor isoform X1 [KO:K16859]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123644674  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123626572  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123622470  ANGPT4; angiopoietin-4 [KO:K05467]
123632816  EFNA2; ephrin-A2 [KO:K05462]
123648052  EFNA5; ephrin-A5 [KO:K05462]
123634049  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123634050  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123634052  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123620742  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
123634790  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123634791  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
123645777  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123635850  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123638075  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123624843  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123648920  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123645784  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123635942  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123638536  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
123642288  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
123634038  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
123632067  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
123645857  SHC3; SHC-transforming protein 3 [KO:K17448]
123622389  SHC4; SHC-transforming protein 4 [KO:K17449]
123626029  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123625473  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123621915  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
123641412  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123636786  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123624374  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
123637224  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
123632516  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
123649961  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
123636000  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123631640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123640104  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123630284  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123622795  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123641343  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123627584  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123648542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123633190  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123623917  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123646542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
123647376  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123637148  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123635536  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123631427  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123647151  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123620748  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123644768  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
123648162  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
123645581  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
123632367  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
123639979  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123636893  CALM2; calmodulin-2 [KO:K02183]
123645611  CALM1; calmodulin-1 [KO:K02183]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123623919  CALM3; calmodulin-3 [KO:K02183]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123636681  calmodulin-alpha-like [KO:K02183]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123639921  KRAS; GTPase KRas [KO:K07827]
123635081  NRAS; GTPase NRas [KO:K07828]
123629770  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
123623815  RRAS; ras-related protein R-Ras [KO:K07829]
123642472  RRAS2; ras-related protein R-Ras2 [KO:K07830]
123620303  NF1; neurofibromin isoform X1 [KO:K08052]
123648443  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
123630043  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123648831  RASA3; LOW QUALITY PROTEIN: ras GTPase-activating protein 3 [KO:K12380]
123632584  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
123632815  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
123626024  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
123635266  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
123636922  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
123623239  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
123627130  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
123622631  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
123630677  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123639294  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123650723  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123642301  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123630427  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123628850  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
123624353  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
123622277  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123624155  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
123623278  RHOA; transforming protein RhoA [KO:K04513]
123643616  transforming protein RhoA-like [KO:K04513]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123634187  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123628746  FOXO4; forkhead box protein O4 [KO:K12358]
123634668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123622656  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
123650100  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
123622339  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
123646555  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
123627034  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
123631826  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
123647769  RALA; ras-related protein Ral-A [KO:K07834]
123643581  RALB; ras-related protein Ral-B [KO:K07835]
123621237  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
123630263  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123638163  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
123639558  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123636942  REL; proto-oncogene c-Rel [KO:K09254]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621506  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123633458  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
123650223  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123630511  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
123632404  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
123625859  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123625933  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123634734  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123634735  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123634736  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
123634737  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
123634738  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123650366  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
123627749  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123635899  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123629407  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
123630054  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
123630120  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123630132  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
123626765  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123639261  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
123642785  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123628633  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123640990  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
123630743  ETS2; protein C-ets-2 [KO:K21932]
123626047  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
123620298  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
123626146  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
123647122  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
123635037  RAP1A; ras-related protein Rap-1A [KO:K04353]
123639540  RAP1B; ras-related protein Rap-1b [KO:K07836]
123650260  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123642892  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
123646592  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
123635258  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123639672  RAB5B; ras-related protein Rab-5B [KO:K07888]
123620954  RAB5C; ras-related protein Rab-5C [KO:K07889]
123649488  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
lcat04010  MAPK signaling pathway
lcat04015  Rap1 signaling pathway
lcat04020  Calcium signaling pathway
lcat04144  Endocytosis
lcat04151  PI3K-Akt signaling pathway
lcat04660  T cell receptor signaling pathway
lcat04720  Long-term potentiation
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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