KEGG   PATHWAY: mcoc04510
Entry
mcoc04510                   Pathway                                
Name
Focal adhesion - Mastomys coucha (southern multimammate mouse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcoc04510  Focal adhesion
mcoc04510

Other DBs
GO: 0005925
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116098542  Col1a2; collagen alpha-2(I) chain [KO:K06236]
116078726  Col1a1; collagen alpha-1(I) chain [KO:K06236]
116078858  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
116096167  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
116068903  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
116068904  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
116088649  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116088650  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
116089039  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116073903  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
116074557  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116074943  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
116088753  Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
116072199  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
116073354  collagen alpha-4(VI) chain [KO:K06238]
116096559  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
116089097  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116091849  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
116097932  Lama2; laminin subunit alpha-2 [KO:K05637]
116088869  Lama1; laminin subunit alpha-1 [KO:K05637]
116086852  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116091524  Lama5; laminin subunit alpha-5 [KO:K06240]
116075456  Lama4; laminin subunit alpha-4 [KO:K06241]
116080788  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
116072107  Lamb2; laminin subunit beta-2 [KO:K06243]
116069150  Lamb3; laminin subunit beta-3 [KO:K06244]
116101239  Lamc1; laminin subunit gamma-1 [KO:K05635]
116101229  Lamc2; laminin subunit gamma-2 [KO:K06246]
116089980  Lamc3; laminin subunit gamma-3 [KO:K06247]
116077683  Chad; chondroadherin [KO:K06248]
116097519  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116083530  Thbs4; thrombospondin-4 [KO:K04659]
116093161  Thbs3; thrombospondin-3 [KO:K04659]
116077949  Thbs2; thrombospondin-2 [KO:K04659]
116069462  Comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
116088545  Fn1; fibronectin isoform X1 [KO:K05717]
116070754  Spp1; osteopontin [KO:K06250]
116077245  Vtn; vitronectin [KO:K06251]
116102168  Tnr; tenascin-R isoform X1 [KO:K06252]
116096134  Tnc; tenascin isoform X1 [KO:K06252]
116074684  Tnxb; tenascin-X isoform X1 [KO:K06252]
116070755  Tnn; tenascin-N isoform X1 [KO:K06252]
116099616  Vwf; von Willebrand factor isoform X1 [KO:K03900]
116070752  Ibsp; bone sialoprotein 2 [KO:K06253]
116083732  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
116083244  Itga2; integrin alpha-2 [KO:K06481]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078986  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
116090371  Itga4; integrin alpha-4 [KO:K06483]
116080860  Itga5; integrin alpha-5 [KO:K06484]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116075887  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
116089710  Itga8; integrin alpha-8 [KO:K06584]
116073780  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
116093463  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
116073011  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077406  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
116085844  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
116090215  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
116080371  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
116080974  Itgb8; integrin beta-8 [KO:K06591]
116085003  Emp2; epithelial membrane protein 2 [KO:K26256]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116079820  Pgf; placenta growth factor [KO:K16859]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116099709  Emp1; epithelial membrane protein 1 [KO:K26255]
116091289  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116101687  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
116080864  Arhgap5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116076329  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
116087062  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116080601  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116070897  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
116069083  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
116091273  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
116070956  Myl10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
116088889  Myl12b; myosin regulatory light chain 12B [KO:K12757]
116088890  myosin regulatory light chain RLC-A [KO:K12757]
116103001  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
116103326  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116104637  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116079614  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
116076104  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116099596  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
116101543  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
116085852  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116069762  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
116091182  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116081489  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116103677  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116093387  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
116075862  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116099290  actin-85C-like [KO:K05692]
116068700  Actb; actin, cytoplasmic 1 [KO:K05692]
116078777  Actg1; actin, cytoplasmic 2 [KO:K05692]
116072459  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
116068107  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116101932  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
116081192  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
116095900  Tln1; talin-1 [KO:K06271]
116072449  Tln2; talin-2 isoform X1 [KO:K06271]
116086142  Flna; filamin-A isoform X1 [KO:K04437]
116072674  Flnb; filamin-B isoform X1 [KO:K27392]
116068255  Pxn; paxillin isoform X1 [KO:K05760]
116102736  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116098520  Zyx; zyxin [KO:K06273]
116101743  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116085275  Vcl; vinculin isoform X1 [KO:K05700]
116102812  Parva; alpha-parvin isoform X1 [KO:K06275]
116077071  Parvb; beta-parvin isoform X1 [KO:K06275]
116077076  Parvg; gamma-parvin isoform X1 [KO:K06275]
116078189  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116073724  Ctnnb1; catenin beta-1 [KO:K02105]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116074581  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
116093653  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116089883  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116102599  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116085808  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116089228  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
116101918  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
116091004  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116090694  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116070207  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116085656  Crkl; crk-like protein [KO:K04438]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116103130  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116089919  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
116092927  ras-related protein Rap-1A-like [KO:K04353]
116093571  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
116075736  Rap1b; ras-related protein Rap-1b [KO:K07836]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116096245  Jun; transcription factor AP-1 [KO:K04448]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116098599  Cav1; caveolin-1 isoform X1 [KO:K06278]
116098598  Cav2; caveolin-2 isoform X1 [KO:K12958]
116098287  Cav3; caveolin-3 [KO:K12959]
116074574  Fyn; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
116093178  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
116076241  Shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
116081462  Shc3; SHC-transforming protein 3 [KO:K17448]
116090849  Shc4; SHC-transforming protein 4 [KO:K17449]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116073994  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
116103285  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116099629  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116075067  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
116072766  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
116072810  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116079101  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04060  Cytokine-cytokine receptor interaction
mcoc04070  Phosphatidylinositol signaling system
mcoc04110  Cell cycle
mcoc04151  PI3K-Akt signaling pathway
mcoc04310  Wnt signaling pathway
mcoc04512  ECM-receptor interaction
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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