KEGG   PATHWAY: morg05166
Entry
morg05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Microtus oregoni (creeping vole)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
morg05166  Human T-cell leukemia virus 1 infection
morg05166

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121448106  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
121446972  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
121461531  Myc; myc proto-oncogene protein [KO:K04377]
121464774  transformation/transcription domain-associated protein isoform X1 [KO:K08874]
121454552  Kat5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
121435389  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
121457663  Itgal; integrin alpha-L [KO:K05718]
121461648  integrin beta-2-like protein [KO:K06464]
121435487  Itgb2; integrin beta-2 [KO:K06464]
121451925  Icam1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
121458090  Hras; GTPase HRas [KO:K02833]
121466497  Kras; GTPase KRas isoform X1 [KO:K07827]
121437938  Nras; GTPase NRas [KO:K07828]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121459389  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121440366  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
121458255  Tln1; talin-1 isoform X1 [KO:K06271]
121465931  Tln2; talin-2 isoform X1 [KO:K06271]
121459677  Ranbp3; ran-binding protein 3 isoform X1 [KO:K15304]
121458531  GTP-binding nuclear protein Ran-like [KO:K07936]
121446431  Ran; GTP-binding nuclear protein Ran [KO:K07936]
121449586  GTP-binding nuclear protein Ran-like [KO:K07936]
121459532  Xpo1; exportin-1 [KO:K14290]
121447496  Calr; calreticulin [KO:K08057]
121448629  calreticulin-like [KO:K08057]
121456301  Canx; calnexin [KO:K08054]
121461739  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121453244  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121438600  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121459616  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
121451753  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
121440145  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121460203  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121447567  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121434994  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121461444  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
121444965  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
121443322  cytokine receptor common subunit gamma-like [KO:K05070]
121448662  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121462728  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
121442359  signal transducer and activator of transcription 5A [KO:K11223]
121442319  Stat5b; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
121452714  Il2; interleukin-2 [KO:K05429]
121435269  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435270  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435271  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435272  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435273  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435274  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435275  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435277  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
121435283  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435313  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435364  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435376  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435377  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435378  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435379  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
121435380  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
121435381  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
121435382  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
121435464  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
121435500  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121435594  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121435668  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
121435669  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435693  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
121435695  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
121435698  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121465699  B2m; beta-2-microglobulin [KO:K08055]
121450614  Fdps; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
121456504  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121452943  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
121451521  ADP/ATP translocase 2-like [KO:K05863]
121451756  ADP/ATP translocase 2 [KO:K05863]
121444701  ADP/ATP translocase 2 [KO:K05863]
121433765  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
121441648  ADP/ATP translocase 2 [KO:K05863]
121435628  ADP/ATP translocase 2-like [KO:K05863]
121438629  voltage-dependent anion-selective channel protein 2 [KO:K15040]
121435027  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121462373  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121461401  Tspo; translocator protein isoform X1 [KO:K05770]
121447578  Vac14; protein VAC14 homolog [KO:K15305]
121465186  Ranbp1; ran-specific GTPase-activating protein [KO:K15306]
121466450  ran-specific GTPase-activating protein-like [KO:K15306]
121464955  mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
121446096  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
121439146  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
121465654  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
121457594  Bub3; mitotic checkpoint protein BUB3 [KO:K02180]
121460067  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
121462918  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121436111  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121442278  Anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
121445984  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
121462431  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
121446583  Anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
121453125  cell division cycle protein 23 homolog [KO:K03355]
121443025  cell division cycle protein 23 homolog [KO:K03355]
121455729  Anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
121444045  anaphase-promoting complex subunit 11 [KO:K03358]
121444615  anaphase-promoting complex subunit 11 [KO:K03358]
121451121  anaphase-promoting complex subunit CDC26-like [KO:K03359]
121433835  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121464313  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
121463686  Anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121450583  Anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
121448551  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
121463915  Pttg1; securin [KO:K06635]
121459432  separin-like [KO:K02365] [EC:3.4.22.49]
121444236  Espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
121466142  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
121448689  Cdkn2b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K06621]
121461982  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
121463961  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121450483  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121435589  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121452823  Ccna2; cyclin-A2 [KO:K06627]
121452921  Ccna1; cyclin-A1 [KO:K06627]
121451458  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
121443216  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
121464192  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121459112  Rb1; retinoblastoma-associated protein [KO:K06618]
121460216  E2f1; transcription factor E2F1 [KO:K17454]
121448904  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
121434086  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
121464308  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
121451627  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
121446253  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
121456449  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121461810  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
121454138  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121435312  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
121435813  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121455832  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
121456383  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
121455025  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121456117  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121440925  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121448148  Jun; transcription factor AP-1 [KO:K04448]
121451900  Mmp7; matrilysin [KO:K01397] [EC:3.4.24.23]
121450585  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
121450964  Il1r2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
121438266  Cd3d; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
121438262  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
121438265  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
121436150  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
121454691  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121462326  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121437198  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
121440264  NF-kappa-B essential modulator isoform X1 [KO:K07210]
121452602  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
121450269  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121454688  Rela; transcription factor p65 isoform X1 [KO:K04735]
121456685  Gps2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
121438240  Ltbr; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
121460322  Cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
121461476  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
121436161  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
121449466  Relb; transcription factor RelB isoform X1 [KO:K09253]
121453851  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
121448921  mRNA decay activator protein ZFP36-like [KO:K15308]
121449445  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
121432686  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
121455882  Il15; interleukin-15 [KO:K05433]
121432570  Il15ra; interleukin-15 receptor subunit alpha [KO:K05074]
121439902  Il6; interleukin-6 [KO:K05405]
121456106  Csf2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427]
121435321  Lta; lymphotoxin-alpha [KO:K05468]
121460139  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
121439471  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
121449432  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
121435842  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121452547  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
121458328  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121464335  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121438761  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121466030  Smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121438756  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121459308  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121433645  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
121439713  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121439725  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121434995  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
121461694  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121441427  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121446853  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
121461516  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121463621  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
121455756  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121451033  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121456769  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
121435294  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
121435295  H-2 class II histocompatibility antigen, A beta chain-like [KO:K06752]
121435296  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
121435298  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
121435299  class II histocompatibility antigen, M alpha chain [KO:K06752]
121435301  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
121435302  H-2 class II histocompatibility antigen, I-E alpha chain-like [KO:K06752]
121435303  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
121435304  RLA class II histocompatibility antigen, DP alpha-1 chain isoform X1 [KO:K06752]
121435309  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
121435311  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
121435709  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
121435710  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
121435711  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
121450833  Srf; serum response factor isoform X1 [KO:K04378]
121445076  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
121452930  ETS domain-containing protein Elk-1-like [KO:K04375]
121449131  ETS domain-containing protein Elk-1 [KO:K04375]
121437675  Spi1; transcription factor PU.1 [KO:K09438]
121451646  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
121461763  Ets2; protein C-ets-2 [KO:K21932]
121462906  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
121466523  TATA-box-binding protein isoform X1 [KO:K03120]
121449284  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
121452580  Fos; proto-oncogene c-Fos [KO:K04379]
121453637  early growth response protein 1 [KO:K09203]
121443037  early growth response protein 1-like [KO:K09203]
121454620  Fosl1; fos-related antigen 1 [KO:K04502]
121450868  Egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
121433487  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121463404  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
121458259  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121459918  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121450873  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
121437635  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121439096  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121439299  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121461039  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121439698  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121435241  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
121462667  Crtc1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
121451067  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
121446077  Crtc3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
121461086  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
121463856  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
121450516  Kat2b; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
121442503  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
121459425  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
121462242  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
121448144  Lck; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
121449799  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
121447806  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
121463282  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
121433658  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
121457874  Ventx; homeobox protein VENTX isoform X1 [KO:K09341]
121453629  Msx2; homeobox protein MSX-2 [KO:K09341]
121436522  Msx1; homeobox protein MSX-1 [KO:K09341]
121444495  homeobox protein MSX-2-like [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
morg03013  Nucleocytoplasmic transport
morg04010  MAPK signaling pathway
morg04064  NF-kappa B signaling pathway
morg04110  Cell cycle
morg04115  p53 signaling pathway
morg04151  PI3K-Akt signaling pathway
morg04210  Apoptosis
morg04350  TGF-beta signaling pathway
morg04612  Antigen processing and presentation
morg04660  T cell receptor signaling pathway
morg04668  TNF signaling pathway
KO pathway
ko05166   
LinkDB

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