KEGG   PATHWAY: otw04621
Entry
otw04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Oncorhynchus tshawytscha (Chinook salmon)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
otw04621  NOD-like receptor signaling pathway
otw04621

Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112236465  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
112227907  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
112227918  nucleotide-binding oligomerization domain-containing protein 1-like isoform X1 [KO:K08727]
112260196  receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
112263564  receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
112249052  receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
112227135  receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
121840490  NF-kappa-B essential modulator-like [KO:K07210]
112221359  ikbkg; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
112239880  NF-kappa-B essential modulator isoform X1 [KO:K07210]
112223895  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112224128  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112223622  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112263933  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112249975  NF-kappa-B inhibitor alpha [KO:K04734]
112244922  NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
112256803  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
112217446  NF-kappa-B inhibitor alpha [KO:K04734]
112220841  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
112256149  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
112260059  transcription factor p65 [KO:K04735]
112214775  putative transcription factor p65 homolog isoform X1 [KO:K04735]
112248882  interleukin-1 beta [KO:K04519]
112219797  il1b; interleukin-1 beta isoform X1 [KO:K04519]
112230772  interleukin-1 beta [KO:K04519]
121847916  interleukin-1 beta-like [KO:K04519]
121847917  interleukin-1 beta-like [KO:K04519]
112262548  interleukin-1 beta-like [KO:K04519]
121838769  interleukin-1 beta-like [KO:K04519]
112235861  il6; interleukin-6 [KO:K05405]
112264462  interleukin-6-like isoform X1 [KO:K05405]
112245031  tumor necrosis factor [KO:K03156]
112238602  tumor necrosis factor [KO:K03156]
112230200  tumor necrosis factor [KO:K03156]
112247217  tumor necrosis factor-like [KO:K03156]
112220612  C-X-C motif chemokine 11-1 [KO:K10030]
112234506  permeability factor 2 [KO:K10030]
112247010  interleukin-8 [KO:K10030]
112234589  permeability factor 2-like [KO:K10030]
112264992  interleukin-8 [KO:K10030]
112239235  nod2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
112261976  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
112217513  mitogen-activated protein kinase kinase kinase 7-like isoform X2 [KO:K04427] [EC:2.7.11.25]
112256531  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
112250048  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112241134  LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
121843572  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
112250087  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
112217538  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
112250635  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
112252030  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like isoform X1 [KO:K12793]
112262493  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251950  mapk3; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251959  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112237408  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112242516  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112252764  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112220751  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112252352  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112224208  mitogen-activated protein kinase 8-like isoform X3 [KO:K04440] [EC:2.7.11.24]
112231415  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
112219617  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112257338  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112223506  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112252549  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112214239  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112214240  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
112221631  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221641  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112215918  mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
112254157  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221833  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
112216970  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112216971  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112235071  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112218743  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112216384  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112260691  transcription factor AP-1 [KO:K04448]
112251077  transcription factor AP-1 [KO:K04448]
112226753  transcription factor AP-1 [KO:K04448]
112248681  jun; transcription factor AP-1 isoform X1 [KO:K04448]
112257314  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
112219784  transcription factor AP-1 [KO:K04448]
112265003  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
112222912  autophagy protein 5 [KO:K08339]
112222925  autophagy protein 5 [KO:K08339]
112240763  ubiquitin-like protein ATG12 [KO:K08336]
112247686  ubiquitin-like protein ATG12 [KO:K08336]
112253764  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112214757  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
112252285  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112229012  gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
112225868  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112238146  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112260042  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
112252256  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
112254127  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
112230156  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112265571  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112218432  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
112221163  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112226681  protein SGT1 homolog isoform X1 [KO:K12795]
112247489  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
112226828  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
112215706  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
112233595  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
112226925  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
112260171  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 isoform X1 [KO:K11974] [EC:2.3.2.31]
112260489  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
112233601  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
112234068  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
112255900  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
112236582  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
112259964  trip6; thyroid receptor-interacting protein 6 [KO:K12792]
112232758  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
112232759  thyroid receptor-interacting protein 6-like [KO:K12792]
112232761  thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
112233830  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
112232756  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
112220319  erbin isoform X1 [KO:K12796]
112230783  erbin isoform X1 [KO:K12796]
112235685  inhibitor of apoptosis protein-like [KO:K16060]
112246336  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
112220313  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
112248690  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112230792  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112220413  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112230971  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
112230449  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112265814  TNF receptor-associated factor 5-like isoform X1 [KO:K09849]
112247822  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112263304  caspase recruitment domain-containing protein 9 [KO:K12794]
112247679  caspase recruitment domain-containing protein 9-like isoform X1 [KO:K12794]
112234622  tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
112224552  tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
112236223  proline-rich protein 36 [KO:K12648]
112244941  traf3; TNF receptor-associated factor 3 [KO:K03174]
112256827  TNF receptor-associated factor 3-like [KO:K03174]
112240934  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
112242097  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
112244673  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112225188  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
112236024  TRAF family member-associated NF-kappa-B activator [KO:K12650]
112235560  irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112252506  interferon regulatory factor 7-like [KO:K09447]
112218673  interferon regulatory factor 8 [KO:K09447]
112259408  interferon a3-like [KO:K05414]
112258504  interferon a3-like [KO:K05414]
112258505  interferon tau-6 [KO:K05414]
112259172  interferon a3-like [KO:K05414]
112258507  interferon a3 isoform X1 [KO:K05414]
112258508  interferon a3 isoform X1 [KO:K05414]
112258510  interferon beta-like [KO:K05414]
112258512  interferon a3-like [KO:K05414]
112259401  interferon alpha-1-like [KO:K05414]
112259402  interferon alpha-13-like [KO:K05414]
112259403  interferon a3-like [KO:K05414]
112259404  interferon beta-like [KO:K05414]
112259405  interferon a3-like [KO:K05414]
112259406  interferon a3-like [KO:K05414]
112225813  interferon alpha-3-like [KO:K05414]
112225814  interferon beta-like [KO:K05414]
112225815  interferon beta-like [KO:K05414]
112225816  interferon a3 isoform X1 [KO:K05414]
112223801  ifnphi4; interferon phi 4 isoform X1 [KO:K05414]
121847201  interferon beta-like [KO:K05414]
121847202  interferon beta-like [KO:K05414]
121847204  interferon a3-like [KO:K05414]
121847206  interferon a3-like [KO:K05414]
121847315  interferon a3-like [KO:K05414]
121847317  interferon a3-like [KO:K05414]
121841054  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05414]
121841055  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05414]
121841056  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05414]
121841057  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05414]
121841106  interferon beta-like [KO:K05414]
121841114  interferon beta-like [KO:K05414]
121841115  interferon beta-like [KO:K05414]
121841118  interferon beta-like [KO:K05414]
121841120  interferon beta-like [KO:K05414]
121841121  interferon beta-like [KO:K05414]
121841123  interferon beta-like [KO:K05414]
112258514  interferon a3-like [KO:K05414]
121847316  interferon a3-like [KO:K05414]
121847318  interferon a3-like [KO:K05414]
112266728  nlrx1; NLR family member X1 [KO:K12653]
112247407  anthrax toxin receptor 2 [KO:K20909]
112248470  LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
112252775  LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
112219431  antxr1b; anthrax toxin receptor 1 [KO:K20909]
112224229  anthrax toxin receptor 1 [KO:K20909]
112264083  anthrax toxin receptor 1 [KO:K20909]
112237590  anthrax toxin receptor 2 [KO:K20909]
112219693  antxr2b; anthrax toxin receptor 2 [KO:K20909]
112223500  anthrax toxin receptor 1 [KO:K20909]
112233908  anthrax toxin receptor 2 [KO:K20909]
112257595  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
112252437  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112231018  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112230319  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112266955  caspase a [KO:K01370] [EC:3.4.22.36]
112227752  apoptosis regulator Bcl-2 [KO:K02161]
112260550  apoptosis regulator Bcl-2 [KO:K02161]
112232698  apoptosis regulator Bcl-2-like [KO:K02161]
112226859  apoptosis regulator Bcl-2 [KO:K02161]
112254374  bcl-2-like protein 1 [KO:K04570]
112215997  bcl-2-like protein 1 isoform X1 [KO:K04570]
112219887  bcl-2-like protein 1 [KO:K04570]
112222374  bcl-2-like protein 1 isoform X1 [KO:K04570]
112261490  cathepsin B [KO:K01363] [EC:3.4.22.1]
112217696  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
112260913  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
112228675  pannexin-1 [KO:K03443]
112266985  pannexin-1-like [KO:K03443]
112248347  P2X purinoceptor 4-like [KO:K05220]
112263059  p2rx7; P2X purinoceptor 4 isoform X1 [KO:K05220]
112238072  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
112249377  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
112231207  casr; extracellular calcium-sensing receptor [KO:K04612]
112227801  LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
112247767  G-protein coupled receptor family C group 6 member A [KO:K04622]
112262138  G-protein coupled receptor family C group 6 member A [KO:K04622]
112244468  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
112241085  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112217984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
112214487  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
112262454  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112246821  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
112251519  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112255750  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
112251520  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
112254359  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112262812  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112220132  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112255286  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112232084  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112218717  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112232649  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112221364  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
112258095  voltage-dependent anion-selective channel protein 1-like isoform X1 [KO:K05862]
112228201  voltage-dependent anion-selective channel protein 1 [KO:K05862]
112258062  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112253177  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112256114  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112224693  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112219591  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112262761  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112248606  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112257487  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112243879  calcium uniporter protein, mitochondrial [KO:K20858]
121840053  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
112236379  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
112251979  mitofusin-1 [KO:K21356] [EC:3.6.5.-]
112250616  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
112260144  mfn1a; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
112233033  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
112260583  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112226835  receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
112252436  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
112259780  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
112262931  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112214356  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112252692  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112218897  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112238280  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
112214341  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
112219097  nampt2; nicotinamide phosphoribosyltransferase 2 isoform X1 [KO:K03462] [EC:2.4.2.12]
112216868  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
112253649  cytochrome b-245 heavy chain-like isoform X1 [KO:K21421] [EC:1.-.-.-]
112266313  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
112249245  cytochrome b-245 light chain isoform X1 [KO:K08009]
112263759  cytochrome b-245 light chain [KO:K08009]
112228584  thioredoxin-interacting protein [KO:K20910]
112229696  thioredoxin-interacting protein [KO:K20910]
112222846  thioredoxin-interacting protein [KO:K20910]
112264677  thioredoxin-interacting protein [KO:K20910]
112226306  thioredoxin, mitochondrial [KO:K03671]
112234542  thioredoxin, mitochondrial isoform X1 [KO:K03671]
112259902  txn; thioredoxin [KO:K03671]
112214624  thioredoxin [KO:K03671]
112250981  nek7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
112238186  serine/threonine-protein kinase Nek7-like [KO:K20876] [EC:2.7.11.34]
112228792  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
112231355  lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
112249973  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
112217874  heat shock protein HSP 90-alpha [KO:K04079]
112250541  heat shock protein HSP 90-alpha [KO:K04079]
112250542  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
112217445  heat shock protein HSP 90-beta isoform X1 [KO:K04079]
112217876  heat shock protein HSP 90-alpha 1 isoform X1 [KO:K04079]
112243578  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
112214566  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
112246932  proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
112252406  proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
112247476  proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
112218582  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
112226687  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112247430  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
112245958  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112225661  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112263517  FAS-associated death domain protein [KO:K02373]
112249032  fadd; protein FADD [KO:K02373]
112217414  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
112219327  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
112254618  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
112254422  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
112241757  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
112244890  transforming protein RhoA [KO:K04513]
112232600  rho-related GTP-binding protein RhoA-C [KO:K04513]
112254214  rho-related GTP-binding protein RhoA-D [KO:K04513]
112222049  rho-related GTP-binding protein RhoA-C [KO:K04513]
112222098  rho-related GTP-binding protein RhoA-B [KO:K04513]
112254897  transforming protein RhoA [KO:K04513]
112215853  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
112239905  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
112226300  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112265254  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112259218  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112245712  serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
112260268  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
112227106  serine/threonine-protein kinase N2 isoform X2 [KO:K23691] [EC:2.7.11.13]
112251474  pkn2b; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
112258043  14-3-3 protein epsilon isoform X1 [KO:K06630]
112266813  14-3-3 protein epsilon isoform X1 [KO:K06630]
112265170  14-3-3 protein epsilon isoform X1 [KO:K06630]
112228389  14-3-3 protein epsilon isoform X1 [KO:K06630]
112250449  guanylate-binding protein 1 [KO:K20899]
112234753  guanylate-binding protein 1-like isoform X1 [KO:K20899]
112234755  guanylate-binding protein 1-like isoform X2 [KO:K20899]
112225523  guanylate-binding protein 1-like [KO:K20899]
112225525  guanylate-binding protein 1-like isoform X1 [KO:K20899]
112225669  LOW QUALITY PROTEIN: guanylate-binding protein 1 [KO:K20899]
112225670  guanylate-binding protein 1-like [KO:K20899]
112225266  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112243175  uncharacterized protein LOC112243175 [KO:K05131]
112234778  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112260228  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112227154  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
112250666  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
112226073  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
112258691  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
112253897  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112244575  stat1b; signal transducer and activator of transcription 1b [KO:K11220]
112235369  signal transducer and activator of transcription 1-alpha/beta isoform X3 [KO:K11220]
112253955  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112253779  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112217577  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112233598  interferon regulatory factor 8 isoform X1 [KO:K04693]
112234069  irf9; interferon regulatory factor 9 [KO:K04693]
112221602  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
112227606  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112218414  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112255958  stimulator of interferon genes protein [KO:K12654]
112221185  stimulator of interferon genes protein-like [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Nat Rev Immunol 12:833-44 (2012)
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Nat Rev Immunol 6:9-20 (2006)
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Semin Cell Dev Biol 39:106-14 (2015)
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PMID:24707857
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NOD1 and NOD2: signaling, host defense, and inflammatory disease.
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Immunity 41:898-908 (2014)
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PMID:19767725
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Murray PJ
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Beyond peptidoglycan for Nod2.
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Nat Immunol 10:1053-4 (2009)
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PMID:20643110
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Lecat A, Piette J, Legrand-Poels S
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The protein Nod2: an innate receptor more complex than previously assumed.
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Biochem Pharmacol 80:2021-31 (2010)
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PMID:26655628
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Man SM, Kanneganti TD
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Converging roles of caspases in inflammasome activation, cell death and innate immunity.
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Nat Rev Immunol 16:7-21 (2016)
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PMID:27291964
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Broz P, Dixit VM
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Inflammasomes: mechanism of assembly, regulation and signalling.
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Nat Rev Immunol 16:407-20 (2016)
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PMID:25879280
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Man SM, Kanneganti TD
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Regulation of inflammasome activation.
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Immunol Rev 265:6-21 (2015)
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Reference
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Jo EK, Kim JK, Shin DM, Sasakawa C
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Molecular mechanisms regulating NLRP3 inflammasome activation.
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Cell Mol Immunol 13:148-59 (2016)
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Reference
PMID:23846113
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Broz P, Monack DM
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Newly described pattern recognition receptors team up against intracellular pathogens.
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Nat Rev Immunol 13:551-65 (2013)
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Reference
PMID:22430786
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Rathinam VA, Vanaja SK, Fitzgerald KA
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Regulation of inflammasome signaling.
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Nat Immunol 13:333-42 (2012)
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PMID:24840700
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Mechanism of NLRP3 inflammasome activation.
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Ann N Y Acad Sci 1319:82-95 (2014)
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Reference
PMID:23702978
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Latz E, Xiao TS, Stutz A
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Activation and regulation of the inflammasomes.
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Nat Rev Immunol 13:397-411 (2013)
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Reference
PMID:25145756
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Blander JM
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A long-awaited merger of the pathways mediating host defence and programmed cell death.
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Nat Rev Immunol 14:601-18 (2014)
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Reference
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von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
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Recognition of bacteria by inflammasomes.
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Annu Rev Immunol 31:73-106 (2013)
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PMID:25330206
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Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
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Antioxid Redox Signal 22:1111-29 (2015)
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PMID:25879288
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Storek KM, Monack DM
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Bacterial recognition pathways that lead to inflammasome activation.
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Immunol Rev 265:112-29 (2015)
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Ubiquitin signaling in immune responses.
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Cell Res 26:457-83 (2016)
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Guo H, Callaway JB, Ting JP
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Inflammasomes: mechanism of action, role in disease, and therapeutics.
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Nat Med 21:677-87 (2015)
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Reference
PMID:26482951
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Man SM, Kanneganti TD
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Gasdermin D: the long-awaited executioner of pyroptosis.
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Cell Res 25:1183-4 (2015)
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Reference
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell 150:606-19 (2012)
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Reference
PMID:21575908
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Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
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Cell Host Microbe 9:363-75 (2011)
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Reference
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Function and mechanism of the pyrin inflammasome.
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Eur J Immunol 48:230-238 (2018)
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Reference
PMID:25816776
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RNase L activates the NLRP3 inflammasome during viral infections.
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Cell Host Microbe 17:466-77 (2015)
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Related
pathway
otw04010  MAPK signaling pathway
otw04140  Autophagy - animal
otw04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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