KEGG   PATHWAY: pov04010
Entry
pov04010                    Pathway                                
Name
MAPK signaling pathway - Paralichthys olivaceus (Japanese flounder)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pov04010  MAPK signaling pathway
pov04010

Other DBs
GO: 0000165
Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109640172  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
109639428  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
109641798  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
109639091  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
109632862  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
109630732  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
109638586  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
109625422  uncharacterized protein LOC109625422 [KO:K04852]
109643736  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
109643812  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
109642986  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
109627122  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
109639495  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
109639443  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
109630550  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109632696  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
109624050  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
109638508  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
109638546  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
109638461  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109635036  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
109632699  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
109624117  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
109634040  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109629793  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
109638934  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
109630938  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
109635185  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
109638020  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
109640071  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
109639409  voltage-dependent calcium channel gamma-1 subunit-like isoform X1 [KO:K04866]
109627744  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
109639255  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
109633975  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109638259  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
109639486  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109646857  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
109627446  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
109638701  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
109627471  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
109645700  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
109633318  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
109643299  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
109633307  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
109643298  vegetative cell wall protein gp1-like [KO:K04872]
109633291  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
109643296  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
109627640  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109634223  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109625861  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109642250  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109627602  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109638270  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109639494  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
109633056  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
109639272  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109639448  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
109625453  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
109636875  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
109633771  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109624436  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109628686  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109634877  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109640863  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
109645661  calcineurin subunit B type 1-like [KO:K06268]
109634942  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109623978  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109624744  ras-specific guanine nucleotide-releasing factor 1-like isoform X1 [KO:K04349]
109625983  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
109636944  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
109627793  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
109630234  RAS guanyl-releasing protein 1-like [KO:K04350]
109637668  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
109629944  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
109640036  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
109630221  nf1; neurofibromin isoform X1 [KO:K08052]
109633794  rasa1; ras GTPase-activating protein 1 [KO:K04352]
109634418  ras GTPase-activating protein 2-like [KO:K08053]
109642729  ras-related protein Rap-1A [KO:K04353]
109635540  ras-related protein Rap-1A-like [KO:K04353]
109625474  egf; pro-epidermal growth factor [KO:K04357]
109638459  epigen-like isoform X1 [KO:K08774]
109637050  proheparin-binding EGF-like growth factor [KO:K09782]
109645500  putative fibroblast growth factor 1 [KO:K18496]
109635763  fgf1; fibroblast growth factor 1 [KO:K18496]
109641290  fgf2; fibroblast growth factor 2 [KO:K18497]
109637250  fgf7; fibroblast growth factor 7 [KO:K04358]
109637331  fibroblast growth factor 4A-like [KO:K04358]
109641285  fgf18; fibroblast growth factor 18 isoform X1 [KO:K04358]
109647470  fibroblast growth factor 18-like [KO:K04358]
109638435  fgf16; fibroblast growth factor 16 [KO:K04358]
109632675  fibroblast growth factor 6-like [KO:K04358]
109627261  fibroblast growth factor 20-like [KO:K04358]
109624838  fibroblast growth factor 4-like [KO:K04358]
109625314  fgf22; fibroblast growth factor 22 [KO:K04358]
109627423  fgf8; fibroblast growth factor 8 [KO:K04358]
109624460  fibroblast growth factor 20-like [KO:K04358]
109626123  fibroblast growth factor 10-like [KO:K04358]
109624637  fibroblast growth factor 6-like [KO:K04358]
109624917  fgf3; fibroblast growth factor 3 [KO:K04358]
109624936  fgf4; fibroblast growth factor 4 [KO:K04358]
109642946  fibroblast growth factor 5-like [KO:K04358]
109637026  fibroblast growth factor 10-like [KO:K04358]
109639862  fibroblast growth factor 8-like [KO:K04358]
109639059  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109645710  fibroblast growth factor 19-like [KO:K22603]
109626716  fgf21; fibroblast growth factor 21 [KO:K22429]
109632765  fgf23; fibroblast growth factor 23 [KO:K22428]
109624635  fibroblast growth factor 23-like [KO:K22428]
109635456  ngf; beta-nerve growth factor [KO:K02582]
109635098  nerve growth factor-like [KO:K02582]
109624905  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109632883  ntf3; neurotrophin-3 [KO:K04356]
109645588  insulin-like [KO:K04526]
109643669  ins; insulin [KO:K04526]
109624754  insulin-like [KO:K04526]
109639654  insulin-like growth factor I [KO:K05459]
109640767  igf1; insulin-like growth factor I [KO:K05459]
109638971  igf2; insulin-like growth factor II isoform X1 [KO:K13769]
109638650  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
109639258  platelet-derived growth factor subunit A-like [KO:K04359]
109639241  uncharacterized protein LOC109639241 [KO:K17386]
109634384  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
109640033  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
109632701  uncharacterized protein LOC109632701 [KO:K05461]
109643127  kitlg; kit ligand [KO:K05461]
109632474  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
109632425  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
109627986  vascular endothelial growth factor A-like [KO:K16859]
109639727  vascular endothelial growth factor C-like [KO:K05449]
109627375  vegfc; vascular endothelial growth factor C [KO:K05449]
109624927  vegfd; vascular endothelial growth factor D [KO:K05449]
109632742  hepatocyte growth factor-like isoform X1 [KO:K05460]
109624365  hgf; hepatocyte growth factor [KO:K05460]
109635371  angiopoietin-4-like isoform X1 [KO:K05465]
109639982  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
109631692  angiopoietin-2-like [KO:K05466]
109632528  angpt2; angiopoietin-2 [KO:K05466]
109639297  efna5; ephrin-A5 isoform X1 [KO:K05462]
109632980  efna1; ephrin-A1 [KO:K05462]
109632997  ephrin-A4-like isoform X1 [KO:K05462]
109633140  efna3; ephrin-A3 [KO:K05462]
109636253  ephrin-A2-like isoform X1 [KO:K05462]
109639118  ephrin-A1-like isoform X1 [KO:K05462]
109639125  ephrin-A3-like isoform X1 [KO:K05462]
109646979  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
109638097  glial cell line-derived neurotrophic factor-like [KO:K05452]
109646294  neurturin-like [KO:K25414]
109642325  uncharacterized protein LOC109642325 [KO:K25415]
109625360  artemin-like [KO:K25415]
109640168  artemin-like [KO:K25416]
109646379  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109646791  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
109645925  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
109641267  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109628857  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
109635017  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
109631409  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
109642369  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
109647136  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
109630558  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
109633786  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
109628630  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
109640682  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
109633551  tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583]
109633980  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
109642014  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109626472  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
109639804  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
109643727  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
109625760  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
109624556  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109625052  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109625664  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109626437  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109626445  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
109642209  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
109637735  mast/stem cell growth factor receptor kita-like isoform X1 [KO:K05091] [EC:2.7.10.1]
109625665  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109642362  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109642360  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109624935  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
109645897  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
109624596  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
109625885  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109624638  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109630850  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
109638578  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
109636804  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109641399  grb2; growth factor receptor-bound protein 2 [KO:K04364]
109636299  sos2; son of sevenless homolog 2 [KO:K03099]
109646414  son of sevenless homolog 1-like [KO:K03099]
109638968  hras; GTPase HRas [KO:K02833]
109641467  GTPase HRas-like [KO:K07827]
109624348  kras; GTPase KRas isoform X1 [KO:K07827]
109636876  rras2; ras-related protein R-Ras2 [KO:K07830]
109642367  mras; ras-related protein M-Ras [KO:K07831]
109633665  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
109637498  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109635227  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109624327  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109625750  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109627823  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
109639504  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
109640677  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109636607  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
109625833  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
109628555  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
109644436  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109628142  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109636733  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
109643580  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109639271  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109646087  ETS domain-containing protein Elk-3-like [KO:K04375]
109628888  ETS domain-containing protein Elk-4-like [KO:K04376]
109629885  myc; myc proto-oncogene protein [KO:K04377]
109642921  transcriptional regulator Myc-2-like [KO:K04377]
109632446  serum response factor-like [KO:K04378]
109648170  serum response factor-like [KO:K04378]
109627836  proto-oncogene c-Fos-like [KO:K04379]
109648142  proto-oncogene c-Fos-like [KO:K04379]
109636028  proto-oncogene c-Fos-like [KO:K04379]
109647001  microtubule-associated protein tau-like [KO:K04380]
109633104  stathmin-like [KO:K04381]
109631876  stathmin-like [KO:K04381]
109636707  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109641948  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
109640782  tumor necrosis factor-like [KO:K03156]
109641260  interleukin-1 beta-like [KO:K04519]
109626174  interleukin-1 beta-like [KO:K04519]
109630415  transforming growth factor beta-1-like [KO:K13375]
109642431  transforming growth factor beta-2-like [KO:K13376]
109631969  tgfb2; transforming growth factor beta-2 [KO:K13376]
109628154  tgfb3; transforming growth factor beta-3 [KO:K13377]
109636158  transforming growth factor beta-3-like [KO:K13377]
109633293  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109644732  interleukin-1 receptor accessory protein-like [KO:K04723]
109638437  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
109631953  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
109647461  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
109639132  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
109625570  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
109631170  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
109638710  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
109626935  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109639279  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109640382  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109626672  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
109641595  cell division control protein 42 homolog [KO:K04393]
109643474  cell division control protein 42 homolog [KO:K04393]
109642445  cell division control protein 42 homolog isoform X1 [KO:K04393]
109629172  cell division control protein 42 homolog isoform X1 [KO:K04393]
109636771  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
109639599  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109631395  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109633912  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
109626283  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109625941  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109644802  daxx; death domain-associated protein 6 [KO:K02308]
109629696  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109645801  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109624486  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109637261  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109644407  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109637499  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109636370  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
109639301  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109625451  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109643194  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109639281  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
109632543  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
109637590  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
109633575  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
109625686  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109643219  serine/threonine-protein kinase PAK 2-like isoform X1 [KO:K04410] [EC:2.7.11.1]
109635565  serine/threonine-protein kinase 3/4-like [KO:K04411]
109635410  stk4; serine/threonine-protein kinase 4 [KO:K04411]
109638820  serine/threonine-protein kinase 3 [KO:K04412]
109637696  mitogen-activated protein kinase kinase kinase kinase 2-like isoform X1 [KO:K04414] [EC:2.7.11.1]
109629507  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
109637656  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
109640231  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
109629552  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
109629839  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
109633995  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
109636300  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109630421  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
109630891  map3k21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
109635271  mitogen-activated protein kinase kinase kinase 12-like isoform X1 [KO:K04423] [EC:2.7.11.25]
109635388  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
109631386  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109638628  mitogen-activated protein kinase kinase kinase 13-A-like [KO:K04424] [EC:2.7.11.25]
109631351  map3k20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
109633076  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
109635968  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
109632517  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109628158  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
109634498  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109630251  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
109635858  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
109641504  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
109641881  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
109643023  serine/threonine-protein kinase TAO3-like isoform X1 [KO:K04429] [EC:2.7.11.1]
109626344  serine/threonine-protein kinase TAO3-like isoform X1 [KO:K04429] [EC:2.7.11.1]
109626687  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
109633989  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
109627519  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109634317  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
109647356  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
109637303  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
109642436  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
109624423  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
109642565  C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
109630731  filamin-A-like isoform X1 [KO:K04437]
109634381  adapter molecule crk-like [KO:K04438]
109626378  crkl; crk-like protein [KO:K04438]
109635835  adapter molecule crk-like [KO:K04438]
109643755  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
109626552  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
109626878  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109633007  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109626434  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109630822  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109632714  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
109632715  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629252  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
109630593  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109630994  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109638988  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109636971  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
109629213  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
109628905  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
109629054  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
109636442  ribosomal protein S6 kinase alpha-5-like isoform X1 [KO:K04445] [EC:2.7.11.1]
109628711  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
109636485  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
109631959  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109625161  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109645229  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
109625845  transcription factor AP-1-like [KO:K04448]
109643961  jun; transcription factor AP-1 [KO:K04448]
109636548  jund; transcription factor jun-D [KO:K04449]
109646467  transcription factor jun-D-like [KO:K04449]
109631016  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109634900  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109635636  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
109627792  protein max-like isoform X1 [KO:K04453]
109636083  max; protein max isoform X1 [KO:K04453]
109633630  mef2c; myocyte-specific enhancer factor 2C [KO:K04454]
109626349  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
109628310  hspb1; heat shock protein beta-1 [KO:K04455]
109626345  heat shock protein beta-1-like [KO:K04455]
109641589  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109630907  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109628065  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109634602  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109642071  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
109628059  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
109630298  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
109628476  protein phosphatase 1B-like isoform X1 [KO:K04457] [EC:3.1.3.16]
109644299  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
109638926  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
109644756  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
109647322  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109647439  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635615  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109642696  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109626466  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109627745  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109636948  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109635299  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109624493  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109636175  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109646860  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109645097  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
109630368  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
109626924  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
109636295  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
109630790  heat shock 70 kDa protein [KO:K03283]
109633109  heat shock cognate 71 kDa protein-like [KO:K03283]
109628428  heat shock cognate 70 kDa protein [KO:K03283]
109628432  heat shock cognate 71 kDa protein [KO:K03283]
109634633  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109637295  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
109641502  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
109640607  probable nuclear hormone receptor HR38 [KO:K04465]
109628858  probable nuclear hormone receptor HR38 isoform X1 [KO:K04465]
109633940  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
109645298  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
109629542  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109644018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109637101  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109630748  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109644700  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
109645211  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
109644052  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
109637639  putative transcription factor p65 homolog isoform X1 [KO:K04735]
109645078  transcription factor RelB homolog isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pov04070  Phosphatidylinositol signaling system
pov04110  Cell cycle
pov04115  p53 signaling pathway
pov04210  Apoptosis
pov04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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