KEGG   PATHWAY: pps05164
Entry
pps05164                    Pathway                                
Name
Influenza A - Pan paniscus (bonobo)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pps05164  Influenza A
pps05164

Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100978423  TPSB2; tryptase beta-2 isoform X2 [KO:K01340] [EC:3.4.21.59]
100983216  tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
100983474  LOW QUALITY PROTEIN: tryptase delta [KO:K01340] [EC:3.4.21.59]
117978660  tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
117978661  TPSD1; tryptase delta [KO:K01340] [EC:3.4.21.59]
100982214  plasminogen [KO:K01315] [EC:3.4.21.7]
100991392  PRSS2; trypsin-2 isoform X2 [KO:K01312] [EC:3.4.21.4]
100992428  trypsin-1 isoform X3 [KO:K01312] [EC:3.4.21.4]
100993827  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
100995726  PRSS3; trypsin-3 isoform X1 [KO:K01312] [EC:3.4.21.4]
100993013  trypsin-1-like [KO:K01312] [EC:3.4.21.4]
100988626  TMPRSS2; transmembrane protease serine 2 isoform X2 [KO:K09633] [EC:3.4.21.122]
100982108  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
100968590  TMPRSS11D; transmembrane protease serine 11D isoform X2 [KO:K09641] [EC:3.4.21.-]
100970296  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100993699  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
100970211  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
103783986  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
100977181  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
100967837  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1-like [KO:K09507]
100971940  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
100974645  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
100982543  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100971732  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100971009  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
100967985  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100981559  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100989144  NLRX1; NLR family member X1 [KO:K12653]
100979730  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117977645  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
100980612  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100972867  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100969354  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
100984258  TLR3; toll-like receptor 3 precursor [KO:K05401]
100974002  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100980798  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100990211  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100992569  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100977114  IRF3; interferon regulatory factor 3 isoform X5 [KO:K05411]
100983185  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100984888  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100980644  TLR4; toll-like receptor 4 precursor [KO:K10160]
100986249  TLR7; toll-like receptor 7 [KO:K05404]
100996159  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100968191  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100994286  IL1A; interleukin-1 alpha [KO:K04383]
100993613  IL1B; interleukin-1 beta [KO:K04519]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100979574  IL12A; interleukin-12 subunit alpha [KO:K05406]
100989950  IL12B; interleukin-12 subunit beta [KO:K05425]
100977674  TNF; tumor necrosis factor [KO:K03156]
100978369  CXCL8; interleukin-8 [KO:K10030]
100981087  CCL2; C-C motif chemokine 2 [KO:K14624]
100968258  CCL5; C-C motif chemokine 5 isoform X2 [KO:K12499]
100992984  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100980120  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
100968579  interferon alpha-7 [KO:K05414]
100968923  interferon alpha-4-like [KO:K05414]
100969275  interferon alpha-10-like [KO:K05414]
100969624  interferon alpha-16 [KO:K05414]
100970300  interferon alpha-17-like [KO:K05414]
100970658  interferon alpha-14 [KO:K05414]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100972005  interferon alpha-1/13-like [KO:K05414]
100972354  interferon alpha-2 [KO:K05414]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100973049  interferon alpha-1/13 [KO:K05414]
100995734  interferon alpha-5 [KO:K05414]
100967539  interferon alpha-21 [KO:K05414]
117981650  interferon alpha-17 [KO:K05414]
117981651  interferon alpha-4-like [KO:K05414]
100968231  LOW QUALITY PROTEIN: interferon alpha-10 [KO:K05414]
117981652  interferon alpha-7-like [KO:K05414]
117981653  interferon alpha-7 [KO:K05414]
100995851  IFNB1; interferon beta [KO:K05415]
100995446  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100995792  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100972202  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100979090  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100978589  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100971620  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
100972085  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100973587  IRF9; interferon regulatory factor 9 isoform X5 [KO:K04693]
100988065  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
100989395  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
100988581  ADAR; double-stranded RNA-specific adenosine deaminase isoform X3 [KO:K12968] [EC:3.5.4.37]
100993007  PML; protein PML [KO:K10054] [EC:2.3.2.-]
100991779  IFNG; interferon gamma [KO:K04687]
100994342  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
100988947  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100973925  CIITA; MHC class II transactivator isoform X4 [KO:K08060] [EC:2.7.11.1]
100995226  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100967723  HLA class II histocompatibility antigen, DO alpha chain isoform X3 [KO:K06752]
100968410  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100972994  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
100973583  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100986750  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100987081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100995577  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
100968989  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100970847  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100979649  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100994561  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
100972641  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100984425  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
100991103  PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
100986637  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
100985633  LOW QUALITY PROTEIN: caspase-1 [KO:K01370] [EC:3.4.22.36]
100971499  IL18; interleukin-18 isoform X1 [KO:K05482]
100987383  IL33; interleukin-33 isoform X1 [KO:K12967]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100976294  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
100981258  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100986991  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
100971044  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
100973227  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
100970360  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100988526  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
100983212  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100989209  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100968673  FADD; FAS-associated death domain protein [KO:K02373]
100978497  CASP8; caspase-8 isoform X4 [KO:K04398] [EC:3.4.22.61]
100989555  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100991820  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
100983246  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100992204  bcl-2 homologous antagonist/killer-like [KO:K14021]
100983168  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100982601  voltage-dependent anion-selective channel protein 1 [KO:K05862]
100991246  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100984012  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100981051  ADP/ATP translocase 3-like [KO:K05863]
100971042  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100986481  cytochrome c [KO:K08738]
103785895  cytochrome c [KO:K08738]
106635415  cytochrome c-like [KO:K08738]
106635123  cytochrome c-like [KO:K08738]
117975808  cytochrome c-like [KO:K08738]
117976221  cytochrome c-like [KO:K08738]
106634558  cytochrome c, somatic-like [KO:K08738]
106634335  cytochrome c-like [KO:K08738]
100969626  cytochrome c-like [KO:K08738]
117981750  cytochrome c-like [KO:K08738]
100995524  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100992567  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100974934  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100977233  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X8 [KO:K14404]
100970032  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
100991758  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
100987014  NXF3; nuclear RNA export factor 3 isoform X2 [KO:K14284]
100995719  NXF1; nuclear RNA export factor 1 isoform X2 [KO:K14284]
100985902  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
100978865  LOW QUALITY PROTEIN: nuclear RNA export factor 2 [KO:K14284]
100984700  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
100969952  NXT1; NTF2-related export protein 1 [KO:K14285]
100979786  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X7 [KO:K15047]
100980561  RAE1; mRNA export factor isoform X3 [KO:K14298]
100988712  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X3 [KO:K14297]
100985295  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
100981763  FDPS; farnesyl pyrophosphate synthase isoform X5 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100974663  LOW QUALITY PROTEIN: farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100988422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100977025  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100988437  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100979542  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
100995567  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100970542  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100990579  actin, cytoplasmic 1 [KO:K05692]
103784606  actin, alpha skeletal muscle-like [KO:K05692]
100987964  LOW QUALITY PROTEIN: actin-like [KO:K05692]
100986633  RAB11A; ras-related protein Rab-11A [KO:K07904]
100971281  RAB11B; ras-related protein Rab-11B [KO:K07905]
100970411  XPO1; exportin-1 [KO:K14290]
100983357  KPNA1; importin subunit alpha-5 [KO:K23940]
100995030  KPNA2; importin subunit alpha-1 [KO:K15043]
100974433  KPNA7; importin subunit alpha-8 [KO:K15043]
100976652  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
100981944  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
pps00900  Terpenoid backbone biosynthesis
pps03013  Nucleocytoplasmic transport
pps03015  mRNA surveillance pathway
pps04010  MAPK signaling pathway
pps04110  Cell cycle
pps04144  Endocytosis
pps04210  Apoptosis
pps04620  Toll-like receptor signaling pathway
pps04621  NOD-like receptor signaling pathway
pps04622  RIG-I-like receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps05416  Viral myocarditis
KO pathway
ko05164   
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