KEGG   PATHWAY: pteh05417
Entry
pteh05417                   Pathway                                
Name
Lipid and atherosclerosis - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
pteh05417  Lipid and atherosclerosis
pteh05417

Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111554482  APOB; apolipoprotein B-100 [KO:K14462]
111540175  APOA4; apolipoprotein A-IV isoform X1 [KO:K08760]
111540177  APOA1; apolipoprotein A-I isoform X1 [KO:K08757]
111527714  LDLR; low-density lipoprotein receptor [KO:K12473]
111528486  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
111554072  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
111540071  MMP1; interstitial collagenase isoform X1 [KO:K01388] [EC:3.4.24.7]
111555593  RHOA; transforming protein RhoA [KO:K04513]
111532006  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
111551457  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
111521403  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111544647  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111523340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111554247  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111539891  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111548774  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111520083  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111522294  BAD; bcl2-associated agonist of cell death [KO:K02158]
111548123  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
111528437  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
111530867  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111535725  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111554538  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111547334  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
111542503  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111554129  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
111539293  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
111540008  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
111530033  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
111531588  CD40LG; CD40 ligand [KO:K03161]
111529702  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
111554025  cytochrome P450 2A13 isoform X1 [KO:K17683] [EC:1.14.14.-]
111554026  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
111529253  cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
111531037  cytochrome P450 2C9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
111552212  cytochrome P450 2C19 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
111522986  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
111528961  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
111536508  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
111536296  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
111547038  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
111553835  cytochrome b-245 light chain [KO:K08009]
111536947  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
111549050  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111553268  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111543300  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
111537369  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111547718  CDC42; cell division control protein 42 homolog [KO:K04393]
111523480  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111522663  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111521118  FOS; proto-oncogene c-Fos [KO:K04379]
111523160  JUN; transcription factor AP-1 [KO:K04448]
111526876  C-C motif chemokine 2 isoform X1 [KO:K14624]
111527756  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
111531283  CXCL8; interleukin-8 [KO:K10030]
111528301  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
111542478  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111542972  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111542973  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111532954  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111549140  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111540622  KRAS; GTPase KRas isoform X1 [KO:K07827]
111549619  NRAS; GTPase NRas [KO:K07828]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111539320  SELE; E-selectin [KO:K06494]
111539317  SELP; P-selectin isoform X1 [KO:K06496]
111525762  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
111540075  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
111530012  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
111551313  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111528224  IL1B; interleukin-1 beta [KO:K04519]
111545050  IL6; interleukin-6 isoform X1 [KO:K05405]
111523940  TNF; tumor necrosis factor [KO:K03156]
111546649  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
113222861  heat shock 70 kDa protein 1 [KO:K03283]
111523910  heat shock 70 kDa protein 1 [KO:K03283]
111525033  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
111523908  heat shock 70 kDa protein 1 [KO:K03283]
111523909  heat shock 70 kDa protein 1-like [KO:K03283]
111540268  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111555857  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
111529330  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
111543094  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
111538310  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
111549509  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
111524308  HSP90B1; endoplasmin [KO:K09487]
111553190  TLR2; toll-like receptor 2 [KO:K10159]
111553292  LBP; lipopolysaccharide-binding protein [KO:K05399]
111528037  CD14; monocyte differentiation antigen CD14 [KO:K04391]
111520969  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
111550322  TLR4; toll-like receptor 4 [KO:K10160]
111540313  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
111523175  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
111520209  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111531307  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
111521878  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111548993  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111523666  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111538092  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111538794  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111544093  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111524454  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111530362  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
111521961  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
111538162  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111539775  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
111535085  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
111546076  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
111522719  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111551230  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111539247  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
111520580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
111519959  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111537187  interferon alpha-14 [KO:K05414]
111537188  interferon alpha-6 [KO:K05414]
111537189  interferon alpha-2 [KO:K05414]
111537190  interferon alpha-8 [KO:K05414]
111537191  interferon alpha-1/13 [KO:K05414]
111526141  interferon alpha-10 [KO:K05414]
111526147  IFNB1; interferon beta [KO:K05415]
111552397  CD36; platelet glycoprotein 4 [KO:K06259]
111546909  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
111523996  photoreceptor-specific nuclear receptor-like [KO:K08524]
111534772  retinoic acid receptor RXR-alpha [KO:K08524]
111542907  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
111539204  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
111524867  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111553372  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111530126  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
111523994  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111522605  VAV1; proto-oncogene vav [KO:K05730]
111550909  TLR6; toll-like receptor 6 [KO:K10169]
111556041  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
111528626  RAP1B; ras-related protein Rap-1b [KO:K07836]
111532119  ras-related protein Rap-1b [KO:K07836]
111525412  CCL5; C-C motif chemokine 5 [KO:K12499]
111529368  C-C motif chemokine 3 [KO:K05408]
111520807  C-C motif chemokine 3-like 1 [KO:K05408]
113221818  C-C motif chemokine 3 [KO:K05408]
111528185  growth-regulated alpha protein-like isoform X2 [KO:K05505]
111531279  growth-regulated protein homolog gamma-like [KO:K05505]
111531286  CXCL1; growth-regulated alpha protein [KO:K05505]
111524574  growth-regulated alpha protein-like [KO:K05505]
111550126  IL12A; interleukin-12 subunit alpha [KO:K05406]
111547191  IL12B; interleukin-12 subunit beta [KO:K05425]
111545191  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
111540136  IL18; interleukin-18 [KO:K05482]
111545930  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
111525029  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
111541810  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
111549442  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
111546970  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111552236  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111552636  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111537843  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111547908  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111528197  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
111519917  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111548140  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111548991  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111542532  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111553030  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111525521  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111525377  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
111536142  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
111526370  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
111542762  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
111525695  PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
111540082  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
113222446  CARD16; caspase recruitment domain-containing protein 16 isoform X1 [KO:K01370] [EC:3.4.22.36]
111543319  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
111543871  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111551042  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111521034  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111541379  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111546451  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
111522292  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111524236  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111546452  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111553217  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111550424  CALM2; calmodulin-2 [KO:K02183]
111520111  CALM3; calmodulin-3 isoform X2 [KO:K02183]
111552915  calmodulin-like [KO:K02183]
111552555  calmodulin-like [KO:K02183]
111553144  calmodulin-alpha-like [KO:K02183]
111533474  CALML6; calmodulin-like protein 6 [KO:K02183]
111554863  CALML3; calmodulin-like protein 3 [KO:K02183]
111554874  CALML5; calmodulin-like protein 5 [KO:K02183]
111538211  CALM1; calmodulin-1 [KO:K02183]
111554058  calmodulin-like [KO:K02183]
111548339  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
111549204  calmodulin-alpha-like [KO:K02183]
111527468  calmodulin-like [KO:K02183]
111540495  calmodulin [KO:K02183]
111545684  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111537850  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111547968  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111550575  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
111536216  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
111543475  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
111545697  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
111545701  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
111555942  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111539343  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111547169  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111527587  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111528103  cytochrome c-like [KO:K08738]
111541425  cytochrome c [KO:K08738]
111551227  cytochrome c-like [KO:K08738]
111551298  cytochrome c-like [KO:K08738]
111551797  cytochrome c [KO:K08738]
111551867  cytochrome c [KO:K08738]
111543337  cytochrome c-like [KO:K08738]
111543628  cytochrome c-like [KO:K08738]
111534452  cytochrome c-like [KO:K08738]
111545049  cytochrome c-like [KO:K08738]
111555014  cytochrome c-like [KO:K08738]
111524229  cytochrome c [KO:K08738]
111525268  cytochrome c-like [KO:K08738]
111539464  cytochrome c-like [KO:K08738]
111526887  cytochrome c-like [KO:K08738]
111540111  cytochrome c-like [KO:K08738]
111520510  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
111527287  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111547887  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
111551382  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
111548479  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111538909  CASP7; caspase-7 isoform X2 [KO:K04397] [EC:3.4.22.60]
111527100  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
Sheedy FJ, Moore KJ
  Title
IL-1 signaling in atherosclerosis: sibling rivalry.
  Journal
Nat Immunol 14:1030-2 (2013)
DOI:10.1038/ni.2711
Reference
PMID:21529710
  Authors
Moore KJ, Tabas I
  Title
Macrophages in the pathogenesis of atherosclerosis.
  Journal
Cell 145:341-55 (2011)
DOI:10.1016/j.cell.2011.04.005
Reference
PMID:22577254
  Authors
Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  Title
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
  Journal
Mediators Inflamm 2012:693083 (2012)
DOI:10.1155/2012/693083
Reference
PMID:17442283
  Authors
Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL
  Title
CD36 and macrophages in atherosclerosis.
  Journal
Cardiovasc Res 75:468-77 (2007)
DOI:10.1016/j.cardiores.2007.03.010
Reference
PMID:19065049
  Authors
Park YM, Febbraio M, Silverstein RL
  Title
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.
  Journal
J Clin Invest 119:136-45 (2009)
DOI:10.1172/JCI35535
Reference
PMID:24903227
  Authors
Park YM
  Title
CD36, a scavenger receptor implicated in atherosclerosis.
  Journal
Exp Mol Med 46:e99 (2014)
DOI:10.1038/emm.2014.38
Reference
PMID:21035758
  Authors
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
  Title
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
  Journal
Cell Metab 12:467-82 (2010)
DOI:10.1016/j.cmet.2010.09.010
Reference
PMID:25869517
  Authors
Nimgulkar C, Ghosh S, Sankar AB, Uday KP, Surekha MV, Madhusudhanachary P, Annapurna BR, Raghu P, Bharatraj DK
  Title
Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.
  Journal
Vascul Pharmacol 72:53-63 (2015)
DOI:10.1016/j.vph.2015.02.014
Reference
PMID:23928573
  Authors
Canton J, Neculai D, Grinstein S
  Title
Scavenger receptors in homeostasis and immunity.
  Journal
Nat Rev Immunol 13:621-34 (2013)
DOI:10.1038/nri3515
Reference
PMID:20375591
  Authors
Erridge C
  Title
The roles of Toll-like receptors in atherosclerosis.
  Journal
J Innate Immun 1:340-9 (2009)
DOI:10.1159/000191413
Reference
PMID:21884686
  Authors
Seneviratne AN, Sivagurunathan B, Monaco C
  Title
Toll-like receptors and macrophage activation in atherosclerosis.
  Journal
Clin Chim Acta 413:3-14 (2012)
DOI:10.1016/j.cca.2011.08.021
Reference
PMID:21252151
  Authors
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL
  Title
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
  Journal
Circ Res 108:235-48 (2011)
DOI:10.1161/CIRCRESAHA.110.223875
Reference
PMID:20884885
  Authors
Tabas I
  Title
The role of endoplasmic reticulum stress in the progression of atherosclerosis.
  Journal
Circ Res 107:839-50 (2010)
DOI:10.1161/CIRCRESAHA.110.224766
Reference
PMID:29360955
  Authors
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR, De Meyer GRY
  Title
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
  Journal
Cardiovasc Res 114:622-634 (2018)
DOI:10.1093/cvr/cvy007
Reference
PMID:12730091
  Authors
Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM
  Title
Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation.
  Journal
Circ Res 92:1115-22 (2003)
DOI:10.1161/01.RES.0000074880.25540.D0
Reference
PMID:28230726
  Authors
Cervantes Gracia K, Llanas-Cornejo D, Husi H
  Title
CVD and Oxidative Stress.
  Journal
J Clin Med 6:E22 (2017)
DOI:10.3390/jcm6020022
Reference
PMID:21321594
  Authors
Hansson GK, Hermansson A
  Title
The immune system in atherosclerosis.
  Journal
Nat Immunol 12:204-12 (2011)
DOI:10.1038/ni.2001
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15451808
  Authors
Lusis AJ, Fogelman AM, Fonarow GC
  Title
Genetic basis of atherosclerosis: part I: new genes and pathways.
  Journal
Circulation 110:1868-73 (2004)
DOI:10.1161/01.CIR.0000143041.58692.CC
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Related
pathway
pteh04020  Calcium signaling pathway
pteh04115  p53 signaling pathway
pteh04141  Protein processing in endoplasmic reticulum
pteh04151  PI3K-Akt signaling pathway
pteh04210  Apoptosis
pteh04620  Toll-like receptor signaling pathway
pteh04621  NOD-like receptor signaling pathway
pteh04668  TNF signaling pathway
pteh04670  Leukocyte transendothelial migration
pteh04975  Fat digestion and absorption
pteh04979  Cholesterol metabolism
pteh05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
LinkDB

DBGET integrated database retrieval system