KEGG   PATHWAY: ptg05132
Entry
ptg05132                    Pathway                                
Name
Salmonella infection - Panthera tigris altaica (Amur tiger)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ptg05132  Salmonella infection
ptg05132

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102961056  PODXL; podocalyxin like [KO:K06817]
102954348  PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
102956448  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102960245  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
102956967  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
102971493  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102966491  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
102960224  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
102964959  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
102956123  VPS11; VPS11, CORVET/HOPS core subunit [KO:K20179]
102950513  VPS16; VPS16, CORVET/HOPS core subunit [KO:K20180]
102954370  VPS18; VPS18, CORVET/HOPS core subunit [KO:K20181]
102968838  VPS33A; VPS33A, CORVET/HOPS core subunit [KO:K20182]
102960247  VPS39; VPS39, HOPS complex subunit [KO:K20183]
102962595  VPS41; VPS41, HOPS complex subunit [KO:K20184]
102957448  RILP; Rab interacting lysosomal protein [KO:K13883]
102967845  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
102950535  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
102962682  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
102965078  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
102960387  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
102966864  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
102952337  DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417]
102954979  DYNLL1; dynein light chain LC8-type 1 [KO:K10418]
102951286  DYNLL2; dynein light chain LC8-type 2 [KO:K10418]
102964177  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
102967886  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
102949182  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
102951205  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
102961867  DCTN1; dynactin subunit 1 [KO:K04648]
102952303  DCTN2; dynactin subunit 2 [KO:K10424]
102964777  DCTN3; dynactin subunit 3 [KO:K10425]
102956992  DCTN4; dynactin subunit 4 [KO:K10426]
102957792  DCTN5; dynactin subunit 5 [KO:K10427]
102966889  DCTN6; dynactin subunit 6 [KO:K10428]
102964800  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
102966337  ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta [KO:K16575]
102958427  ACTR10; actin-related protein 10 homolog [KO:K16576]
102969257  TUBAL3; tubulin alpha like 3 [KO:K07374]
102953141  tubulin alpha-1A chain [KO:K07374]
102954023  tubulin alpha-1A chain-like [KO:K07374]
102953725  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102950928  TUBA8; tubulin alpha 8 [KO:K07374]
102962068  TUBA4A; tubulin alpha 4a [KO:K07374]
102951399  tubulin alpha-8 chain [KO:K07374]
102969214  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102963137  tubulin beta-2B chain-like [KO:K07375]
102963413  tubulin beta-2B chain-like [KO:K07375]
102963307  TUBB; tubulin beta class I [KO:K07375]
102971239  uncharacterized LOC102971239 [KO:K07375]
102971736  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
102955872  tubulin beta chain-like [KO:K07375]
102949211  TUBB6; tubulin beta 6 class V [KO:K07375]
102953030  FYCO1; FYVE and coiled-coil domain containing 1 [KO:K21954]
102962013  ARL8B; ADP ribosylation factor like GTPase 8B [KO:K07955]
102948640  ARL8A; ADP ribosylation factor like GTPase 8A [KO:K07955]
102964529  PLEKHM2; pleckstrin homology and RUN domain containing M2 [KO:K15348]
102967932  KIF5A; kinesin family member 5A [KO:K10396]
102971278  KIF5C; kinesin family member 5C [KO:K10396]
102965837  KIF5B; kinesin family member 5B [KO:K10396]
102966188  KLC2; kinesin light chain 2 [KO:K10407]
102970489  KLC1; kinesin light chain 1 [KO:K10407]
102971570  KLC3; kinesin light chain 3 [KO:K10407]
102962356  KLC4; kinesin light chain 4 [KO:K10407]
102950747  ACBD3; acyl-CoA binding domain containing 3 [KO:K23935]
102952555  RHOA; ras homolog family member A [KO:K04513]
102962749  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
102957623  RAB9A; ras-related protein Rab-9A [KO:K07899]
102961877  RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
102951256  GCC2; GRIP and coiled-coil domain containing 2 [KO:K20282]
102953386  STX10; syntaxin 10 [KO:K23937]
102966154  PFN4; profilin family member 4 [KO:K05759]
102955353  PFN1; profilin 1 [KO:K05759]
102962391  profilin-2-like [KO:K05759]
102968383  PFN3; profilin 3 [KO:K05759]
102966655  PFN2; profilin 2 [KO:K05759]
102969406  FLNA; filamin A [KO:K04437]
102965535  EXOC7; exocyst complex component 7 [KO:K07195]
102957131  EXOC5; exocyst complex component 5 [KO:K19984]
102955077  EXOC4; exocyst complex component 4 [KO:K06111]
102968999  EXOC2; exocyst complex component 2 [KO:K17637]
102961464  RALA; RAS like proto-oncogene A [KO:K07834]
102971629  ACTG1; actin gamma 1 [KO:K05692]
102971401  ACTB; actin beta [KO:K05692]
102961966  S100A10; S100 calcium binding protein A10 [KO:K17274]
102953799  ANXA2; annexin A2 [KO:K17092]
102950218  AHNAK; AHNAK nucleoprotein [KO:K23934]
102963244  AHNAK2; AHNAK nucleoprotein 2 [KO:K23934]
102950339  RHOJ; ras homolog family member J [KO:K07864]
102956570  ARHGEF26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
102954676  RHOG; ras homolog family member G [KO:K07863]
102965418  rho-related GTP-binding protein RhoG-like [KO:K07863]
102961652  ELMO1; engulfment and cell motility 1 [KO:K12366]
102962506  ELMO2; engulfment and cell motility 2 [KO:K18985]
102949986  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102954811  MYL2; myosin light chain 2 [KO:K10351]
102958022  MYL5; myosin light chain 5 [KO:K12753]
102965729  MYL7; myosin light chain 7 [KO:K12754]
102964789  MYL9; myosin light chain 9 [KO:K12755]
102969892  MYL10; myosin light chain 10 [KO:K12756]
102971233  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102971525  myosin regulatory light polypeptide 9 [KO:K12757]
102950335  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
102959606  FHOD1; formin homology 2 domain containing 1 [KO:K23938]
102973021  CDC42; cell division cycle 42 [KO:K04393]
102968561  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102965307  NCKAP1; NCK associated protein 1 [KO:K05750]
102968758  NCKAP1L; NCK associated protein 1 like [KO:K05750]
102955961  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
102952996  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
102957036  ABI1; abl interactor 1 [KO:K23649]
102964962  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
102958125  WASF3; WAS protein family member 3 [KO:K06083]
102971744  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
102965409  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
102965872  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
102963554  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
102963836  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
102952821  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
102951259  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
102956425  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
102953170  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
102968345  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
102963927  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102960506  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102957133  MYO6; myosin VI [KO:K10358]
102953082  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102965070  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102972487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102953306  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
102967722  PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
102970607  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
102966367  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
102952283  CYTH1; cytohesin 1 [KO:K18441]
102961646  CYTH4; cytohesin 4 [KO:K18441]
102966777  CYTH2; cytohesin 2 [KO:K18441]
102959274  ARF6; ADP ribosylation factor 6 [KO:K07941]
102971253  ARF1; ADP ribosylation factor 1 [KO:K07937]
102966853  ADP-ribosylation factor 2 [KO:K07937]
102958322  SNX18; sorting nexin 18 [KO:K17923]
102972475  SNX33; sorting nexin 33 [KO:K17923]
102972920  SNX9; sorting nexin 9 [KO:K17923]
102972678  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
102965772  DNM2; dynamin 2 [KO:K23484] [EC:3.6.5.5]
102956461  TLR6; toll like receptor 6 [KO:K10169]
102962241  toll-like receptor 2 [KO:K10159]
102964242  toll-like receptor 2 [KO:K10159]
102970131  TIRAP; TIR domain containing adaptor protein [KO:K05403]
102952059  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102956253  CD14; CD14 molecule [KO:K04391]
102959529  TLR4; toll like receptor 4 [KO:K10160]
102958453  LY96; lymphocyte antigen 96 [KO:K05400]
102965281  TLR5; toll like receptor 5 [KO:K10168]
102969160  TLR9; toll like receptor 9 [KO:K10161]
102962570  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102960157  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102963341  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102950874  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102959790  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102964345  TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3 [KO:K12793]
102949289  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102963734  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102956127  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102964232  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102951132  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102951010  NOD1; nucleotide binding oligomerization domain containing 1 [KO:K08727]
102954497  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102950898  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102959647  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
102957311  RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
102971571  CSE1L; chromosome segregation 1 like [KO:K18423]
102952427  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
102961480  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
102970432  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
102950271  RPS3; ribosomal protein S3 [KO:K02985]
102952119  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102955852  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102969757  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102956808  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102964841  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102960964  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102949954  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102966485  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102968191  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102960306  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102960590  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102968482  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102966812  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102949140  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102959159  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102950880  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102963096  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102952769  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102958666  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102958919  TNF; tumor necrosis factor [KO:K03156]
102951272  IL1B; interleukin 1 beta [KO:K04519]
102968780  IL6; interleukin 6 [KO:K05405]
102953898  interleukin-8-like [KO:K10030]
102953024  IL8; interleukin-8 [KO:K10030]
102959570  CTNNB1; catenin beta 1 [KO:K02105]
102957988  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
102958078  TCF7L1; transcription factor 7 like 1 [KO:K04490]
102961321  TCF7L2; transcription factor 7 like 2 [KO:K04491]
102970026  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
102954147  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102960418  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102952725  FBXO22; F-box protein 22 [KO:K10302]
102957702  SKP1; S-phase kinase associated protein 1 [KO:K03094]
102956793  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102966802  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102968597  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102972419  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
102951731  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102964459  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
102972075  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102956216  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102952748  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102969425  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
107180331  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102961605  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
102963342  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
102952670  tumor necrosis factor receptor superfamily member 1A-like [KO:K04722]
102962460  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102965180  RIPK3; receptor interacting serine/threonine kinase 3 [KO:K08847] [EC:2.7.11.1]
102949153  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102970767  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102966744  cytochrome c 2-like [KO:K08738]
102952864  cytochrome c-like [KO:K08738]
102960081  cytochrome c [KO:K08738]
102953487  BCL2; BCL2, apoptosis regulator [KO:K02161]
102954729  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102951959  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
102968952  RHOB; ras homolog family member B [KO:K07856]
102962916  RHOH; ras homolog family member H [KO:K07873]
102968314  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
102952603  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102954757  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102969693  thioredoxin [KO:K03671]
102963917  TXN2; thioredoxin 2 [KO:K03671]
102954761  NACHT, LRR and PYD domains-containing protein 3-like [KO:K12800]
102972559  NAIP; NLR family apoptosis inhibitory protein [KO:K12807]
102958929  NLRC4; NLR family CARD domain containing 4 [KO:K12805]
102965910  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102952004  IL18; interleukin 18 [KO:K05482]
102967742  caspase-1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
102959421  GSDMD; gasdermin D [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ptg04010  MAPK signaling pathway
ptg04064  NF-kappa B signaling pathway
ptg04210  Apoptosis
ptg04217  Necroptosis
ptg04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
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