KEGG   PATHWAY: sara05167
Entry
sara05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Sorex araneus (European shrew)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
sara05167  Kaposi sarcoma-associated herpesvirus infection
sara05167

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101550718  C3; complement C3 [KO:K03990]
101550987  complement C3-like [KO:K03990]
101552190  TLR3; toll-like receptor 3 [KO:K05401]
101557102  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101538970  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101552901  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101542553  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101545292  IRF7; interferon regulatory factor 7 [KO:K09447]
101549593  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
101542890  IRF3; interferon regulatory factor 3 [KO:K05411]
101542504  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101558222  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101548268  IFNB1; interferon beta [KO:K05415]
101558656  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101559190  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101556525  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101550098  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101554357  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101550386  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101556712  IRF9; interferon regulatory factor 9 [KO:K04693]
101542873  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101552098  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101542881  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101551599  ZFP36; tristetraprolin [KO:K15308]
101540363  IL6; interleukin-6 [KO:K05405]
101537997  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101550176  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101553092  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101553361  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101555452  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101540315  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101537769  FADD; FAS-associated death domain protein [KO:K02373]
101543078  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101546492  BID; BH3-interacting domain death agonist [KO:K04726]
101540951  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101538133  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101558408  cytochrome c, somatic [KO:K08738]
101538879  cytochrome c-like [KO:K08738]
101549686  cytochrome c, somatic [KO:K08738]
101543860  cytochrome c 2 [KO:K08738]
101537803  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101539340  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101541261  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101557571  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101550002  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101543163  RELA; transcription factor p65 [KO:K04735]
101558045  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
101543917  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101559274  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101556590  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101548470  RB1; retinoblastoma-associated protein [KO:K06618]
101555654  E2F1; transcription factor E2F1 [KO:K17454]
101544935  E2F2; transcription factor E2F2 [KO:K09389]
101551523  HLA class I histocompatibility antigen, Cw-15 alpha chain-like [KO:K06751]
101539702  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
101546686  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
101541581  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101545992  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
101555446  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101551788  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101546424  HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751]
101541316  HLA class I histocompatibility antigen, B-13 alpha chain-like [KO:K06751]
101542112  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
101555963  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
101548018  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101550657  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
101553053  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101539305  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101546718  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101549044  ICAM1; LOW QUALITY PROTEIN: intercellular adhesion molecule 1 [KO:K06490]
101559128  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
101539364  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
101536941  UBC; polyubiquitin-C [KO:K02927]
101538261  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101552443  ubiquitin-like [KO:K02977]
101558944  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
101557880  BECN1; beclin-1 [KO:K08334]
101556389  BECN2; beclin-2 [KO:K08334]
101543712  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101554294  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101543645  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
101543261  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101548940  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101542668  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101556740  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101547419  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101556046  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101542101  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101537346  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101539394  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101558836  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101548469  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101558565  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101538909  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101539743  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101551468  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101537808  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101554656  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101550798  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101540882  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
101544946  CD200R1L; cell surface glycoprotein CD200 receptor 2 [KO:K21668]
101551795  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101556901  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
101544577  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101542924  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101554595  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101554088  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101556467  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101556630  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101555935  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101554401  CALM1; calmodulin isoform X1 [KO:K02183]
101552535  CALML3; calmodulin-like protein 3 [KO:K02183]
101545302  CALML5; calmodulin-like protein 5 [KO:K02183]
101546941  CALML4; calmodulin-like protein 4 [KO:K02183]
101541555  CALM2; calmodulin [KO:K02183]
101543973  calmodulin-like [KO:K02183]
101559307  CALM3; calmodulin [KO:K02183]
101557366  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101558512  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101555223  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101556800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101541742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101554287  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101555053  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101549236  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101538630  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101559441  CXCL8; interleukin-8 [KO:K10030]
101543763  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101544994  growth-regulated protein homolog [KO:K05505]
101545791  growth-regulated protein homolog gamma-like [KO:K05505]
101556217  RCAN1; calcipressin-1 [KO:K17901]
101555369  FGF2; fibroblast growth factor 2 [KO:K18497]
101548477  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101556671  ANGPT2; angiopoietin-2 [KO:K05466]
101551921  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101550196  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101552896  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101536841  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101538379  CTNNB1; catenin beta-1 [KO:K02105]
101540913  TCF7; transcription factor 7 [KO:K02620]
101550691  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101546297  TCF7L2; transcription factor 7-like 2 isoform X2 [KO:K04491]
101547696  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101552417  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101555422  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101541387  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
Reference
PMID:24710493
  Authors
Pratt ZL, Sugden B
  Title
How human tumor viruses make use of autophagy.
  Journal
Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
DOI:10.1128/JVI.78.14.7667-7676.2004
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
PMID:15573137
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
PMID:17329974
  Authors
Montaner S
  Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
  Journal
Cell Cycle 6:438-43 (2007)
DOI:10.4161/cc.6.4.3843
Reference
PMID:23028325
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
  Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
  Journal
Proc Natl Acad Sci U S A 96:5704-9 (1999)
DOI:10.1073/pnas.96.10.5704
Reference
PMID:26192396
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
PMID:25187543
  Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
PMID:16585191
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
  Authors
Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
sara04010  MAPK signaling pathway
sara04064  NF-kappa B signaling pathway
sara04110  Cell cycle
sara04115  p53 signaling pathway
sara04140  Autophagy - animal
sara04144  Endocytosis
sara04151  PI3K-Akt signaling pathway
sara04210  Apoptosis
sara04310  Wnt signaling pathway
sara04610  Complement and coagulation cascades
sara04620  Toll-like receptor signaling pathway
sara04630  JAK-STAT signaling pathway
sara04650  Natural killer cell mediated cytotoxicity
sara04668  TNF signaling pathway
KO pathway
ko05167   
LinkDB

DBGET integrated database retrieval system