KEGG   PATHWAY: uar05203
Entry
uar05203                    Pathway                                
Name
Viral carcinogenesis - Ursus americanus (American black bear)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
uar05203  Viral carcinogenesis
uar05203

Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123801699  KRAS; GTPase KRas isoform X1 [KO:K07827]
123795037  NRAS; GTPase NRas [KO:K07828]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123798247  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123794100  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123780649  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123799579  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
123781164  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123788905  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
123796787  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123783374  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123789128  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123790975  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123785111  DDB1; DNA damage-binding protein 1 [KO:K10610]
123793974  14-3-3 protein zeta/delta-like [KO:K16197]
123797024  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
123797829  14-3-3 protein zeta/delta [KO:K16197]
123778546  YWHAQ; 14-3-3 protein theta [KO:K16197]
123776839  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
123788197  YWHAH; 14-3-3 protein eta [KO:K16198]
123784761  YWHAG; 14-3-3 protein gamma [KO:K16198]
123795350  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123781851  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
123781848  signal transducer and activator of transcription 5A [KO:K11223]
123781849  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
123784520  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123791724  HPN; LOW QUALITY PROTEIN: serine protease hepsin [KO:K08665] [EC:3.4.21.106]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123778302  RELA; transcription factor p65 [KO:K04735]
123785956  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
123795903  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123788912  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123792132  TP53; cellular tumor antigen p53 [KO:K04451]
123797872  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123791375  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123787272  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123783100  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
123777370  EGR3; early growth response protein 3 [KO:K12497]
123780315  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123781561  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
123790084  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
123781411  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
123779575  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123796561  ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
123789892  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
123799832  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
123801768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123795272  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123800260  histone H2B subacrosomal variant-like [KO:K11252]
123794127  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794183  histone H2B type 1-K [KO:K11252]
123794184  histone H2B type 1-J [KO:K11252]
123794185  histone H2B type 1-K [KO:K11252]
123794187  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794188  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794189  histone H2B type 1-N [KO:K11252]
123794190  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794192  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
123794222  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794223  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794225  histone H2B type 1-M-like [KO:K11252]
123794226  histone H2B type 2-E-like [KO:K11252]
123794227  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794228  histone H2B type 1-C/E/F/G/I [KO:K11252]
123794229  histone H2B type 1-B [KO:K11252]
123794230  histone H2B type 1-L [KO:K11252]
123794244  histone H2B type 1-A [KO:K11252]
123794245  histone H2B type 1-A [KO:K11252]
123780463  late histone H2B.L4-like [KO:K11252]
123780471  late histone H2B.L4-like [KO:K11252]
123787926  late histone H2B.L4-like [KO:K11252]
123796494  histone H2B type 3-B-like [KO:K11252]
123796496  histone H2B type 3-B [KO:K11252]
123779210  histone H2B type 2-E [KO:K11252]
123779214  histone H2B type 2-E [KO:K11252]
123779215  histone H2B type 2-E [KO:K11252]
123779216  histone H2B type 2-F-like [KO:K11252]
123776190  late histone H2B.L4-like [KO:K11252]
123776191  late histone H2B.L4-like [KO:K11252]
123779217  histone H4 [KO:K11254]
123781722  histone H4 [KO:K11254]
123794193  histone H4 [KO:K11254]
123794194  histone H4 [KO:K11254]
123794195  histone H4 [KO:K11254]
123794196  histone H4 [KO:K11254]
123794231  histone H4 [KO:K11254]
123794232  histone H4 [KO:K11254]
123794233  histone H4 [KO:K11254]
123776228  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123802938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123803514  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123783025  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
123800753  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
123797572  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
123775433  TATA-box-binding protein [KO:K03120]
123783212  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
123787146  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123793455  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
123796937  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
123798933  SNW1; SNW domain-containing protein 1 [KO:K06063]
123799503  GTF2H1; general transcription factor IIH subunit 1 isoform X1 [KO:K03141]
123800234  general transcription factor IIH subunit 2 [KO:K03142]
123779959  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
123794268  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
123784013  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
123780363  GTF2E2; transcription initiation factor IIE subunit beta [KO:K03137]
123788989  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
123780918  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
123783593  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
123795241  GTF2B; transcription initiation factor IIB [KO:K03124]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123781570  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123779180  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123789288  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123793313  CCNA2; cyclin-A2 [KO:K06627]
123791767  CCNA1; cyclin-A1 [KO:K06627]
123785481  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
123794288  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
123788020  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
123796334  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123779266  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
123785826  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
123779986  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
123786722  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
123776440  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123803430  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
123797913  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
123790748  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
123802097  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123779329  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
123788286  PXN; paxillin isoform X1 [KO:K05760]
123790912  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
123776252  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
123798900  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
123791847  RB1; retinoblastoma-associated protein [KO:K06618]
123796962  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
123798407  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
123781751  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123782115  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123781566  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
123792970  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
123782225  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
123790221  HDAC3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
123803228  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
123790010  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
123790885  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
123794809  HDAC7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
123791742  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
123789200  HDAC9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
123803774  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
123802026  HDAC11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
123790712  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
123795756  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
123783331  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
123788338  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
123781916  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
123798924  GTF2A1; transcription initiation factor IIA subunit 1 [KO:K03122]
123779443  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
123794694  SRF; serum response factor [KO:K04378]
123791737  NF-kappa-B essential modulator-like [KO:K07210]
123793902  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123788433  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123803163  cell division control protein 42 homolog [KO:K04393]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123780073  RHOA; transforming protein RhoA [KO:K04513]
123788015  GSN; gelsolin isoform X1 [KO:K05768]
123789222  SCIN; adseverin [KO:K05768]
123784522  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123799050  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123787201  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123781143  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
123781261  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
123792711  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
123793802  CDC20; cell division cycle protein 20 homolog [KO:K03363]
123802533  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
123800544  VAC14; protein VAC14 homolog [KO:K15305]
123803545  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
123780308  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
123775465  IRF7; interferon regulatory factor 7 [KO:K09447]
123790182  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
123780012  C-C chemokine receptor type 5 [KO:K04180]
123792786  CCR8; C-C chemokine receptor type 8 [KO:K04183]
123780036  C-C chemokine receptor type 3 [KO:K04178]
123792792  CCR4; C-C chemokine receptor type 4 [KO:K04179]
123785786  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123798200  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
123778440  BAD; bcl2-associated agonist of cell death [KO:K02158]
123787524  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
123779001  C3; complement C3 [KO:K03990]
123785045  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
123793445  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
123794160  uncharacterized protein LOC123794160 [KO:K06751]
123780238  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
123791023  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123791025  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
123791026  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
123791029  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
Reference
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PMID:16459163
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Zhang X, Zhang H, Ye L
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Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
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PMID:12686421
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Hepatitis viruses and the MAPK pathway: is this a survival strategy?
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Virus Res 92:131-40 (2003)
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J Gastroenterol 46:974-90 (2011)
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  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
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Reference
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  Title
Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
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Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
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Reference
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Liver cell transformation in chronic HBV infection.
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Viruses 1:630-46 (2009)
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X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
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J Biol Chem 276:8328-40 (2001)
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J Gastroenterol Hepatol 15:357-68 (2000)
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FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
uar03022  Basal transcription factors
uar03320  PPAR signaling pathway
uar04010  MAPK signaling pathway
uar04062  Chemokine signaling pathway
uar04064  NF-kappa B signaling pathway
uar04110  Cell cycle
uar04115  p53 signaling pathway
uar04142  Lysosome
uar04151  PI3K-Akt signaling pathway
uar04210  Apoptosis
uar04630  JAK-STAT signaling pathway
uar04662  B cell receptor signaling pathway
uar04810  Regulation of actin cytoskeleton
uar05160  Hepatitis C
uar05161  Hepatitis B
uar05165  Human papillomavirus infection
uar05166  Human T-cell leukemia virus 1 infection
uar05167  Kaposi sarcoma-associated herpesvirus infection
uar05169  Epstein-Barr virus infection
KO pathway
ko05203   
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