KEGG   PATHWAY: pleu05167
Entry
pleu05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Peromyscus leucopus (white-footed mouse)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
pleu05167  Kaposi sarcoma-associated herpesvirus infection
pleu05167

Disease
H00041  Kaposi sarcoma
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114681254  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114681285  Ccr8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
114681403  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114681418  Calm3; calmodulin-3 [KO:K02183]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681591  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
114681747  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114682099  Rela; transcription factor p65 [KO:K04735]
114682519  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114682640  [KO:K06751]
114682644  [KO:K06751]
114682645  [KO:K06751]
114682649  [KO:K06751]
114682653  [KO:K06751]
114682654  [KO:K06751]
114682655  [KO:K06751]
114682656  [KO:K06751]
114682666  [KO:K06751]
114682671  [KO:K06751]
114682672  [KO:K06751]
114682673  [KO:K06751]
114682677  [KO:K06751]
114682685  [KO:K06751]
114682688  [KO:K06751]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682786  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114682800  Becn1; beclin-1 isoform X1 [KO:K08334]
114682816  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
114682888  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
114682947  Ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
114683055  Tcf7; transcription factor 7 isoform X2 [KO:K02620]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683622  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114683746  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684433  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114684653  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
114685101  Ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
114685127  [KO:K02833]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685202  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114685947  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
114685948  [KO:K04176]
114685951  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686090  [KO:K05132]
114686366  [KO:K06751]
114686534  C3; complement C3 isoform X1 [KO:K03990]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686598  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114686769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
114687018  [KO:K06751]
114687019  [KO:K06751]
114687020  [KO:K06751]
114687039  [KO:K07826]
114687156  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
114687652  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114687676  Cd86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
114687933  [KO:K06751]
114687935  [KO:K06751]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114688303  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114688340  [KO:K04545]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688482  [KO:K06751]
114688488  [KO:K02833]
114688490  [KO:K06751]
114688492  [KO:K06751]
114688790  [KO:K06751]
114688816  [KO:K06751]
114688817  [KO:K06751]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689480  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689745  [KO:K08738]
114689756  Il6; interleukin-6 [KO:K05405]
114690390  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114690458  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114690605  Becn2; beclin-2 [KO:K08334]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691640  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
114691662  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114692651  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114692919  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693118  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114693143  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
114693144  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693293  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693442  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114693493  [KO:K02833]
114693495  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693632  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
114693732  Jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114694276  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114694299  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114694958  Atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X2 [KO:K08343]
114694962  [KO:K21668]
114695009  [KO:K21668]
114695010  [KO:K21668]
114695207  Icam1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
114695212  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695341  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114695408  [KO:K08738]
114695816  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
114696032  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
114696553  [KO:K02833]
114696775  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
114697060  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
114697224  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114697589  [KO:K03174]
114697928  [KO:K08738]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698053  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114698057  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
114698273  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114698418  Rcan1; calcipressin-1 isoform X1 [KO:K17901]
114698435  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
114698437  Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
114698582  Nras; GTPase NRas [KO:K07828]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698792  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114698806  [KO:K04348] [EC:3.1.3.16]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700391  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114700813  [KO:K08738]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700920  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114700956  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114701050  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
114701168  Tlr3; toll-like receptor 3 isoform X2 [KO:K05401]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701719  [KO:K05505]
114701735  [KO:K05505]
114701736  [KO:K05505]
114701876  Angpt2; angiopoietin-2 [KO:K05466]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703073  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114703139  [KO:K02977]
114703574  [KO:K08738]
114703579  Il6st; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704185  [KO:K10435]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114705020  Calm1; calmodulin-1 [KO:K02183]
114705035  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
114705057  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705554  Hck; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705846  [KO:K06751]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706510  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114706553  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707170  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114708260  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
114708288  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114708319  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114708453  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708668  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
114708726  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114708768  [KO:K02183]
114708779  Calml3; calmodulin-like protein 3 [KO:K02183]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708827  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
114709020  [KO:K08738]
114709086  [KO:K04542]
114709209  Calm2; calmodulin-2 [KO:K02183]
114709238  Ccr4; LOW QUALITY PROTEIN: C-C chemokine receptor type 4 [KO:K04179]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114710194  Ubc; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
114710233  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114710287  [KO:K08738]
114710385  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
114710614  [KO:K04498] [EC:2.3.1.48]
119086111  [KO:K21668]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
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Related
pathway
pleu04010  MAPK signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04140  Autophagy - animal
pleu04144  Endocytosis
pleu04151  PI3K-Akt signaling pathway
pleu04210  Apoptosis
pleu04310  Wnt signaling pathway
pleu04610  Complement and coagulation cascades
pleu04620  Toll-like receptor signaling pathway
pleu04630  JAK-STAT signaling pathway
pleu04650  Natural killer cell mediated cytotoxicity
pleu04668  TNF signaling pathway
KO pathway
ko05167   

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