KEGG   PATHWAY: ptr04621
Entry
ptr04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Pan troglodytes (chimpanzee)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
ptr04621  NOD-like receptor signaling pathway
ptr04621

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
472336  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X2 [KO:K08727]
464277  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K08846] [EC:2.7.11.1]
100610002  NF-kappa-B essential modulator isoform X1 [KO:K07210]
100609537  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
450673  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
472749  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
456014  NFKBIB; NF-kappa-B inhibitor beta isoform X5 [KO:K02581]
467426  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
461406  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
466665  RELA; transcription factor P65 [KO:K04735]
450200  IL1B; interleukin-1 beta [KO:K04519]
739011  IL18; interleukin-18 isoform X1 [KO:K05482]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
494186  TNF; tumor necrosis factor [KO:K03156]
471205  CXCL8; interleukin-8 [KO:K10030]
740567  CXCL1; growth-regulated alpha protein [KO:K05505]
461255  CXCL3; C-X-C motif chemokine 3 [KO:K05505]
748205  CCL2; C-C motif chemokine 2 [KO:K14624]
747004  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
741881  CAMP; cathelicidin antimicrobial peptide precursor [KO:K13916]
619354  DEFA6; defensin-6 precursor [KO:K05230]
463972  DEFA5; defensin alpha 5 precursor [KO:K05230]
463971  DEFA4; defensin alpha 4 isoform X1 [KO:K05230]
619353  DEFA7; defensin-7 precursor [KO:K05230]
107973256  neutrophil defensin 1 isoform X1 [KO:K05230]
742808  DEFA1; neutrophil defensin 1 isoform X1 [KO:K05230]
450193  DEFB4A; defensin beta 4A precursor [KO:K21100]
129388399  defensin beta 4A [KO:K21100]
450106  DEFB103A; beta-defensin 103A precursor [KO:K23126]
129388394  beta-defensin 103A [KO:K23126]
454083  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
462888  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
458845  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
463057  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
473550  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
450161  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
462644  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
747077  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
104003820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
456893  JUN; transcription factor Jun [KO:K04448]
460022  ATG16L1; autophagy-related protein 16-1 isoform X7 [KO:K17890]
462905  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
462011  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
467760  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
454251  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
737951  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X2 [KO:K08341]
748888  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
746157  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
457857  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
740518  MAP1LC3B2; microtubule-associated proteins 1A/1B light chain 3 beta 2 [KO:K10435]
744937  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100614312  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100611313  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
452744  SUGT1; protein SGT1 homolog isoform X2 [KO:K12795]
747207  sharpin [KO:K20894]
458025  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 [KO:K10630] [EC:2.3.2.31]
452810  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X2 [KO:K11974] [EC:2.3.2.31]
473765  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
461902  CARD6; caspase recruitment domain-containing protein 6 isoform X2 [KO:K12797]
100609508  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
471527  ERBIN; erbin isoform X8 [KO:K12796]
451508  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X3 [KO:K16060]
451507  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
464876  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
457711  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
451702  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
464917  CARD9; caspase recruitment domain-containing protein 9 isoform X4 [KO:K12794]
472136  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
470026  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
453178  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
452047  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
742813  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
459685  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
747565  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
450927  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
473185  IFNA21; interferon alpha-21 [KO:K05414]
473193  IFNA14; interferon alpha-14 [KO:K05414]
473196  IFNA6; interferon alpha-6 [KO:K05414]
473198  IFNA2; interferon alpha-2 [KO:K05414]
473199  IFNA8; interferon alpha-8 [KO:K05414]
741660  interferon alpha-17 [KO:K05414]
473195  IFNA5; interferon alpha-5 [KO:K05414]
741747  interferon alpha-7 [KO:K05414]
742651  interferon alpha-1/13 [KO:K05414]
741978  interferon alpha-16 [KO:K05414]
744748  interferon alpha-17 [KO:K05414]
473191  interferon alpha-17 [KO:K05414]
473197  interferon alpha-1/13 [KO:K05414]
741797  interferon alpha-4 [KO:K05414]
473183  IFNB1; interferon beta [KO:K05415]
451605  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
471191  ANTXR2; anthrax toxin receptor 2 isoform X2 [KO:K20909]
470393  ANTXR1; anthrax toxin receptor 1 isoform X2 [KO:K20909]
468451  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
742444  PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X2 [KO:K12799]
101058924  CASP1; caspase-1 isoform X4 [KO:K01370] [EC:3.4.22.36]
735456  LOW QUALITY PROTEIN: caspase-1 [KO:K01370] [EC:3.4.22.36]
738409  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
458156  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
463993  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
469743  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
466751  PANX1; pannexin-1 [KO:K03443]
452318  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
470101  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X2 [KO:K04977] [EC:3.6.1.13]
453429  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
455014  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X2 [KO:K04971]
460628  CASR; extracellular calcium-sensing receptor [KO:K04612]
472105  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X2 [KO:K04622]
453330  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
458093  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
469875  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
451290  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
460134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
473389  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
462618  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
745717  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
742793  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
738876  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
737891  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
466291  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
739230  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
452267  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X2 [KO:K14216] [EC:2.7.7.84]
739129  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
469607  RNASEL; 2-5A-dependent ribonuclease isoform X2 [KO:K01165]
468453  DHX33; ATP-dependent RNA helicase DHX33 isoform X2 [KO:K17820] [EC:5.6.2.6]
460861  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
457958  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
462397  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
452820  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X2 [KO:K08847] [EC:2.7.11.1]
465266  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
463648  NAMPT; nicotinamide phosphoribosyltransferase isoform X1 [KO:K03462] [EC:2.4.2.12]
741031  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
465566  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
468068  CYBA; cytochrome b-245 light chain [KO:K08009]
457986  TXNIP; thioredoxin-interacting protein [KO:K20910]
107966247  LOW QUALITY PROTEIN: thioredoxin-interacting protein [KO:K20910]
129135295  thioredoxin-interacting protein-like [KO:K20910]
740248  TXN; thioredoxin [KO:K03671]
104003761  TXN2; thioredoxin, mitochondrial [KO:K03671]
104006062  thioredoxin-like [KO:K03671]
134806977  thioredoxin-like [KO:K03671]
736415  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
465951  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2 [KO:K11864] [EC:3.4.19.-]
743883  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
737497  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
100608599  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
129135367  caspase recruitment domain-containing protein 8 isoform X5 [KO:K12801]
100614569  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
462586  GPSM3; G-protein-signaling modulator 3 isoform X2 [KO:K15838]
471699  IRGM; immunity-related GTPase family M protein [KO:K14139] [EC:3.6.5.-]
742490  PYDC1; pyrin domain-containing protein 1 [KO:K12802]
471040  PYDC2; pyrin domain-containing protein 2 [KO:K20911]
107968776  MEFV; pyrin isoform X1 [KO:K12803]
100613166  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
746477  CASP8; caspase-8 isoform X9 [KO:K04398] [EC:3.4.22.61]
451389  FADD; FAS-associated death domain protein [KO:K02373]
466766  CASP12; inactive caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
451519  CARD16; caspase recruitment domain-containing protein 16 isoform X4 [KO:K12806]
466301  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
456292  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform X1 [KO:K20864]
469002  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X4 [KO:K20865]
471523  NAIP; baculoviral IAP repeat-containing protein 1 isoform X2 [KO:K12807]
459135  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
460442  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
457003  GBP2; guanylate-binding protein 2 isoform X2 [KO:K20897]
100608671  GBP5; guanylate-binding protein 5 isoform X1 [KO:K20898]
457425  AIM2; interferon-inducible protein AIM2 isoform X2 [KO:K12966]
457424  IFI16; gamma-interferon-inducible protein 16 isoform X1 [KO:K20914]
467668  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
104003331  PYDC5; pyrin domain-containing protein 5 [KO:K20916]
461014  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
455785  PKN1; serine/threonine-protein kinase N1 isoform X4 [KO:K06071] [EC:2.7.11.13]
456998  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
454409  YWHAE; 14-3-3 protein epsilon isoform X3 [KO:K06630]
454608  PHD finger protein 14-like [KO:K06630]
459638  14-3-3 protein epsilon-like [KO:K06630]
457004  GBP4; guanylate-binding protein 4 [KO:K20899]
738075  GBP1; guanylate-binding protein 1 [KO:K20899]
457000  GBP3; guanylate-binding protein 3 isoform X1 [KO:K20899]
738189  GBP7; guanylate-binding protein 7 [KO:K20899]
735478  CASP5; caspase-5 isoform X2 [KO:K04395] [EC:3.4.22.58]
451518  CASP4; caspase-4 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
739712  GSDMD; gasdermin-D isoform X2 [KO:K20917]
458516  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
743373  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
455703  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
459834  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
451996  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
744767  IRF9; interferon regulatory factor 9 isoform X4 [KO:K04693]
743242  TLR4; toll-like receptor 4 precursor [KO:K10160]
468677  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
460269  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
462107  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
ptr04010  MAPK signaling pathway
ptr04064  NF-kappa B signaling pathway
ptr04140  Autophagy - animal
ptr04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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