KEGG   PATHWAY: zca05165
Entry
zca05165                    Pathway                                
Name
Human papillomavirus infection - Zalophus californianus (California sea lion)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
zca05165  Human papillomavirus infection
zca05165

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113907859  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
113907908  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
113907934  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
113907956  WNT9B; protein Wnt-9b [KO:K01064]
113907957  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
113908035  AXIN2; axin-2 isoform X1 [KO:K04385]
113908051  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
113908129  [KO:K02152]
113908138  ITGA3; integrin alpha-3 [KO:K06482]
113908204  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113908302  ITGA2B; integrin alpha-IIb [KO:K06476]
113908519  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
113908643  [KO:K04393]
113908652  FZD6; frizzled-6 isoform X1 [KO:K02376]
113908816  TRAF3; LOW QUALITY PROTEIN: TNF receptor-associated factor 3 [KO:K03174]
113908849  THBS1; thrombospondin-1 [KO:K16857]
113908853  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
113908855  HES3; transcription factor HES-3 [KO:K09088]
113908914  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
113908939  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
113908972  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113908976  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113908979  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113909041  [KO:K02152]
113909061  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
113909120  MPP5; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 5 [KO:K06091]
113909122  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
113909320  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
113909515  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113909595  ITGA11; integrin alpha-11 [KO:K06587]
113909784  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
113909919  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910123  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113910424  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
113910856  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
113910930  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113911010  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113911106  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113911233  RHEB; GTP-binding protein Rheb [KO:K07208]
113911235  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113911293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
113911404  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
113911439  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
113911563  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
113911578  WNT2; protein Wnt-2 [KO:K00182]
113911646  FZD1; frizzled-1 [KO:K02432]
113911688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113911763  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
113911877  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113911882  LAMB1; laminin subunit beta-1 [KO:K05636]
113911883  LAMB4; laminin subunit beta-4 [KO:K06245]
113911953  WNT16; protein Wnt-16 [KO:K01558]
113911972  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
113912007  HES5; transcription factor HES-5 [KO:K06055]
113912225  [KO:K05414]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113912609  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
113912633  PXN; paxillin isoform X1 [KO:K05760]
113912763  [KO:K07205]
113912921  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
113913122  FZD10; frizzled-10 [KO:K02842]
113913157  LAMA1; laminin subunit alpha-1 [KO:K05637]
113913246  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
113913247  [KO:K14608]
113913592  [KO:K02149]
113913854  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113913870  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113913921  FZD4; frizzled-4 isoform X1 [KO:K02354]
113913952  MAML2; mastermind-like protein 2 [KO:K06061]
113913990  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
113914083  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113914217  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
113914285  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113914325  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113914497  WNT11; protein Wnt-11 [KO:K01384]
113914533  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
113914539  BAD; bcl2-associated agonist of cell death [KO:K02158]
113914747  FADD; FAS-associated death domain protein [KO:K02373]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113914948  RELA; transcription factor p65 [KO:K04735]
113915498  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
113915700  [KO:K06751]
113915714  [KO:K06751]
113915741  [KO:K06751]
113915998  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
113916079  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
113916105  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
113916148  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
113916178  [KO:K06238]
113916181  [KO:K02153]
113916244  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113916257  [KO:K02149]
113916395  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
113916429  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
113916433  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
113916548  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
113916549  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
113916566  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
113916637  CRB3; protein crumbs homolog 3 [KO:K06090]
113916638  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
113916665  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
113916679  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
113916706  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
113916707  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
113916866  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113916959  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
113917002  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
113917006  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
113917022  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113917132  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
113917133  [KO:K04659]
113917179  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113917235  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
113917247  HES1; transcription factor HES-1 [KO:K06054]
113917509  WNT7A; protein Wnt-7a [KO:K00572]
113917714  CTNNB1; catenin beta-1 [KO:K02105]
113917900  [KO:K02152]
113917982  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
113918049  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
113918089  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
113918374  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
113918381  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
113918397  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113918459  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
113918500  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
113918509  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113918625  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113918785  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113918898  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113918902  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
113919207  FZD5; frizzled-5 [KO:K02375]
113919296  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
113919318  FN1; fibronectin isoform X1 [KO:K05717]
113919387  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113919409  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
113919482  FOXO1; forkhead box protein O1 [KO:K07201]
113919503  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113919533  [KO:K02150]
113919574  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
113919651  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
113919813  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
113919873  [KO:K02146]
113919931  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
113919967  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
113919982  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
113919983  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113920047  [KO:K04393]
113920081  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
113920227  WNT10A; protein Wnt-10a [KO:K01357]
113920510  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
113920585  [KO:K02154]
113920600  FZD7; frizzled-7 [KO:K02432]
113920632  WNT6; protein Wnt-6 [KO:K00445]
113920658  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
113920890  CCNA1; cyclin-A1 [KO:K06627]
113921399  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
113921510  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
113921697  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113921708  PARD3; partitioning defective 3 homolog isoform X2 [KO:K04237]
113921719  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
113921783  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113921804  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113921844  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113921869  ITGA5; integrin alpha-5 [KO:K06484]
113921903  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X2 [KO:K11643] [EC:5.6.2.-]
113921916  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
113921955  WNT10B; protein Wnt-10b [KO:K01357]
113921956  WNT1; proto-oncogene Wnt-1 [KO:K03209]
113921986  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113922015  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113922098  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
113922102  [KO:K00873] [EC:2.7.1.40]
113922345  WNT8B; protein Wnt-8b [KO:K00714]
113922348  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
113922447  WNT7B; protein Wnt-7b [KO:K00572]
113922486  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
113922626  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113922684  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
113922712  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
113922860  VWF; von Willebrand factor isoform X1 [KO:K03900]
113922890  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113923025  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
113923054  FZD8; frizzled-8 [KO:K02375]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113923921  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
113924083  [KO:K06253]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113924241  CCNA2; cyclin-A2 [KO:K06627]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113924415  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
113924504  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113924526  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113924761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113924804  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
113924824  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
113924857  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
113924910  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113925060  FZD3; frizzled-3 [KO:K02329]
113925121  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113925290  SPP1; osteopontin isoform X1 [KO:K06250]
113925370  [KO:K06627]
113925832  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113925871  [KO:K02153]
113925885  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
113925887  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
113926169  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
113926298  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
113926316  [KO:K06751]
113926341  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
113926525  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
113926585  [KO:K06751]
113926669  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
113926702  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
113926716  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
113927036  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
113927071  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
113927248  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
113927327  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
113927365  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
113927446  [KO:K03120]
113927548  THBS2; thrombospondin-2 [KO:K04659]
113927625  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
113927740  TNF; tumor necrosis factor [KO:K03156]
113927761  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
113927768  [KO:K06751]
113927959  VEGFA; vascular endothelial growth factor A [KO:K05448]
113927989  [KO:K06751]
113928377  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
113928407  TCF7; transcription factor 7 isoform X1 [KO:K02620]
113928431  ITGA2; integrin alpha-2 [KO:K06481]
113928600  WNT8A; protein Wnt-8a [KO:K00714]
113928748  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
113928897  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113928980  MAML1; mastermind-like protein 1 [KO:K06061]
113929021  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113929051  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113929209  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
113929210  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
113929378  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113929507  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
113929550  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
113929600  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
113929757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113929833  ATP6V0E1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
113929897  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
113929950  IRF1; interferon regulatory factor 1 isoform X2 [KO:K09444]
113930219  PATJ; inaD-like protein isoform X1 [KO:K06092]
113930489  [KO:K06067] [EC:3.5.1.98]
113930564  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
113930597  [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930651  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
113930731  [KO:K04382] [EC:3.1.3.16]
113930753  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
113930837  [KO:K02150]
113930905  [KO:K02150]
113931046  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
113931151  [KO:K02373]
113931270  [KO:K02152]
113931429  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
113931430  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
113931467  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
113931754  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113931821  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113931879  NRAS; GTPase NRas [KO:K07828]
113931903  [KO:K04498] [EC:2.3.1.48]
113931995  [KO:K04393]
113931997  LAMC2; laminin subunit gamma-2 [KO:K06246]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932059  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
113932092  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
113932244  TNN; tenascin-N [KO:K06252]
113932254  LAMB3; laminin subunit beta-3 [KO:K06244]
113932448  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
113932692  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
113932728  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
113932759  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
113932845  [KO:K02150]
113932932  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
113932963  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
113932981  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
113932986  AXIN1; axin-1 isoform X1 [KO:K02157]
113933091  [KO:K02150]
113933192  TNR; tenascin-R isoform X1 [KO:K06252]
113933221  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113933431  TSC2; tuberin isoform X1 [KO:K07207]
113933479  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
113933515  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
113933593  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
113933699  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113933743  [KO:K07205]
113934022  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113934167  TNC; tenascin isoform X1 [KO:K06252]
113934213  TSC1; hamartin isoform X1 [KO:K07206]
113934277  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
113934366  [KO:K02155]
113934419  IFNB1; interferon beta [KO:K05415]
113934570  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
113934655  [KO:K05414]
113934667  [KO:K05414]
113934678  [KO:K05414]
113934682  [KO:K05414]
113934727  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
113934729  [KO:K00873] [EC:2.7.1.40]
113934985  [KO:K05414]
113934992  [KO:K04393]
113935130  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
113935299  [KO:K02152]
113935342  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113935677  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113935694  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
113935781  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113935813  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113936171  [KO:K08957] [EC:2.7.11.1]
113936173  [KO:K04393]
113936398  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113936412  [KO:K04393]
113936464  [KO:K02152]
113936652  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
113936714  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
113936966  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
113936968  [KO:K04632]
113937000  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
113937127  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113937377  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
113937499  HES2; transcription factor HES-2 [KO:K09087]
113937628  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
113937694  JAG1; LOW QUALITY PROTEIN: protein jagged-1 [KO:K06052]
113937743  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
113937768  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
113937949  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
113938047  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
113938288  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
113938298  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
113938302  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
113938320  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
113938493  E2F1; transcription factor E2F1 [KO:K17454]
113938536  LAMA5; laminin subunit alpha-5 [KO:K06240]
113938904  WNT9A; protein Wnt-9a [KO:K01064]
113938914  WNT3A; protein Wnt-3a [KO:K00312]
113938999  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113939369  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
113939402  VTN; vitronectin [KO:K06251]
113939450  TUBG1; tubulin gamma-1 chain [KO:K10389]
113939451  [KO:K10389]
113939460  CHAD; chondroadherin [KO:K06248]
113939531  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
113939578  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
113939579  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113939623  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
113939702  ITGB3; integrin beta-3 [KO:K06493]
113939732  FZD2; frizzled-2 [KO:K02235]
113939804  [KO:K02152]
113939875  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
118356554  [KO:K07210]
118356749  [KO:K04393]
118357226  [KO:K06751]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
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Viruses 7:2485-506 (2015)
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Reference
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Reference
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Human papillomavirus proteins as prospective therapeutic targets.
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Reference
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
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Wolf JK, Ramirez PT.
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The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
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McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
PMID:23175122
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Banks L, Pim D, Thomas M
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
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Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
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Human papillomaviruses, cervical cancer and cell polarity.
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
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Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Mol Cancer 10:140 (2011)
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Oncogene 20:7866-73 (2001)
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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The E5 proteins.
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Breaking the DNA damage response to improve cervical cancer treatment.
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Cancer Treat Rev 42:30-40 (2016)
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Reference
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Control of interferon signaling in human papillomavirus infection.
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Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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PMID:22499770
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Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
zca04064  NF-kappa B signaling pathway
zca04110  Cell cycle
zca04115  p53 signaling pathway
zca04150  mTOR signaling pathway
zca04151  PI3K-Akt signaling pathway
zca04210  Apoptosis
zca04310  Wnt signaling pathway
zca04330  Notch signaling pathway
zca04510  Focal adhesion
zca04520  Adherens junction
zca04530  Tight junction
zca04612  Antigen processing and presentation
zca04620  Toll-like receptor signaling pathway
zca04630  JAK-STAT signaling pathway
KO pathway
ko05165   

DBGET integrated database retrieval system