KEGG   ORTHOLOGY: K07887
Entry
K07887                      KO                                     
Symbol
RAB5A
Name
Ras-related protein Rab-5A
Pathway
map04014  Ras signaling pathway
map04137  Mitophagy - animal
map04144  Endocytosis
map04145  Phagosome
map04148  Efferocytosis
map04962  Vasopressin-regulated water reabsorption
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05146  Amoebiasis
map05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07887  RAB5A; Ras-related protein Rab-5A
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K07887  RAB5A; Ras-related protein Rab-5A
   04145 Phagosome
    K07887  RAB5A; Ras-related protein Rab-5A
   04137 Mitophagy - animal
    K07887  RAB5A; Ras-related protein Rab-5A
   04148 Efferocytosis
    K07887  RAB5A; Ras-related protein Rab-5A
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K07887  RAB5A; Ras-related protein Rab-5A
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K07887  RAB5A; Ras-related protein Rab-5A
   05152 Tuberculosis
    K07887  RAB5A; Ras-related protein Rab-5A
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K07887  RAB5A; Ras-related protein Rab-5A
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K07887  RAB5A; Ras-related protein Rab-5A
   05022 Pathways of neurodegeneration - multiple diseases
    K07887  RAB5A; Ras-related protein Rab-5A
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07887  RAB5A; Ras-related protein Rab-5A
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07887  RAB5A; Ras-related protein Rab-5A
   04031 GTP-binding proteins
    K07887  RAB5A; Ras-related protein Rab-5A
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab GTPases
    K07887  RAB5A; Ras-related protein Rab-5A
 Endosome - Lysosome transport
  Rab GTPases and associated proteins
   Rab GTPases
    K07887  RAB5A; Ras-related protein Rab-5A
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of other body fluids (saliva and urine)
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of colorectal cancer cells
   K07887  RAB5A; Ras-related protein Rab-5A
  Exosomal proteins of bladder cancer cells
   K07887  RAB5A; Ras-related protein Rab-5A
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Rab Family
   Rab5/17/22/31 [OT]
    K07887  RAB5A; Ras-related protein Rab-5A
Genes
HSA: 5868(RAB5A)
PTR: 460217(RAB5A)
PPS: 100972222(RAB5A)
GGO: 101144180(RAB5A)
PON: 100446432(RAB5A)
NLE: 100585666(RAB5A)
HMH: 116473751(RAB5A)
MCC: 697712(RAB5A)
MCF: 102144117(RAB5A)
MTHB: 126945267 126946715
MNI: 105488903(RAB5A)
CSAB: 103241745(RAB5A)
CATY: 105578300(RAB5A)
PANU: 100999279(RAB5A)
TGE: 112619083(RAB5A)
MLEU: 105530773(RAB5A)
RRO: 104665706(RAB5A)
RBB: 108521254(RAB5A)
TFN: 117077586 117084230(RAB5A)
PTEH: 111539482(RAB5A)
CANG: 105505780(RAB5A)
CJC: 100389972(RAB5A) 100894569
SBQ: 101034494(RAB5A)
CIMI: 108299936(RAB5A)
CSYR: 103275058(RAB5A)
MMUR: 105881575(RAB5A)
LCAT: 123628394(RAB5A)
PCOQ: 105826386(RAB5A)
OGA: 100949283(RAB5A)
MMU: 271457(Rab5a)
MCAL: 110312675(Rab5a)
MPAH: 110336058(Rab5a)
RNO: 100361891(Rab5al1) 64633(Rab5a)
MCOC: 116074344(Rab5a)
ANU: 117722351(Rab5a)
MUN: 110565695(Rab5a)
CGE: 100772343(Rab5a)
MAUA: 101838485(Rab5a)
PROB: 127236500(Rab5a)
PLEU: 114707466(Rab5a)
MORG: 121450580(Rab5a)
MFOT: 126515452
AAMP: 119822397(Rab5a)
NGI: 103734275(Rab5a)
HGL: 101710661(Rab5a)
CPOC: 100723790(Rab5a)
CCAN: 109692646(Rab5a) 109703335
DORD: 105989904(Rab5a)
DSP: 122108082(Rab5a)
PLOP: 125358649(Rab5a)
MMMA: 107149587(Rab5a)
OCU: 100350923
OPI: 101522222(RAB5A)
TUP: 102473232(RAB5A)
GVR: 103599706(RAB5A)
CFA: 404008(RAB5A)
CLUD: 112660999(RAB5A)
VVP: 112925603(RAB5A)
VLG: 121478865(RAB5A)
NPO: 129507132(RAB5A)
AML: 100481281(RAB5A)
UMR: 103679620(RAB5A)
UAH: 113253888(RAB5A)
UAR: 123788339(RAB5A)
ELK: 111155079
LLV: 125104900
MPUF: 101684536(RAB5A)
MNP: 132011760(RAB5A)
MLK: 131824499(RAB5A)
NVS: 122909015(RAB5A)
ORO: 101370301(RAB5A)
EJU: 114205639(RAB5A)
ZCA: 113916627(RAB5A)
MLX: 118003146(RAB5A)
NSU: 110570855(RAB5A)
LWW: 102744182(RAB5A)
FCA: 101099995(RAB5A)
PYU: 121033616(RAB5A)
PCOO: 112850392(RAB5A)
PBG: 122492036(RAB5A)
LRUF: 124526069
PTG: 102956448(RAB5A)
PPAD: 109258513(RAB5A)
PUC: 125921347
AJU: 106981292
HHV: 120222031(RAB5A)
BTA: 539764(RAB5A)
BOM: 102272703(RAB5A)
BIU: 109561892(RAB5A)
BBUB: 102409692(RAB5A)
BBIS: 105000723(RAB5A)
CHX: 102184478(RAB5A)
OAS: 100302084(RAB5A)
BTAX: 128060293(RAB5A)
ODA: 120880188(RAB5A)
CCAD: 122445528(RAB5A)
MBEZ: 129549747(RAB5A)
SSC: 100144499(RAB5A)
CFR: 102515139(RAB5A)
CBAI: 105072592(RAB5A)
CDK: 105085148(RAB5A)
VPC: 102538668(RAB5A)
BACU: 103004707(RAB5A)
LVE: 103075981(RAB5A)
OOR: 101273864(RAB5A) 101275059
DLE: 111164777(RAB5A)
PCAD: 102984481(RAB5A)
PSIU: 116753147(RAB5A)
NASI: 112397778(RAB5A)
ECB: 100051997(RAB5A)
EPZ: 103559349(RAB5A)
EAI: 106831752(RAB5A)
MYB: 102239794(RAB5A)
MYD: 102755118(RAB5A)
MMYO: 118668224(RAB5A)
MLF: 102439178(RAB5A)
MNA: 107526355(RAB5A)
PKL: 118715392(RAB5A)
EFUS: 103296869(RAB5A)
HAI: 109393991(RAB5A)
DRO: 112309570(RAB5A)
SHON: 119004015(RAB5A)
AJM: 119048325(RAB5A) 119050791
PDIC: 114501435(RAB5A)
PHAS: 123815479 123830616(RAB5A)
MMF: 118633623(RAB5A)
RFQ: 117017475 117036886(RAB5A)
PPAM: 129088376(RAB5A)
PALE: 102896851(RAB5A)
PGIG: 120581665(RAB5A)
PVP: 105289298(RAB5A)
RAY: 107497819(RAB5A)
MJV: 108409860(RAB5A)
TOD: 119257198(RAB5A)
SARA: 101546359(RAB5A)
LAV: 100676912(RAB5A)
TMU: 101358523
ETF: 101652509(RAB5A) 101652923
DNM: 101424456(RAB5A)
MDO: 100024447(RAB5A)
GAS: 123248760(RAB5A)
SHR: 100925458(RAB5A)
AFZ: 127539208
PCW: 110209035(RAB5A)
OAA: 100076995(RAB5A)
GGA: 420649(RAB5A)
PCOC: 116227097(RAB5A)
MGP: 100543312(RAB5A)
CJO: 107309277(RAB5A)
TPAI: 128085178(RAB5A)
LMUT: 125695933(RAB5A)
NMEL: 110393039(RAB5A)
APLA: 101789931(RAB5A)
ACYG: 106030269(RAB5A)
CATA: 118252824(RAB5A)
AFUL: 116485829(RAB5A)
TGU: 100230163(RAB5A)
LSR: 110474606(RAB5A)
SCAN: 103812923(RAB5A)
PMOA: 120503502(RAB5A)
OTC: 121339556(RAB5A)
PRUF: 121353028(RAB5A)
GFR: 102042464(RAB5A)
FAB: 101819219(RAB5A)
OMA: 130249109(RAB5A)
PHI: 102107036(RAB5A)
PMAJ: 107200272(RAB5A)
CCAE: 111923465(RAB5A)
CCW: 104689064(RAB5A)
CBRC: 103614122(RAB5A)
ETL: 114069095(RAB5A)
ZAB: 102063112(RAB5A)
ACHL: 103809148(RAB5A)
SVG: 106857354(RAB5A)
MMEA: 130582771(RAB5A)
HRT: 120751546(RAB5A)
FPG: 101922651(RAB5A)
FCH: 102055723(RAB5A)
CLV: 102087403(RAB5A)
EGZ: 104126123(RAB5A)
NNI: 104013901(RAB5A)
PCRI: 104032836(RAB5A)
PLET: 104620435(RAB5A)
EHS: 104504918(RAB5A)
PCAO: 104050986(RAB5A)
ACUN: 113476514(RAB5A)
TALA: 104361239(RAB5A)
PADL: 103921524(RAB5A)
AFOR: 103906647(RAB5A)
ACHC: 115339064(RAB5A)
HALD: 104312326(RAB5A)
HLE: 104843133(RAB5A)
AGEN: 126037936
GCL: 127030006
CCRI: 104156550(RAB5A)
CSTI: 104551906(RAB5A)
CMAC: 104483545(RAB5A)
MUI: 104548876(RAB5A)
BREG: 104634026(RAB5A)
FGA: 104074858(RAB5A)
GSTE: 104254657
LDI: 104353058(RAB5A)
MNB: 103782211(RAB5A)
OHA: 104333312(RAB5A)
NNT: 104400940(RAB5A)
SHAB: 115604163(RAB5A)
DPUB: 104303103(RAB5A)
PGUU: 104467365(RAB5A)
ACAR: 104525751(RAB5A)
CPEA: 104397548(RAB5A)
AVIT: 104269311(RAB5A)
CVF: 104289902(RAB5A)
RTD: 128905317(RAB5A)
CUCA: 104067570(RAB5A)
TEO: 104381290(RAB5A)
BRHI: 104493680(RAB5A)
AAM: 106483486(RAB5A)
AROW: 112972069(RAB5A)
NPD: 112957210(RAB5A)
TGT: 104575960(RAB5A)
DNE: 112985288(RAB5A)
SCAM: 104145066(RAB5A)
ASN: 102388201(RAB5A)
AMJ: 102571945(RAB5A)
CPOO: 109310618(RAB5A)
GGN: 109291670(RAB5A)
PSS: 102447823(RAB5A)
CMY: 102943972(RAB5A)
CCAY: 125631613(RAB5A)
DCC: 119852294(RAB5A)
CPIC: 101947027(RAB5A)
TST: 117872380(RAB5A)
CABI: 116816616(RAB5A)
MRV: 120398106(RAB5A)
ACS: 100552994(rab5a)
ASAO: 132778704(RAB5A)
PVT: 110086461(RAB5A)
SUND: 121934513(RAB5A)
PBI: 103058604(RAB5A)
PMUR: 107282901(RAB5A)
CTIG: 120310459(RAB5A)
TSR: 106537670(RAB5A)
PGUT: 117655132(RAB5A)
APRI: 131198762(RAB5A)
PTEX: 113441268(RAB5A)
NSS: 113415948(RAB5A)
VKO: 123033046(RAB5A)
PMUA: 114607170(RAB5A)
PRAF: 128398376(RAB5A)
ZVI: 118091849(RAB5A)
HCG: 128330789(RAB5A)
GJA: 107123665(RAB5A)
STOW: 125440796(RAB5A)
EMC: 129337575(RAB5A)
XLA: 108719951(rab5a.S) 380227(rab5a.L)
XTR: 493430(rab5a)
NPR: 108797632(RAB5A)
RTEM: 120940247(RAB5A)
BBUF: 121001784(RAB5A)
BGAR: 122938335(RAB5A)
MUO: 115469933(RAB5A)
GSH: 117353992(RAB5A)
DRE: 337737(rab5aa) 393945(rab5ab)
LROH: 127178892(rab5ab) 127181597(rab5aa)
OMC: 131522155(rab5ab) 131525403(rab5aa)
PPRM: 120483794(rab5aa) 120491156(rab5ab)
RKG: 130076413(rab5ab) 130085141(rab5aa)
MAMB: 125243050(rab5ab) 125275421(rab5aa)
TROS: 130557618(rab5ab) 130566701(rab5aa)
TDW: 130415325(rab5aa) 130432898(rab5ab)
MANU: 129448779(rab5ab) 129455445(rab5aa)
IPU: 100528297(rab5ab)
IFU: 128600069(rab5ab)
SMEO: 124375507(rab5ab) 124382072(rab5aa)
TFD: 113649573(rab5aa) 113649746(rab5ab)
TVC: 132840078(rab5ab) 132842940(rab5aa)
CMAO: 118798713(rab5ab) 118805874(rab5aa)
CHAR: 105904716(rab5aa) 122132150
LCO: 104923118 104931780(rab5a)
NCC: 104947906 104953323(rab5a)
TBEN: 117468499(rab5ab) 117477963(rab5aa)
CGOB: 115016257 115021364(rab5a)
PGEO: 117455002 117460554(rab5ab)
GACU: 117543275(rab5ab) 117562985
ELY: 117263853 117265762(rab5ab)
EFO: 125893047(rab5ab) 125904696
PLEP: 121945795(rab5ab) 121957446(rab5aa)
SLUC: 116036000(rab5ab) 116066840(rab5aa)
ECRA: 117945613(rab5ab) 117956770(rab5aa)
PFLV: 114556504(rab5a) 114567838
GAT: 120810577(rab5ab) 120826032(rab5aa)
PPUG: 119197878(rab5ab) 119219417(rab5aa)
AFB: 129096752(rab5aa) 129109400(rab5ab)
MSAM: 119897085(rab5ab) 119906669
CUD: 121513770(rab5ab) 121523937(rab5aa)
ALAT: 119006113(rab5ab) 119016765
ONL: 100701272(rab5a) 100704868
OAU: 116311339(rab5ab) 116312049(rab5aa)
OML: 112136549(rab5ab) 112162956(rab5aa)
XHE: 116717259 116730690(rab5a)
PRET: 103472355(rab5a) 103477863
PFOR: 103135088 103153896(rab5a)
PLAI: 106939424(rab5a) 106961574
GAF: 122830625(rab5ab) 122843641
CVG: 107082990 107083283(rab5a)
CTUL: 119785928(rab5aa) 119790066(rab5ab)
GMU: 124865722(rab5ab) 124879818(rab5aa)
KMR: 108241608(rab5aa) 108249324
ALIM: 106523087(rab5a)
NWH: 119409622(rab5ab) 119425663(rab5aa)
MCEP: 125016640(rab5ab) 125019807(rab5aa)
SSEN: 122774669(rab5ab) 122786010(rab5aa)
HHIP: 117770628 117777113(rab5ab)
HSP: 118113846(rab5ab) 118125278
SDU: 111223299 111236892(rab5a)
XGL: 120784336(rab5ab) 120786746
HCQ: 109521099
SSCV: 125974838
PEE: 133395641 133401588(rab5ab)
BSPL: 114843335(rab5ab) 114865393(rab5aa)
SJO: 128366676(rab5ab) 128374415(rab5aa)
AANG: 118207179(rab5ab) 118233394(rab5aa)
LOC: 102696266(rab5a)
PSEX: 120515347(rab5aa)
LCM: 102365669(RAB5A)
CMK: 103181250(rab5aa)
RTP: 109936986(rab5a)
CPLA: 122549941
HOC: 132815754
LERI: 129709834(rab5aa)
LRJ: 133345181
AJC: 117104846
ALAB: 122718998
AFLR: 100869671
BBIF: 117204914
BVK: 117234098
BVAN: 117163762
BAFF: 126920471
BPYO: 122570836
BPAS: 132906018
FVI: 122533035
MGEN: 117224588
NMEA: 116425515
LHT: 122500293
LBD: 127284016
AGIF: 122858450
CINS: 118072397
VCAN: 122411582
MQU: 129001557
LSM: 121116746
DPOL: 127857858
OSN: 115228380
XEN: 124453295
 » show all
Reference
  Authors
Hoffenberg S, Liu X, Nikolova L, Hall HS, Dai W, Baughn RE, Dickey BF, Barbieri MA, Aballay A, Stahl PD, Knoll BJ
  Title
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.
  Journal
J Biol Chem 275:24661-9 (2000)
DOI:10.1074/jbc.M909600199
  Sequence
[hsa:5868]
Reference
PMID:2501306
  Authors
Zahraoui A, Touchot N, Chardin P, Tavitian A
  Title
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
  Journal
J Biol Chem 264:12394-401 (1989)
  Sequence
[hsa:5868]
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