KEGG   PATHWAY: oas05167
Entry
oas05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Ovis aries (sheep)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05167

Organism
Ovis aries (sheep) [GN:oas]
Gene
101108131  C3; complement C3 [KO:K03990]
114114921  complement C3-like isoform X1 [KO:K03990]
554258  TLR3; toll-like receptor 3 precursor [KO:K05401]
101111016  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100036758  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101116923  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101110830  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101103683  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101111435  interferon alpha-H-like [KO:K05414]
105601948  interferon alpha-H-like [KO:K05414]
492823  IFN1; interferon alpha-1 [KO:K05414]
101102963  interferon alpha-H-like [KO:K05414]
101105135  interferon alpha-H [KO:K05414]
101103872  interferon alpha-2-like [KO:K05414]
114113084  interferon alpha-14-like [KO:K05414]
114113089  interferon alpha-2-like [KO:K05414]
114113090  interferon alpha-H-like [KO:K05414]
114112827  interferon alpha-3-like [KO:K05414]
101105632  interferon alpha-H-like [KO:K05414]
121818512  interferon alpha-2-like [KO:K05414]
780485  IRF3; interferon regulatory factor 3 [KO:K05411]
101110136  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101123600  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101103702  interferon beta-2-like [KO:K05415]
101103376  interferon beta-2-like [KO:K05415]
101103623  interferon beta-2 [KO:K05415]
114113004  interferon beta-2-like [KO:K05415]
114113016  interferon beta-2-like [KO:K05415]
114113206  interferon beta-2-like [KO:K05415]
114112819  interferon beta-2-like [KO:K05415]
114112835  interferon beta-2-like [KO:K05415]
114112840  interferon beta-2-like [KO:K05415]
114112883  interferon beta-2 [KO:K05415]
114112830  interferon beta-2-like [KO:K05415]
121818657  interferon beta-2-like [KO:K05415]
443126  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
443363  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
101110716  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101117248  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100307049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101108211  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101116656  IRF9; interferon regulatory factor 9 isoform X3 [KO:K04693]
101121673  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100194428  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100217411  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101116223  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
101115956  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101118118  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101115047  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
443283  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
443406  IL6; interleukin-6 precursor [KO:K05405]
443400  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
443111  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101117453  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101103766  C-C chemokine receptor type 1-like [KO:K04176]
101117971  C-C chemokine receptor type 1 [KO:K04176]
101105364  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101113281  CCR8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
100144426  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
101116783  FADD; FAS-associated death domain protein [KO:K02373]
101107334  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101117837  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
443059  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
443062  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
106990363  cytochrome c-like [KO:K08738]
106990092  cytochrome c [KO:K08738]
101117527  cytochrome c [KO:K08738]
114108777  cytochrome c [KO:K08738]
101104844  cytochrome c-like [KO:K08738]
101110611  cytochrome c-like [KO:K08738]
101111101  cytochrome c-like [KO:K08738]
101113375  cytochrome c-like [KO:K08738]
101118037  cytochrome c-like [KO:K08738]
101123328  cytochrome c-like [KO:K08738]
105602596  cytochrome c-like [KO:K08738]
105603035  cytochrome c-like [KO:K08738]
114113248  cytochrome c-like [KO:K08738]
114115222  cytochrome c [KO:K08738]
114115598  cytochrome c-like [KO:K08738]
114115604  cytochrome c-like [KO:K08738]
114115652  cytochrome c-like [KO:K08738]
114117847  cytochrome c-like [KO:K08738]
101107359  cytochrome c [KO:K08738]
101110953  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
443031  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100135698  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101111042  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101105235  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101111143  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
780484  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101107332  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
780520  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101108228  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101102191  RELA; transcription factor p65 [KO:K04735]
443421  TP53; cellular tumor antigen p53 [KO:K04451]
100302083  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100144756  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100144761  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100144755  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
101117526  E2F1; transcription factor E2F1 [KO:K17454]
105606975  E2F2; transcription factor E2F2 [KO:K09389]
101121809  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100171394  OVAR; MHC class I antigen precursor [KO:K06751]
101107908  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
106990117  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
101107641  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
101119545  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101104866  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
101111694  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101112480  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
114109630  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X6 [KO:K06751]
101105609  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
132658253  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
101112907  IFNGR1; interferon gamma receptor 1 isoform X2 [KO:K05132]
443045  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
554318  CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
114109639  MHC class I polypeptide-related sequence B-like isoform X1 [KO:K07985]
101105860  MHC class I polypeptide-related sequence B isoform X1 [KO:K07985]
101120999  C-type lectin domain family 2 member B [KO:K10071]
443296  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
101110438  ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
443297  ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
100135694  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
105614945  ubiquitin-like [KO:K02977]
101112274  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
101122127  ubiquitin-ribosomal protein eS31 fusion protein-like [KO:K02977]
443016  UBB; polyubiquitin-B [KO:K04551]
101115230  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
100913170  BECN1; beclin-1 isoform X1 [KO:K08334]
101108148  BECN2; beclin-2 [KO:K08334]
101119220  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101105709  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
101121560  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
101118292  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
101120002  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101105939  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105604794  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
101104166  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [KO:K04536]
101102864  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101110493  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101108976  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101106267  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101106689  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101114066  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101114927  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101110631  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105611474  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101116593  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114112926  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100192421  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106991180  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101115838  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101112183  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101114097  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
105608415  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
114114919  GTPase HRas-like [KO:K02833]
101114005  KRAS; GTPase KRas isoform X1 [KO:K07827]
101102438  NRAS; GTPase NRas [KO:K07828]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
101113846  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
443519  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
443219  JUN; transcription factor Jun [KO:K04448]
443218  FOS; protein c-Fos [KO:K04379]
101102896  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101109983  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101109720  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100271659  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101115893  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101114747  cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
101122319  cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
101105303  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101103084  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101113167  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
100302103  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
101115045  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
100302082  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101122126  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101103341  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101108864  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X4 [KO:K04958]
101113317  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
114109674  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
101105840  calmodulin [KO:K02183]
443230  CALM2; calmodulin [KO:K02183]
105614854  calmodulin-alpha [KO:K02183]
101116338  CALM3; calmodulin-3 [KO:K02183]
101115216  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100037684  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121820456  calmodulin-1-like [KO:K02183]
101123572  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101108104  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101115429  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101122602  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
101120802  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
114108765  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101108097  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446]
101119239  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101117607  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
101118617  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
443418  CXCL8; interleukin-8 precursor [KO:K10030]
443460  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
443380  CXCL1; growth-regulated alpha protein precursor [KO:K05505]
101104661  growth-regulated protein homolog gamma isoform X1 [KO:K05505]
114108665  growth-regulated alpha protein [KO:K05505]
443255  RCAN1; calcipressin-1 [KO:K17901]
443306  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
443103  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
443545  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
497273  ANGPT2; angiopoietin-2 [KO:K05466]
101113174  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101113909  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100294659  STAT3; signal transducer and activator of transcription 3 isoform X10 [KO:K04692]
100169938  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100294600  CTNNB1; catenin beta-1 [KO:K02105]
101101980  TCF7; transcription factor 7 isoform X6 [KO:K02620]
100913162  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
101118068  TCF7L2; transcription factor 7-like 2 isoform X19 [KO:K04491]
780521  LEF1; lymphoid enhancer-binding factor 1 isoform X8 [KO:K04492]
443118  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100144763  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
443447  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
  Journal
Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
Reference
PMID:11413168
  Authors
Coscoy L, Ganem D
  Title
A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
  Journal
J Clin Invest 107:1599-606 (2001)
DOI:10.1172/JCI12432
Reference
PMID:24710493
  Authors
Pratt ZL, Sugden B
  Title
How human tumor viruses make use of autophagy.
  Journal
Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:11960692
  Authors
Jenner RG, Boshoff C
  Title
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
  Journal
Biochim Biophys Acta 1602:1-22 (2002)
DOI:10.1016/S0304-419X(01)00040-3
Reference
PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
  Journal
J Virol 78:7667-76 (2004)
DOI:10.1128/JVI.78.14.7667-7676.2004
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
PMID:15573137
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529
Reference
PMID:17329974
  Authors
Montaner S
  Title
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
  Journal
Cell Cycle 6:438-43 (2007)
DOI:10.4161/cc.6.4.3843
Reference
PMID:23028325
  Authors
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
  Journal
PLoS Pathog 8:e1002927 (2012)
DOI:10.1371/journal.ppat.1002927
Reference
PMID:10318948
  Authors
Lagunoff M, Majeti R, Weiss A, Ganem D
  Title
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
  Journal
Proc Natl Acad Sci U S A 96:5704-9 (1999)
DOI:10.1073/pnas.96.10.5704
Reference
PMID:26192396
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
PMID:25187543
  Authors
Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
  Title
Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
  Journal
J Virol 88:13161-72 (2014)
DOI:10.1128/JVI.01766-14
Reference
PMID:17050609
  Authors
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
J Virol 81:42-58 (2007)
DOI:10.1128/JVI.00648-06
Reference
PMID:16585191
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
PMID:22521915
  Authors
Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
  Title
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
  Authors
Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
  Journal
Viruses 7:116-53 (2015)
DOI:10.3390/v7010116
Reference
PMID:14991150
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
PMID:26870016
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
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pathway
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oas04144  Endocytosis
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KO pathway
ko05167   
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