KEGG   PATHWAY: gja04010
Entry
gja04010                    Pathway                                
Name
MAPK signaling pathway - Gekko japonicus (Schlegel's Japanese gecko)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gja04010  MAPK signaling pathway
gja04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Gekko japonicus (Schlegel's Japanese gecko) [GN:gja]
Gene
107105445  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
107105448  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
107105466  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
107105698  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
107105721  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
107105754  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
107105761  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
107105835  STK3; serine/threonine kinase 3 [KO:K04412]
107106022  TRADD; TNFRSF1A associated via death domain [KO:K03171]
107106035  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
107106036  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107106275  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
107106285  [KO:K03283]
107106337  [KO:K19662] [EC:2.7.11.13]
107106394  [KO:K22429]
107106414  CSF1; colony stimulating factor 1 [KO:K05453]
107106747  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107106759  AREG; amphiregulin [KO:K09782]
107106894  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
107106941  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
107106952  [KO:K16342] [EC:3.1.1.4]
107107052  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
107107196  [KO:K04373] [EC:2.7.11.1]
107107221  RASA1; RAS p21 protein activator 1 [KO:K04352]
107107269  ECSIT; ECSIT signalling integrator [KO:K04405]
107107352  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
107107364  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
107107366  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
107107456  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107107537  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
107107708  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
107107812  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
107107910  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
107107943  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
107107944  NGF; nerve growth factor [KO:K02582]
107107945  FGF5; fibroblast growth factor 5 [KO:K04358]
107107946  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
107107951  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
107108106  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07830]
107108139  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107108180  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
107108204  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
107108206  [KO:K16342] [EC:3.1.1.4]
107108207  [KO:K16342] [EC:3.1.1.4]
107108277  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
107108364  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
107108391  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
107108519  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
107108632  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
107108692  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
107108719  NGFR; nerve growth factor receptor [KO:K02583]
107108795  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
107108893  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
107109116  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
107109400  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
107109403  [KO:K08018]
107109560  FGF2; fibroblast growth factor 2 [KO:K18497]
107109638  [KO:K04380]
107109763  [KO:K04439]
107109909  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107110017  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
107110018  GRB2; growth factor receptor bound protein 2 [KO:K04364]
107110211  [KO:K04386]
107110247  TGFB2; transforming growth factor beta 2 [KO:K13376]
107110308  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
107110402  FGF23; fibroblast growth factor 23 [KO:K22428]
107110406  FGF6; fibroblast growth factor 6 [KO:K04358]
107110492  HGF; hepatocyte growth factor [KO:K05460]
107110539  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
107110808  STMN1; stathmin 1 [KO:K04381]
107110949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107110955  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
107110972  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
107110975  [KO:K04441] [EC:2.7.11.24]
107111245  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
107111331  [KO:K04852]
107111515  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
107111538  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107111599  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
107111822  [KO:K16342] [EC:3.1.1.4]
107111851  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
107111867  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
107112057  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
107112158  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
107112269  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
107112354  RASA2; RAS p21 protein activator 2 [KO:K08053]
107112547  FGF18; fibroblast growth factor 18 [KO:K04358]
107112647  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
107112868  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
107113004  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
107113006  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
107113068  FGF1; fibroblast growth factor 1 [KO:K18496]
107113125  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
107113126  CACNG8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
107113141  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
107113155  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
107113195  [KO:K03283]
107113203  [KO:K03283]
107113274  ANGPT2; angiopoietin 2 [KO:K05466]
107113289  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
107113294  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
107113333  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
107113343  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
107113370  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
107113460  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
107113523  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
107113540  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
107113978  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
107114113  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
107114159  [KO:K05465]
107114224  [KO:K04440] [EC:2.7.11.24]
107114301  [KO:K07210]
107114354  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
107114357  GNG12; G protein subunit gamma 12 [KO:K04347]
107114377  [KO:K04347]
107114445  FGF8; fibroblast growth factor 8 [KO:K04358]
107114483  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
107114504  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
107114511  NTF3; neurotrophin 3 [KO:K04356]
107114744  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
107114874  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
107114884  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
107114939  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
107115164  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
107115192  VEGFB; vascular endothelial growth factor B [KO:K16858]
107115203  [KO:K13376]
107115204  RPS6KA4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
107115220  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
107115252  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107115357  FGF9; fibroblast growth factor 9 [KO:K04358]
107115509  PDGFA; platelet derived growth factor subunit A [KO:K04359]
107115547  ELK1; ELK1, ETS transcription factor [KO:K04375]
107115654  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
107115673  DAXX; death domain associated protein [KO:K02308]
107115689  [KO:K03283]
107115841  VEGFD; vascular endothelial growth factor D [KO:K05449]
107115985  [KO:K04389]
107116010  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
107116155  STK4; serine/threonine kinase 4 [KO:K04411]
107116186  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
107116191  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
107116257  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
107116323  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107116392  [KO:K04421] [EC:2.7.11.25]
107116455  TGFB3; transforming growth factor beta 3 [KO:K13377]
107116611  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
107116614  [KO:K07827]
107116647  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
107116700  CDC42; cell division cycle 42 [KO:K04393]
107116703  GNA12; G protein subunit alpha 12 [KO:K04346]
107116735  MEF2C; myocyte enhancer factor 2C [KO:K04454]
107116759  FGF20; fibroblast growth factor 20 [KO:K04358]
107116832  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
107116856  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
107116985  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
107117013  [KO:K12363]
107117078  EFNA4; ephrin A4 [KO:K05462]
107117079  EFNA3; ephrin A3 [KO:K05462]
107117086  EFNA1; ephrin A1 [KO:K05462]
107117114  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
107117129  ATF4; activating transcription factor 4 [KO:K04374]
107117132  PDGFB; platelet derived growth factor subunit B [KO:K17386]
107117159  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
107117206  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
107117259  ELK4; ELK4, ETS transcription factor [KO:K04376]
107117304  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
107117359  [KO:K04853]
107117453  TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
107117455  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107117460  [KO:K04438]
107117544  PPP5C; protein phosphatase 5 catalytic subunit [KO:K04460] [EC:3.1.3.16]
107117579  [KO:K04345] [EC:2.7.11.11]
107117625  [KO:K04468] [EC:2.7.11.24]
107117647  [KO:K04426] [EC:2.7.11.25]
107117671  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
107117758  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
107117807  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
107117965  GDNF; glial cell derived neurotrophic factor [KO:K05452]
107118023  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
107118111  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
107118240  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107118248  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107118266  [KO:K03173] [EC:2.3.2.27]
107118325  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
107118328  PGF; placental growth factor [KO:K16859]
107118349  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
107118386  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
107118450  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
107118694  PSPN; persephin [KO:K25416]
107118762  TGFA; transforming growth factor alpha [KO:K08774]
107118765  [KO:K04519]
107118784  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
107118948  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
107118957  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
107119112  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107119225  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
107119252  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
107119264  [KO:K04440] [EC:2.7.11.24]
107119269  EFNA2; ephrin A2 [KO:K05462]
107119310  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
107119408  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
107119450  NF1; neurofibromin 1 [KO:K08052]
107119464  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
107119520  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
107119535  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
107119537  [KO:K04429] [EC:2.7.11.1]
107119674  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
107119827  [KO:K03156]
107119840  [KO:K16342] [EC:3.1.1.4]
107119841  [KO:K16342] [EC:3.1.1.4]
107119842  [KO:K16342] [EC:3.1.1.4]
107119848  [KO:K16342] [EC:3.1.1.4]
107119991  IGF1; insulin like growth factor 1 [KO:K05459]
107120055  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
107120058  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
107120099  [KO:K02583]
107120231  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
107120232  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
107120279  ARTN; artemin [KO:K25415]
107120325  FGF17; fibroblast growth factor 17 [KO:K04358]
107120388  NTF4; neurotrophin 4 [KO:K12457]
107120465  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107120519  [KO:K04432] [EC:2.7.12.2]
107120631  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
107120657  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
107120717  [KO:K08845] [EC:2.7.11.1]
107120851  DUSP9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
107120883  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
107121067  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
107121068  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
107121069  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
107121079  TP53; tumor protein p53 [KO:K04451]
107121194  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107121241  KITLG; KIT ligand [KO:K05461]
107121500  FGF3; fibroblast growth factor 3 [KO:K04358]
107121501  FGF19; fibroblast growth factor 19 [KO:K22603]
107121519  [KO:K04456] [EC:2.7.11.1]
107121520  FGF4; fibroblast growth factor 4 [KO:K04358]
107121547  FGF10; fibroblast growth factor 10 [KO:K04358]
107121596  [KO:K03158]
107121607  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107121652  FAS; Fas cell surface death receptor [KO:K04390]
107121673  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
107121705  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
107121825  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107121841  [KO:K05096] [EC:2.7.10.1]
107121946  MAX; MYC associated factor X [KO:K04453]
107121969  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
107122037  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107122186  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
107122192  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
107122300  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
107122462  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
107122472  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
107122488  EFNA5; ephrin A5 [KO:K05462]
107122569  BDNF; brain derived neurotrophic factor [KO:K04355]
107122585  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107122628  [KO:K03099]
107122639  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
107122699  EGF; epidermal growth factor [KO:K04357]
107122828  MRAS; muscle RAS oncogene homolog [KO:K07831]
107122829  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107123053  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
107123088  SRF; serum response factor [KO:K04378]
107123125  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
107123230  FGF16; fibroblast growth factor 16 [KO:K04358]
107123263  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
107123375  IGF2; insulin like growth factor 2 [KO:K13769]
107123376  INS; insulin-like [KO:K04526]
107123377  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107123397  ATF2; activating transcription factor 2 [KO:K04450]
107123584  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
107123710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
107123857  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
107123907  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
107123911  TGFB1; transforming growth factor beta 1 [KO:K13375]
107123993  [KO:K25414]
107124264  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107124410  ARRB2; arrestin beta 2 [KO:K04439]
107124462  FGF7; fibroblast growth factor 7 [KO:K04358]
107124531  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
107124567  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
107124620  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
107124642  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
107124748  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107124817  VEGFC; vascular endothelial growth factor C [KO:K05449]
107124864  [KO:K04437]
107124877  [KO:K04437]
107125145  [KO:K04388] [EC:2.7.11.30]
107125445  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
107125527  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
107125583  [KO:K04388] [EC:2.7.11.30]
107125599  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
107125678  [KO:K09784]
107125774  VEGFA; vascular endothelial growth factor A [KO:K05448]
107125835  [KO:K16859]
107125917  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
107125967  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
107126140  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
107126145  PDGFD; platelet derived growth factor D [KO:K05450]
107126231  FGF22; fibroblast growth factor 22 [KO:K04358]
107126248  PDGFC; platelet derived growth factor C [KO:K05450]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
gja04070  Phosphatidylinositol signaling system
gja04110  Cell cycle
gja04115  p53 signaling pathway
gja04210  Apoptosis
gja04310  Wnt signaling pathway
KO pathway
ko04010   

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