KEGG   PATHWAY: hmh05010
Entry
hmh05010                    Pathway                                
Name
Alzheimer disease - Hylobates moloch (silvery gibbon)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
hmh05010  Alzheimer disease
hmh05010

Disease
H00056  Alzheimer disease
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456097  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
116456270  [KO:K03959]
116456295  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
116456332  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
116456610  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
116456615  FRAT1; proto-oncogene FRAT1 [KO:K03069]
116456710  [KO:K02271]
116456788  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
116456796  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116456926  [KO:K02265]
116457035  [KO:K02272]
116457103  [KO:K00417]
116457218  [KO:K07375]
116457338  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116457478  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
116457564  PSEN2; presenilin-2 isoform X4 [KO:K04522] [EC:3.4.23.-]
116457630  [KO:K02272]
116457644  BECN2; beclin-2 [KO:K08334]
116457665  [KO:K03947]
116457725  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116457885  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116458043  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
116458060  DKK1; dickkopf-related protein 1 [KO:K02165]
116458095  WNT3A; protein Wnt-3a [KO:K00312]
116458096  WNT9A; protein Wnt-9a [KO:K01064]
116458229  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
116458509  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116458510  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
116458524  [KO:K02271]
116458613  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116458727  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116458738  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
116458807  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
116458970  WNT7B; protein Wnt-7b [KO:K00572]
116459021  [KO:K00419]
116459066  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
116459108  [KO:K03949]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116459247  SNCA; alpha-synuclein [KO:K04528]
116459291  [KO:K07374]
116459316  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
116459388  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
116459428  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
116459453  BID; BH3-interacting domain death agonist [KO:K04726]
116459475  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116459671  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116459956  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116460085  TUBB; tubulin beta chain [KO:K07375]
116460115  TNF; tumor necrosis factor isoform X2 [KO:K03156]
116460270  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
116460298  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116460305  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
116460404  [KO:K07375]
116460447  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
116460468  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
116460740  [KO:K02271]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116461175  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461312  [KO:K02263]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116461465  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
116461471  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116461657  ATG101; autophagy-related protein 101 [KO:K19730]
116461664  TUBA1A; tubulin alpha-1A chain [KO:K07374]
116461665  [KO:K07374]
116461669  [KO:K07374]
116461710  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
116461712  [KO:K03061]
116461713  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
116461764  FZD3; frizzled-3 [KO:K02329]
116461832  DKK4; dickkopf-related protein 4 [KO:K02165]
116461833  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116461844  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116461914  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
116462013  WNT10B; protein Wnt-10b [KO:K01357]
116462014  WNT1; proto-oncogene Wnt-1 [KO:K03209]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116462124  SLC11A2; natural resistance-associated macrophage protein 2 isoform X4 [KO:K21398]
116462258  [KO:K00134] [EC:1.2.1.12]
116462285  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
116462359  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
116462417  AXIN1; axin-1 isoform X1 [KO:K02157]
116462643  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116462964  [KO:K07374]
116462985  KIF5C; kinesin heavy chain [KO:K10396]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463284  [KO:K02135]
116463286  [KO:K07375]
116463372  [KO:K07375]
116463374  [KO:K02135]
116463450  [KO:K05864] [EC:5.2.1.8]
116463478  [KO:K05864] [EC:5.2.1.8]
116463538  [KO:K06704] [EC:3.4.24.81]
116463631  [KO:K06704] [EC:3.4.24.81]
116463675  [KO:K20858]
116463690  [KO:K20858]
116463760  [KO:K04385]
116463765  [KO:K04385]
116463829  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
116464026  [KO:K03956]
116464030  [KO:K03956]
116464049  [KO:K00235] [EC:1.3.5.1]
116464170  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
116464274  [KO:K03939]
116464279  [KO:K03939]
116464297  [KO:K07375]
116464384  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
116464528  [KO:K07375]
116464579  [KO:K07375]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116465307  [KO:K07375]
116465541  [KO:K07375]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116466073  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
116466323  [KO:K02265]
116466356  [KO:K03949]
116466389  [KO:K02135]
116466514  [KO:K02272]
116466559  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116466621  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
116466681  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116466764  WNT7A; protein Wnt-7a [KO:K00572]
116466871  [KO:K02183]
116466891  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116467072  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
116467188  [KO:K07374]
116467516  [KO:K02183]
116467551  [KO:K02128]
116467557  IRS2; insulin receptor substrate 2 [KO:K07187]
116467991  [KO:K02264]
116468102  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
116468192  [KO:K03948]
116468460  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
116468490  [KO:K02128]
116468579  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
116468590  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
116468603  SLC39A6; zinc transporter ZIP6 [KO:K14712]
116468740  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
116468766  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
116468858  [KO:K02270]
116468912  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116468915  [KO:K07374]
116468923  RTN3; reticulon-3 isoform X1 [KO:K20723]
116468931  [KO:K02273]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116468972  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
116468992  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116469037  KLC2; kinesin light chain 2 isoform X2 [KO:K10407]
116469089  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
116469098  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
116469103  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116469207  NCSTN; nicastrin [KO:K06171]
116469377  SLC39A1; zinc transporter ZIP1 [KO:K14709]
116469443  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
116469451  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
116469491  APH1A; gamma-secretase subunit APH-1A isoform X1 [KO:K06172]
116469568  NRAS; GTPase NRas [KO:K07828]
116469600  WNT2B; protein Wnt-2b [KO:K00182]
116469616  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116469641  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
116469659  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
116469688  [KO:K03948]
116469796  [KO:K03948]
116470186  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116470472  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
116470666  [KO:K07375]
116470741  [KO:K02263]
116470828  [KO:K00418]
116470936  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116471025  [KO:K02272]
116471120  [KO:K00415]
116471141  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
116471160  [KO:K08738]
116471161  [KO:K03062]
116471190  [KO:K03947]
116471196  [KO:K02266]
116471218  [KO:K03949]
116471321  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
116471357  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X4 [KO:K04532]
116471451  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
116471501  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116471600  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
116471700  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
116471795  [KO:K00417]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116472519  WNT5B; protein Wnt-5b [KO:K00444]
116472525  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116472560  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
116472585  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
116472692  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
116472713  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116472781  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116472793  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116472932  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
116472984  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
116473013  [KO:K02728] [EC:3.4.25.1]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116473111  [KO:K00416]
116473320  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
116473332  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
116473340  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
116473363  WNT5A; protein Wnt-5a [KO:K00444]
116473372  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
116473447  [KO:K00414]
116473623  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
116473755  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
116474162  WNT9B; protein Wnt-9b [KO:K01064]
116474164  WNT3; proto-oncogene Wnt-3 [KO:K00312]
116474191  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
116474472  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
116474473  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
116474589  [KO:K03938]
116474604  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116474634  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116474681  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
116474730  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
116474767  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
116474889  BECN1; beclin-1 isoform X1 [KO:K08334]
116474949  FZD2; frizzled-2 [KO:K02235]
116475002  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
116475178  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116475268  [KO:K17908]
116475348  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116475617  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
116475643  PSMB7; proteasome subunit beta type-7 isoform X4 [KO:K02739] [EC:3.4.25.1]
116475658  [KO:K03959]
116475788  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116475911  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
116475928  TUBB4B; tubulin beta-4B chain [KO:K07375]
116476180  [KO:K11351]
116476195  [KO:K04741] [EC:3.4.22.-]
116476238  [KO:K03957]
116476254  TUBB8B; LOW QUALITY PROTEIN: tubulin beta 8B [KO:K07375]
116476267  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
116476272  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
116476273  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
116476294  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
116476298  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
116476488  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
116476587  APBB1; amyloid beta precursor protein binding family B member 1 isoform X1 [KO:K04529]
116476737  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
116476785  FZD4; frizzled-4 [KO:K02354]
116476791  [KO:K02726] [EC:3.4.25.1]
116476794  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
116476796  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
116476907  [KO:K08738]
116476941  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
116476984  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
116477384  WNT11; protein Wnt-11 [KO:K01384]
116477673  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
116477784  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
116477827  [KO:K02266]
116477857  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
116477947  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116478253  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116478308  CALM3; calmodulin-3 [KO:K02183]
116478333  TUBB4A; tubulin beta-4A chain [KO:K07375]
116478375  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116478399  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
116478601  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116478746  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
116478821  [KO:K00411] [EC:7.1.1.8]
116478869  [KO:K00420]
116478914  [KO:K02267]
116478920  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
116478944  [KO:K02270]
116479108  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
116479141  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
116479184  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
116479218  [KO:K02267]
116479340  [KO:K02128]
116479382  FZD10; frizzled-10 [KO:K02842]
116479486  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
116479887  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
116479902  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
116479914  [KO:K00134] [EC:1.2.1.12]
116479923  [KO:K03938]
116480043  [KO:K00418]
116480052  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
116480204  DKK2; dickkopf-related protein 2 [KO:K02165]
116480211  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116480690  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
116480744  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
116480828  [KO:K00416]
116480862  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
116480869  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
116480897  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
116480918  SLC39A5; zinc transporter ZIP5 [KO:K14711]
116480936  FZD8; frizzled-8 [KO:K02375]
116480990  ATP5MC2; LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
116481179  MME; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481268  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
116481500  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
116481681  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
116481803  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
116481858  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
116481919  [KO:K02264]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116482010  [KO:K04809]
116482164  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116482310  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116482501  PSMA4; proteasome subunit alpha type-4 isoform X2 [KO:K02728] [EC:3.4.25.1]
116482614  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
116482617  RYR3; ryanodine receptor 3 [KO:K04963]
116482923  APOE; apolipoprotein E [KO:K04524]
116482949  SLC39A11; zinc transporter ZIP11 isoform X3 [KO:K14717]
116482986  [KO:K02265]
116483009  RTN4; reticulon-4 isoform X1 [KO:K20720]
116483081  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
116483082  [KO:K03960]
116483105  SLC39A3; zinc transporter ZIP3 [KO:K14709]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116483180  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
116483230  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
116483240  IL1A; interleukin-1 alpha [KO:K04383]
116483283  IL1B; interleukin-1 beta [KO:K04519]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116483357  KLC3; kinesin light chain 3 [KO:K10407]
116483412  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
116483464  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
116483520  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116483631  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
116483634  SLC39A8; metal cation symporter ZIP8 isoform X1 [KO:K14714]
116483639  [KO:K02270]
116483666  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
116483814  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
116483820  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
116483925  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
116484013  [KO:K00420]
116484067  [KO:K02272]
116484171  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
116484273  [KO:K16195] [EC:2.7.11.1]
116484501  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
116484546  [KO:K00420]
116484618  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
116484631  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
116484654  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
116484774  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
116484834  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
116484857  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
116484906  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
116485009  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
116485066  WNT8B; protein Wnt-8b [KO:K00714]
116485090  [KO:K02273]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485158  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116809676  [KO:K08738]
116809684  [KO:K03062]
116809726  [KO:K02127]
116810091  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
116810145  IRS1; insulin receptor substrate 1 [KO:K16172]
116810171  [KO:K02126]
116810281  WNT10A; protein Wnt-10a [KO:K01357]
116810282  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
116810323  [KO:K02735] [EC:3.4.25.1]
116810327  [KO:K04374]
116810383  FZD5; frizzled-5 [KO:K02375]
116810400  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
116810440  FZD7; frizzled-7 [KO:K02432]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116810507  [KO:K02126]
116810515  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
116810638  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
116810659  [KO:K00134] [EC:1.2.1.12]
116810748  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
116810832  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
116811106  [KO:K02271]
116811135  NOX1; NADPH oxidase 1 [KO:K08008]
116811178  [KO:K03948]
116811200  [KO:K00134] [EC:1.2.1.12]
116811267  [KO:K02128]
116811370  [KO:K17908]
116811446  [KO:K08738]
116811486  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
116811503  [KO:K03960]
116811598  [KO:K21421] [EC:1.-.-.-]
116811635  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
116811640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116811686  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116811705  [KO:K00419]
116811708  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
116811758  FZD9; frizzled-9 [KO:K02842]
116811837  [KO:K05862]
116811948  IRS4; insulin receptor substrate 4 [KO:K17446]
116811994  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
116811998  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116812249  [KO:K03946]
116812505  [KO:K02271]
116812514  PSMA2; proteasome subunit alpha type-2 isoform X1 [KO:K02726] [EC:3.4.25.1]
116812582  [KO:K02271]
116812776  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812918  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116812984  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
116812987  [KO:K08738]
116813045  WNT4; protein Wnt-4 [KO:K00408]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116813279  [KO:K03064]
116813298  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
116813443  [KO:K00417]
116813467  [KO:K02268]
116813496  FZD6; frizzled-6 isoform X1 [KO:K02376]
116813580  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
116813617  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
116813689  [KO:K00413]
116813839  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
116813856  [KO:K02090] [EC:2.7.11.22]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116814122  FZD1; frizzled-1 [KO:K02432]
116814198  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
116814280  WNT2; protein Wnt-2 [KO:K00182]
116814291  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
116814302  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
116814342  [KO:K04369] [EC:2.7.12.2]
116814392  [KO:K00237]
116814428  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116814430  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
116814514  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3 [KO:K03954]
116814541  CDK5; cyclin-dependent kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
hmh00190  Oxidative phosphorylation
hmh03050  Proteasome
hmh04020  Calcium signaling pathway
hmh04140  Autophagy - animal
hmh04141  Protein processing in endoplasmic reticulum
hmh04210  Apoptosis
hmh04310  Wnt signaling pathway
hmh04910  Insulin signaling pathway
hmh04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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