KEGG   PATHWAY: mcc04015
Entry
mcc04015                    Pathway                                
Name
Rap1 signaling pathway - Macaca mulatta (rhesus monkey)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04015  Rap1 signaling pathway
mcc04015

Other DBs
GO: 0007264
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100424899  [KO:K04632]
100425123  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
100426259  [KO:K08732]
100429880  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
106992479  [KO:K08732]
106995478  [KO:K08732]
106995524  [KO:K08732]
114670406  [KO:K08732]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574142  CNR1; cannabinoid receptor 1 [KO:K04277]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574254  KITLG; kit ligand isoform X1 [KO:K05461]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
574304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
574352  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
574380  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
574394  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
692343  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
693359  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7 [KO:K05629]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693560  AFDN; afadin isoform X1 [KO:K05702]
693750  [KO:K07836]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
693914  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
693951  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
694181  DRD2; D(2) dopamine receptor [KO:K04145]
694289  [KO:K04632]
694485  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 [KO:K17701]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695382  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
695852  RALB; ras-related protein Ral-B [KO:K07835]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
696298  TLN1; talin-1 isoform X1 [KO:K06271]
696306  [KO:K10785]
696584  CRKL; crk-like protein [KO:K04438]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
696759  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
696848  ADORA2B; adenosine receptor A2b [KO:K04267]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697017  ANGPT1; angiopoietin-1 precursor [KO:K05465]
697043  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697904  [KO:K10785]
698092  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13 [KO:K05631]
698148  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698571  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698785  [KO:K10785]
698830  HRAS; GTPase HRas [KO:K02833]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699310  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
699351  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
699479  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
699625  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700374  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
700559  ENAH; protein enabled homolog isoform X1 [KO:K05746]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701179  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701219  PGF; placenta growth factor isoform X2 [KO:K16859]
701400  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
701758  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
702288  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
702532  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
702623  KRIT1; krev interaction trapped protein 1 [KO:K17705]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
703029  [KO:K10785]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703440  RALA; ras-related protein Ral-A [KO:K07834]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
703726  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
703780  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
703967  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
703982  PFN3; profilin-3 [KO:K05759]
704212  CTNND1; catenin delta-1 [KO:K05690]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704351  EFNA5; ephrin-A5 precursor [KO:K05462]
704387  CDH1; cadherin-1 [KO:K05689]
704404  RAP1A; ras-related protein Rap-1A [KO:K04353]
704416  PFN4; profilin-4 [KO:K05759]
704534  INS; insulin [KO:K04526]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704656  LAT; linker for activation of T-cells family member 1 isoform X2 [KO:K07362]
704717  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X13 [KO:K08018]
705008  TLN2; talin-2 isoform X1 [KO:K06271]
705195  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
705413  THBS1; thrombospondin-1 [KO:K16857]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
705671  [KO:K05692]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
706316  EVL; ena/VASP-like protein isoform X7 [KO:K23487]
706351  [KO:K02183]
706455  RHOA; transforming protein RhoA [KO:K04513]
706472  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
706541  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X11 [KO:K08020]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
707170  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
707225  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
707383  [KO:K17704]
707455  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707865  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
707977  KRAS; GTPase KRas [KO:K07827]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708507  P2RY1; P2Y purinoceptor 1 [KO:K04270]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
708940  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
709089  NRAS; GTPase NRas [KO:K07828]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
709208  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
709341  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
709647  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710149  [KO:K10784]
710293  [KO:K08732]
710340  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710577  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
710753  PFN1; profilin-1 [KO:K05759]
710828  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
710997  [KO:K08732]
711158  [KO:K08732]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711512  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
711681  NGF; beta-nerve growth factor [KO:K02582]
711698  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
711945  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
712004  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
713160  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713249  [KO:K08732]
713283  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
713460  PFN2; profilin-2 isoform X1 [KO:K05759]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
713965  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
714436  RALGDS; ral guanine nucleotide dissociation stimulator isoform X4 [KO:K08732]
714601  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714832  ITGAM; integrin alpha-M isoform X3 [KO:K06461]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
715213  ANGPT4; angiopoietin-4 [KO:K05467]
715270  CALM2; calmodulin-2 [KO:K02183]
715272  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
715958  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
716022  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
716736  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
716811  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
716937  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
717315  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
717373  EFNA3; ephrin-A3 precursor [KO:K05462]
717379  ITGB3; integrin beta-3 [KO:K06493]
717399  EFNA1; ephrin-A1 [KO:K05462]
717686  [KO:K02183]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
717830  RAP1GAP; rap1 GTPase-activating protein 1 isoform X8 [KO:K17700]
718171  RAP1B; ras-related protein Rap-1b [KO:K07836]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718843  F2RL3; proteinase-activated receptor 4 [KO:K04236]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719782  FPR1; fMet-Leu-Phe receptor [KO:K04172]
719844  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
721231  EFNA2; ephrin-A2 [KO:K05462]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
722044  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mcc04010  MAPK signaling pathway
mcc04014  Ras signaling pathway
mcc04020  Calcium signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04510  Focal adhesion
mcc04520  Adherens junction
mcc04660  T cell receptor signaling pathway
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

DBGET integrated database retrieval system