KEGG   PATHWAY: mcc04024
Entry
mcc04024                    Pathway                                
Name
cAMP signaling pathway - Macaca mulatta (rhesus monkey)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04024  cAMP signaling pathway
mcc04024

Other DBs
GO: 0019933
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424113  ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262]
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100424899  [KO:K04632]
100425114  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
100426104  PLN; cardiac phospholamban [KO:K05852]
100426598  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100429401  LHB; lutropin subunit beta precursor [KO:K08521]
100429880  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
106994905  SSTR5; somatostatin receptor type 5 [KO:K04221]
114673757  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
574095  CRHR1; corticotropin-releasing factor receptor 1 precursor [KO:K04578]
574114  NPY; pro-neuropeptide Y precursor [KO:K05232]
574203  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
574206  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
574208  SOX9; transcription factor SOX-9 [KO:K18435]
574251  TSHR; thyrotropin receptor precursor [KO:K04249]
574280  GHRL; appetite-regulating hormone precursor [KO:K05254]
574317  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
574344  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
574346  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
574362  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
574380  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
613250  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
693385  EDN3; endothelin-3 isoform X4 [KO:K05227]
693418  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693560  AFDN; afadin isoform X1 [KO:K05702]
693750  [KO:K07836]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
693924  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
694181  DRD2; D(2) dopamine receptor [KO:K04145]
694289  [KO:K04632]
694430  POMC; pro-opiomelanocortin [KO:K05228]
694587  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
694758  CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X1 [KO:K04953]
694963  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
694991  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
695407  ABCC4; multidrug resistance-associated protein 4 isoform X3 [KO:K05673]
695483  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
695526  SSTR2; somatostatin receptor type 2 [KO:K04218]
695735  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
695803  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
695960  EDN2; endothelin-2 [KO:K16367]
696160  ATP1B4; protein ATP1B4 [KO:K01540]
696255  BVES; blood vessel epicardial substance [KO:K21108]
696350  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
696377  POPDC3; popeye domain-containing protein 3 [KO:K26207]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697317  FSHB; follitropin subunit beta [KO:K05250]
697404  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
697598  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
697718  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697796  DRD1; D(1A) dopamine receptor [KO:K04144]
697859  CGA; glycoprotein hormones alpha chain [KO:K08522]
698089  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
698123  SSTR1; somatostatin receptor type 1 [KO:K04217]
698148  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
698335  GIP; gastric inhibitory polypeptide [KO:K05258]
698396  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
698470  TNNI3; troponin I, cardiac muscle isoform X2 [KO:K12044]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
698566  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698571  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
698954  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699216  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
699309  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
699310  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
699982  EDN1; endothelin-1 [KO:K16366]
700190  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
700443  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
701149  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
701205  HHIP; hedgehog-interacting protein precursor [KO:K06231]
701245  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
701312  [KO:K04200]
701400  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
701758  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
702048  OXTR; oxytocin receptor [KO:K04229]
702077  FOS; proto-oncogene c-Fos [KO:K04379]
702288  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
702494  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
702504  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
702712  [KO:K08402]
702825  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
702877  CRH; corticoliberin [KO:K05256]
703302  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
703368  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
703398  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
703566  VIP; vasoactive intestinal peptide precursor [KO:K05264]
703638  ADORA1; adenosine receptor A1 [KO:K04265]
703780  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
703967  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
704049  [KO:K01538]
704135  EDNRA; endothelin-1 receptor precursor [KO:K04197]
704331  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
704404  RAP1A; ras-related protein Rap-1A [KO:K04353]
704486  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
704524  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
704891  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
705197  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
705414  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
705508  GCG; glucagon [KO:K05259]
705722  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
705794  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
705980  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
706073  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
706258  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
706344  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
706351  [KO:K02183]
706455  RHOA; transforming protein RhoA [KO:K04513]
706513  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
706977  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11 [KO:K04515] [EC:2.7.11.17]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
707768  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
707865  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
707872  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
707997  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
708024  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
708058  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
708444  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
708626  SST; somatostatin precursor [KO:K05237]
708705  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
708706  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
708717  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
708940  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
708987  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 precursor [KO:K04615]
709026  FFAR2; free fatty acid receptor 2 [KO:K04328]
709102  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
709374  TSHB; thyrotropin subunit beta [KO:K05251]
709379  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709784  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
709935  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710046  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
710146  ADRB2; beta-2 adrenergic receptor [KO:K04142]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710368  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710540  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710702  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711776  SUCNR1; succinate receptor 1 [KO:K10042]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
712180  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X8 [KO:K13293] [EC:3.1.4.53]
712322  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
712850  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
712853  POPDC2; popeye domain-containing protein 2 [KO:K26206]
712862  DRD5; D(1B) dopamine receptor [KO:K05840]
713010  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713391  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
714117  GRIA1; glutamate receptor 1 precursor [KO:K05197]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714780  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
714843  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
714981  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
714983  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
714994  NPPA; natriuretic peptides A [KO:K12334]
715270  CALM2; calmodulin-2 [KO:K02183]
715598  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715787  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
715951  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
715999  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
716093  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716123  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
716192  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
716452  JUN; transcription factor AP-1 [KO:K04448]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
716682  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
716704  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
716776  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
716892  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
717068  OXT; oxytocin-neurophysin 1 [KO:K05243]
717179  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
717261  GPHA2; glycoprotein hormone alpha-2 precursor [KO:K25483]
717539  AMH; muellerian-inhibiting factor [KO:K04665]
717686  [KO:K02183]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717945  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
718019  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
718171  RAP1B; ras-related protein Rap-1b [KO:K07836]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718751  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719548  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
719623  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
719662  [KO:K11265] [EC:4.6.1.1]
720079  SLC9A1; sodium/hydrogen exchanger 1 isoform X3 [KO:K05742]
720171  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
720191  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
721155  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
721573  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
721628  FXYD1; phospholemman isoform X3 [KO:K13360]
721721  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X13 [KO:K04850]
721735  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
721825  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
722634  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
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Related
pathway
mcc00071  Fatty acid degradation
mcc04015  Rap1 signaling pathway
mcc04020  Calcium signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04210  Apoptosis
mcc04260  Cardiac muscle contraction
mcc04340  Hedgehog signaling pathway
mcc04720  Long-term potentiation
mcc04740  Olfactory transduction
mcc04972  Pancreatic secretion
mcc04976  Bile secretion
KO pathway
ko04024   

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