KEGG   PATHWAY: opi04510
Entry
opi04510                    Pathway                                
Name
Focal adhesion - Ochotona princeps (American pika)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
opi04510  Focal adhesion
opi04510

Other DBs
GO: 0005925
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101516087  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516330  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101516340  RAP1A; ras-related protein Rap-1A [KO:K04353]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101516513  ITGA9; integrin alpha-9 [KO:K06585]
101516514  [KO:K05719]
101516762  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101516820  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101517070  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101517134  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101517477  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101517508  [KO:K12757]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101517756  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101517781  TNXB; tenascin-X [KO:K06252]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101518056  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101518086  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101518147  EMP2; epithelial membrane protein 2 [KO:K26256]
101518161  RELN; reelin [KO:K06249] [EC:3.4.21.-]
101518247  CAV2; caveolin-2 isoform X1 [KO:K12958]
101518490  CAV1; caveolin-1 isoform X1 [KO:K06278]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101518721  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101518739  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519209  CRKL; crk-like protein [KO:K04438]
101519262  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101519558  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101519888  [KO:K05096] [EC:2.7.10.1]
101520387  [KO:K06274]
101520550  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101520786  ITGA2B; integrin alpha-IIb [KO:K06476]
101520957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101521183  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101521262  ZYX; zyxin isoform X1 [KO:K06273]
101521365  THBS1; thrombospondin-1 [KO:K16857]
101521451  LAMA1; laminin subunit alpha-1 [KO:K05637]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101521997  [KO:K04659]
101522080  SHC2; SHC-transforming protein 2 [KO:K17447]
101522199  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101522201  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101522287  SHC3; SHC-transforming protein 3 [KO:K17448]
101522465  ITGB7; integrin beta-7 [KO:K06590]
101522546  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
101522659  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101523058  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101523170  LAMC2; laminin subunit gamma-2 [KO:K06246]
101523218  PXN; paxillin isoform X1 [KO:K05760]
101523287  LAMA2; laminin subunit alpha-2 [KO:K05637]
101523383  EMP1; epithelial membrane protein 1 [KO:K26255]
101523409  LAMC1; laminin subunit gamma-1 [KO:K05635]
101523439  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101523524  THBS4; thrombospondin-4 [KO:K04659]
101523549  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101523577  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
101523632  LAMC3; laminin subunit gamma-3 [KO:K06247]
101523798  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101523885  VAV1; proto-oncogene vav [KO:K05730]
101523908  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101523913  LAMB2; laminin subunit beta-2 [KO:K06243]
101523918  ITGB8; integrin beta-8 [KO:K06591]
101524034  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101524206  FN1; fibronectin isoform X1 [KO:K05717]
101524273  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101524600  FLNA; filamin-A isoform X1 [KO:K04437]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101525041  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
101525072  ACTB; actin, cytoplasmic 1 [KO:K05692]
101525073  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101525255  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101525278  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101525305  TNR; tenascin-R isoform X1 [KO:K06252]
101525317  ITGB5; integrin beta-5 [KO:K06588]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101525427  [KO:K04371] [EC:2.7.11.24]
101525478  TLN2; talin-2 [KO:K06271]
101525699  PARVA; alpha-parvin isoform X1 [KO:K06275]
101525767  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101525898  ITGA1; integrin alpha-1 [KO:K06480]
101525955  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101526004  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101526036  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101526040  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101526057  CAV3; caveolin-3 [KO:K12959]
101526149  ITGA2; integrin alpha-2 [KO:K06481]
101526160  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101526282  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101526395  ITGA5; integrin alpha-5 [KO:K06484]
101526404  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101526619  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101526659  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101526852  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101526925  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101527001  CRK; adapter molecule crk isoform X1 [KO:K04438]
101527484  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101527518  [KO:K04392]
101527578  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X4 [KO:K05083] [EC:2.7.10.1]
101527580  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101527612  LAMB3; laminin subunit beta-3 [KO:K06244]
101527700  PTK2; focal adhesion kinase 1 isoform X21 [KO:K05725] [EC:2.7.10.2]
101527710  PGF; placenta growth factor [KO:K16859]
101527736  CHAD; chondroadherin [KO:K06248]
101527820  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101528030  [KO:K02649]
101528071  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101528096  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101528242  SPP1; osteopontin [KO:K06250]
101528456  FLNB; filamin-B isoform X1 [KO:K27392]
101528473  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101528760  [KO:K08131]
101528934  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101529033  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101529134  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101529159  THBS2; thrombospondin-2 [KO:K04659]
101529212  [KO:K06253]
101529215  COL1A1; collagen alpha-1(I) chain [KO:K06236]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529445  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101529472  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101529725  TNC; tenascin isoform X2 [KO:K06252]
101529832  [KO:K05735] [EC:2.7.11.1]
101529934  VCL; vinculin isoform X1 [KO:K05700]
101529935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101530065  VWF; von Willebrand factor [KO:K03900]
101530070  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101530158  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
101530210  PARVB; beta-parvin isoform X1 [KO:K06275]
101530218  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101530290  [KO:K04725] [EC:2.3.2.27]
101530378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101530576  ITGA11; integrin alpha-11 [KO:K06587]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101530829  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101530917  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101531037  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101531364  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101531375  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101531631  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101531636  HRAS; GTPase HRas [KO:K02833]
101531684  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101531698  VEGFD; vascular endothelial growth factor D [KO:K05449]
101531703  [KO:K05636]
101531844  TNN; tenascin-N [KO:K06252]
101531922  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101531979  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101532148  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101532362  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101532426  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101532446  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
101532470  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101532667  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101532669  [KO:K05719]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101533043  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101533077  [KO:K12757]
101533159  TLN1; talin-1 [KO:K06271]
101533176  LAMA5; laminin subunit alpha-5 [KO:K06240]
101533284  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101533422  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101533474  [KO:K12757]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101533680  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101533693  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533860  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101533973  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101533998  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101534072  PARVG; gamma-parvin [KO:K06275]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101534827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101534862  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101535058  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101535157  ITGAV; integrin alpha-V [KO:K06487]
101535171  VEGFC; vascular endothelial growth factor C [KO:K05449]
101535208  MYL10; myosin regulatory light chain 10 [KO:K12756]
101535218  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101535284  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101535305  [KO:K04513]
101535483  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101535575  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101535581  [KO:K04393]
101535885  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101535964  ITGB3; integrin beta-3 [KO:K06493]
101535980  SHC4; SHC-transforming protein 4 [KO:K17449]
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101536231  ITGA8; integrin alpha-8 [KO:K06584]
101536351  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101536586  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
105941538  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
105942284  VTN; vitronectin [KO:K06251]
118758092  [KO:K06240]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
opi04010  MAPK signaling pathway
opi04060  Cytokine-cytokine receptor interaction
opi04070  Phosphatidylinositol signaling system
opi04110  Cell cycle
opi04151  PI3K-Akt signaling pathway
opi04310  Wnt signaling pathway
opi04512  ECM-receptor interaction
opi04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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