KEGG   PATHWAY: cang04151
Entry
cang04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Colobus angolensis palliatus (Angola colobus)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cang04151  PI3K-Akt signaling pathway
cang04151

Other DBs
GO: 0043491
Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105514419  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105514084  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105501302  EREG; proepiregulin [KO:K09784]
105501303  AREG; amphiregulin [KO:K09782]
105510120  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105516422  FGF2; fibroblast growth factor 2 [KO:K18497]
105515618  FGF16; fibroblast growth factor 16 [KO:K04358]
105502192  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
105515843  FGF18; fibroblast growth factor 18 [KO:K04358]
105523862  FGF9; fibroblast growth factor 9 [KO:K04358]
105510170  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105503934  FGF6; fibroblast growth factor 6 [KO:K04358]
105511582  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105525388  FGF10; fibroblast growth factor 10 [KO:K04358]
105506665  FGF20; fibroblast growth factor 20 [KO:K04358]
105527667  FGF22; fibroblast growth factor 22 [KO:K04358]
105507121  FGF8; fibroblast growth factor 8 [KO:K04358]
105512318  FGF19; fibroblast growth factor 19 [KO:K22603]
105514795  FGF21; fibroblast growth factor 21 [KO:K22429]
105503933  FGF23; fibroblast growth factor 23 [KO:K22428]
105505307  NGF; beta-nerve growth factor [KO:K02582]
105507710  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105518596  NTF3; neurotrophin-3 [KO:K04356]
105514785  NTF4; neurotrophin-4 [KO:K12457]
105506748  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105503231  IGF2; insulin-like growth factor II [KO:K13769]
105522469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105527767  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105524451  PDGFC; platelet-derived growth factor C [KO:K05450]
105500952  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105516054  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105525591  KITLG; kit ligand isoform X1 [KO:K05461]
105514768  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105524898  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105512347  VEGFB; vascular endothelial growth factor B [KO:K16858]
105517147  PGF; placenta growth factor isoform X1 [KO:K16859]
105523129  FIGF; vascular endothelial growth factor D [KO:K05449]
105524499  VEGFC; vascular endothelial growth factor C [KO:K05449]
105501675  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105503825  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105525751  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105512796  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105502019  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105502022  EFNA3; ephrin-A3 [KO:K05462]
105502023  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105516973  EFNA5; ephrin-A5 [KO:K05462]
105527681  EFNA2; ephrin-A2 [KO:K05462]
105513505  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105515329  ARTN; artemin [KO:K25415]
105512880  PSPN; persephin [KO:K25416]
105500265  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105503119  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105500614  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105504791  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105525157  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
105503366  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105508015  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105515122  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105524594  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105502088  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105514498  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105512899  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105523056  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105523780  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105504227  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105504224  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105525907  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105523475  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
105524018  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105518645  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105525909  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105508514  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105523238  angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105510220  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105520189  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105513930  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105522392  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
105507449  SOS1; son of sevenless homolog 1 [KO:K03099]
105503192  HRAS; GTPase HRas isoform X1 [KO:K02833]
105515217  KRAS; GTPase KRas isoform X1 [KO:K07827]
105504520  GTPase NRas [KO:K07828]
105505387  NRAS; GTPase NRas [KO:K07828]
105519101  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105510526  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105512832  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105515489  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105505634  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105518803  IRS1; insulin receptor substrate 1 [KO:K16172]
105524473  toll-like receptor 2 [KO:K10159]
105517525  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105506322  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105514391  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
105509184  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105525086  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 isoform X1 [KO:K06856]
105525098  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105525110  uncharacterized protein LOC105525110 [KO:K06856]
105525116  uncharacterized protein LOC105525116 [KO:K06856]
105516007  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
105505618  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105518280  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
105515980  somatotropin isoform X1 [KO:K05438]
105515982  somatotropin-like isoform X1 [KO:K05438]
105515983  somatotropin-like [KO:K05438]
105515984  somatotropin-like isoform X1 [KO:K05438]
105515997  LOW QUALITY PROTEIN: somatotropin-like [KO:K05438]
105519388  somatotropin-like [KO:K05438]
105526699  PRL; prolactin [KO:K05439]
105522991  OSM; oncostatin-M isoform X1 [KO:K05418]
105516414  IL2; interleukin-2 [KO:K05429]
105518178  IL3; interleukin-3 [KO:K04736]
105513330  IL6; interleukin-6 isoform X1 [KO:K05405]
105518194  IL4; interleukin-4 isoform X1 [KO:K05430]
105508296  IL7; interleukin-7 isoform X1 [KO:K05431]
105503436  interferon alpha-1/13 [KO:K05414]
105503438  IFNA8; interferon alpha-8 [KO:K05414]
105503439  IFNA2; interferon alpha-2 [KO:K05414]
105503440  interferon alpha-1/13-like [KO:K05414]
105503441  interferon alpha-1/13-like [KO:K05414]
105503442  interferon alpha-6 [KO:K05414]
105503444  IFNA14; interferon alpha-14 [KO:K05414]
105503445  interferon alpha-4 [KO:K05414]
105503446  interferon alpha-4-like [KO:K05414]
105503447  interferon alpha-17-like [KO:K05414]
105503449  interferon alpha-10 [KO:K05414]
105503452  IFNB1; interferon beta [KO:K05415]
105513101  EPO; erythropoietin [KO:K05437]
105503107  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
105520629  GHR; growth hormone receptor isoform X1 [KO:K05080]
105513479  PRLR; prolactin receptor isoform X1 [KO:K05081]
105513516  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
105522527  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105527810  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105512612  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
105500637  interleukin-3 receptor subunit alpha-like [KO:K04737]
105502117  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105505602  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
105513481  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105524762  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105524754  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105520838  EPOR; erythropoietin receptor [KO:K05079]
105521209  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105510845  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105508462  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
105500328  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105524613  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105521049  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105507669  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105523763  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105518615  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105518868  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105518869  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105505899  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105505963  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105502917  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105505747  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105505750  collagen alpha-4(VI) chain-like [KO:K06238]
105505804  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
105520448  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105520489  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105522510  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105506415  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105521151  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105523104  LAMA1; laminin subunit alpha-1 [KO:K05637]
105518612  LAMA2; laminin subunit alpha-2 [KO:K05637]
105509784  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105506417  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105506752  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105516115  LAMB1; laminin subunit beta-1 [KO:K05636]
105509715  LAMB2; laminin subunit beta-2 [KO:K06243]
105508979  LAMB3; laminin subunit beta-3 [KO:K06244]
105516136  LAMB4; laminin subunit beta-4 [KO:K06245]
105511892  laminin subunit gamma-1 [KO:K05635]
105501365  LAMC2; laminin subunit gamma-2 [KO:K06246]
105504146  LAMC3; laminin subunit gamma-3 [KO:K06247]
105524618  CHAD; chondroadherin [KO:K06248]
105501731  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105504981  THBS1; thrombospondin-1 [KO:K16857]
105502035  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105506252  THBS4; thrombospondin-4 [KO:K04659]
105500355  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105504788  FN1; fibronectin [KO:K05717]
105518722  SPP1; osteopontin isoform X1 [KO:K06250]
105510824  VTN; vitronectin [KO:K06251]
105517531  TNC; tenascin isoform X1 [KO:K06252]
105526381  TNN; tenascin-N [KO:K06252]
105526385  TNR; tenascin-R [KO:K06252]
105513771  TNXB; tenascin-X [KO:K06252]
105521211  VWF; von Willebrand factor [KO:K03900]
105518724  IBSP; bone sialoprotein 2 [KO:K06253]
105509853  ITGA1; integrin alpha-1 [KO:K06480]
105509855  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105510369  ITGA2B; integrin alpha-IIb [KO:K06476]
105524607  ITGA3; integrin alpha-3 [KO:K06482]
105524239  ITGA4; integrin alpha-4 [KO:K06483]
105503537  ITGA5; integrin alpha-5 [KO:K06484]
105514539  ITGA6; integrin alpha-6 [KO:K06485]
105500580  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105506207  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105519885  ITGA9; integrin alpha-9 [KO:K06585]
105518329  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105510513  ITGA11; integrin alpha-11 [KO:K06587]
105507806  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105521847  ITGB1; integrin beta-1 [KO:K05719]
105526547  ITGB3; integrin beta-3 [KO:K06493]
105515230  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105517981  ITGB5; integrin beta-5 [KO:K06588]
105515325  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105503578  ITGB7; integrin beta-7 [KO:K06590]
105513318  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105509031  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105523405  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105523708  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105507333  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105524169  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105500411  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105515019  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105524190  F2R; proteinase-activated receptor 1 [KO:K03914]
105512245  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105511157  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105520723  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105500383  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105521796  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105515608  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105518801  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105510051  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105503945  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105513099  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105519004  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105523712  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105502226  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105525968  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
105512258  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105507261  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105521045  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105520803  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
105521044  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105524588  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105516130  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105523658  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105523698  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105501470  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105527615  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105511429  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105513523  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105501725  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105503993  TSC1; hamartin isoform X1 [KO:K07206]
105526466  TSC2; tuberin [KO:K07207]
105511346  RHEB; GTP-binding protein Rheb [KO:K07208]
105526414  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105507357  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105505404  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105525209  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105515115  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105505234  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
105518849  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105512091  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105520079  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105503584  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105515431  40S ribosomal protein S6-like [KO:K02991]
105503463  40S ribosomal protein S6 [KO:K02991]
105503488  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105519750  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105521764  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
105504045  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
105526195  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105502478  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
105510903  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
105518411  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105519178  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105521497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105515375  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
105501726  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
105509510  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105508937  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
105518213  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105513620  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105501007  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105514683  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105504188  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105511770  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
105526564  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
105507054  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105523363  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105513130  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
105500869  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105509327  PPP2R5A; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105524923  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
105518448  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105512191  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105526061  PPP2R5E; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
105515285  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
105524884  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
105518443  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105510280  LOW QUALITY PROTEIN: putative endoplasmin-like protein [KO:K09487]
105506873  HSP90B1; endoplasmin [KO:K09487]
105520869  CDC37; hsp90 co-chaperone Cdc37 isoform X1 [KO:K09554]
105501990  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
105526012  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
105520029  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105518493  TCL1A; T-cell leukemia/lymphoma protein 1A isoform X1 [KO:K10167]
105518494  TCL1B; T-cell leukemia/lymphoma protein 1B isoform X1 [KO:K16836]
105527018  MTCP1; protein p13 MTCP-1 [KO:K16837]
105511327  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105503134  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
105510739  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105514878  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105521051  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105507958  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105503742  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105502979  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
105510359  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105525061  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
105509076  MYC; myc proto-oncogene protein [KO:K04377]
105512055  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105514162  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
105520264  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
105500566  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105500487  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
105521035  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105503930  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105513014  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105508203  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105516826  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105519466  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
105514935  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105526354  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105519653  BCL2L11; bcl-2-like protein 11 [KO:K16341]
105502458  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105504209  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
105525333  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
105521605  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105509185  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
105503266  YWHAG; 14-3-3 protein gamma [KO:K16198]
105512212  BAD; bcl2-associated agonist of cell death [KO:K02158]
105524720  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105520028  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105510236  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105517357  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105513158  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105527761  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
105501991  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105517772  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105511389  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105512935  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105527110  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105509398  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105513814  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
105508841  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
105503967  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105503620  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105527033  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105507149  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105525125  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105512156  RELA; transcription factor p65 [KO:K04735]
105512675  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105526188  MYB; transcriptional activator Myb [KO:K09420]
105502659  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105523626  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cang00010  Glycolysis / Gluconeogenesis
cang04010  MAPK signaling pathway
cang04012  ErbB signaling pathway
cang04062  Chemokine signaling pathway
cang04064  NF-kappa B signaling pathway
cang04068  FoxO signaling pathway
cang04110  Cell cycle
cang04115  p53 signaling pathway
cang04150  mTOR signaling pathway
cang04210  Apoptosis
cang04370  VEGF signaling pathway
cang04510  Focal adhesion
cang04620  Toll-like receptor signaling pathway
cang04630  JAK-STAT signaling pathway
cang04662  B cell receptor signaling pathway
cang04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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