KEGG   PATHWAY: cge04014
Entry
cge04014                    Pathway                                
Name
Ras signaling pathway - Cricetulus griseus (Chinese hamster)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
cge04014  Ras signaling pathway
cge04014

Other DBs
GO: 0032318
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100763146  Egf; pro-epidermal growth factor isoform X2 [KO:K04357]
100754730  Tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha isoform X2 [KO:K08774]
100764257  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100757429  Fgf2; fibroblast growth factor 2 isoform X2 [KO:K18497]
100764611  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100772115  Fgf6; fibroblast growth factor 6 [KO:K04358]
103160353  Fgf22; fibroblast growth factor 22 isoform X2 [KO:K04358]
100758023  Fgf4; fibroblast growth factor 4 isoform X2 [KO:K04358]
100773578  Fgf20; fibroblast growth factor 20 [KO:K04358]
100759509  Fgf9; fibroblast growth factor 9 [KO:K04358]
100761599  Fgf7; fibroblast growth factor 7 [KO:K04358]
100750999  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
100757734  Fgf3; fibroblast growth factor 3 isoform X2 [KO:K04358]
100751051  Fgf10; fibroblast growth factor 10 [KO:K04358]
100767099  Fgf16; fibroblast growth factor 16 isoform X2 [KO:K04358]
100763237  Fgf5; fibroblast growth factor 5 [KO:K04358]
100761504  fibroblast growth factor 18 isoform X2 [KO:K04358]
100758307  Fgf19; fibroblast growth factor 19 isoform X2 [KO:K22603]
100757339  Fgf21; fibroblast growth factor 21 [KO:K22429]
100763837  Fgf23; fibroblast growth factor 23 [KO:K22428]
100750778  Ngf; beta-nerve growth factor [KO:K02582]
113836414  LOW QUALITY PROTEIN: brain-derived neurotrophic factor-like [KO:K04355]
100774728  Ntf3; neurotrophin-3 [KO:K04356]
113836309  neurotrophin-4 [KO:K12457]
100760716  Ins; insulin [KO:K04526]
100751642  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100762359  Igf2; LOW QUALITY PROTEIN: insulin-like growth factor II isoform X2 [KO:K13769]
100771503  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
100774990  Pdgfb; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100756952  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
100765334  Pdgfc; platelet-derived growth factor C [KO:K05450]
100767142  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100752139  Kitlg; kit ligand isoform X1 [KO:K05461]
100773162  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100755957  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A isoform X2 [KO:K05448]
100759545  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100754799  Pgf; placenta growth factor [KO:K16859]
100773421  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
100753419  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
100764472  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100774625  angiopoietin-1 isoform X2 [KO:K05465]
100756240  Angpt2; angiopoietin-2 [KO:K05466]
100761260  Angpt4; angiopoietin-4 [KO:K05467]
100773125  Efna3; ephrin-A3 isoform X2 [KO:K05462]
100756587  Efna5; ephrin-A5 isoform X2 [KO:K05462]
100758074  Efna1; ephrin-A1 [KO:K05462]
100755670  Efna2; ephrin-A2 isoform X2 [KO:K05462]
113833115  Efna4; ephrin-A4 isoform X2 [KO:K05462]
100774580  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100773586  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100763455  Fgfr2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
100764560  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100765320  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100755566  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100751271  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
100754339  Ntrk2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
100766818  Insr; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
100768531  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
100760258  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100764374  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100763221  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100751027  Kit; mast/stem cell growth factor receptor Kit isoform X3 [KO:K05091] [EC:2.7.10.1]
100761902  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
100761329  Flt1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
100766609  Flt4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
100756294  Kdr; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100751933  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100764854  Tek; LOW QUALITY PROTEIN: angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
100752851  Epha2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100769627  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100753832  Gab1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
100771626  Gab2; GRB2-associated-binding protein 2 isoform X3 [KO:K08091]
100758936  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
100761269  Shc2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
100760879  Shc3; SHC-transforming protein 3 isoform X2 [KO:K17448]
100763505  Shc4; SHC-transforming protein 4 isoform X2 [KO:K17449]
100771077  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
100757521  Sos1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100769325  Sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
100769697  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100752475  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100762037  Rasgrp1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
100757059  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
100764463  Rasgrp3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
100765723  Rasgrp4; RAS guanyl-releasing protein 4 isoform X2 [KO:K12363]
100757609  T-cell receptor beta-2 chain C region [KO:K10785]
100767740  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
100764497  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
103163243  Htr7; 5-hydroxytryptamine receptor 7 isoform X4 [KO:K04163]
100689442  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100756281  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X2 [KO:K04537]
100756790  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100757050  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100764899  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100768753  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100755128  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100769650  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118238929  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826]
100755432  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100767992  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100757206  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103162614  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100752390  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103163959  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
113832276  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100765832  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113837383  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100755995  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X2 [KO:K04545]
100761038  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100757536  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107978884  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100774382  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100760746  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100754408  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100756976  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100759959  ras-specific guanine nucleotide-releasing factor 2 isoform X3 [KO:K12326]
100770880  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100764315  Grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
118239276  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100766751  Calml3; calmodulin-like protein 3 [KO:K02183]
100767046  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
100762749  Calm3; calmodulin-3 isoform X2 [KO:K02183]
100765281  Calm2; calmodulin-2 isoform X2 [KO:K02183]
100771772  Calm1; calmodulin-1 isoform X2 [KO:K02183]
100757500  Calml4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100751814  calmodulin-like isoform X2 [KO:K02183]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100767950  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100771410  Rras2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100770202  neurofibromin isoform X2 [KO:K08052]
100762440  Rasa1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
100765379  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
100752063  Rasa3; ras GTPase-activating protein 3 isoform X2 [KO:K12380]
100765808  Rasa4b; ras GTPase-activating protein 4B [KO:K17630]
100752061  LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP isoform X2 [KO:K17631]
100772012  Rasal1; rasGAP-activating-like protein 1 [KO:K17632]
100754098  Rasal2; ras GTPase-activating protein nGAP isoform X3 [KO:K17633]
100772454  Rasal3; RAS protein activator like-3 isoform X1 [KO:K17634]
100769756  ras association domain-containing protein 1 isoform X2 [KO:K09850]
100758747  Rassf5; ras association domain-containing protein 5 isoform X3 [KO:K08015]
100757702  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100756100  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100767225  ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100757479  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
100767503  Pak1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
100751503  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100774215  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
100760399  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100770198  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100758984  serine/threonine-protein kinase PAK 6 isoform X2 [KO:K05735] [EC:2.7.11.1]
100762797  Rhoa; transforming protein RhoA [KO:K04513]
100757042  transforming protein RhoA isoform X1 [KO:K04513]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100759762  Ikbkg; NF-kappa-B essential modulator isoform X6 [KO:K07210]
100754432  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5 [KO:K04467] [EC:2.7.11.10]
100750488  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100760426  Bad; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100689371  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
100756577  Foxo4; forkhead box protein O4 [KO:K12358]
100773293  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100753551  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X3 [KO:K25768]
100770884  Ralgapa2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
100760158  Ralgapb; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
100771841  Ralgds; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
100762723  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
100752656  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 isoform X2 [KO:K17636]
100769632  Rala; ras-related protein Ral-A [KO:K07834]
100769446  LOW QUALITY PROTEIN: ras-related protein Ral-A-like [KO:K07834]
100757867  Ralb; ras-related protein Ral-B [KO:K07835]
100752582  Pld2; phospholipase D2 isoform X4 [KO:K01115] [EC:3.1.4.4]
100689404  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100755817  Exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
100770091  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
100756087  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
100771734  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100754361  mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100764964  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100756078  Ralbp1; ralA-binding protein 1 [KO:K08773]
100765433  Cdc42; cell division control protein 42 homolog [KO:K04393]
100751158  Afdn; afadin isoform X11 [KO:K05702]
100767502  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100759743  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
100765466  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
100752205  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100767324  Pla2g12a; group XIIA secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
100756208  Pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100761489  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100766341  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100763432  phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
100758369  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
100753835  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100754426  Pla2g5; phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
100754712  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100754136  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100764593  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100765177  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100765755  phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100755005  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100756754  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
113835677  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
113833875  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
100750927  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100770894  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100771756  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
100770605  Pla2g4f; cytosolic phospholipase A2 zeta isoform X3 [KO:K16342] [EC:3.1.1.4]
100754559  Pla2g4c; cytosolic phospholipase A2 gamma isoform X2 [KO:K16342] [EC:3.1.1.4]
103158591  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100751421  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X4 [KO:K16343] [EC:3.1.1.4]
100768312  phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100763890  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
100767456  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
100774407  Ets2; protein C-ets-2 [KO:K21932]
100763856  Brap; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
100769629  Ksr1; kinase suppressor of Ras 1 isoform X2 [KO:K14958]
118238735  Ksr2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
100769866  Rapgef5; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 5 isoform X2 [KO:K08019]
100751497  Rap1a; ras-related protein Rap-1A [KO:K04353]
100769542  Rap1b; ras-related protein Rap-1b [KO:K07836]
100754217  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100766006  Prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
100760922  Prkcb; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100762950  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100762837  Rin1; ras and Rab interactor 1 isoform X1 [KO:K17638]
100768098  Abl1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
100772469  Abl2; tyrosine-protein kinase ABL2 isoform X10 [KO:K08887] [EC:2.7.10.2]
100772343  Rab5a; ras-related protein Rab-5A [KO:K07887]
100768837  Rab5b; ras-related protein Rab-5B [KO:K07888]
100754413  Rab5c; ras-related protein Rab-5C [KO:K07889]
100774654  Arf6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
cge04010  MAPK signaling pathway
cge04015  Rap1 signaling pathway
cge04020  Calcium signaling pathway
cge04144  Endocytosis
cge04151  PI3K-Akt signaling pathway
cge04660  T cell receptor signaling pathway
cge04720  Long-term potentiation
cge04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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