KEGG   PATHWAY: clum04210
Entry
clum04210                   Pathway                                
Name
Apoptosis - Cyclopterus lumpus (lumpfish)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
clum04210  Apoptosis
clum04210

Other DBs
GO: 0006915
Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117749953  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
117751134  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117735912  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
117740781  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
117737089  cd40lg; CD40 ligand [KO:K04389]
117729612  faslg; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117744372  fas; tumor necrosis factor receptor superfamily member 23 [KO:K04390]
117747456  fadd; FAS-associated death domain protein [KO:K02373]
117745471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117734050  si:ch211-112c15.8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 25 [KO:K03158]
117750749  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117750145  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
117750208  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117746198  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
117746199  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
117731871  caspase-6-like isoform X1 [KO:K04396] [EC:3.4.22.59]
117730679  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117737645  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117748561  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
117740104  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
117732008  bida; BH3 interacting domain death agonist [KO:K04726]
117725985  zgc:153993; apoptosis regulator BAX [KO:K02159]
117734463  apoptosis regulator BAX-like [KO:K02159]
117741982  diablo homolog, mitochondrial-like [KO:K10522]
117741614  diablo homolog, mitochondrial-like [KO:K10522]
117742940  LOW QUALITY PROTEIN: septin-5-like [KO:K16943]
117741574  sept4b; septin 4b isoform X1 [KO:K16943]
117751278  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
117744473  cytochrome c [KO:K08738]
117750947  cytochrome c-like [KO:K08738]
117739467  cytochrome c-a-like [KO:K08738]
117726060  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117733395  casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117736927  prf1.5; perforin 1.5 [KO:K07818]
117732074  perforin-1-like [KO:K07818]
117732124  perforin-1-like [KO:K07818]
117732204  perforin-1-like [KO:K07818]
117733743  perforin-1-like [KO:K07818]
117735687  perforin-1-like [KO:K07818]
117735695  perforin-1-like [KO:K07818]
117735697  perforin-1-like [KO:K07818]
117750893  granzyme B(G,H)-like isoform X1 [KO:K01353] [EC:3.4.21.79]
117729490  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
117729652  granzyme E-like [KO:K01353] [EC:3.4.21.79]
117742161  tubulin alpha chain-like isoform X1 [KO:K07374]
117731092  tubulin alpha-1B chain-like [KO:K07374]
117742354  tubulin alpha-1C chain-like [KO:K07374]
117727250  tubulin alpha chain-like [KO:K07374]
117732969  tuba1c; tubulin alpha-1C chain [KO:K07374]
117733118  tubulin alpha chain-like [KO:K07374]
117733119  tubulin alpha chain-like [KO:K07374]
117733120  tubulin alpha chain-like [KO:K07374]
117733121  tubulin alpha chain-like [KO:K07374]
117733122  tubulin alpha chain-like [KO:K07374]
117733123  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117733290  tubulin alpha chain-like [KO:K07374]
117745611  si:ch211-114n24.6; tubulin alpha-1A chain [KO:K07374]
117751049  tubulin alpha chain [KO:K07374]
117751050  tubulin alpha chain-like [KO:K07374]
117751051  tubulin alpha chain-like [KO:K07374]
117733892  tuba5; LOW QUALITY PROTEIN: tubulin alpha 5 [KO:K07374]
117745893  mcl1b; induced myeloid leukemia cell differentiation protein Mcl-1b [KO:K02539]
117739169  actb1; actin, cytoplasmic 1 [KO:K05692]
117734597  actb2; actin, cytoplasmic 2 [KO:K05692]
117740309  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
117726277  lmnl3; lamin L3 [KO:K12641]
117727979  lamin-A-like [KO:K12641]
117739604  lamin-A-like isoform X1 [KO:K12641]
117729234  lmnb2; lamin-B2 [KO:K07611]
117740752  lmnb1; lamin-B1 [KO:K07611]
117727663  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
117731382  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
117750123  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
117746860  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
117734060  dffa; DNA fragmentation factor subunit alpha isoform X1 [KO:K02310]
117733500  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
117736836  endog; endonuclease G, mitochondrial [KO:K01173]
117742701  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
117731145  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117734683  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117735999  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117740351  traf2b; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117740886  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117731168  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
117730310  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117732901  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117733021  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
117725453  zgc:136872; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
117743049  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117744466  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
117730292  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
117747843  capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
117743953  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117743954  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117729021  LOW QUALITY PROTEIN: calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117751315  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
117727312  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
117730854  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117735515  atf4b; activating transcription factor 4b [KO:K04374]
117730290  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117749121  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
117741381  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
117728690  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
117735516  napsa; napsin-A isoform X1 [KO:K01379] [EC:3.4.23.5]
117737777  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
117728662  ctsh; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
117745145  ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
117736179  ctsla; cathepsin La isoform X1 [KO:K01365] [EC:3.4.22.15]
117751378  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
117729986  cts12; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
117737451  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
117745280  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117730970  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
117747062  cathepsin Z isoform X1 [KO:K08568] [EC:3.4.18.1]
117743263  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117737091  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
117748663  birc5a; baculoviral IAP repeat-containing protein 5a [KO:K08731]
117733821  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
117733597  bcl2l1; bcl-2-like protein 1 [KO:K04570]
117730382  bcl-2-like protein 1 [KO:K04570]
117746625  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117738884  daxx; death domain-associated protein 6 [KO:K02308]
117746125  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
117736907  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
117740275  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
117727038  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117745695  si:ch211-1i11.3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117748413  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117737372  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117743832  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117740127  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117747774  badb; BCL2 associated agonist of cell death b [KO:K02158]
117740649  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117746578  jun; transcription factor AP-1 [KO:K04448]
117725194  fosaa; proto-oncogene c-Fos [KO:K04379]
117727586  proto-oncogene c-Fos-like [KO:K04379]
117727588  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117747715  tp53; cellular tumor antigen p53 [KO:K04451]
117749129  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
117734462  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117748347  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117744348  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117736821  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117732959  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117727519  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
117751264  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117737787  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117747396  rela; transcription factor p65 isoform X1 [KO:K04735]
117740517  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
117725426  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117736875  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
117745927  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117740530  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
117740536  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117730054  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117730108  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117741262  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
117732302  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
117745464  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
117731293  ngfb; nerve growth factor [KO:K02582]
117733451  ngfa; neurotrophin-7 [KO:K02582]
117728257  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117735483  csf2rb; cytokine receptor common subunit beta [KO:K04738]
117732996  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117729144  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117746514  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117741125  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117747650  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117736025  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
117740185  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117746515  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117729683  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117729698  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117746960  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117748707  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117742397  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117743684  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117732835  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117751396  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117741120  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117732119  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117731941  kras; GTPase KRas isoform X1 [KO:K07827]
117735017  zgc:55558; GTPase HRas [KO:K07827]
117733950  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117732847  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117746647  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117729985  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117736137  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117735491  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
clum04010  MAPK signaling pathway
clum04020  Calcium signaling pathway
clum04115  p53 signaling pathway
clum04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
LinkDB

DBGET integrated database retrieval system