KEGG   PATHWAY: clum04010
Entry
clum04010                   Pathway                                
Name
MAPK signaling pathway - Cyclopterus lumpus (lumpfish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
clum04010  MAPK signaling pathway
clum04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Cyclopterus lumpus (lumpfish) [GN:clum]
Gene
117725120  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117725166  [KO:K04350]
117725189  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
117725194  fosaa; proto-oncogene c-Fos [KO:K04379]
117725278  sos2; son of sevenless homolog 2 [KO:K03099]
117725314  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
117725418  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117725426  [KO:K04402]
117725794  [KO:K04868]
117725940  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117725949  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117726064  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
117726077  cacna2d1a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
117726155  fgf6b; fibroblast growth factor 6b [KO:K04358]
117726173  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
117726208  [KO:K04441] [EC:2.7.11.24]
117726239  [KO:K07836]
117726245  hgfa; hepatocyte growth factor a [KO:K05460]
117726264  ntf3; neurotrophin-3 [KO:K04356]
117726295  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
117726343  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117726372  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
117726382  fgf23; fibroblast growth factor 23 [KO:K22428]
117726413  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
117726892  bdnf; brain-derived neurotrophic factor [KO:K04355]
117727038  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117727064  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117727088  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117727179  max; protein max isoform X1 [KO:K04453]
117727180  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117727239  fgf4; fibroblast growth factor 4 [KO:K04358]
117727293  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117727370  [KO:K13377]
117727586  [KO:K04379]
117727588  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117727840  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117728115  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117728169  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117728235  vegfd; vascular endothelial growth factor D [KO:K05449]
117728254  [KO:K04446]
117728257  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117728311  tgfb2; LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [KO:K13376]
117728595  fgf3; fibroblast growth factor 3 [KO:K04358]
117728633  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
117728661  [KO:K04349]
117728785  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117729085  [KO:K03099]
117729101  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117729122  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
117729215  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117729226  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
117729286  [KO:K04852]
117729425  cacna1ab; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
117729437  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
117729448  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
117729612  faslg; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117729629  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117729746  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117729797  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
117729903  fgf22; fibroblast growth factor 22 [KO:K04358]
117729953  efna2a; ephrin-A2 [KO:K05462]
117729985  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117730015  [KO:K04449]
117730031  [KO:K04449]
117730054  [KO:K04402]
117730084  [KO:K25415]
117730099  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117730108  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117730130  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117730290  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117730294  cdc42; cell division control protein 42 homolog [KO:K04393]
117730302  [KO:K04411]
117730311  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117730340  [KO:K04353]
117730366  [KO:K04857]
117730481  [KO:K04851]
117730534  tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
117730555  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
117730558  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
117730569  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117730577  [KO:K04423] [EC:2.7.11.25]
117730622  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
117730672  [KO:K04856]
117730679  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117730776  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117730790  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
117730823  angpt4; angiopoietin-4 [KO:K05465]
117730854  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117730882  [KO:K04859]
117730912  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117730957  [KO:K04465]
117730983  [KO:K04867]
117731006  [KO:K04860]
117731025  [KO:K04444] [EC:2.7.11.1]
117731084  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117731203  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
117731293  ngfb; nerve growth factor [KO:K02582]
117731337  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
117731446  fgf8b; fibroblast growth factor 8b [KO:K04358]
117731704  [KO:K04434]
117731873  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117731941  kras; GTPase KRas isoform X1 [KO:K07827]
117731943  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117731944  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117732029  [KO:K04858]
117732055  [KO:K17333]
117732119  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117732145  dusp5; LOW QUALITY PROTEIN: dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117732269  kitb; LOW QUALITY PROTEIN: KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
117732391  kitlga; kit ligand a [KO:K05461]
117732415  rasgrf1; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117732418  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
117732507  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117732547  [KO:K04358]
117732564  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117732668  igf2b; insulin-like growth factor 2b [KO:K13769]
117732749  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117732755  [KO:K22428]
117732775  [KO:K04861]
117732827  [KO:K05460]
117732835  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117732847  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117732959  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117732983  [KO:K04393]
117733039  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
117733046  elk1; ETS domain-containing protein Elk-3 [KO:K04375]
117733050  [KO:K18019] [EC:3.1.3.48]
117733162  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117733176  [KO:K04864]
117733200  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117733217  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117733308  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
117733406  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
117733451  ngfa; neurotrophin-7 [KO:K02582]
117733467  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117733499  [KO:K25416]
117733547  [KO:K04857]
117733562  flna; filamin-A isoform X1 [KO:K04437]
117733655  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117733658  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
117733820  igf3; insulin-like growth factor 3 [KO:K05459]
117733899  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
117733950  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117733982  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117734019  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
117734021  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117734039  [KO:K04443] [EC:2.7.11.1]
117734050  si:ch211-112c15.8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 25 [KO:K03158]
117734083  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
117734117  [KO:K04864]
117734128  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
117734164  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117734462  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117734495  [KO:K04392]
117734562  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117734564  [KO:K03283]
117734581  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117734588  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
117734603  [KO:K04344]
117734621  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117734626  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117734765  [KO:K16342] [EC:3.1.1.4]
117734780  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117734810  [KO:K04856]
117734821  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
117734871  rras; ras-related protein R-Ras [KO:K07830]
117734905  [KO:K04869]
117734944  [KO:K19662] [EC:2.7.11.13]
117734951  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117734977  vegfc; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
117735017  zgc:55558; GTPase HRas [KO:K07827]
117735020  [KO:K16342] [EC:3.1.1.4]
117735036  [KO:K04870]
117735077  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117735148  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
117735195  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
117735196  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
117735244  cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
117735288  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117735289  [KO:K04870]
117735291  [KO:K04358]
117735363  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117735370  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117735377  [KO:K04433] [EC:2.7.12.2]
117735378  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117735440  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117735445  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
117735491  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117735515  atf4b; activating transcription factor 4b [KO:K04374]
117735672  si:ch211-195b15.8; tyrosine-protein phosphatase MSG5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117735798  fgf5; fibroblast growth factor 5 [KO:K04358]
117735938  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
117735957  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
117735964  [KO:K04358]
117735999  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117736012  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
117736060  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117736063  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
117736133  [KO:K04352]
117736137  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117736192  [KO:K09784]
117736317  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117736319  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
117736333  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
117736366  efna5b; ephrin-A5b isoform X1 [KO:K05462]
117736475  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117736643  [KO:K05452]
117736707  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
117736821  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117736875  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
117736885  [KO:K04519]
117736979  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117737089  cd40lg; CD40 ligand [KO:K04389]
117737140  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117737231  egf; pro-epidermal growth factor [KO:K04357]
117737233  pdgfc; platelet-derived growth factor C [KO:K05450]
117737240  fgf24; fibroblast growth factor 24 [KO:K04358]
117737267  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117737301  fgf2; fibroblast growth factor 2 [KO:K18497]
117737310  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
117737372  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117737393  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117737528  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117737530  fgf18a; fibroblast growth factor 18a [KO:K04358]
117737645  [KO:K02187] [EC:3.4.22.56]
117737649  vegfba; vascular endothelial growth factor A [KO:K05448]
117737659  fgf16; fibroblast growth factor 16 [KO:K04358]
117737673  fgf20b; fibroblast growth factor 20b [KO:K04358]
117737683  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117737754  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
117737787  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117737823  kdrl; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117737855  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117737870  [KO:K04373] [EC:2.7.11.1]
117737924  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117737933  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117738559  efna1a; ephrin-A1a isoform X1 [KO:K05462]
117738685  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
117738694  [KO:K04388] [EC:2.7.11.30]
117738765  [KO:K04873]
117738768  [KO:K04872]
117738786  [KO:K04871]
117738805  [KO:K04393]
117738884  daxx; death domain-associated protein 6 [KO:K02308]
117739038  efna3a; ephrin-A3 [KO:K05462]
117739144  angpt1; angiopoietin-1 [KO:K05465]
117739252  angpt2b; LOW QUALITY PROTEIN: angiopoietin-2b [KO:K05466]
117739288  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117739523  stmn1a; stathmin 1a [KO:K04381]
117740038  [KO:K05462]
117740043  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
117740127  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117740242  cacna1bb; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
117740248  crkl; crk-like protein [KO:K04438]
117740282  mef2ca; LOW QUALITY PROTEIN: myocyte enhancer factor 2ca [KO:K04454]
117740351  traf2b; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117740443  [KO:K05085] [EC:2.7.10.1]
117740508  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
117740530  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
117740536  [KO:K04402]
117740567  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
117740591  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117740649  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117740707  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
117740803  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117740886  [KO:K03173] [EC:2.3.2.27]
117741001  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117741003  [KO:K04455]
117741093  relb; proto-oncogene c-Rel isoform X1 [KO:K09253]
117741096  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117741120  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117741179  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
117741200  nf1a; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
117741227  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
117741251  [KO:K04723]
117741287  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
117741316  mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
117741354  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117741517  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
117741616  pdgfd; platelet-derived growth factor D [KO:K05450]
117741622  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
117741646  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
117741848  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117741967  crk; adapter molecule crk [KO:K04438]
117741992  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117742265  [KO:K18496]
117742358  [KO:K04439]
117742364  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
117742390  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117742397  [KO:K04456] [EC:2.7.11.1]
117742456  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117742575  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
117742580  [KO:K05449]
117742640  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117742708  hspb1; heat shock protein beta-1 [KO:K04455]
117742730  [KO:K04438]
117742816  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
117742832  ins; insulin [KO:K04526]
117742953  [KO:K05089] [EC:2.7.10.1]
117743026  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
117743271  [KO:K04407] [EC:2.7.11.1]
117743633  angpt2a; angiopoietin-2a isoform X1 [KO:K05466]
117743641  srfb; serum response factor b isoform X1 [KO:K04378]
117743684  [KO:K04456] [EC:2.7.11.1]
117743721  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
117743752  [KO:K04406] [EC:2.7.11.1]
117743832  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117743930  nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
117743982  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
117744023  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117744071  [KO:K16342] [EC:3.1.1.4]
117744109  fgf8a; fibroblast growth factor 8 [KO:K04358]
117744147  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117744218  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
117744259  [KO:K06268]
117744339  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117744344  [KO:K16342] [EC:3.1.1.4]
117744348  [KO:K04467] [EC:2.7.11.10]
117744372  fas; tumor necrosis factor receptor superfamily member 23 [KO:K04390]
117744375  [KO:K16342] [EC:3.1.1.4]
117744997  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
117745218  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
117745269  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
117745270  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117745387  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117745471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117745495  cdc42l; cell division cycle 42, like [KO:K04393]
117745523  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
117745532  efna1b; ephrin-A1b [KO:K05462]
117745595  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
117745661  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
117745695  si:ch211-1i11.3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117745712  efna3b; ephrin-A3b isoform X1 [KO:K05462]
117745826  [KO:K04865]
117745831  stmn1b; stathmin 1b [KO:K04381]
117745927  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117745928  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
117745971  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
117746102  [KO:K04852]
117746316  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117746330  [KO:K04424] [EC:2.7.11.25]
117746347  [KO:K25414]
117746578  jun; transcription factor AP-1 [KO:K04448]
117746640  [KO:K25415]
117746647  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117746810  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117746918  [KO:K04449]
117747396  rela; transcription factor p65 isoform X1 [KO:K04735]
117747422  [KO:K12361]
117747715  tp53; cellular tumor antigen p53 [KO:K04451]
117747723  [KO:K04348] [EC:3.1.3.16]
117747879  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117747981  arrb2b; arrestin, beta 2b [KO:K04439]
117748179  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
117748188  [KO:K04419] [EC:2.7.11.25]
117748305  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
117748311  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117748329  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117748347  [KO:K04467] [EC:2.7.11.10]
117748372  [KO:K04380]
117748413  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117748510  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117748530  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
117748550  fgf19; fibroblast growth factor 19 [KO:K22603]
117748613  fgf21; fibroblast growth factor 21 [KO:K22429]
117748690  [KO:K04392]
117748744  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117748955  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117749018  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117749129  [KO:K04466] [EC:2.7.11.25]
117749224  ngfrb; nerve growth factor receptor b [KO:K02583]
117749226  [KO:K04430] [EC:2.7.12.2]
117749255  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117749293  myca; transcriptional regulator Myc-A [KO:K04377]
117749305  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117749425  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117749433  [KO:K19662] [EC:2.7.11.13]
117749486  myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117749501  [KO:K04361] [EC:2.7.10.1]
117749526  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117749675  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
117749691  flt3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117749693  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117749788  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a [KO:K04863]
117750136  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117750221  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
117750246  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
117750481  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117750585  fgf7; fibroblast growth factor 7 [KO:K04358]
117750749  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117750797  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117750850  [KO:K04407] [EC:2.7.11.1]
117750860  [KO:K04386]
117750870  fgf9; fibroblast growth factor 4A [KO:K04358]
117750877  [KO:K05085] [EC:2.7.10.1]
117750921  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117751112  [KO:K04410] [EC:2.7.11.1]
117751126  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
117751233  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117751396  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117751516  [KO:K04427] [EC:2.7.11.25]
117751575  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117751643  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
117751675  [KO:K04453]
117751696  pgfb; placenta growth factor isoform X1 [KO:K16859]
117751718  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
clum04070  Phosphatidylinositol signaling system
clum04110  Cell cycle
clum04115  p53 signaling pathway
clum04210  Apoptosis
clum04310  Wnt signaling pathway
KO pathway
ko04010   

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