KEGG   PATHWAY: csyr05169
Entry
csyr05169                   Pathway                                
Name
Epstein-Barr virus infection - Carlito syrichta (Philippine tarsier)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
csyr05169  Epstein-Barr virus infection
csyr05169

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103270786  CR2; complement receptor type 2 isoform X1 [KO:K04012]
103252092  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
103262681  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X2 [KO:K06752]
103262695  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103271929  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
103271936  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
103272282  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103262757  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103256945  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
103266905  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
103267365  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
103267988  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
103274468  TLR2; toll-like receptor 2 [KO:K10159]
103270832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103276369  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103274081  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103263671  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103254079  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103259721  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103252103  RELA; transcription factor p65 [KO:K04735]
103270149  TNF; tumor necrosis factor [KO:K03156]
103268608  IL6; interleukin-6 [KO:K05405]
103263504  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
103268983  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103260907  interferon alpha-5-like [KO:K05414]
103260908  interferon alpha-5-like [KO:K05414]
103260910  interferon alpha-5-like [KO:K05414]
103274154  interferon alpha-5-like [KO:K05414]
103274155  interferon alpha-5-like [KO:K05414]
103274156  interferon alpha-10-like [KO:K05414]
103274157  interferon alpha-17-like [KO:K05414]
103274161  interferon alpha-5-like [KO:K05414]
103274163  interferon alpha-17-like [KO:K05414]
103274165  interferon alpha-5-like [KO:K05414]
103274168  interferon alpha-5-like [KO:K05414]
103260915  IFNB1; interferon beta [KO:K05415]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103269362  interferon alpha/beta receptor 2 [KO:K05131]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103258295  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
103272248  IRF9; interferon regulatory factor 9 [KO:K04693]
103271654  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
103255383  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271660  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103271661  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
103264095  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
103264100  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103264101  2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103264102  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103259695  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
103271589  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
103250044  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
103273943  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103274231  BID; BH3-interacting domain death agonist [KO:K04726]
103255208  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103274703  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103256231  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103262464  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103255326  cytochrome c 2 [KO:K08738]
110596190  cytochrome c, somatic-like [KO:K08738]
103274909  cytochrome c, somatic [KO:K08738]
103251017  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103260483  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103257846  caspase-3 [KO:K02187] [EC:3.4.22.56]
103270208  LOW QUALITY PROTEIN: immunoglobulin delta heavy chain-like [KO:K10785]
103270219  uncharacterized protein LOC103270219 [KO:K10785]
103252367  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103252237  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103252246  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
103252862  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
103250392  26S protease regulatory subunit 7 [KO:K03061]
103265114  26S protease regulatory subunit 7-like [KO:K03061]
103252809  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
103257018  PSMC4; 26S protease regulatory subunit 6B isoform X1 [KO:K03063]
103275752  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
103256297  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
103252067  PSMC5; 26S protease regulatory subunit 8 isoform X2 [KO:K03066]
103265072  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
103257341  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
103267584  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
103271133  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
103251065  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
103254114  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
103272535  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
103254938  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
103274334  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
103251331  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
103276877  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103259777  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
110595742  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
103271934  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103271932  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103262563  TAPBP; tapasin [KO:K08058]
103262024  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103249397  CALR; calreticulin [KO:K08057]
103269400  calreticulin-like [KO:K08057]
103251393  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103273534  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103268467  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
103271436  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103273536  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
103276998  HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
103277080  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103254879  B2M; beta-2-microglobulin [KO:K08055]
103265674  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
103266070  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
103269606  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103269170  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103275368  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103249826  histone deacetylase complex subunit SAP30L [KO:K19202]
103267146  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
103257989  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
103259852  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
103254216  HES1; transcription factor HES-1 [KO:K06054]
103257927  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
103264057  MYC; myc proto-oncogene protein [KO:K04377]
103262979  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
103250373  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103266974  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103266579  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
103261208  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103253831  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103260228  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103262848  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103253541  RELB; transcription factor RelB [KO:K09253]
103269228  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103276940  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
103271240  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
103274589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103251143  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103252280  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103272968  MAPK8; mitogen-activated protein kinase 8 isoform X5 [KO:K04440] [EC:2.7.11.24]
103255312  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103252426  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103272007  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103264569  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103254297  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103274529  JUN; transcription factor AP-1 [KO:K04448]
103255971  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103256299  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
103275022  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103260263  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
103272101  CD44; CD44 antigen [KO:K06256]
103260120  ITGAL; integrin alpha-L [KO:K05718]
103276097  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
103262952  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103262495  vimentin isoform X1 [KO:K07606]
103258679  VIM; vimentin isoform X1 [KO:K07606]
103268872  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
103273032  signal transducer and activator of transcription 3 [KO:K04692]
103267743  STAT3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 3 [KO:K04692]
103277171  LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like [KO:K04692]
103259066  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103261598  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103265389  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103264336  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103273938  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103254974  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
103261489  BLNK; B-cell linker protein [KO:K07371]
103267377  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103251986  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103264812  CDKN1B; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B [KO:K06624]
103252197  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103250109  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103264876  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103264423  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103276439  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103270886  CCNA2; cyclin-A2 [KO:K06627]
103262730  CCNA1; cyclin-A1 [KO:K06627]
103267956  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103277250  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103266414  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103259274  RB1; retinoblastoma-associated protein [KO:K06618]
103253965  E2F1; transcription factor E2F1 [KO:K17454]
103264171  E2F2; transcription factor E2F2 [KO:K09389]
103260979  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
csyr03050  Proteasome
csyr04010  MAPK signaling pathway
csyr04020  Calcium signaling pathway
csyr04064  NF-kappa B signaling pathway
csyr04110  Cell cycle
csyr04115  p53 signaling pathway
csyr04210  Apoptosis
csyr04612  Antigen processing and presentation
csyr04620  Toll-like receptor signaling pathway
csyr04622  RIG-I-like receptor signaling pathway
csyr04630  JAK-STAT signaling pathway
csyr04662  B cell receptor signaling pathway
KO pathway
ko05169   
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