KEGG   PATHWAY: fca04020
Entry
fca04020                    Pathway                                
Name
Calcium signaling pathway - Felis catus (domestic cat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
fca04020  Calcium signaling pathway
fca04020

Other DBs
GO: 0019722
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
100141386  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100144611  NGF; beta-nerve growth factor [KO:K02582]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101080484  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
101080493  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101080520  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101080595  FGF21; fibroblast growth factor 21 [KO:K22429]
101080675  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
101080742  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101081054  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101081108  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101081184  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
101081345  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101081534  CALM2; calmodulin-2 [KO:K02183]
101081603  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101081711  OXTR; oxytocin receptor [KO:K04229]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101082635  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101082643  NTSR1; neurotensin receptor type 1 [KO:K04211]
101082667  [KO:K03916]
101082678  CASQ2; calsequestrin-2 [KO:K23445]
101082911  TRDN; triadin isoform X3 [KO:K23449]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101082936  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101082986  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101083101  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4 [KO:K13755] [EC:3.1.4.17]
101083419  EDNRA; endothelin-1 receptor [KO:K04197]
101083455  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101083728  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101083952  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101084129  [KO:K04161]
101084178  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X6 [KO:K08794] [EC:2.7.11.17]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101084342  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101084366  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101084482  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101084599  HRH2; histamine H2 receptor isoform X2 [KO:K04150]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101084611  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101084866  [KO:K04282]
101084918  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101085098  DRD1; D(1A) dopamine receptor [KO:K04144]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
101085388  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
101085548  NTRK3; NT-3 growth factor receptor isoform X4 [KO:K05101] [EC:2.7.10.1]
101085554  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
101085906  PTAFR; platelet-activating factor receptor [KO:K04279]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101086125  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
101086294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101086345  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086518  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
101086531  EDNRB; endothelin receptor type B [KO:K04198]
101086541  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101086789  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
101086796  TNNC2; troponin C, skeletal muscle [KO:K12042]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101087020  NOS2; nitric oxide synthase, inducible isoform X2 [KO:K13241] [EC:1.14.13.39]
101087099  FGF19; fibroblast growth factor 19 [KO:K22603]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101087547  ITPKB; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101087714  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101087777  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3 [KO:K05857] [EC:3.1.4.11]
101087780  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
101087822  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101087993  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101088154  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101088202  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101088269  SLN; sarcolipin [KO:K22642]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101088314  HRH1; histamine H1 receptor isoform X2 [KO:K04149]
101088391  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101088408  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101088635  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
101088695  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101088713  AVPR1B; vasopressin V1b receptor [KO:K04227]
101088723  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101089070  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
101089081  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
101089398  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101089682  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101089993  MST1R; macrophage-stimulating protein receptor isoform X5 [KO:K05100] [EC:2.7.10.1]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090071  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101090094  TACR1; substance-P receptor [KO:K04222]
101090190  RYR3; ryanodine receptor 3 [KO:K04963]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
101090455  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101090666  ORAI2; protein orai-2 [KO:K16057]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101091032  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101091060  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
101091063  CALM3; calmodulin-3 [KO:K02183]
101091082  CASQ1; calsequestrin-1 [KO:K23468]
101091278  DRD5; D(1B) dopamine receptor [KO:K05840]
101091330  ORAI3; protein orai-3 [KO:K16058]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101091492  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
101091691  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
101091740  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101091744  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101091895  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101092019  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101092238  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101092572  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101092793  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101093352  CB1H4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
101093603  TACR3; neuromedin-K receptor [KO:K04224]
101093801  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101093985  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X4 [KO:K04852]
101094104  GRM1; metabotropic glutamate receptor 1 isoform X2 [KO:K04603]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101094224  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101094457  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
101094541  TACR2; substance-K receptor isoform X2 [KO:K04223]
101094608  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101094679  CALM1; calmodulin-1 [KO:K02183]
101094708  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
101094736  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X3 [KO:K05214]
101094827  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344]
101094921  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101095061  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
101095198  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095400  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101095762  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
101095813  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101095941  [KO:K05863]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101096309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101096463  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101096789  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101096922  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101096951  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101097246  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101097250  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X3 [KO:K08794] [EC:2.7.11.17]
101097569  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
101097703  [KO:K02183]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101097794  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
101097856  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101097871  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101097897  PLN; cardiac phospholamban [KO:K05852]
101097922  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
101097951  MCOLN1; mucolipin-1 isoform X3 [KO:K04992]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101098090  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101098171  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
101098221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101098235  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
101098262  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
101098375  ADRA1A; alpha-1A adrenergic receptor isoform X2 [KO:K04135]
101098392  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101098395  MCOLN2; mucolipin-2 isoform X3 [KO:K04993]
101098453  [KO:K04632]
101098515  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
101098615  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
101098646  MCOLN3; mucolipin-3 [KO:K04994]
101098743  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
101098757  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101099117  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101099307  [KO:K02183]
101099589  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X4 [KO:K09565] [EC:5.2.1.8]
101099620  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
101099673  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101099790  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101099802  TFEB; transcription factor EB isoform X1 [KO:K15590]
101099960  CCKAR; cholecystokinin receptor type A isoform X2 [KO:K04194]
101100063  FGF23; fibroblast growth factor 23 [KO:K22428]
101100073  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
101100185  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101100229  AVPR1A; vasopressin V1a receptor [KO:K04226]
101100342  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101100466  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101100861  F2R; LOW QUALITY PROTEIN: proteinase-activated receptor 1 [KO:K03914]
101100864  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
101100868  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101100919  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101101086  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101101259  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101101308  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101101347  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101101451  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101101538  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101101678  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102899304  [KO:K05862]
102900772  [KO:K04632]
102900830  SMIM6; small integral membrane protein 6 [KO:K26468]
102901653  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102902023  MRLN; myoregulin isoform X1 [KO:K22643]
102902352  [KO:K15041]
102902667  [KO:K02183]
105260207  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X8 [KO:K00476] [EC:1.14.11.16]
109492578  HTR7; 5-hydroxytryptamine receptor 7 isoform X3 [KO:K04163]
109494208  ADORA2B; adenosine receptor A2b [KO:K04267]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
111559549  [KO:K10785]
111560862  LTB4R2; LOW QUALITY PROTEIN: leukotriene B4 receptor 2 [KO:K04297]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
493676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
493691  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493767  ADRB2; beta-2 adrenergic receptor [KO:K04142]
493807  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
493930  ADRB3; beta-3 adrenergic receptor [KO:K04143]
493933  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
493971  ADRB1; beta-1 adrenergic receptor [KO:K04141]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
751113  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
751615  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
751616  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
fca04010  MAPK signaling pathway
fca04070  Phosphatidylinositol signaling system
fca04210  Apoptosis
fca04720  Long-term potentiation
fca04730  Long-term depression
KO pathway
ko04020   

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