KEGG   PATHWAY: gfr04010
Entry
gfr04010                    Pathway                                
Name
MAPK signaling pathway - Geospiza fortis (medium ground-finch)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
gfr04010  MAPK signaling pathway
gfr04010

Other DBs
GO: 0000165
Organism
Geospiza fortis (medium ground-finch) [GN:gfr]
Gene
102043304  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102031898  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
102035179  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102043868  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
102041637  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
102036826  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
102037487  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
102037957  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102042376  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
102043893  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
102037102  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
102035174  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
102038997  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
102033186  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
102035820  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
102039314  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
102032944  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
102042082  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
102043314  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
102039488  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
102039982  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102043485  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102041922  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102040754  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102044790  GNA12; G protein subunit alpha 12 [KO:K04346]
102042757  GNG12; G protein subunit gamma 12 [KO:K04347]
102037249  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102037137  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102039738  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102034017  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102036258  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102037623  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102045446  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102041260  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102042003  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102044806  NF1; neurofibromin 1 [KO:K08052]
102035204  RASA1; RAS p21 protein activator 1 [KO:K04352]
102040076  ras GTPase-activating protein 1 [KO:K04352]
102031397  RASA2; RAS p21 protein activator 2 [KO:K08053]
102036447  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102042554  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102034269  EGF; epidermal growth factor [KO:K04357]
102032034  uncharacterized LOC102032034 [KO:K08774]
102038525  EREG; epiregulin [KO:K09784]
102040687  AREG; amphiregulin [KO:K09782]
102031991  FGF1; fibroblast growth factor 1 [KO:K18496]
102035880  FGF2; fibroblast growth factor 2 [KO:K18497]
102044043  FGF20; fibroblast growth factor 20 [KO:K04358]
102039340  FGF8; fibroblast growth factor 8 [KO:K04358]
102039970  FGF9; fibroblast growth factor 9 [KO:K04358]
102032503  FGF10; fibroblast growth factor 10 [KO:K04358]
102039574  FGF5; fibroblast growth factor 5 [KO:K04358]
102036865  FGF7; fibroblast growth factor 7 [KO:K04358]
102033173  FGF3; fibroblast growth factor 3 [KO:K04358]
102033341  FGF4; fibroblast growth factor 4 [KO:K04358]
102045202  FGF18; fibroblast growth factor 18 [KO:K04358]
102034856  FGF6; fibroblast growth factor 6 [KO:K04358]
102033508  FGF19; fibroblast growth factor 19 [KO:K22603]
102038755  FGF23; fibroblast growth factor 23 [KO:K22428]
102040631  NGF; nerve growth factor [KO:K02582]
102041696  BDNF; brain derived neurotrophic factor [KO:K04355]
102040677  NTF3; neurotrophin 3 [KO:K04356]
102044590  INS; insulin [KO:K04526]
102032215  IGF1; insulin like growth factor 1 [KO:K05459]
102032627  IGF2; insulin like growth factor 2 [KO:K13769]
102032936  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102036985  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102035549  PDGFC; platelet derived growth factor C [KO:K05450]
102044886  PDGFD; platelet derived growth factor D [KO:K05450]
102039316  CSF1; colony stimulating factor 1 [KO:K05453]
102045131  KITLG; KIT ligand [KO:K05461]
102038819  VEGFA; vascular endothelial growth factor A [KO:K05448]
102038207  PGF; placental growth factor [KO:K16859]
102036850  VEGFC; vascular endothelial growth factor C [KO:K05449]
102037618  VEGFD; vascular endothelial growth factor D [KO:K05449]
102042539  HGF; hepatocyte growth factor [KO:K05460]
102038740  ANGPT1; angiopoietin 1 [KO:K05465]
102045525  ANGPT2; angiopoietin 2 [KO:K05466]
102036809  ANGPT4; angiopoietin 4 [KO:K05467]
102038189  EFNA2; ephrin A2 [KO:K05462]
102041701  EFNA5; ephrin A5 [KO:K05462]
102038527  EFNA3; ephrin-A3 [KO:K05462]
102040743  EFNA1; ephrin-A1 [KO:K05462]
102035017  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102045482  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102045033  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102033908  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102038840  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102044988  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102044508  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102037350  NGFR; nerve growth factor receptor [KO:K02583]
102039729  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102044793  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102036061  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102036037  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102044274  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102045343  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102045177  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102042215  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102039519  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102037593  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102034196  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102039974  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102042381  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102035281  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102042810  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102036322  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102042884  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102038068  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102038427  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102033314  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102044012  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102035876  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102039955  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102033064  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102033145  MRAS; muscle RAS oncogene homolog [KO:K07831]
102032961  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102034977  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102031727  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102041148  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102037306  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102043401  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102040722  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
102036897  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
102044170  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102035007  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102034354  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102038515  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102036875  ATF4; activating transcription factor 4 [KO:K04374]
102037964  ELK4; ELK4, ETS transcription factor [KO:K04376]
102040133  SRF; serum response factor [KO:K04378]
102037526  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102033466  microtubule-associated protein tau-like [KO:K04380]
102039549  STMN1; stathmin 1 [KO:K04381]
102035277  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102043393  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102035444  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102043566  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102043225  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102045411  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102042951  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102035113  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102035617  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102036126  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
102041770  IL1B; interleukin-1 beta [KO:K04519]
102037698  TGFB2; transforming growth factor beta 2 [KO:K13376]
102037028  TGFB3; transforming growth factor beta 3 [KO:K13377]
102036131  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102040488  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102034831  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102037879  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102044945  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
102040558  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102045588  FASLG; Fas ligand [KO:K04389]
102033034  FAS; Fas cell surface death receptor [KO:K04390]
102035279  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102031835  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102043334  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102036055  CDC42; cell division cycle 42 [KO:K04393]
102042632  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102035830  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102033115  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102044578  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102032992  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102040197  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102037151  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102037601  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102035251  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102037095  NRK; Nik related kinase [KO:K04407] [EC:2.7.11.1]
102040657  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102033628  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102034742  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102031383  STK4; serine/threonine kinase 4 [KO:K04411]
102041006  STK3; serine/threonine kinase 3 [KO:K04412]
102035976  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102044899  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102033648  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102044243  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
102032306  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102034934  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102041684  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102040792  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102033703  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102034507  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102039929  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102043718  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102043586  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
102045349  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
102037348  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102038813  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102039295  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102039445  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102031934  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
102043533  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
102039553  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102040219  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102031974  beta-arrestin-1 [KO:K04439]
102036009  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102043776  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102043222  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102043521  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102038787  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102044158  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102042160  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102033005  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102044089  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102043737  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102033196  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102038895  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102038668  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102039078  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102034606  ATF2; activating transcription factor 2 [KO:K04450]
102043365  MAX; protein max [KO:K04453]
102041745  MEF2C; myocyte enhancer factor 2C [KO:K04454]
102035750  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
102036745  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102036791  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102041842  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
102036691  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
102042583  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102037449  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102033656  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102035606  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102032096  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102038395  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102043394  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102032382  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102045296  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102036851  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102039792  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102045045  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
102044992  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102039580  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
102032727  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102032525  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102038763  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102042264  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102035648  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102033058  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102038208  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102035904  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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