KEGG   PATHWAY: gvr05166
Entry
gvr05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Galeopterus variegatus (Sunda flying lemur)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
gvr05166  Human T-cell leukemia virus 1 infection
gvr05166

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103590819  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
103606832  NRP1; neuropilin-1 [KO:K06724]
103587820  MYC; myc proto-oncogene protein [KO:K04377]
103604206  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
103595328  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
103603964  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103609616  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103599334  ITGB2; integrin beta-2 [KO:K06464]
103594756  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103599501  KRAS; GTPase KRas [KO:K07827]
103589329  NRAS; GTPase NRas [KO:K07828]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103586411  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
103594553  TLN1; talin-1 [KO:K06271]
103608330  talin-2 [KO:K06271]
103602492  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
103583871  GTP-binding nuclear protein Ran [KO:K07936]
103605991  GTP-binding nuclear protein Ran [KO:K07936]
103586185  GTP-binding nuclear protein Ran-like [KO:K07936]
103601388  XPO1; exportin-1 [KO:K14290]
103596637  calreticulin-like [KO:K08057]
103585635  CALR; calreticulin [KO:K08057]
103597477  CANX; calnexin [KO:K08054]
103591114  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103598106  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598210  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103604521  PPP3R2; calcineurin subunit B type 2 isoform X1 [KO:K06268]
103585050  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103598251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103586032  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
103590142  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103606392  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103586318  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
103591505  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103593677  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103595355  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
103595352  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B-like [KO:K11224]
103593609  IL2; interleukin-2 [KO:K05429]
103609219  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
103610244  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103602353  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103610772  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103606064  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
103586434  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103592560  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103601963  B2M; beta-2-microglobulin [KO:K08055]
103603650  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103592400  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103602232  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103589291  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103597742  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103586826  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103605434  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103589264  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103595193  TSPO; translocator protein [KO:K05770]
103591054  TSPO2; translocator protein 2 [KO:K05770]
103588108  VAC14; protein VAC14 homolog [KO:K15305]
103600299  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
103588751  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
103598414  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
103591299  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
103595986  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
103592413  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
103593494  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
103582008  CDC27; cell division cycle protein 27 homolog [KO:K03350]
103594030  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
103588690  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
103598617  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
103588682  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
103590547  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
103594690  anaphase-promoting complex subunit 10-like [KO:K03357]
103593332  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
103587269  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
103586871  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
103585876  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
103598481  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
103598916  anaphase-promoting complex subunit 16-like [KO:K25229]
103598282  CDC20; cell division cycle protein 20 homolog [KO:K03363]
103602622  PTTG1; securin isoform X1 [KO:K06635]
103592226  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
103602482  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
103593976  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
103608705  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
103608706  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
103609174  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103607082  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103587459  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103607313  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103602373  CCNA1; cyclin-A1 [KO:K06627]
103608004  CCNA2; cyclin-A2 [KO:K06627]
103602907  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103603724  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103610793  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103593663  RB1; retinoblastoma-associated protein [KO:K06618]
103586861  E2F1; transcription factor E2F1 [KO:K17454]
103590624  E2F2; transcription factor E2F2 [KO:K09389]
103590253  E2F3; transcription factor E2F3 [KO:K06620]
103597510  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103601244  serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
103608913  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
103583154  serine/threonine-protein kinase Chk1-like [KO:K02216] [EC:2.7.11.1]
103598989  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
103591400  TP53; cellular tumor antigen p53 [KO:K04451]
103585463  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103593683  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103608454  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103586572  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103586784  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103587883  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103596384  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103590279  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103598325  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103605698  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103601545  disks large homolog 1-like [KO:K12076]
103592918  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103592383  TNF; tumor necrosis factor [KO:K03156]
103605365  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103600330  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103600274  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103582610  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103603521  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103592390  JUN; transcription factor AP-1 [KO:K04448]
103596076  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
103610948  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
103610385  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
103582933  uncharacterized protein LOC103582933 [KO:K10784]
103604227  uncharacterized protein LOC103604227 [KO:K10784]
103605353  uncharacterized protein LOC103605353 [KO:K10785]
103592269  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
103592268  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103592270  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103589229  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103588798  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103589266  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103604367  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103591436  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103595334  RELA; transcription factor p65 [KO:K04735]
103591429  GPS2; G protein pathway suppressor 2 [KO:K15307]
103605117  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
103589570  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
103591922  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
103595998  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103602190  RELB; transcription factor RelB [KO:K09253]
103588100  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103598176  ZFP36; tristetraprolin [KO:K15308]
103607987  interleukin-2 receptor subunit alpha-like [KO:K05068]
103607305  IL15; interleukin-15 [KO:K05433]
103587845  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
103585928  IL6; interleukin-6 [KO:K05405]
103590058  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
103592384  LTA; lymphotoxin-alpha [KO:K05468]
103594063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103610749  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
103608053  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103599185  transforming growth factor beta-1 [KO:K13375]
103599191  transforming growth factor beta-1-like [KO:K13375]
103604625  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103585960  TGFB3; transforming growth factor beta-3 [KO:K13377]
103587310  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103591905  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103595293  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
103590291  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
103600109  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
103599611  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103597918  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103588815  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103590144  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103588664  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103588863  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103594947  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103583204  adenylate cyclase type 7-like [KO:K08047] [EC:4.6.1.1]
103591872  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103591384  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103589593  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103585135  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103588561  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
103605486  nuclear transcription factor Y subunit beta-like [KO:K08065]
103608747  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
103602253  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
103602254  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103602258  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103602259  HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752]
103602260  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
103610538  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
103581584  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103582505  HLA class II histocompatibility antigen, DRB1-9 beta chain-like [KO:K06752]
103582509  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103582925  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
103583986  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103584069  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103597932  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103597933  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
103585764  SRF; serum response factor [KO:K04378]
103596809  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
103594186  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103592089  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
103585512  ETS1; protein C-ets-1 [KO:K02678]
103595890  ETS2; protein C-ets-2 [KO:K21932]
103581293  TATA-box-binding protein [KO:K03120]
103596695  TBPL1; TATA box-binding protein-like protein 1 isoform X1 [KO:K03120]
103606962  TATA-box-binding protein-like [KO:K03120]
103593655  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
103605891  FOS; proto-oncogene c-Fos [KO:K04379]
103590540  EGR1; early growth response protein 1 [KO:K09203]
103582221  FOSL1; fos-related antigen 1 [KO:K04502]
103607840  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
103586701  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103594556  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
103588716  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103584009  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103585217  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103586347  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103600172  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103605275  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103599295  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103595172  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103603638  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103596524  CRTC1; CREB-regulated transcription coactivator 1 [KO:K15309]
103586351  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
103583960  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
103595030  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103591893  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103609171  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
103595344  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
103606025  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
103589265  POLB; LOW QUALITY PROTEIN: DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
103594929  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
103587762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103600891  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
103581500  MSX2; homeobox protein MSX-2 [KO:K09341]
103585843  MSX1; homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
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J Virol 90:7607-17 (2016)
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Retrovirology 1:20 (2004)
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
gvr03013  Nucleocytoplasmic transport
gvr04010  MAPK signaling pathway
gvr04064  NF-kappa B signaling pathway
gvr04110  Cell cycle
gvr04115  p53 signaling pathway
gvr04151  PI3K-Akt signaling pathway
gvr04210  Apoptosis
gvr04350  TGF-beta signaling pathway
gvr04612  Antigen processing and presentation
gvr04660  T cell receptor signaling pathway
gvr04668  TNF signaling pathway
KO pathway
ko05166   
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