KEGG   PATHWAY: lww05169
Entry
lww05169                    Pathway                                
Name
Epstein-Barr virus infection - Leptonychotes weddellii (Weddell seal)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
lww05169  Epstein-Barr virus infection
lww05169

Organism
Leptonychotes weddellii (Weddell seal) [GN:lww]
Gene
102737455  complement receptor type 1 [KO:K04012]
102740776  CD19; B-lymphocyte antigen CD19 [KO:K06465]
102733188  HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752]
102748173  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
102747192  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
102734456  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102740784  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
102741082  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102747485  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
102748462  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
102750166  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102750454  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102737828  TLR2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
102737954  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102741856  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102726302  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102728739  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102750010  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102732150  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102741918  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102728853  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102750184  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102742694  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102725682  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102732435  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
102739707  RELA; transcription factor p65 [KO:K04735]
102743506  TNF; tumor necrosis factor [KO:K03156]
102745902  IL6; interleukin-6 isoform X1 [KO:K05405]
102746318  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
102727031  MAVS; LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein [KO:K12648]
102749350  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102748381  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102737602  IRF7; interferon regulatory factor 7 isoform X3 [KO:K09447]
102732139  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102748540  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
102747471  interferon alpha-1/2-like [KO:K05414]
102747757  interferon alpha-1/2-like [KO:K05414]
102750324  interferon alpha-2-like [KO:K05414]
102727550  interferon alpha-1/2-like [KO:K05414]
102749740  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
102748842  IFNB1; interferon beta [KO:K05415]
102734634  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102750819  interferon alpha/beta receptor 2-like [KO:K05131]
102736730  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102749508  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
102731818  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102739614  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102750742  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102731171  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
102733293  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
102731487  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
102731794  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
102740919  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102728615  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
102738718  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102737084  FADD; FAS-associated death domain protein [KO:K02373]
102733039  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
115943885  BH3-interacting domain death agonist-like [KO:K04726]
102746004  BCL2L11; bcl-2-like protein 11 isoform X3 [KO:K16341]
102744561  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102729504  apoptosis regulator BAX-like isoform X1 [KO:K02159]
102731986  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102725978  cytochrome c 2-like [KO:K08738]
102750923  cytochrome c [KO:K08738]
102726669  cytochrome c [KO:K08738]
102729908  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102725545  caspase-9-like [KO:K04399] [EC:3.4.22.62]
102735000  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102729553  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102730162  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102734398  T-cell surface glycoprotein CD3 gamma chain-like [KO:K06452]
102729861  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
102738396  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
102738766  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
102735127  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
102742710  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
102733587  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
102734962  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
102730851  26S proteasome regulatory subunit 6A-like [KO:K03065]
102738844  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A-like [KO:K03065]
102744184  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
102740490  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
102729219  26S proteasome non-ATPase regulatory subunit 2 isoform X2 [KO:K03028]
102726381  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
102732142  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
102737946  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
102733625  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
102727443  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
102734157  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
102730277  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
102745794  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
102738935  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
102742786  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
102728548  PSMD8; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102727548  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
102746580  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
102749278  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102733853  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
102730147  TAPBP; tapasin [KO:K08058]
102733223  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102740350  CALR; calreticulin [KO:K08057]
102749162  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102735909  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
102746195  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102730025  HLA class I histocompatibility antigen, A-24 alpha chain-like [KO:K06751]
102736667  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
102728163  B2M; beta-2-microglobulin [KO:K08055]
102731237  SNW domain-containing protein 1 [KO:K06063]
102745186  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
102729230  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
102733999  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
102749387  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
102732993  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
102731594  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
102741314  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
102739398  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
102738480  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
102740261  HES1; transcription factor HES-1 [KO:K06054]
102726621  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
102738657  RUNX3; runt-related transcription factor 3 [KO:K09279]
102739954  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
102734420  ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
102730468  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102726420  TP53; cellular tumor antigen p53 [KO:K04451]
102737261  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102739495  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102734323  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102748139  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102739956  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
102728319  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
102740611  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
102743753  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4 [KO:K00922] [EC:2.7.1.153]
102749194  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102738988  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102751021  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102726443  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102728383  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102747309  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102749871  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102734291  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102734276  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
102736584  LOW QUALITY PROTEIN: transcription factor RelB-like [KO:K09253]
102727693  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102750365  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102732489  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
102740748  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
102737019  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102744013  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102739504  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102733548  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102736169  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102738552  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102727515  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
102725552  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102743800  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102746987  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
115942902  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102738377  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102725695  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102727222  JUN; transcription factor AP-1 [KO:K04448]
102734788  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X7 [KO:K01510] [EC:3.6.1.5]
102732996  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
102742087  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
102732296  CD40; tumor necrosis factor receptor superfamily member 5 isoform X9 [KO:K03160]
102740377  CD44; CD44 antigen [KO:K06256]
102726508  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102747999  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
102742641  vimentin [KO:K07606]
102732823  vimentin [KO:K07606]
102738254  vimentin-like [KO:K07606]
102750812  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
102727785  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
102748936  signal transducer and activator of transcription 3 [KO:K04692]
102748833  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
102734956  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102729622  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102733229  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102733386  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
102740366  B-cell linker protein-like [KO:K07371]
102741483  BLNK; B-cell linker protein [KO:K07371]
102736340  S-phase kinase-associated protein 2 [KO:K03875]
102749650  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102747216  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102747548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102736121  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
102746891  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102737670  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102730469  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
102746125  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
102740596  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102746341  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102732832  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102737296  RB1; retinoblastoma-associated protein [KO:K06618]
102743808  E2F1; transcription factor E2F1 [KO:K17454]
102749663  E2F2; transcription factor E2F2 [KO:K09389]
102736623  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
lww03050  Proteasome
lww04010  MAPK signaling pathway
lww04020  Calcium signaling pathway
lww04064  NF-kappa B signaling pathway
lww04110  Cell cycle
lww04115  p53 signaling pathway
lww04210  Apoptosis
lww04612  Antigen processing and presentation
lww04620  Toll-like receptor signaling pathway
lww04622  RIG-I-like receptor signaling pathway
lww04630  JAK-STAT signaling pathway
lww04662  B cell receptor signaling pathway
KO pathway
ko05169   
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