KEGG   PATHWAY: mcoc05165
Entry
mcoc05165                   Pathway                                
Name
Human papillomavirus infection - Mastomys coucha (southern multimammate mouse)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcoc05165  Human papillomavirus infection
mcoc05165

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116082044  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
116098605  Wnt2; protein Wnt-2 [KO:K00182]
116093560  Wnt2b; protein Wnt-2b isoform X1 [KO:K00182]
116077475  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
116078862  Wnt3a; protein Wnt-3a [KO:K00312]
116096876  Wnt4; protein Wnt-4 [KO:K00408]
116099495  Wnt5b; protein Wnt-5b [KO:K00444]
116084455  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
116088584  Wnt6; protein Wnt-6 [KO:K00445]
116099270  Wnt7a; protein Wnt-7a [KO:K00572]
116077324  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
116103897  Wnt8b; protein Wnt-8b [KO:K00714]
116087814  Wnt8a; protein Wnt-8a [KO:K00714]
116078860  Wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
116088586  Wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
116079174  Wnt10b; protein Wnt-10b [KO:K01357]
116102613  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
116098622  Wnt16; protein Wnt-16 [KO:K01558]
116097454  Fzd1; frizzled-1 [KO:K02432]
116088479  Fzd7; frizzled-7 [KO:K02432]
116078405  Fzd2; frizzled-2 isoform X1 [KO:K02235]
116085420  Fzd3; frizzled-3 isoform X1 [KO:K02329]
116102539  Fzd4; frizzled-4 [KO:K02354]
116086824  Fzd8; frizzled-8 [KO:K02375]
116088518  Fzd5; frizzled-5 [KO:K02375]
116081996  Fzd6; frizzled-6 [KO:K02376]
116068468  Fzd10; frizzled-10 [KO:K02842]
116070947  Fzd9; frizzled-9 [KO:K02842]
116097159  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
116085718  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
116079062  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116076684  Axin1; axin-1 isoform X1 [KO:K02157]
116076714  Axin2; axin-2 [KO:K04385]
116075850  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
116086966  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116073724  Ctnnb1; catenin beta-1 [KO:K02105]
116087233  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
116083456  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
116077224  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
116099088  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
116104020  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
116102312  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
116069217  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
116075485  Ticam1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
116080944  Traf3; TNF receptor-associated factor 3 [KO:K03174]
116098877  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116076589  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
116102161  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116095400  Ifnb1; interferon beta [KO:K05415]
116084175  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116076368  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
116099393  Tada3; transcriptional adapter 3 isoform X1 [KO:K11315]
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116099295  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116070446  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116087400  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
116070066  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116091834  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
116095037  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
116095810  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116074274  Scrib; protein scribble homolog isoform X1 [KO:K16175]
116085801  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
116102565  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
116087114  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
116076874  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
116078070  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
116074273  Crb3; protein crumbs homolog 3 [KO:K06090]
116096267  Patj; inaD-like protein isoform X1 [KO:K06092]
116080056  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
116099616  Vwf; von Willebrand factor isoform X1 [KO:K03900]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116083530  Thbs4; thrombospondin-4 [KO:K04659]
116093161  Thbs3; thrombospondin-3 [KO:K04659]
116077949  Thbs2; thrombospondin-2 [KO:K04659]
116069462  Comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
116088545  Fn1; fibronectin isoform X1 [KO:K05717]
116098542  Col1a2; collagen alpha-2(I) chain [KO:K06236]
116078726  Col1a1; collagen alpha-1(I) chain [KO:K06236]
116078858  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
116096167  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
116068903  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
116068904  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
116088649  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116088650  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
116089039  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116073903  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
116074557  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116074943  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
116088753  Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
116072199  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
116073354  collagen alpha-4(VI) chain [KO:K06238]
116096559  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
116089097  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116091849  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
116097932  Lama2; laminin subunit alpha-2 [KO:K05637]
116088869  Lama1; laminin subunit alpha-1 [KO:K05637]
116086852  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116091524  Lama5; laminin subunit alpha-5 [KO:K06240]
116075456  Lama4; laminin subunit alpha-4 [KO:K06241]
116080788  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
116072107  Lamb2; laminin subunit beta-2 [KO:K06243]
116069150  Lamb3; laminin subunit beta-3 [KO:K06244]
116101239  Lamc1; laminin subunit gamma-1 [KO:K05635]
116101229  Lamc2; laminin subunit gamma-2 [KO:K06246]
116089980  Lamc3; laminin subunit gamma-3 [KO:K06247]
116077683  Chad; chondroadherin [KO:K06248]
116097519  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116070754  Spp1; osteopontin [KO:K06250]
116077245  Vtn; vitronectin [KO:K06251]
116102168  Tnr; tenascin-R isoform X1 [KO:K06252]
116096134  Tnc; tenascin isoform X1 [KO:K06252]
116074684  Tnxb; tenascin-X isoform X1 [KO:K06252]
116070755  Tnn; tenascin-N isoform X1 [KO:K06252]
116070752  Ibsp; bone sialoprotein 2 [KO:K06253]
116083732  Itga1; integrin alpha-1 isoform X1 [KO:K06480]
116083244  Itga2; integrin alpha-2 [KO:K06481]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078986  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
116090371  Itga4; integrin alpha-4 [KO:K06483]
116080860  Itga5; integrin alpha-5 [KO:K06484]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116075887  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
116089710  Itga8; integrin alpha-8 [KO:K06584]
116073780  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
116093463  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
116073011  Itga11; integrin alpha-11 isoform X1 [KO:K06587]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077406  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
116085844  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
116090215  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
116080371  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
116080974  Itgb8; integrin beta-8 [KO:K06591]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116068255  Pxn; paxillin isoform X1 [KO:K05760]
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116099614  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116070032  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116103761  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116103283  Fadd; FAS-associated death domain protein [KO:K02373]
116088467  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116077263  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
116104772  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116077586  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116079262  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116073310  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
116103147  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116085366  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116087108  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116070475  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
116081027  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
116073268  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
116103440  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
116075523  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
116068891  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
116080027  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
116080458  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
116089904  Tsc1; hamartin isoform X1 [KO:K07206]
116078562  Tsc2; tuberin isoform X1 [KO:K07207]
116097567  Rheb; GTP-binding protein Rheb [KO:K07208]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116069093  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116103319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116079205  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116075029  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116094452  Foxo1; forkhead box protein O1 [KO:K07201]
116099702  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116075178  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116103285  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116099629  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116075067  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
116075684  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116097440  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116102054  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
116088079  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116076163  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116085075  Rb1; retinoblastoma-associated protein [KO:K06618]
116091283  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
116069845  Rbl2; retinoblastoma-like protein 2 [KO:K16332]
116079645  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
116091213  E2f1; transcription factor E2F1 [KO:K17454]
116095103  Ccna2; cyclin-A2 [KO:K06627]
116092877  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
116073222  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
116072586  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103881  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116069014  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116086280  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116075923  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116095830  Nfx1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
116096707  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
116074400  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116099598  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
116078253  Irf1; interferon regulatory factor 1 [KO:K09444]
116097835  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
116077338  Tbp; TATA-box-binding protein [KO:K03120]
116091873  Tbpl2; TATA box-binding protein-like protein 2 isoform X1 [KO:K03120]
116074338  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
116074448  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
116074449  HLA class I histocompatibility antigen, A-32 alpha chain-like [KO:K06751]
116074450  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
116074451  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
116074620  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
116074623  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
116074625  H-2 class I histocompatibility antigen, K-D alpha chain-like isoform X1 [KO:K06751]
116074627  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
116074637  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
116074638  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
116074642  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
116074645  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
116074664  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
116075017  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
116075078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
116075380  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
116075381  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
116085998  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
116085932  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
116099943  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
116069414  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
116080803  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
116081555  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
116080061  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
116099516  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
116079860  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
116098665  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
116096127  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
116074659  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
116070370  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
116088138  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
116103300  Tcirg1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116098742  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116068441  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
116079228  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116070056  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
116088998  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
116098857  Atp6v0e2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
116077943  Atp6v0e1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
116078194  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
116096509  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
116075967  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116070506  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116083366  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
116091495  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
116091496  neuroendocrine secretory protein 55 [KO:K04632]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116088513  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116095903  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116098735  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
116093212  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116076210  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
116090490  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
116098936  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
116096926  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
116078737  Tubg1; tubulin gamma-1 chain [KO:K10389]
116078738  tubulin gamma-2 chain [KO:K10389]
116072132  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
116095401  interferon alpha-7-like [KO:K05414]
116095403  interferon alpha-1-like [KO:K05414]
116095406  interferon alpha-9-like [KO:K05414]
116095408  interferon alpha-12-like [KO:K05414]
116095410  interferon alpha-1 [KO:K05414]
116095416  interferon alpha-1-like [KO:K05414]
116095417  interferon alpha-4-like [KO:K05414]
116095418  interferon alpha-12 [KO:K05414]
116095419  interferon alpha-7-like [KO:K05414]
116095420  interferon alpha-12-like [KO:K05414]
116095421  interferon alpha-7-like [KO:K05414]
116096218  interferon alpha-11 [KO:K05414]
116086128  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
116086124  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116096295  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
116073782  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
116088407  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116076236  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
116084367  Irf9; interferon regulatory factor 9 [KO:K04693]
116080069  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
116068236  Oasl; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
116086632  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
116095717  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
116091010  Jag1; protein jagged-1 [KO:K06052]
116089856  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
116093487  Notch2; neurogenic locus notch homolog protein 2 [KO:K20994]
116075773  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
116075324  Notch4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
116079629  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
116075628  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
116068671  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
116077482  Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
116094449  Maml3; mastermind-like protein 3 isoform X1 [KO:K06061]
116077843  Maml1; mastermind-like protein 1 [KO:K06061]
116072917  Maml2; mastermind-like protein 2 [KO:K06061]
116092515  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
116070869  Rbpj; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless [KO:K06053]
116085780  Hes1; transcription factor HES-1 [KO:K06054]
116095696  Hes2; transcription factor HES-2 [KO:K09087]
116078681  Hes7; transcription factor HES-7 [KO:K09087]
116089300  Hes6; transcription cofactor HES-6 isoform X1 [KO:K09087]
116095697  Hes3; transcription factor HES-3 [KO:K09088]
116097131  Hes5; transcription factor HES-5 [KO:K06055]
116094931  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
116096579  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
116097880  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
PMID:25752815
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Chen J
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
PMID:26008697
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Tummers B, Burg SH
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
PMID:19684440
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Lehoux M, D'Abramo CM, Archambault J
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
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Pang CL, Thierry F
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Reference
PMID:19156753
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Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
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Narisawa-Saito M, Kiyono T
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
PMID:16259056
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Kim YT, Zhao M
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
  Authors
McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
PMID:26289783
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Shah M, Anwar MA, Park S, Jafri SS, Choi S
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
PMID:19029942
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Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Arch Virol 151:2321-35 (2006)
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Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Mol Cancer 14:87 (2015)
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Reference
PMID:22078316
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Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
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Mol Cancer 10:140 (2011)
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Reference
PMID:11753669
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DiMaio D, Mattoon D
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Oncogene 20:7866-73 (2001)
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Reference
PMID:22262402
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Ganguly N
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Cell Oncol (Dordr) 35:67-76 (2012)
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PMID:23731971
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DiMaio D, Petti LM
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The E5 proteins.
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Virology 445:99-114 (2013)
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Reference
PMID:23403708
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Oxidative stress and HPV carcinogenesis.
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Viruses 5:708-31 (2013)
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Reference
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Breaking the DNA damage response to improve cervical cancer treatment.
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Cancer Treat Rev 42:30-40 (2016)
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Reference
PMID:19861444
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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PMID:11325599
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Control of interferon signaling in human papillomavirus infection.
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Cytokine Growth Factor Rev 12:157-70 (2001)
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PMID:10702232
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Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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J Biol Chem 275:6764-9 (2000)
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Reference
PMID:22499770
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Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
mcoc04064  NF-kappa B signaling pathway
mcoc04110  Cell cycle
mcoc04115  p53 signaling pathway
mcoc04150  mTOR signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04210  Apoptosis
mcoc04310  Wnt signaling pathway
mcoc04330  Notch signaling pathway
mcoc04510  Focal adhesion
mcoc04520  Adherens junction
mcoc04530  Tight junction
mcoc04612  Antigen processing and presentation
mcoc04620  Toll-like receptor signaling pathway
mcoc04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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