KEGG   PATHWAY: oga05205
Entry
oga05205                    Pathway                                
Name
Proteoglycans in cancer - Otolemur garnettii (small-eared galago)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
oga05205  Proteoglycans in cancer
oga05205

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100943911  CD44; CD44 antigen isoform X1 [KO:K06256]
100941865  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100957467  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100949589  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100953964  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100948701  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100963265  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100947275  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100950628  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100951644  HRAS; GTPase HRas isoform X1 [KO:K02833]
100953050  KRAS; GTPase KRas isoform X3 [KO:K07827]
100949583  NRAS; GTPase NRas isoform X1 [KO:K07828]
100948262  RRAS; ras-related protein R-Ras [KO:K07829]
100958945  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100967191  MRAS; ras-related protein M-Ras [KO:K07831]
100955336  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100941062  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100947929  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100959926  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100956072  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100951533  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100957343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100951369  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100959408  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100947706  cell division control protein 42 homolog [KO:K04393]
100950992  CDC42; cell division control protein 42 homolog [KO:K04393]
100949181  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100954847  ESR1; estrogen receptor isoform X2 [KO:K08550]
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100966429  actin, cytoplasmic 1-like [KO:K05692]
100953854  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100960800  ACTB; actin, cytoplasmic 1 [KO:K05692]
100953848  FLNA; filamin-A isoform X2 [KO:K04437]
100950236  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100950232  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100951083  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
100954771  RHOA; transforming protein RhoA [KO:K04513]
100964845  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100953342  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100951942  ANK1; ankyrin-1 isoform X1 [KO:K10380]
100956317  ANK2; ankyrin-2 isoform X1 [KO:K09255]
100946791  ANK3; ankyrin-3 isoform X1 [KO:K09259]
100949240  GAB1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
100947138  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100953367  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100954109  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100956838  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100952580  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100949858  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100959825  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100955276  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100945977  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100948977  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100941909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100960152  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100945379  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
100955707  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100963170  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100957349  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100947727  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100964437  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100954512  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100942290  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100941825  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100955681  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100956846  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100950655  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100942949  NANOG; homeobox protein NANOG isoform X1 [KO:K10164]
100955141  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
100958469  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100942016  TWIST2; twist-related protein 2 [KO:K09069]
100964565  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100945946  DCN; decorin [KO:K04660]
100951094  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100944394  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100957753  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100950210  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100945805  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100940650  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X5 [KO:K04688] [EC:2.7.11.1]
100952411  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
100960641  RPS6; 40S ribosomal protein S6 [KO:K02991]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100948513  CAV1; caveolin-1 [KO:K06278]
100961631  CAV2; caveolin-2 isoform X1 [KO:K12958]
100960553  CAV3; caveolin-3 [KO:K12959]
100963095  CD63; CD63 antigen [KO:K06497]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100961435  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100949640  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
100964048  TLR2; toll-like receptor 2 [KO:K10159]
100956359  TLR4; toll-like receptor 4 [KO:K10160]
100947023  PDCD4; programmed cell death protein 4 [KO:K16865]
100963613  TNF; tumor necrosis factor [KO:K03156]
100962204  IL12B; interleukin-12 subunit beta [KO:K05425]
100966253  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100950688  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100966689  CTNNB1; catenin beta-1 [KO:K02105]
100941157  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
100944090  TFAP4; transcription factor AP-4 [KO:K09108]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100944640  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100948196  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100958294  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100966526  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
100949247  THBS1; thrombospondin-1 [KO:K16857]
100965003  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100942813  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100946463  LUM; lumican [KO:K08122]
100951008  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100957582  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100961605  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100947328  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100953808  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111727809  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100956747  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
100960336  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100965397  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
100953978  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100950816  SDC1; syndecan-1 isoform X1 [KO:K06257]
100942138  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100952775  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
100955384  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100951428  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100949511  ITGA2; integrin alpha-2 [KO:K06481]
100955745  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100955362  VTN; vitronectin [KO:K06251]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100948167  FN1; fibronectin isoform X2 [KO:K05717]
100941684  ITGB5; integrin beta-5 [KO:K06588]
100963467  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100943890  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100963272  FZD7; frizzled-7 [KO:K02432]
100948251  FZD1; frizzled-1 [KO:K02432]
100963711  FZD2; frizzled-2 [KO:K02235]
100956711  FZD3; frizzled-3 [KO:K02329]
100964395  FZD4; frizzled-4 [KO:K02354]
100947964  FZD8; frizzled-8 [KO:K02375]
100963379  FZD5; frizzled-5 [KO:K02375]
100955382  FZD6; frizzled-6 isoform X2 [KO:K02376]
100943205  FZD10; frizzled-10 [KO:K02842]
100943348  FZD9; frizzled-9 [KO:K02842]
100951353  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100957790  SDC2; syndecan-2 [KO:K16336]
100955030  EZR; ezrin isoform X1 [KO:K08007]
100956512  RDX; radixin isoform X1 [KO:K05762]
100965374  MSN; moesin isoform X1 [KO:K05763]
100965933  SDC4; syndecan-4 [KO:K16338]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100956213  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100955860  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
100958517  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100943020  SOS2; son of sevenless homolog 2 [KO:K03099]
100948398  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100948829  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100947145  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
100941877  PXN; paxillin isoform X1 [KO:K05760]
100962373  PTK2; focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
100955169  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
100952867  GPC1; glypican-1 [KO:K08107]
100958631  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
100948009  GPC3; glypican-3 isoform X1 [KO:K08109]
100946400  WNT2; protein Wnt-2 [KO:K00182]
100960603  WNT2B; protein Wnt-2b [KO:K00182]
100964130  WNT3A; protein Wnt-3a [KO:K00312]
100954489  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100950370  WNT4; protein Wnt-4 [KO:K00408]
100962307  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100950006  WNT5B; protein Wnt-5b [KO:K00444]
100947622  WNT6; protein Wnt-6 [KO:K00445]
100959243  WNT7A; protein Wnt-7a [KO:K00572]
100943606  WNT7B; protein Wnt-7b [KO:K00572]
100947970  WNT8B; protein Wnt-8b [KO:K00714]
100963978  WNT8A; protein Wnt-8a [KO:K00714]
100957093  WNT9A; protein Wnt-9a [KO:K01064]
100954800  WNT9B; protein Wnt-9b [KO:K01064]
100943567  WNT10B; protein Wnt-10b [KO:K01357]
100947304  WNT10A; protein Wnt-10a [KO:K01357]
100954223  WNT11; protein Wnt-11 [KO:K01384]
100959119  WNT16; protein Wnt-16 [KO:K01558]
100946098  SHH; sonic hedgehog protein [KO:K11988]
100946168  IHH; indian hedgehog protein [KO:K11989]
100961156  PTCH1; protein patched homolog 1 isoform X2 [KO:K06225]
100954610  SMO; smoothened homolog [KO:K06226]
100951313  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
100963673  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100958924  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100956269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100957118  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100963993  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100964304  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100961445  HSPB2; heat shock protein beta-2 [KO:K09543]
100946957  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
oga04010  MAPK signaling pathway
oga04020  Calcium signaling pathway
oga04066  HIF-1 signaling pathway
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04210  Apoptosis
oga04310  Wnt signaling pathway
oga04340  Hedgehog signaling pathway
oga04350  TGF-beta signaling pathway
oga04370  VEGF signaling pathway
oga04510  Focal adhesion
oga04520  Adherens junction
oga04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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