KEGG   PATHWAY: panu05166
Entry
panu05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Papio anubis (olive baboon)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
panu05166  Human T-cell leukemia virus 1 infection
panu05166

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100381181  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101006565  NRP1; neuropilin-1 isoform X5 [KO:K06724]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
101017331  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
101014826  KAT5; histone acetyltransferase KAT5 isoform X6 [KO:K11304] [EC:2.3.1.48]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101022225  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101014955  ITGB2; integrin beta-2 isoform X3 [KO:K06464]
101021731  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
100303658  CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454]
101018767  TLN1; talin-1 isoform X2 [KO:K06271]
116268521  talin-2-like [KO:K06271]
101009767  talin-2 isoform X1 [KO:K06271]
100997083  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
101006459  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
101007107  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran [KO:K07936]
101010054  XPO1; exportin-1 isoform X1 [KO:K14290]
101007652  CALR; calreticulin [KO:K08057]
101017726  CANX; LOW QUALITY PROTEIN: calnexin [KO:K08054]
101024785  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101026693  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101025310  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
103877032  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101004981  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100997330  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101002848  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101000384  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
100997355  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101014683  IL2RB; interleukin-2 receptor subunit beta isoform X4 [KO:K05069]
101008968  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101014985  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100998364  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101000002  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100126754  IL2; interleukin-2 precursor [KO:K05429]
101021987  HLA class I histocompatibility antigen, B-27 alpha chain isoform X1 [KO:K06751]
101019755  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-38 alpha chain [KO:K06751]
101025045  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
116272574  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
100997583  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
116272784  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101022333  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101003522  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101021633  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101006198  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
116268677  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
116272937  HLA class I histocompatibility antigen, Cw-6 alpha chain-like isoform X1 [KO:K06751]
101012738  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
101026217  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
101002482  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
116273056  HLA class I histocompatibility antigen, Cw-8 alpha chain-like isoform X1 [KO:K06751]
116273133  HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
116273134  HLA class I histocompatibility antigen, B-7 alpha chain-like [KO:K06751]
101020363  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101021052  HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
101024059  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E [KO:K06751]
101015220  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751]
101009503  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
100126713  PACA-F; major histocompatibility complex, class I, F precursor [KO:K06751]
101007932  patr class I histocompatibility antigen, A-126 alpha chain-like precursor [KO:K06751]
100381194  B2M; beta-2-microglobulin precursor [KO:K08055]
101017660  FDPS; farnesyl pyrophosphate synthase isoform X2 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
101002939  LOW QUALITY PROTEIN: farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100998956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101009750  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
101025041  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101000631  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101025066  TSPO; translocator protein isoform X2 [KO:K05770]
101020668  TSPO2; translocator protein 2 isoform X1 [KO:K05770]
101002938  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
101025885  RANBP1; ran-specific GTPase-activating protein isoform X4 [KO:K15306]
101008228  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
101022443  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100137358  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101009307  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X4 [KO:K06637] [EC:2.7.11.1]
101011923  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
101015415  ANAPC1; anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
101003223  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
101010691  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
101011179  ANAPC4; anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
101020484  ANAPC5; anaphase-promoting complex subunit 5 isoform X3 [KO:K03352]
101004072  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
101026357  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
101016424  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101015461  ANAPC10; anaphase-promoting complex subunit 10 isoform X4 [KO:K03357]
101007414  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
103878141  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
101025444  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100999272  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
101006219  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
101001004  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101000383  PTTG1; securin [KO:K06635]
101001092  LOW QUALITY PROTEIN: putative pituitary tumor-transforming gene 3 protein [KO:K06635]
101019541  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
116272568  G2/mitotic-specific cyclin-B2 [KO:K21770]
101025984  G2/mitotic-specific cyclin-B2 [KO:K21770]
101014127  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101017208  cyclin-dependent kinase inhibitor 2A isoform X2 [KO:K06621]
101015078  tumor suppressor ARF-like [KO:K06621]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100999197  CCNA2; cyclin-A2 [KO:K06627]
101003474  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
101015623  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101025116  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
101021695  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101017442  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101019580  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101015280  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101017325  DLG1; disks large homolog 1 isoform X23 [KO:K12076]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100137396  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101015667  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101010894  JUN; transcription factor AP-1 [KO:K04448]
100998570  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
101003909  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101003327  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
101015440  uncharacterized protein LOC101015440 [KO:K10785]
101006392  LOW QUALITY PROTEIN: uncharacterized protein LOC101006392 [KO:K10785]
101017443  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
101017085  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101017793  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
101023704  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101023349  GPS2; G protein pathway suppressor 2 isoform X4 [KO:K15307]
101014795  tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
116268823  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
116268824  tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
101002143  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
101010036  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
101024657  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101019033  RELB; transcription factor RelB isoform X1 [KO:K09253]
101020366  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X4 [KO:K04469]
101005944  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
101004576  IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068]
101006955  IL15; interleukin-15 isoform X2 [KO:K05433]
101003876  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
100381195  IL6; interleukin-6 precursor [KO:K05405]
100126743  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
101019436  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100998457  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
101022825  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101006627  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101009253  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100997116  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101016512  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101023107  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101004882  SMAD2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101019266  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100998237  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101006754  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101006469  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101021139  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101014828  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101008785  ADCY6; adenylate cyclase type 6 isoform X3 [KO:K08046] [EC:4.6.1.1]
101000833  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101007115  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
101004325  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101026251  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X15 [KO:K04345] [EC:2.7.11.11]
101026282  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101020553  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101018373  NFYB; nuclear transcription factor Y subunit beta isoform X3 [KO:K08065]
110743061  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
103883612  HLA class II histocompatibility antigen, DM alpha chain isoform X2 [KO:K06752]
101016766  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101017941  HLA class II histocompatibility antigen, DO alpha chain isoform X7 [KO:K06752]
101014430  HLA class II histocompatibility antigen, DRB1-15 beta chain isoform X1 [KO:K06752]
116268485  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101018551  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101000981  HLA class II histocompatibility antigen, DP beta 1 chain-like precursor [KO:K06752]
101018895  HLA class II histocompatibility antigen, DP alpha 1 chain precursor [KO:K06752]
101015448  SRF; serum response factor [KO:K04378]
101009700  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101021974  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101023581  SPI1; transcription factor PU.1 isoform X4 [KO:K09438]
101000568  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
100999646  ETS2; protein C-ets-2 [KO:K21932]
101018561  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
101006949  TBP; TATA-box-binding protein [KO:K03120]
101003400  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
101021141  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101019411  EGR1; early growth response protein 1 [KO:K09203]
101008571  FOSL1; fos-related antigen 1 [KO:K04502]
101021894  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
101017891  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101004296  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101020406  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101004434  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101008452  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101011350  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101013627  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101007514  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
101021603  CRTC1; CREB-regulated transcription coactivator 1 [KO:K15309]
101017183  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
101006421  CRTC3; CREB-regulated transcription coactivator 3 isoform X3 [KO:K16334]
101027061  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101002586  CREBBP; CREB-binding protein isoform X5 [KO:K04498] [EC:2.3.1.48]
101007062  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
101000225  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
110741428  TCF3; LOW QUALITY PROTEIN: transcription factor E2-alpha [KO:K09063]
101018348  POLB; DNA polymerase beta isoform X2 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
101006803  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
100998894  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101024790  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101008621  MSX2; homeobox protein MSX-2 [KO:K09341]
101003135  MSX1; homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
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Retrovirology 1:20 (2004)
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
panu03013  Nucleocytoplasmic transport
panu04010  MAPK signaling pathway
panu04064  NF-kappa B signaling pathway
panu04110  Cell cycle
panu04115  p53 signaling pathway
panu04151  PI3K-Akt signaling pathway
panu04210  Apoptosis
panu04350  TGF-beta signaling pathway
panu04612  Antigen processing and presentation
panu04660  T cell receptor signaling pathway
panu04668  TNF signaling pathway
KO pathway
ko05166   
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